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Handbook of Microdialysis

Handbook of Microdialysis
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007-02-02
  • Total pages :712
  • ISBN : 9780080469669
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Summary : Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience. * Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods * Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology * Includes clinical applications of microdialysis

Handbook of Microdialysis

Handbook of Microdialysis
  • Author : B. H. C. Westerink,Thomas Ivo Franciscus Hubert Cremers
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :697
  • ISBN : 9780444522764
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Summary : Contributions are: 'Interpretation and Significance', 'Methods', 'Analytical Chemical Aspects of Microdialysis', 'Microdialysis and the Study of Behaviour', 'CNS Pathology Models', 'Role of Microdialysis in Drug Development' and 'Clinical Applications'.

Handbook of Non-Invasive Methods and the Skin, Second Edition

Handbook of Non-Invasive Methods and the Skin, Second Edition
  • Author : Jorgen Serup,Gregor B. E. Jemec,Gary L. Grove
  • Publisher :Unknown
  • Release Date :2006-02-23
  • Total pages :1056
  • ISBN : 9781420003307
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Summary : Firmly established as the leading international reference in this field, Non-Invasive Methods and the Skin broke new ground with its comprehensive coverage of methods used in both clinical and experimental dermatology. Completely revised and updated, containing more than twice as much information, the Second Edition continues the tradition. The authors' thorough research and clear organization make this book a baseline reference for those using noninvasive biophysical methods to study the skin. Arranged by physical modality and structured to provide educational and practical information, the second edition, like its predecessor, will prove to be of value to young researchers and senior scientists alike. The coverage of major evaluation and measurement methods share a consistent format, including scope, sources of error, application, and validity. This edition incorporates 69 revised chapters with more than 90 new chapters covering topics such as computer technique, imaging techniques, skin friction, barrier functions, and more. New chapters provide coverage of: computers, computer techniques, and image analysis imaging techniques, including clinical photography legal situations and guidelines behind instrumental use skin friction barrier functions important new techniques such as in vitro confocal microscopy, OCT, and Raman spectroscopy veterinary/animal research use of methods The truly interdisciplinary, international panel of contributors includes experts from the specialties of dermatology, bioengineering, pathology, manufacturing engineering, medical physics, pharmacology, microbiology, neurology, surgery, obstetrics and gynecology, cardiovascular research, and pharmacy from academic institutions and hospitals in countries such as Denmark, Germany, the United Kingdom, the United States, Japan, Israel, Taiwan, and Singapore. The revision is extensive and covers a broad spectrum of methods while providing the same caliber of authoritative information that made the previous edition so popular. Application oriented, practical, and instructive, this Second Edition will meet the needs of the researchers today, and in years to come.

Chemical Analysis

Chemical Analysis
  • Author : David D. Cunningham,Julie A. Stenken
  • Publisher :Unknown
  • Release Date :1941
  • Total pages :450
  • ISBN : CHI:092101800
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Summary :

Handbook of Clinical Automation, Robotics, and Optimization

Handbook of Clinical Automation, Robotics, and Optimization
  • Author : Gerald J. Kost,Judith Welsh (R.N.)
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :952
  • ISBN : UOM:39015038159078
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Summary : This comprehensive landmark book describes the technology of the future in diagnostic medicine, how to integrate it into the modern hospital and how to work with people to adapt, change and plan for a smooth transition to a fully robotic laboratory. Features an extensive section on point-of-care testing along with a modern perspective of how this will transform medicine. Global experts in their fields have authored all chapters which include a unique one on machine vision and another (with several plates) that discusses the automation of a clinical laboratory in Japan.

Handbook of Neurosurgery

Handbook of Neurosurgery
  • Author : Mark S. Greenberg
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :1337
  • ISBN : 1604063262
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Summary : The seventh edition of Dr. Greenbergs classic text covers the breadth of neurosurgery and its allied specialties and provides the latest information on anatomy and physiology, differential diagnosis, and currently accepted principles of clinical management

Applications of Microdialysis in Pharmaceutical Science

Applications of Microdialysis in Pharmaceutical Science
  • Author : Tung-Hu Tsai
  • Publisher :Unknown
  • Release Date :2011-07-13
  • Total pages :584
  • ISBN : 1118011287
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Summary : Discover new and emerging applications for microdialysis in drug evaluation Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research. Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include: Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases Continuous measurement of glucose concentrations in diabetics Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.

Coupling in Vivo Microdialysis Sampling to Mass Spectrometry to Detect Neuropeptides in a Decapod Crustacean

Coupling in Vivo Microdialysis Sampling to Mass Spectrometry to Detect Neuropeptides in a Decapod Crustacean
  • Author : Heidi Leigh Behrens
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :116
  • ISBN : WISC:89100582519
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Summary :

Neurotransmitters and Neuromodulators

Neurotransmitters and Neuromodulators
  • Author : Oliver von Bohlen und Halbach,Rolf Dermietzel
  • Publisher :Unknown
  • Release Date :2006-12-13
  • Total pages :402
  • ISBN : 9783527609079
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Summary : A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

The Protein Protocols Handbook

The Protein Protocols Handbook
  • Author : John M. Walker
  • Publisher :Unknown
  • Release Date :2009-10-07
  • Total pages :1991
  • ISBN : STANFORD:36105215315776
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Summary : The third edition of The Protein Protocols Handbook introduces 57 critically important new chapters, and significantly updates the previous edition's tried-and-trusted methods. The book offers over 200 key, readily reproducible protocols that ensure results.

