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History of Toxicology and Environmental Health

History of Toxicology and Environmental Health
  • Author : Philip Wexler
  • Publisher :Unknown
  • Release Date :2014-05-22
  • Total pages :154
  • ISBN : 9780128004630
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Summary : Toxicology in Antiquity is the first in a series of short format works covering key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents. Provides the historical background for understanding modern toxicology Illustrates the ways ancient civilizations learned to distinguish safe from hazardous substances, how to avoid the hazardous substances and how to use them against enemies Details scholars who compiled compendia of toxic agents

History of Toxicology and Environmental Health

History of Toxicology and Environmental Health
  • Author : Philip Wexler
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :229
  • ISBN : OCLC:903002770
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Summary :

Toxicology in Antiquity

Toxicology in Antiquity
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-10-22
  • Total pages :510
  • ISBN : 9780128153406
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Summary : Toxicology in Antiquity provides an authoritative and fascinating exploration into the use of toxins and poisons in antiquity. It brings together the two previously published shorter volumes on the topic, as well as adding considerable new information. Part of the History of Toxicology and Environmental Health series, it covers key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents. New chapters in this edition focus chiefly on evidence for the use of toxic agents derived from religious texts. Provides the historical background for understanding modern toxicology Illustrates the ways previous civilizations learned to distinguish safe from hazardous substances, how to avoid the hazardous substances and how to use them against enemies Explores the way famous historical figures used toxins New chapters focus on evidence of the use of toxins derived from religious texts

History of Toxicology and Environmental Health

History of Toxicology and Environmental Health
  • Author : Philip Wexler
  • Publisher :Unknown
  • Release Date :2014-09-18
  • Total pages :152
  • ISBN : 9780128016343
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Summary : This volume, Toxicology in Antiquity II, continues to tell the story of the roots of toxicology in ancient times. Readers learn that before scientific research methods were developed, toxicology thrived as a very practical discipline. Toxicologists are particularly proud of the rich and storied history of their field and there are few resources available that cover the discipline from a historical perspective. People living in ancient civilizations readily learned to distinguish safe from hazardous substances, how to avoid these hazardous substances and how to use them to inflict harm on enemies. Volume II explores the use of poison as weapons in war and assassinations, early instances of air pollution, the use of hallucinogens and entheogens, and the role of the snake in ancient toxicology. Provides the historical background for understanding modern toxicology Illustrates the ways ancient civilizations learned to distinguish safe from hazardous substances, how to avoid the hazardous substances and how to use them against enemies Details scholars who compiled compendia of toxic agents

The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-10-20
  • Total pages :352
  • ISBN : 9780128136980
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Summary : The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

Toxicology in the Middle Ages and Renaissance

Toxicology in the Middle Ages and Renaissance
  • Author : Philip Wexler
  • Publisher :Unknown
  • Release Date :2017-03-13
  • Total pages :192
  • ISBN : 9780128095591
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Summary : Toxicology in the Middle Ages and Renaissance provides an authoritative and fascinating exploration into the use of toxins and poisons in the Middle Ages and Renaissance. Part of the History of Toxicology and Environmental Health series, this volume is a follow-up, chronologically, to the first two volumes which explored toxicology in antiquity. The book approximately covers the 1100s through the 1600s, delving into different aspects of toxicology, such as the contributions of scientific scholars of the time, sensational poisoners and poisoning cases, as well as myths. Historical figures, such as the Borgias and Catherine de Medici are discussed. Toxicologists, students, medical researchers, and those interested in the history of science will find insightful and relevant material in this volume. Provides the historical background for understanding modern toxicology Illustrates the ways previous civilizations learned to distinguish safe from hazardous substances, how to avoid them, and how to use them against enemies Explores the way famous historical figures used toxins

History of Risk Assessment in Toxicology

History of Risk Assessment in Toxicology
  • Author : Sol Bobst
  • Publisher :Unknown
  • Release Date :2017-09-20
  • Total pages :50
  • ISBN : 9780128095430
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Summary : History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect. The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries. Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested. Presents the first dedicated history on the evolution of risk assessment in toxicology Reviews the development of major US and EU regulatory bodies Provides a context to current debates surrounding the future of risk assessment Reviews examples from early scientific and health studies to showcase the foundations of risk assessment

