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Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
  • Author : Bimal K. Banik
  • Publisher :Unknown
  • Release Date :2020-04
  • Total pages :610
  • ISBN : 9780128175927
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Summary : Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

Contemporary Chemical Approaches for Green and Sustainable Drugs

Contemporary Chemical Approaches for Green and Sustainable Drugs
  • Author : Marianna Torok
  • Publisher :Unknown
  • Release Date :2021-07-15
  • Total pages :500
  • ISBN : 0128222484
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Summary : The design, discovery, development and use of medicinal agents produces a whole range of environmental contaminants which have a damaging ecological impact. By acknowledging and addressing these issues, chemists can take preventative steps at multiple stages in the process, from using computational models and selecting green solvents, to designing for degradation and creating new remediation tools. Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate such sustainable approaches into their work. After an introduction to the major focus areas in the field, the book includes four parts, each dealing with different aspects of green and sustainable drug development from design to disposal. These include computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, Contemporary Chemical Approaches for Green and Sustainable Drugs provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs, making it a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practise through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science
  • Author : Inamuddin,Rajender Boddula,Mohammed Muzibur Rahman,Abdullah M. Asiri
  • Publisher :Unknown
  • Release Date :2021-03-18
  • Total pages :453
  • ISBN : 9780128225561
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Summary : Green Sustainable Process for Chemical and Environmental Engineering and Science: Solid State Synthetic Methods cover recent advances made in the field of solid-state materials synthesis and its various applications. The book provides a brief introduction to the topic and the fundamental principles governing the various methods. Sustainable techniques and green processes development in solid-state chemistry are also highlighted. This book also provides a comprehensive literature on the industrial application using solid-state materials and solid-state devices. Overall, this book is intended to explore green solid-state techniques, eco-friendly materials involved in organic synthesis and real-time applications. Provides a broad overview of solid-state chemistry Outlines an eco-friendly solid-state synthesis of modern nanomaterials, organometallic, coordination compounds and pure organic Gives a detailed account of solid-state chemistry, fundamentals, concepts, techniques and applications Deliberates cutting-edge recent advances in industrial technologies involved in energy, environmental, medicinal and organic chemistry fields

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2014-11-17
  • Total pages :632
  • ISBN : 9780128005903
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Summary : Green Synthetic Approaches for Biologically Relevant Heterocycles reviews this significant group of organic compounds within the context of sustainable methods and processes. Each clearly structured chapter features in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles classified on the basis of ring-size and/or presence of heteratoms(s). Techniques covered include microwave heating, ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous catalysis, and aqueous media, along with multi-component reaction strategies. This book also integrates advances in green chemistry research into industrial applications and process developments. Green Synthetic Approaches for Biologically Relevant Heterocycles is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in medicinal, organic, natural product, and agricultural chemistry. Includes global coverage of a wide variety of green synthetic techniques Features cutting-edge research in the field of bioactive heterocyclic compounds Focuses extensively on applications, with numerous examples of biologically relevant heterocycles

Green Chemistry

Green Chemistry
  • Author : Hosam El-Din M. Saleh,Martin Koller
  • Publisher :Unknown
  • Release Date :2018-02-28
  • Total pages :190
  • ISBN : 9789535138471
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Summary : To an increasing extent, "green chemistry" is a new chemical and engineering approach of chemistry and engineering, dedicated to make manufacturing processes and our world as a whole more sustainable world with a growing tendency. "Green chemistry" approaches are based on ecofriendly technologies, aiming to reduce or eliminate the use of solvents, or render them efficient and safer. Moreover, this scientific field is devoted to reduction or elimination of prevailing environmental and health threats, which typically accompany chemical products and traditional processes. The present book "Green Chemistry" contains 9 selected chapters, starting with a general introductory chapter on "green chemistry," and covers many recent applications and developments based on the principles of "green chemistry." This book is considered the appropriate way to communicate the advances in green materials and their applications to the scientific community. Chemists, scientists and researchers from related areas, and undergraduates involved in environmental issues and interested in approaches to improve the quality of life could find an inspiring and effective guide by reading this book.

Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis

Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2019-09-06
  • Total pages :188
  • ISBN : 9780128175576
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Summary : Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated. Provides an overview of the status of some of the current novel compounds in development as well as new emerging treatment options targeting novel mechanisms of action Identification of hits from phenotypic whole cell screening, followed by target identification Strategies aimed at improving the efficacy of existing clinically used anti-TB drugs by taking advantage inhibitors of mycobacterial transcriptional regulators to boost the anti-tubercular activity, and circumvent acquired-resistance

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2019-04-15
  • Total pages :458
  • ISBN : 9780128157244
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Summary : Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Green and Sustainable Pharmacy

Green and Sustainable Pharmacy
  • Author : Klaus Kümmerer,Maximilian Hempel
  • Publisher :Unknown
  • Release Date :2010-06-16
  • Total pages :313
  • ISBN : 9783642051999
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Summary : Within recent years pharmaceuticals have come into focus as contaminants of the environment (see for example Kümmerer, K. editor: Pharmaceuticals in the Environment). At the same time the issue of sustainable chemistry gained momentum. Bringing both together would result in sustainable pharmacy. Sustainable pharmacy is a totally new issue and approach. It addresses environmental, economical and social aspects of pharmacy. In the present stage the focus will be on environmental issues along the whole lifecycle of a pharmaceutical entity. That is dealing with resources and energy input but also with waste issues for example during the synthesis and production of an active pharmaceutical ingredient. Furthermore, it would also look on the compounds themselves and will aim to improve the degradability of the compounds after their use in the environment to reduce the environmental risk caused by pharmaceuticals in the environment. Another issue is the people using pharmaceuticals such as pharmacists, medical doctors and patients. How can they contribute to more efficient use of pharmaceuticals with less environmental burden and less risk for drinking water. The book "Sustainable Pharmacy" will address all these issues and will be the first one dealing with this important topic.

Green and Sustainable Medicinal Chemistry

Green and Sustainable Medicinal Chemistry
  • Author : Louise Summerton,Helen F Sneddon,Leonie C Jones,James H Clark
  • Publisher :Unknown
  • Release Date :2016-03-08
  • Total pages :272
  • ISBN : 9781782625940
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Summary : Pharmaceutical manufacturing was one of the first industries to recognize the importance of green chemistry, with pioneering work including green chemistry metrics and alternative solvents and reagents. Today, other topical factors also have to be taken into consideration, such as rapidly depleting resources, high energy costs and new legislation. This book addresses current challenges in modern green chemical technologies and sustainability thinking. It encompasses a broad range of topics covered by the CHEM21 project – Europe’s largest public-private partnership project which aims to develop a toolbox of sustainable technologies for green chemical intermediate manufacture. Divided into two sections, the book first gives an overview of the key green chemistry tools, guidance and considerations aimed at developing greener processes, before moving on to look at cutting-edge synthetic methodologies. Featuring innovative research, this book is an invaluable reference for chemists across academia and industry wanting to further their knowledge and understanding of this important topic.

Process Selection

Process Selection
  • Author : K. G. Swift,J. D. Booker
  • Publisher :Unknown
  • Release Date :2003-06-02
  • Total pages :336
  • ISBN : 0080474004
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Summary : The definitive practical guide to choosing the optimum manufacturing process, written for students and engineers. Process Selection provides engineers with the essential technological and economic data to guide the selection of manufacturing processes. This fully revised second edition covers a wide range of important manufacturing processes and will ensure design decisions are made to achieve optimal cost and quality objectives. Expanded and updated to include contemporary manufacturing, fabrication and assembly technologies, the book puts process selection and costing into the context of modern product development and manufacturing, based on parameters such as materials requirements, design considerations, quality and economic factors. Key features of the book include: manufacturing process information maps (PRIMAs) provide detailed information on the characteristics and capabilities of 65 processes and their variants in a standard format; process capability charts detailing the processing tolerance ranges for key material types; strategies to facilitate process selection; detailed methods for estimating costs, both at the component and assemby level. The approach enables an engineer to understand the consequences of design decisions on the technological and economic aspects of component manufacturing, fabrication and assembly. This comprehensive book provides both a definitive guide to the subject for students and an invaluable source of reference for practising engineers. * manufacturing process information maps (PRIMAs) provide detailed information on the characteristics and capabilities of 65 processes in a standard format * process capability charts detail the processing tolerance ranges for key material types * detailed methods for estimating costs, both at the component and assembly level