Handbook of Sample Preparation

Handbook of Sample Preparation
  • Author : Janusz Pawliszyn,Heather L. Lord
  • Publisher :Unknown
  • Release Date :2011-03-17
  • Total pages :480
  • ISBN : 0813823625
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Summary : Discover new keys to solving analytical problems using the Latest sample preparation methods Commonly viewed of as a routine task rather than as an integral component in the analytical process, sample preparation has long been undervalued as a science and underdeveloped as a technology. In an effort to reverse this trend, Handbook of Sample Preparation shows why sample preparation deserves closer scientific scrutiny, and makes a compelling case for colleges and professional laboratories to devote more resources to promote the benefits of its correct application. Handbook of Sample Preparation includes: A solid overview of standard sampling methodologies and their analytical capabilities An introduction of non-traditional sampling technologies, which address the need for solvent-free alternatives, automation, and miniaturization A discussion of the analytical shift toward performing sampling on-site, rather than in the laboratory An examination of various extraction technologies and their applications for different types of matrices A look at how to take advantage of new sampling strategies to streamline laboratory procedures, reduce research costs, and increase overall productivity An excellent primer on the fundamentals of extraction as well as a sound guide on the latest technological upgrades influencing current sampling techniques, this versatile text serves as an important and accessible tool for both students and seasoned practitioners as they seek new avenues for improving the accuracy of their analyses.

Stevens' Handbook of Experimental Psychology, Perception and Motivation

Stevens' Handbook of Experimental Psychology, Perception and Motivation
  • Author : Richard C. Atkinson,Richard J. Herrnstein,Gardner Lindzey,R. Duncan Luce
  • Publisher :Unknown
  • Release Date :1988-06-21
  • Total pages :928
  • ISBN : 047104203X
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Summary : This is a new edition of the established reference and graduate text on experimental psychology. Widely used for over 25 years, this edition has been completely updated and expanded into two volumes; contributors to these works are among the most highly renowned professionals in the field. Volume 1 includes coverage of the physics and retinal physiology of vision; the nature of auditory perception, speech, and emotional patterns; and the latest theories and findings in the area of behavioral genetics. Volume 2 includes studies exploring such topics as the psychobiology of learning and memory; the influences of choice and reinforcement in human behavior; psycholinguistics; individual variations in cognitive functioning, and much more.

Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research
  • Author : Steven L. Peterson,Timothy E. Albertson
  • Publisher :Unknown
  • Release Date :2019-05-07
  • Total pages :272
  • ISBN : 9781420048889
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Summary : There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

The British National Bibliography

The British National Bibliography
  • Author : Arthur James Wells
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : UOM:39015066381453
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Summary :

Handbook of Physiology

Handbook of Physiology
  • Author : American Physiological Society (1887- )
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :229
  • ISBN : UCLA:L0063536387
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Summary :

Handbook of Pharmaceutical Biotechnology

Handbook of Pharmaceutical Biotechnology
  • Author : Shayne C. Gad
  • Publisher :Unknown
  • Release Date :2007-06-11
  • Total pages :1659
  • ISBN : UOM:39015064951935
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Summary : Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Handbook of HPLC

Handbook of HPLC
  • Author : Danilo Corradini
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :715
  • ISBN : 9781420016949
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Summary : High performance liquid chromatography (HPLC) is one of the most widespread analytical and preparative scale separation techniques used for both scientific investigations and industrial and biomedical analysis. Now in its second edition, this revised and updated version of the Handbook of HPLC examines the new advances made in this field since the

Microdialysis in the Neurosciences

Microdialysis in the Neurosciences
  • Author : T.E. Robinson,J.B. Justice
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :476
  • ISBN : 9781483164656
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Summary : Techniques in the Behavioral and Neural Sciences, Volume 7: Microdialysis in the Neurosciences focuses on the neurochemical methods employed in behavioral and neural sciences. The selection first elaborates on the introduction to intracerebral microdialysis, quantitative microdialysis, and microdialysis compared with other in vivo release models. Discussions focus on computational methods, post-mortem tissue analysis, perfusion methods, and features, development, and future applications of microdialysis. The text then takes a look at the practical aspects of using microdialysis for determination of brain interstitial concentrations and microdialysis and liquid chromatography. The publication examines the procedures for microdialysis with smallbore HPLC, use of microdialysis in pharmacokinetics and pharmacodynamics, and brain dialysis of monoamines. Topics include significance of monoamine concentrations in dialysates; criteria for brain dialysis of monoamines; distribution of drugs to the interstitium of various tissues; methods to measure the extracellular concentration by microdialysis; and application to studies on drug abuse. The manuscript then elaborates on the feasibility of repeated microdialysis for within-subjects design experiments and microdialysis and automated on-line analysis approach to study central cholinergic transmission in vivo. The text is a dependable reference for readers interested in the use of microdialysis in neurosciences.

Handbook of Neuropsychology: pt. 1. Child neuropsychology

Handbook of Neuropsychology: pt. 1. Child neuropsychology
  • Author : Fran├žois Boller,Jordan Grafman
  • Publisher :Unknown
  • Release Date :2001-12-01
  • Total pages :477
  • ISBN : CHI:63548527
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Summary :

Comprehensive Handbook of Alcohol Related Pathology

Comprehensive Handbook of Alcohol Related Pathology
  • Author : Victor R. Preedy,Ronald Ross Watson
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :1670
  • ISBN : UOM:39015060540484
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Summary : This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.*Over 100 chapters conveniently divided into 3 sections*Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes*Each chapter is highly illustrated with tables as well as figures

Danish Medical Bulletin

Danish Medical Bulletin
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :229
  • ISBN : NWU:35558004514911
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Summary :