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Analysis of Triplet Repeat Disorders

Analysis of Triplet Repeat Disorders
  • Author : Michael Hayden,Dr David Rubinsztein
  • Publisher :Unknown
  • Release Date :2020-07-26
  • Total pages :352
  • ISBN : 9781000144703
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Summary : Analysis of Triplet Repeat Disorders is aimed at clinicians and scientists who work with these diseases or who have an interest in the field. Using the clinical picture of these diseases as a starting point, the book reviews and integrates the current understanding of their molecular pathologies, the genotype-phenotype relationships, the mutational processes of trinucleotide repeats, and the laboratory and clinical issues relating to genetic testing for these disorders.

Advances in Research on Neurodegeneration

Advances in Research on Neurodegeneration
  • Author : Y. Mizuno,D.B. Calne,R. Horowski,W. Poewe,P. Riederer,M.B.H. Youdim
  • Publisher :Unknown
  • Release Date :2000-11-06
  • Total pages :216
  • ISBN : 3211834850
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Summary : 7th International Winter Conference on Neurodegeneration

Current Advances in Amyotrophic Lateral Sclerosis

Current Advances in Amyotrophic Lateral Sclerosis
  • Author : Alvaro Estévez
  • Publisher :Unknown
  • Release Date :2013-09-11
  • Total pages :266
  • ISBN : 9789535111955
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Summary : Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :342
  • ISBN : 9780987073051
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Summary : The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

The Cell Death Machine

The Cell Death Machine
  • Author : Arul M. Chinnaiyan
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : UOM:39015043228173
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Summary :

Hypothalamus in Health and Diseases

Hypothalamus in Health and Diseases
  • Author : Stavros Baloyannis,Jan Gordeladze
  • Publisher :Unknown
  • Release Date :2018-12-05
  • Total pages :142
  • ISBN : 9781789844443
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Summary : The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :229
  • ISBN : UIUC:30112048174681
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Summary :

Cell Death

Cell Death
  • Author : Tobias Ntuli
  • Publisher :Unknown
  • Release Date :2015-12-16
  • Total pages :446
  • ISBN : 9789535122364
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Summary : This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : UCSD:31822020896494
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Summary :

Apoptosis

Apoptosis
  • Author : Douglas R. Green
  • Publisher :Unknown
  • Release Date :2011-08-22
  • Total pages :229
  • ISBN : 9781139498739
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Summary : Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.

Heat Shock Proteins in Neural Cells

Heat Shock Proteins in Neural Cells
  • Author : Christiane Richter-Landsberg
  • Publisher :Unknown
  • Release Date :2009-05-22
  • Total pages :115
  • ISBN : 0387399542
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Summary : This valuable new title addresses the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Heat shock proteins are involved in many physiological processes, including development and differentiation, organisation of the cytoarchitecture by binding to cytoskeletal elements, and regulation of the balance between cell death and survival.

Abstract Book

Abstract Book
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :229
  • ISBN : UOM:39015053967405
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Summary :

Hypoxia and Human Diseases

Hypoxia and Human Diseases
  • Author : Jing Zheng,Chi Zhou
  • Publisher :Unknown
  • Release Date :2017-02-01
  • Total pages :454
  • ISBN : 9789535128953
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Summary : This book contains a total of 21 chapters, each of which was written by experts in the corresponding field. The objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions in the detection, recognition, and management of hypoxia-related disorders. This collection of articles provides a clear update in the area of hypoxia research for biomedical researchers, medical students, nurse practitioners, and practicing clinicians in the fields of high altitude biology, cardiovascular biology and medicine, tumor oncology, obstetrics, pediatrics, and orthodontics and for others who may be interested in hypoxia.

Neurodegenerative Diseases

Neurodegenerative Diseases
  • Author : Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
  • Publisher :Unknown
  • Release Date :2017-07-21
  • Total pages :542
  • ISBN : 9783319571935
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Summary : Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Regulated Cell Death Part B

Regulated Cell Death Part B
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2014-07-24
  • Total pages :352
  • ISBN : 9780128016190
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Summary : Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Leucine-Rich Repeat Kinase 2 (LRRK2)

Leucine-Rich Repeat Kinase 2 (LRRK2)
  • Author : Hardy J. Rideout
  • Publisher :Unknown
  • Release Date :2017-03-28
  • Total pages :271
  • ISBN : 9783319499697
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Summary : This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
  • Author : G. Ali Qureshi,S. Hasan Parvez
  • Publisher :Unknown
  • Release Date :2007-03-22
  • Total pages :794
  • ISBN : 0080489494
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Summary : Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Cell Biology

Cell Biology
  • Author : Stevo Najman
  • Publisher :Unknown
  • Release Date :2016-01-20
  • Total pages :206
  • ISBN : 9789535122425
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Summary : Cell biology is a multidisciplinary scientific field that its modern expansion in new knowledge and applications owes to important support of new technologies with the rapid development, such as ICTs. By integrating knowledge from nano-, molecular, micro-, and macroareas, it represents a strong foundation for almost all biological sciences and disciplines, as well as for biomedical research and application. This book is a compilation of inspiring reviews/original studies, which are divided into sections: New Methods in Cell Biology, Molecular and Cellular Regulatory Mechanisms, and Cellular Basis of Disease and Therapy. The book will be very useful for students and beginners to gain insight into new area, as well as for experts and scientists to find new facts and expand their scientific horizons through biological sciences and biomedicine.

Zinc Biochemistry, Physiology, and Homeostasis

Zinc Biochemistry, Physiology, and Homeostasis
  • Author : W. Maret
  • Publisher :Unknown
  • Release Date :2013-11-11
  • Total pages :232
  • ISBN : 9789401737289
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Summary : Chapters in this book review the remarkable advances in the field of zinc biology over the last decade. Zinc is essential for life, in particular for growth and development, through its role in hundreds of zinc enzymes and thousands of zinc proteins. Its catalytic, structural, and regulatory functions in these proteins impact metabolism, gene expression, and signal transduction, including neurotransmission. Among the micronutrients, zinc may rank with iron as to its importance for public health. The topics covered range from single molecules to cells and to whole organisms: the chemistry, design, and application of fluorophores for the determination of cellular zinc; the role of zinc in proliferation, differentiation, and apoptosis of cells; proteins that transport, sense, and distribute zinc and together form a cellular homeostatic system; the coordination chemistry of zinc in metalloproteins; the role of zinc in the brain as a neuromodulator/transmitter; the dependence of the immune system on zinc; zinc homeostasis in the whole human body.

Cyclin Dependent Kinase 5 (Cdk5)

Cyclin Dependent Kinase 5 (Cdk5)
  • Author : Nancy Y. Ip,Li-Huei Tsai
  • Publisher :Unknown
  • Release Date :2009-02-28
  • Total pages :313
  • ISBN : 0387788875
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Summary : Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :229
  • ISBN : STANFORD:36105022035849
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Summary :