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New Therapeutic Strategies in Low-grade Gliomas

New Therapeutic Strategies in Low-grade Gliomas
  • Author : Luc Taillandier,Laurent Capelle,Hugues Duffau
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :99
  • ISBN : 1600210643
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Summary : Low-grade glioma (LGG) (grade 2 or G2G) is a brain infiltrative neoplasia, often invading cortical and subcortical functional structures, while displaying as a rule a somewhat indolent course initially (no patent deficit). It affects essentially young, fully active patients, who usually present with seizures. However, these lesions progress relentlessly, and their final fate is anaplastic transformation, leading to neurological impairment and death, with an overall median survival of around 10 years since the onset of symptoms. Due to their apparent biological variability, commonly admitted spontaneous prognostic factors are of limited use if not questionable; consequently, the management of LGGs remains difficult to define (individually), and subject to controversies in the literature. However, most studies have evaluated the eventual impact of treatment(s) independently of the individual natural history and of the global therapeutic strategy. Thus, the goal of the present review is to give new insights regarding the different therapeutic strategies that need to be considered for each patient, and the parameters that can help the decision making. First, it is now possible to benefit from data allowing a better understanding of the natural history of a given LGG: (1) initial tumoral volume (2) tumoral growth rate evaluated on at least two MRIs (3) tumoral metabolic profile, using new radiological methods such as PET and SRM (4) tumoral molecular biology, completing the information provided by classical histopathology. Second, it is mandatory to perform a complete neurological examination, extensive neuropsychological assessment and evaluation of the quality of life from the time of diagnosis throughout the follow-up. Moreover, the analysis of the brain functional (re)organisation and connectivity is needed via the use of new neurofunctional imaging methods (PET, MEG, fMRI, DTI), in order to understand the individual mechanisms of functional compensation in reaction to the glioma growth -- explaining the frequent lack of deficit despite a classical invasion of so called "eloquent" areas. Third, the advantages and limits of each treatment have to be considered for each patient. In this way, the use of intraoperative electrical functional mapping as well as the integration, up to the operating room, of preoperative anatomo-functional data, has allowed the minimisation of the risk of postoperative sequelae, while improving the quality of tumor removal, even in eloquent regions. However, the actual long-term impact of surgery on survival still remains to ascertain. Concerning radiotherapy, the adaptation of doses, fractionation and volume of irradiation has enabled to decrease its risks, especially regarding cognitive functions. Nevertheless, despite an impact on the progression free survival, the effect on the overall survival is not proven. Finally, the recent use of new chemotherapeutic drugs has allowed a better tolerance and a frequent improvement of the quality of life via an impact on seizures, with a stabilisation or even partial regression of the LGG; however, the follow-up is still too short to conclude. On the basis of these (non exhaustive) parameters, we propose in the last part of this book to consider not "a standard treatment", but rather alternative "multiple dynamic therapeutic strategies" adapted to each patient, to be evaluated according to the clinico-radiological evolution of the LGG.

Gliomas

Gliomas
  • Author : Andreas Deimling
  • Publisher :Unknown
  • Release Date :2009-03-26
  • Total pages :259
  • ISBN : 9783540312062
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Summary : Gliomas, which comprise astrocytic, oligodendroglial, and ependymal lesions, are the most frequent primary intracranial tumors. This volume summarizes the enormous advances in our knowledge of gliomas that have occurred during recent years. The first part of the book focuses on the glial tumor entities, with detailed discussion of diagnosis, molecular genetics, and tumor origin. This section also contains a chapter on hereditary tumor syndromes associated with gliomas and the molecular mechanisms underlying these specific diseases. The second part is devoted to the clinical management of gliomas and provides insights into novel developments regarding neuroimaging, surgical management, radiation therapy, adjuvant therapy, experimental approaches, and the neurotoxicity of treatment. The final part of the book addresses angiogenesis and epigenetic regulation of gene expression in gliomas.