Systems Biology in Toxicology and Environmental Health

Systems Biology in Toxicology and Environmental Health
  • Author : Rebecca Fry
  • Publisher :Unknown
  • Release Date :2015-06-11
  • Total pages :284
  • ISBN : 9780128015681
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Summary : Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

Encyclopedia of Toxicology

Encyclopedia of Toxicology
  • Author : Bruce Anderson,Ann de Peyster,Shayne C. Gad,P.J. Bert Hakkinen,Michael Kamrin,Betty Locey,Harihara M. Mehendale,Carey Pope,Lee Shugart
  • Publisher :Unknown
  • Release Date :2005-05-31
  • Total pages :2000
  • ISBN : 9780080548005
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Summary : The second edition of the Encyclopedia of Toxicology continues its comprehensive survey of toxicology. This new edition continues to present entries devoted to key concepts and specific chemicals. There has been an increase in entries devoted to international organizations and well-known toxic-related incidents such as Love Canal and Chernobyl. Along with the traditional scientifically based entries, new articles focus on the societal implications of toxicological knowledge including environmental crimes, chemical and biological warfare in ancient times, and a history of the U.S. environmental movement. With more than 1150 entries, this second edition has been expanded in length, breadth and depth, and provides an extensive overview of the many facets of toxicology. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. *Second edition has been expanded to 4 volumes *Encyclopedic A-Z arrangement of chemicals and all core areas of the science of toxicology *Covers related areas such as organizations, toxic accidents, historical and social issues, and laws *New topics covered include computational toxicology, cancer potency factors, chemical accidents, non-lethal chemical weapons, drugs of abuse, and consumer products and many more!

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Sara Humes,Antoinette Hayes
  • Publisher :Unknown
  • Release Date :2020-03
  • Total pages :750
  • ISBN : 0128216115
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Summary : This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. This book represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume I: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume II: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. The most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences In 2 volumes, over 120 chapters contributed by experts and leaders in their respective sub-disciplines within toxicology Highlights resources both by topic and format Contains chapters representing more than 40 countries authored by renowned toxicologists of those countries Newly updated with all relevant key references and Web links Includes concise narratives about toxicologic sub-disciplines and valuable appendices such as the IUPAC Glossary of Terms in Toxicology

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : P.J. Bert Hakkinen
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :921
  • ISBN : 9780127447704
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Summary : History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...

A Handbook of Environmental Toxicology

A Handbook of Environmental Toxicology
  • Author : J.P.F. D'Mello
  • Publisher :Unknown
  • Release Date :2019-12-04
  • Total pages :673
  • ISBN : 9781786394675
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Summary : Written by an international team of authors from a range of educational, medical and research establishments, this book is an essential reference for advanced students and researchers in the areas of environmental sciences, ecology, agriculture, environmental health and medicine, in addition to industry and government personnel responsible for environmental regulations and directives. A Handbook of Environmental Toxicology focuses on two key aspects: human disorders and ecotoxicology as affected by major toxins originating from biological sources and pollutants, as well as radiation generated spontaneously or as a result of anthropogenic activity. A diverse array of these potentially harmful agents regularly appear in the atmosphere, soil, water and food, compromising both human health and biodiversity in natural and managed ecosystems.

Toxicology

Toxicology
  • Author : Hans Marquardt,Siegfried G. Schäfer,Roger O. McClellan,Frank Welsch
  • Publisher :Unknown
  • Release Date :1999-10-05
  • Total pages :1330
  • ISBN : 9780080543116
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Summary : Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments. Key Features * Comprehensive text, covering all aspects of the field of toxicology * Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects * Identifies the various classes of chemical compounds responsible for the toxic effects * Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention * Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables

Environmental Risk Assessment

Environmental Risk Assessment
  • Author : Ted Simon
  • Publisher :Unknown
  • Release Date :2014-02-05
  • Total pages :406
  • ISBN : 9781466598300
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Summary : The purpose of risk assessment is to support science-based decisions about how to solve complex societal problems. The problems we face in the twenty-first century have many social, political, and technical complexities. Environmental risk assessment in particular is of increasing importance as a means of seeking to address the potential effects of chemicals in the environment in both the developed and developing world. Environmental Risk Assessment: A Toxicological Approach examines various aspects of problem formulation, exposure, toxicity, and risk characterization that apply to both human health and ecological risk assessment. The book is aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments. It delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk. Written in an engaging and lively style by a highly experienced risk assessment practitioner, the text: Introduces the science of risk assessment—past, present, and future Covers problem formation and the development of exposure factors Explains how human epidemiology and animal testing data are used to determine toxicity criteria Provides environmental sampling data for conducting practice risk assessments Examines the use of in vitro and ‘omics methods for toxicity testing Describes the political and social aspects of science-based decisions in the twenty-first century Includes fully worked examples, case studies, discussion questions, and links to legislative hearings Readers of this volume will not only learn how to execute site-specific human health and ecological risk assessments but also gain a greater understanding of how science is used in deciding environmental regulations.

Toxicology and Human Environments

Toxicology and Human Environments
  • Author : Ernest Hodgson
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :435
  • ISBN : 9780124158139
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Summary : Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Handbook of Arsenic Toxicology

Handbook of Arsenic Toxicology
  • Author : Swaran Jeet Singh Flora
  • Publisher :Unknown
  • Release Date :2014-12-26
  • Total pages :752
  • ISBN : 9780124199552
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Summary : Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasure

A Small Dose of Toxicology

A Small Dose of Toxicology
  • Author : Steven G. Gilbert
  • Publisher :Unknown
  • Release Date :2004-02-18
  • Total pages :280
  • ISBN : 0203461738
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Summary : Everyday, we come into contact with many relatively harmless substances that could, at certain concentrations, be toxic. This applies not only to obvious candidates such as asbestos, lead, and gasoline, but also to compounds such as caffeine and headache tablets. While the field of toxicology has numerous texts devoted to aspects of biology, chemis

Ecosystems and Human Health

Ecosystems and Human Health
  • Author : Richard B. Philp
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :352
  • ISBN : 1420032372
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Summary : Renamed to reflect the expanded scope of the second edition, Ecosystems and Human Health: Toxicology and Environmental Hazards builds on the foundation created by the author in the first edition, Environmental Hazards and Human Health. Written in a journalistic, easily accessible style, this book bridges the gap between toxicology and environmental sciences by exploring man-made and natural hazards, and the risks they pose to wildlife and human health. See what's new in the Second Edition: Coverage of environmental hormone disrupters Section on Multiple Chemical Sensitivity Expanded discussion of the controversy over genetically modified foods New information on mechanisms of action of marine venoms and poisons Ecosystems and Human Health: Toxicology and Environmental Hazards, Second Edition explores the broad range of environmental and human health aspects of chemical and biological hazards. The author covers the basic principles of pharmacology and toxicology as well as risk analysis, air and water pollution, and various toxicants, hazards, and poisons. He presents numerous examples of the intimate relationship between ecosystem health and human health and of the need to consider this relationship whenever human activities are likely to have a significant environmental impact.

Clinical Environmental Health and Toxic Exposures

Clinical Environmental Health and Toxic Exposures
  • Author : John Burke Sullivan,Gary R. Krieger
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :1323
  • ISBN : 068308027X
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Summary : Now in its revised and updated Second Edition, this volume is the most comprehensive and authoritative text in the rapidly evolving field of environmental toxicology. The book provides the objective information that health professionals need to prevent environmental health problems, plan for emergencies, and evaluate toxic exposures in patients.Coverage includes safety, regulatory, and legal issues; clinical toxicology of specific organ systems; emergency medical response to hazardous materials releases; and hazards of specific industries and locations. Nearly half of the book examines all known toxins and environmental health hazards. A Brandon-Hill recommended title.

Principles of Toxicology

Principles of Toxicology
  • Author : Phillip L. Williams,Robert C. James,Stephen M. Roberts
  • Publisher :Unknown
  • Release Date :2003-10-10
  • Total pages :624
  • ISBN : 9780471459231
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Summary :

Environmental Toxicology

Environmental Toxicology
  • Author : Ming-Ho Yu,Humio Tsunoda
  • Publisher :Unknown
  • Release Date :2004-10-28
  • Total pages :368
  • ISBN : 9780203495469
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Summary : An Indispensable Reference of Air, Soil, and Water Pollutants This second edition of Environmental Toxicology focuses on the biological and health effects toxins have on living organisms. It also stresses the relationship between human activity and the environment, relating changes in the environment with the changing patterns of human d