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Human Pituitary Gonadotropins

Human Pituitary Gonadotropins
  • Author : Alexander Albert
  • Publisher :Unknown
  • Release Date :1961
  • Total pages :434
  • ISBN : UOM:39015057723291
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Summary :

100 Years of Human Chorionic Gonadotropin

100 Years of Human Chorionic Gonadotropin
  • Author : Laurence A. Cole,Stephen A. Butler
  • Publisher :Unknown
  • Release Date :2020-02-07
  • Total pages :358
  • ISBN : 9780128216095
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Summary : 100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. Provides updated information on a complex and changing subject in five sections Reviews historical perspectives and developments over the last 100 years Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. Includes chapters on the development and use of hCG vaccines Includes a section on hCG and in subunits in cancer

Human Gonadotropins

Human Gonadotropins
  • Author : Laurence A. Cole
  • Publisher :Unknown
  • Release Date :2020-07-29
  • Total pages :400
  • ISBN : 012821676X
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Summary : Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice. Covers the evolution, structure, synthesis, and functions of gonadotropins in meticulous detail Includes sections on Degradation, Antibodies and Immunoassays, Commercial Products and Standards, and Receptors and Intermediaries Details a section on Reproduction and Cancer, covering gestational trophoblastic diseases, ovarian cystic disorders, and hCG and cancer

Human Chorionic Gonadotropin (hCG)

Human Chorionic Gonadotropin (hCG)
  • Author : Laurence A. Cole,Stephen A. Butler
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :382
  • ISBN : 9780123849076
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Summary : This resource describes the detailed biology, clinical chemistry, and clinical perspectives of HCG and associated molecules and examines HCG, hyperglycosylated HCG, and HCG free-subunit, three separate and independent molecules with totally sovereign physiological functions.

Human Chorionic Gonadotropin (hCG)

Human Chorionic Gonadotropin (hCG)
  • Author : Laurence A. Cole
  • Publisher :Unknown
  • Release Date :2014-12-11
  • Total pages :446
  • ISBN : 9780128008218
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Summary : Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus. It provides comprehensive information on hCG from basic science to clinical medicine The second edition will include coverage of the many new discoveries that have been made in the last five years Updated material with new findings in the field

100 Years of Human Chorionic Gonadotropin

100 Years of Human Chorionic Gonadotropin
  • Author : Laurence A. Cole,Stephen A. Butler
  • Publisher :Unknown
  • Release Date :2020-02-17
  • Total pages :358
  • ISBN : 9780128200506
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Summary : 100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. Provides updated information on a complex and changing subject in five sections Reviews historical perspectives and developments over the last 100 years Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. Includes chapters on the development and use of hCG vaccines Includes a section on hCG and in subunits in cancer

Israel Journal of Medical Sciences

Israel Journal of Medical Sciences
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1975
  • Total pages :229
  • ISBN : CORNELL:31924053161562
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Summary :

Human Chorionic Gonadotropin (hCG)

Human Chorionic Gonadotropin (hCG)
  • Author : Laurence A. Cole
  • Publisher :Unknown
  • Release Date :2010-09-21
  • Total pages :400
  • ISBN : 9780123849083
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Summary : Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. It provides comprehensive information on hCG from basic science to clinical medicine Written by specialists in the field

Clinical Application of Human Gonadotropins

Clinical Application of Human Gonadotropins
  • Author : Gerhard Bettendorf,Vaclav Insler
  • Publisher :Unknown
  • Release Date :1970
  • Total pages :180
  • ISBN : UOM:39015072267910
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Summary :

Biology of Reproduction

Biology of Reproduction
  • Author : Joseph Thomas Velardo
  • Publisher :Unknown
  • Release Date :1972
  • Total pages :421
  • ISBN : UIUC:30112111571979
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Summary :

Human Growth Hormone and Gonadotrophins in Health and Disease

Human Growth Hormone and Gonadotrophins in Health and Disease
  • Author : Paul Franchimont,Henry G. Burger
  • Publisher :Unknown
  • Release Date :1975
  • Total pages :494
  • ISBN : UCAL:B4532492
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Summary :

Biology in Human Affairs

Biology in Human Affairs
  • Author : Harry Boardman,Stuart A. Ross
  • Publisher :Unknown
  • Release Date :1974
  • Total pages :329
  • ISBN : UOM:39015056470688
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Summary : Collection of various articles by various authors.

International Journal of Fertility

International Journal of Fertility
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1972
  • Total pages :229
  • ISBN : UCLA:31158000583806
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Summary : Most issues include Current bibliography index of mammalian reproduction.

Contributions from the Pathological Laboratory ...

Contributions from the Pathological Laboratory ...
  • Author : University of Michigan. Pathological Laboratory
  • Publisher :Unknown
  • Release Date :1972
  • Total pages :229
  • ISBN : CHI:22489663
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Summary :

The Gonadotropins

The Gonadotropins
  • Author : Carlo Flamigni,James R. Givens
  • Publisher :Unknown
  • Release Date :1982
  • Total pages :492
  • ISBN : UOM:39015003195693
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Summary :

Endocrinology

Endocrinology
  • Author : Leslie J. DeGroot
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :2776
  • ISBN : 0721628885
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Summary : Revised throughout, the 5th Edition of this leading reference presents a complete and up-to-date review and analysis of all aspects of endocrinology, diabetes, and bone metabolism. Readers will also find state-of-the-art information on genetics, proteinomics, and hormone signaling, and coverage of the field's hottest topics in nearly 20 new chapters. Joined by an international team of leading expertsmany new to this editionDrs. Jameson and DeGroot provide guidance that integrates the basic science of endocrinology with clinical medicine and the practical management of endocrine disorders. A clinical focus emphasizes diagnosis and therapy.