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry
  • Author : Peter J. Dunn,Andrew Wells,Michael T. Williams
  • Publisher :Unknown
  • Release Date :2010-02-02
  • Total pages :388
  • ISBN : 3527629696
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Summary : Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Asperger Syndrome, the Universe and Everything

Asperger Syndrome, the Universe and Everything
  • Author : Kenneth Hall
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :109
  • ISBN : 1853029300
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Summary : Kenneth Hall was diagnosed with Asperger's Syndrome at the age of eight. Here he describes some of the inner experiences and perceptions of autism in childhood. He has a warm and positive attitude which other children will find inspiring. Insights, struggles and joys are recounted vividly in a frank and humorous way.

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis
  • Author : Inamuddin,Abdullah M. Asiri
  • Publisher :Unknown
  • Release Date :2020-07-02
  • Total pages :499
  • ISBN : 9783030441760
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Summary : Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Citrus

Citrus
  • Author : Pierre Laszlo
  • Publisher :Unknown
  • Release Date :2008-10
  • Total pages :252
  • ISBN : 9780226470283
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Summary : Laszlo traces the spectacular rise and spread of citrus across the globe, from southeast Asia in 4000 BC to modern Spain and Portugal, whose explorers inroduced the fruit to the Americas. This book explores the numerous roles that citrus has played in agriculture, horticulture, cooking, nutrition, religion, and art.

Chimie Pure Et Appliquée

Chimie Pure Et Appliquée
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :229
  • ISBN : UCSB:31205039622186
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Summary :

Seeking Spatial Justice

Seeking Spatial Justice
  • Author : Edward W. Soja
  • Publisher :Unknown
  • Release Date :2013-11-30
  • Total pages :280
  • ISBN : 1452915288
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Summary : In 1996, the Los Angeles Bus Riders Union, a grassroots advocacy organization, won a historic legal victory against the city’s Metropolitan Transit Authority. The resulting consent decree forced the MTA for a period of ten years to essentially reorient the mass transit system to better serve the city’s poorest residents. A stunning reversal of conventional governance and planning in urban America, which almost always favors wealthier residents, this decision is also, for renowned urban theorist Edward W. Soja, a concrete example of spatial justice in action. In Seeking Spatial Justice, Soja argues that justice has a geography and that the equitable distribution of resources, services, and access is a basic human right. Building on current concerns in critical geography and the new spatial consciousness, Soja interweaves theory and practice, offering new ways of understanding and changing the unjust geographies in which we live. After tracing the evolution of spatial justice and the closely related notion of the right to the city in the influential work of Henri Lefebvre, David Harvey, and others, he demonstrates how these ideas are now being applied through a series of case studies in Los Angeles, the city at the forefront of this movement. Soja focuses on such innovative labor–community coalitions as Justice for Janitors, the Los Angeles Alliance for a New Economy, and the Right to the City Alliance; on struggles for rent control and environmental justice; and on the role that faculty and students in the UCLA Department of Urban Planning have played in both developing the theory of spatial justice and putting it into practice. Effectively locating spatial justice as a theoretical concept, a mode of empirical analysis, and a strategy for social and political action, this book makes a significant contribution to the contemporary debates about justice, space, and the city.