Malignant Gliomas: RMR V3 I2

Malignant Gliomas: RMR V3 I2
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-10-09
  • Total pages :252
  • ISBN : 9781617051487
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Summary : Radiation Medicine Rounds is a trinary, hard cover periodical designed to provide an up-to-date review of a dedicated radiation medicine topic of interest to clinicians and scientists who are involved in the care of patients receiving radiotherapy. It is intended to serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinicians, medical physicists, cancer biologists, radiobiologists, and interdisciplinary colleagues throughout the oncology spectrum. This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for malignant gliomas. The specialty of radiation therapy has increased in complexity over the years, yet as technology improves, the goal of improving outcomes while decreasing toxicity remains critical. Malignant gliomas remain among the most devastating of all malignancies, yet as conventional treatments (surgery, radiation, and chemotherapy) have become optimized overall survival has improved. The underlying molecular and genetic mechanisms of these tumors are becoming better understood, with one of the most important realizations being that histopathologically identical malignant gliomas often demonstrate very distinct clinical behaviors. Malignant Gliomas provides the practitioner with a current overview of best practices, recent research, and future directions in the management of this complex and challenging cancer.

Gliomas

Gliomas
  • Author : J. Hekmatpanah
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :166
  • ISBN : 9783642809163
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Summary : When I was asked by the Cancer Teaching Committee of the University of Chicago to set up a Symposium on Brain Tumors, I welcomed the opportunity to do so. But I felt that "Brain Tumors" was far too broad a subject to cover in a day and a half meeting. Furthermore, during the past decade, there have been a great many papers and symposiums on technical advancements in the treatment of benign brain tumors. On the other hand, while gliomas make up somewhere around 50% of all brain tumors, there have certainly been far fewer communications about them. For this reason I thought that it would be highly valuable to invite some of the leading investigators to share with us their experience with gliomas. The hope was to learn the current concepts about these tumors biologically and therapeutically, specifically to find out what we are doing and where we are going in these respects. Naturally all aspects could not be covered. Nevertheless, it was a widely expressed opinion by the speakers that they too learned while they came to teach. It is therefore hoped that the publication of their works and ideas through this mono graph will also be useful for the reader. Most of the manu scripts were handed in at the time of the Symposium, and a few were sent later. Except for minor editorial changes the words are entirely those of the speakers and authors.

Diffuse Low-Grade Gliomas in Adults

Diffuse Low-Grade Gliomas in Adults
  • Author : Hugues Duffau
  • Publisher :Unknown
  • Release Date :2017-06-21
  • Total pages :790
  • ISBN : 9783319554662
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Summary : The second edition of this well-received volume has been revised and updated to reflect the advances in pathological classification and molecular epidemiology of diffuse low-grade gliomas (DLGG) in adults and offers an updated review on individualized therapies. This book presents the latest research pertaining to the diagnosis, genetics, therapy and management of DLGGs. It extensively covers recent research on the natural history of DLGGs and their interaction with the brain and reviews the new diagnostic and therapeutic strategies which increase survival and quality of life of the patient. New topics covered are the management of DLGGs during pregnancy, functional rehabilitation of patients with DLGG and the onco-functional balance in DLGG, among others. The reader will have the opportunity to gain insight in both clinical and basic science aspects of this type of tumor and learn about the application of novel imaging techniques such as diffussion tensor imaging. Edited by a leading expert in the field and authored by a team of recognised specialists, this book is a valuable resource for medical oncologists, neuro-oncologists and neurologists.

Intracranial Gliomas Part I - Surgery

Intracranial Gliomas Part I - Surgery
  • Author : M.F. Chernov,Y. Muragaki,S. Kesari,I.E. McCutcheon
  • Publisher :Unknown
  • Release Date :2017-12-14
  • Total pages :252
  • ISBN : 9783318060577
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Summary : Aggressive surgical removal is generally considered the main initial management option for most intracranial gliomas. It often results in resolution or alleviation of neurological symptoms and signs, normalizes intracranial pressure, facilitates characterization of the neoplasm, creates optimal conditions for adjuvant therapy and neurorehabilitation, and leads to prolongation of progression-free and overall survival of patients. Leading experts in neurosurgical oncology have contributed to this volume, highlighting modern principles of surgery for both newly-diagnosed and recurrent intracranial gliomas in adult as well as pediatric patients. The first of a three-volume set, it details epidemiological aspects, defines the importance of preoperative imaging, and describes current perioperative adjuvant needs. In addition, contemporary methods of intraoperative neurophysiological monitoring, the value of brain mapping for functional preservation, tips to prevent complications, and postoperative results are presented and discussed. This book and its accompanying volumes are mainly directed at neurosurgeons, neuro-oncologists and other clinicians treating patients with brain tumors.