Acta Geneticae Medicae Et Gemellologiae

Acta Geneticae Medicae Et Gemellologiae
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1965
  • Total pages :229
  • ISBN : UCLA:31158001018471
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Summary :

TRANSCRIPTIONAL REGULATION OF

TRANSCRIPTIONAL REGULATION OF
  • Author : L. C. Hoo,何麗莊
  • Publisher :Unknown
  • Release Date :2017-01-27
  • Total pages :146
  • ISBN : 1374718513
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Summary : This dissertation, "Transcriptional Regulation of the Human Gonadotropin-releasing Hormone (GnRH) II and GnRH Receptor Genes" by L C, Hoo, 何麗莊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled TRANSCRIPTIONAL REGULATION OF THE HUMAN GONADOTROPIN-RELEASING HORMONE (GnRH) II AND GnRH RECEPTOR GENES Submitted by Ruby L. C. Hoo for the degree of Doctor of Philosophy at The University of Hong Kong in December 2003 The human gonadotropin-releasing hormone receptor (hGnRHR) gene is regulated by multiple promoters and several cell-specific cis-elements. In this study, a proximal promoter responsible for a cluster of 3' CAP sites from -635 to -538 was identified by 5' and 3' progressive deletion of a 2.3 kb 5' flanking region of the hGnRHR gene followed by transient luciferase reporter gene assays. This proximal promoter, located at -677/-558 (relative to ATG), was able to drive a 13.10.6 fold increase in reporter gene activity in an orientation-dependent manner. Site-directed mutation analysis revealed that the sequences residing -607/-568 were crucial for the basal promoter activity as any mutations within this region would completely abrogate promoter function. Within the core promoter element, two pyrimidine-rich initiator elements (Inr) that interact with the same protein factors with different affinities were evident by gel mobility shift assays. Southwestern blot analysis showed that multiple nuclear factors of sizes ranging from 36-150 kDa were able to interact specifically with the core proximal promoter element and so as a previously identified distal promoter of the hGnRHR gene. Taken together, our results demonstrated that these two promoters share common protein factors to regulate transcription initiations at two different regions. Recent studies of the hGnRH II gene demonstrated that its expression is regulated by cAMP, gonadotropins and estrogen, and a minimal promoter was identified at -1124 to -750 (relative to ATG). In this report, an intronic silencer element (-620/-650) was identified as deletion of this 30 bp led to drastic increases in the promoter activities. This intronic silencer was found to be position-dependent and orientation-independent. By site-directed mutagenesis, a NF-kB motif and a hGII-SNOG motif, were found to be crucial for the repressor's function. However, by mobility shift and supershift assays, instead of NF-kB subunits, Sp1 and Sp3 were found to interact with the NF-kB site. Based on this observation, we hypothesized that the in vivo competition of Sp1/Sp3 proteins with the NF-kB subunits may play an important role in inducing gene repression. Interestingly, different protein factors from TE671 and JEG-3 cells were found to interact with the M1-SNOG motif. It is possible that these cells use different mechanisms to mediate the functions of the hGnRH II silencer element. In summary, we have identified two Inr elements within the proximal promoter of the hGnRHR gene that are responsible for the transcription initiation of a cluster of 3' CAP sites residing -635 to -538. In addition, NF-kB and hGII-SNOG motifs were identified to be crucial for the repressor function of the hGnRH II gene. DOI: 10.5353/th_b2929701 Subjects: Luteinizing hormone releasing hormone Hormone receptors Genetic regulation

Induction of Ovulation

Induction of Ovulation
  • Author : Robert Benjamin Greenblatt
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :167
  • ISBN : UOM:39015003241356
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Summary :

Risks in the Practice of Modern Obstetrics

Risks in the Practice of Modern Obstetrics
  • Author : Silvio Aladjem
  • Publisher :Unknown
  • Release Date :1975
  • Total pages :425
  • ISBN : UOM:39015000785306
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Summary :

Structure and Function of the Gonadotropins

Structure and Function of the Gonadotropins
  • Author : Kenneth W. McKerns
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :630
  • ISBN : 9781468434149
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Summary : In September of 1977 scientists from many countries met at the Asticou Inn in Maine to present and discuss papers written especially for this monograph. The presentations were informal and directed to the special interests of the audience in order to generate discussions. The authors, many of whom are pioneers and leaders in their field, then had the oppor tunity to revise their contributions, which were brought together with the edited discussions to form this volume. The basic research studies presented here are important because of the essential role of gonadotropins in regulating the ovary and testis. This monograph will therefore be of interest to those concerned with fertility regulation, population control, possible new methods for contraception, and to those concerned with reproduction in domestic animals. Re searchers in other fields may find this monograph useful, as it has been de termined that gonadotropins are secreted by many tumors and are im plicated in many cancers. Human choriogonadotropin also seems to be found in most, if not all, cells of the human body. The significance of this, however, is unknown.