Green Metrics

Green Metrics
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-02-01
  • Total pages :400
  • ISBN : 9783527695270
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Summary : Volume 11 of the Handbook of Green Chemistry series identifies, explains and expands on green chemistry and engineering metrics, describing how the two work together, backed by numerous practical applications. Up-to-date and authoritative, this ready reference covers the development and application of sustainable chemistry along with engineering metrics in both academia and industry, providing the latest information on fundamental aspects of metrics, practical realizations and example case studies. Additionally, it outlines how metrics have been used to facilitate developments in sustainable and green chemistry. The different concepts of and approaches to metrics are applied to fundamental problems in chemistry and the focus is firmly placed on their use to promote the development and implementation of more sustainable and green chemistry and technology in the production of chemicals and related products. Starting with molecular design, followed by chemical route evaluation, chemical process metrics and product assessment, by the end readers will have a complete set of metrics to choose from as they move a chemical conception to final product. Of high interest to academics and chemists working in industry.

The Courage to Teach

The Courage to Teach
  • Author : Parker J. Palmer
  • Publisher :Unknown
  • Release Date :2009-05-18
  • Total pages :224
  • ISBN : 9780470469279
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Summary : "This book is for teachers who have good days and bad -- and whose bad days bring the suffering that comes only from something one loves. It is for teachers who refuse to harden their hearts, because they love learners, learning, and the teaching life." - Parker J. Palmer [from the Introduction] Teachers choose their vocation for reasons of the heart, because they care deeply about their students and about their subject. But the demands of teaching cause too many educators to lose heart. Is it possible to take heart in teaching once more so that we can continue to do what good teachers always do -- give heart to our students? In The Courage to Teach, Parker Palmer takes teachers on an inner journey toward reconnecting with their vocation and their students -- and recovering their passion for one of the most difficult and important of human endeavors.

Financialization and Strategy

Financialization and Strategy
  • Author : Julie Froud,Sukhdev Johal,Adam Leaver,Karel Williams
  • Publisher :Unknown
  • Release Date :2006-04-18
  • Total pages :416
  • ISBN : 9781134314546
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Summary : Considering the recent impact of the capital market on corporate strategy, this text analyzes, through argument and supportive case studies, how pressures from the capital bull market of the 1990s and bear market of the early 2000s, have reshaped management action and calculation in large, publicly quoted US and UK corporations. Beginning with the dissatisfaction with classical strategy and its limited engagement with the processes of financialization, the book moves on to cover three detailed company case studies (General Electric, Ford and GlaxoSmithKline) which use long run financial data and analysis of company and industry narratives to illustrate and explore key themes. The book emphasizes the importance of company and industry narrative, while also analyzing long term financial results, and helps to explain the limits of management action and the burden of expectations placed on corporate governance. Presenting financial and market information on trajectory in an accessible way, this book provides a distinctive, critical social science account of management in large UK and US corporations, and it is a valuable resource for students, scholars and researchers of business, management, political economy and non-mainstream economics. short listed for the 2007 IPEG Book Prize

Public Relations Ethics and Professionalism

Public Relations Ethics and Professionalism
  • Author : Johanna Fawkes
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :244
  • ISBN : 9781136223747
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Summary : Do professions really place duty to society above clients' or their own interests? If not, how can they be trusted? While some public relations (PR) scholars claim that PR serves society and enhances the democratic process, others suggest that it is little more than propaganda, serving the interests of global corporations. This is not an argument about definitions, but about ethics - yet this topic is barely explored in texts and theories that seek to explain PR and its function in society. This book places PR ethics in the wider context of professional ethics and the sociology of professions. By bringing together literature from fields beyond public relations - sociology, professional and philosophical ethics, and Jungian psychology - it integrates a new body of ideas into the debate. The unprecedented introduction of Jungian psychology to public relations scholarship shifts the debate beyond a traditional Western 'Good/Bad' ethical dichotomy towards a new holistic approach, with dynamic implications for theory and practice. This thought-provoking book will be essential reading for students, academics and professionals with an interest in public relations, ethics and professionalism.

Drug Design

Drug Design
  • Author : Gerhard Klebe
  • Publisher :Unknown
  • Release Date :2013-07-10
  • Total pages :901
  • ISBN : 3642179061
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Summary : Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.