Gliomas: New Insights for the Healthcare Professional: 2011 Edition

Gliomas: New Insights for the Healthcare Professional: 2011 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :175
  • ISBN : 9781464901416
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Summary : Gliomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Gliomas. The editors have built Gliomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Gliomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gliomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Avastin and Malignant Gliomas

Avastin and Malignant Gliomas
  • Author : Thomas C. Chen,Marc C. Chamberlain
  • Publisher :Unknown
  • Release Date :2010-12-28
  • Total pages :195
  • ISBN : 1608051323
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Summary : "Neuro-oncology is an embryonic field of cancer research with a number of clinical trials in progress. However, the prognosis on neuro-oncologic patients has remained poor. Moreover, several small scale phase I/II trials performed have proved to be inconcl"

High-Grade Gliomas

High-Grade Gliomas
  • Author : Gene H. Barnett
  • Publisher :Unknown
  • Release Date :2007-11-21
  • Total pages :495
  • ISBN : 9781597451857
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Summary : This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such “breakthrough” in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).

Current Understanding and Treatment of Gliomas

Current Understanding and Treatment of Gliomas
  • Author : Jeffrey Raizer,Andrew Parsa
  • Publisher :Unknown
  • Release Date :2014-12-02
  • Total pages :184
  • ISBN : 9783319120485
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Summary : This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.

Gliomas: New Insights for the Healthcare Professional: 2013 Edition

Gliomas: New Insights for the Healthcare Professional: 2013 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2013-07-22
  • Total pages :404
  • ISBN : 9781481658997
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Summary : Gliomas: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Gliomas: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gliomas: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Imaging Gliomas After Treatment

Imaging Gliomas After Treatment
  • Author : Tommaso Scarabino
  • Publisher :Unknown
  • Release Date :2012-03-12
  • Total pages :201
  • ISBN : 9788847023703
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Summary : This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy, and chemotherapy. Normal and pathological findings are displayed in detailed MR images that illustrate the potential modifications due to treatment. Particular emphasis is placed on characteristic appearances on the newer functional MR imaging techniques, including MR spectroscopy, diffusion-weighted imaging, and perfusion imaging. These techniques are revolutionizing neuroradiology by going beyond the demonstration of macroscopic alterations to the depiction of preceding metabolic changes at the cellular and subcellular level, thereby allowing earlier and more specific diagnosis. A key section comprising some 40 clinical cases and more than 500 illustrations offers an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, radiotherapists, and medical oncologists.

Local Therapies for Glioma

Local Therapies for Glioma
  • Author : M. Westphal,J.-C. Tonn,Z. Ram
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :186
  • ISBN : 9783709160909
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Summary : In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.

Gliomas

Gliomas
  • Author : David Cory Adamson
  • Publisher :Unknown
  • Release Date :2014-01-01
  • Total pages :294
  • ISBN : 1631178687
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Summary : Gliomas represent some of the most difficult tumors to understand and most challenging to treat. As illustrated in this book, the difficulty in understanding them is apparent in various ways. They have significant diversity in histology, genomic alternations, protein expression, clinical presentation, radiographic appearance, treatment approaches, and ideas of how to cure them. Our current understanding of the genetic mutations and signaling pathways that drive these tumors has greatly expanded our knowledge and at the same time, our uncertainty about how to combat these tumors. Added to this complexity is the fact that we are typically talking about tumors that infiltrate through an organ that many of us consider the "seat of our souls," where we must exercise the utmost caution in how we deliver treatments with great risks. This book begins with an introduction to this complex topic with a broad overview of grading criteria, histological features, common genomic alterations and affected signaling pathways, and current treatments. Most exciting is an extensive discussion on new therapeutic concepts and delivering mechanisms that arise from the complex field of nanotechnology where nanoparticles, nanotubes, and nanocrystals may someday become the Trojan horse.

Modern Management of High Grade Glioma, Part I, An Issue of Neurosurgery Clinics - E-Book

Modern Management of High Grade Glioma, Part I, An Issue of Neurosurgery Clinics - E-Book
  • Author : Isaac Yang,Seunggu J. Han
  • Publisher :Unknown
  • Release Date :2012-04-28
  • Total pages :174
  • ISBN : 9781455744183
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Summary : Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts to highlight the latest updates on various forms of management of high grade glioma. Some of the articles included in this issue focus on Extent of Resection for Glioblastoma; Role of adjuvant radiation therapy; Survival benefit of the Temozolomide protocol; Alternative chemotherapeutic agents; The role of avastin; Radiology; Pseuodprogression and Treatment effect; Pathology; Medical Management; Management of insular gliomas; Use of motor mapping; GBM treatment with clinical trials for surgical resection; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Future role of CED for GBM treatment; Application of a vault nanoparticle therapy for GBM therapy; Management of high grade gliomas in pediatric populations; Targeting Glioma Stem Like Cells with a focus on CD 133; and Potential Role for STAT3 inhibitors in glioblastoma.

Modern Management of High Grade Glioma, Part II, An Issue of Neurosurgery Clinics - E-Book

Modern Management of High Grade Glioma, Part II, An Issue of Neurosurgery Clinics - E-Book
  • Author : Isaac Yang,Seunggu J. Han
  • Publisher :Unknown
  • Release Date :2012-07-15
  • Total pages :240
  • ISBN : 9781455747689
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Summary : Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

The Glioma Book

The Glioma Book
  • Author : Michael E. Sughrue
  • Publisher :Unknown
  • Release Date :2019-10-25
  • Total pages :350
  • ISBN : 9781626234451
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Summary : A unique resource on glioma leverages advances and firsthand insights to enact meaningful change Glioblastoma (GBM) or glioma is an extremely aggressive and malignant brain tumor, with cell infiltration, rapid invasion, and a high frequency of relapse. The Glioma Book by neurosurgeon Michael Sughrue is a highly personal book — a culmination of two years of writing and more than 1,000 surgeries. It presents a unique viewpoint with the potential to transform the traditional paradigm that too often informs treatment of this universally fatal brain tumor. The book reinterprets the role of the cerebrum and sub-cortex, leverages scientific advances to improve cytoreduction and reduce neurological deficits, and challenges the myth of the "inoperable" glioma. This is the first step-by-step technical guide focused on aggressively resecting different types of gliomas. The book is logically organized, starting with a foundation of fundamental knowledge, then progressing to practical applications. Chapters focus on the skills necessary to perform glioma surgery, specific techniques, and systematic approaches to gliomas in different brain regions. Numerous case examples illuminate concepts introduced earlier in the book and explain how to perform these procedures About 30 high quality videos posted online provide insightful procedural guidance The role of connectomic imaging in visualizing the cerebrum, and other innovative techniques including awake brain mapping and diffusion tensor tractography Neurosurgeons who embrace the concepts in this book will realize they can change the glioma treatment paradigm. Continually improving techniques and viewing a glioma diagnosis as a battle for a patient's life, rather than an exercise in inevitable failure can impart progress in treating this devastating disease.

Cerebral Gliomas

Cerebral Gliomas
  • Author : Giovanni Broggi,M. A. Gerosa
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :260
  • ISBN : UOM:39015014485976
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Summary :

The Gliomas

The Gliomas
  • Author : Mitchel S. Berger,Charles B. Wilson
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :796
  • ISBN : 0721648258
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Summary : Provides up-to-date information on the variety of complex, diagnostic and therapeutic modalities available to neurosurgeons and oncologists today! Topics include epidemiology, pathology, preoperative management, neuroanesthesia, biopsy methods, intraoperative tumor localization, ICU care, pain management, chemotherapy, immunotherapy, and more.

MicroRNA in Human Gliomas

MicroRNA in Human Gliomas
  • Author : Alfredo Conti
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :229
  • ISBN : OCLC:1154230165
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Summary : MicroRNA in Human Gliomas.

Gene Expression Profiling of Gliomas

Gene Expression Profiling of Gliomas
  • Author : William Alexander Freije
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :310
  • ISBN : UCLA:L0091234013
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Summary :