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Immunomodulatory Biomaterials

Immunomodulatory Biomaterials
  • Author : Stephen F. Badylak,Jennifer Elisseeff
  • Publisher :Unknown
  • Release Date :2021-07-15
  • Total pages :345
  • ISBN : 0128214406
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Summary : Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Biomaterials and Immune Response

Biomaterials and Immune Response
  • Author : Nihal Engin Vrana
  • Publisher :Unknown
  • Release Date :2018-07-20
  • Total pages :249
  • ISBN : 9781351377553
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Summary : The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Immunomodulatory Biomaterials to Mitigate Material-induced Host Responses

Immunomodulatory Biomaterials to Mitigate Material-induced Host Responses
  • Author : Yoon Kyung Kim
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :111
  • ISBN : 1303444976
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Summary : The foreign body response to biomaterial implants has been a major challenge in translating many medical devices into the clinic. The presence of inflammatory cells around the implanted device prevents its functional interaction with the surrounding tissue, and although some inflammation may be desirable to mediate the healing process, a persistent inflammatory response will eventually lead to device failure. Significant efforts to reduce foreign body response have been largely focused on developing hydrophilic and anti-fouling coating materials, however, simply preventing protein adsorption and immune cell adhesion has only had moderate success at reducing inflammation in vivo. In this thesis, we describe a novel approach to mitigate the foreign body response, whereby materials are designed to mimic host tissue by displaying endogenously expressed immunomodulatory molecules that interact with specific inhibitory receptors expressed on immune cells. More specifically, biomaterial surfaces are coated with the recombinantly produced immunomodulatory molecule, CD200, which interacts with the inhibitory receptor CD200R on myeloid cells, preventing material-induced host response by suppressing activation of infiltrated myeloid cells. In Chapter One, a brief introduction and background information is presented, followed by a description of the production and purification of recombinant CD200 protein from both mammalian cells and bacterial cells in Chapter Two. In Chapter Three, we examine whether immobilization of CD200 onto polystyrene surfaces influences on suppressing the activation of macrophages. We found that CD200 indeed suppresses the release of inflammatory mediators secreted by macrophage cells in vitro, and elicited less inflammation in vivo when compared to uncoated materials after subcutaneous implantation. In Chapter Four, we examine whether CD200 influences tissue regeneration after spinal cord injury. CD200-embedded fibrin gel was implanted to spinal cord injured mice, and the effect of CD200 on inflammation and regenerative process was examined. Lastly, Chapter Five concludes the work performed in this Ph.D. study and presents future directions. This work suggests that coating of endogenously expressed immunomodulatory proteins can be used as a strategy to reduce inflammatory response to biomaterials and may potentially be generalized to implants throughout the body.

Biomaterials in Regenerative Medicine and the Immune System

Biomaterials in Regenerative Medicine and the Immune System
  • Author : Laura Santambrogio
  • Publisher :Unknown
  • Release Date :2015-09-04
  • Total pages :280
  • ISBN : 9783319180458
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Summary : The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

Handbook of Biomaterials Biocompatibility

Handbook of Biomaterials Biocompatibility
  • Author : Masoud Mozafari
  • Publisher :Unknown
  • Release Date :2020-06-17
  • Total pages :758
  • ISBN : 9780081029688
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Summary : Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials

The Immune Response to Implanted Materials and Devices

The Immune Response to Implanted Materials and Devices
  • Author : Bruna Corradetti
  • Publisher :Unknown
  • Release Date :2016-11-30
  • Total pages :241
  • ISBN : 9783319454337
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Summary : This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Biomaterials and Immune Response

Biomaterials and Immune Response
  • Author : Nihal Engin Vrana
  • Publisher :Unknown
  • Release Date :2018-07-20
  • Total pages :249
  • ISBN : 9781351377560
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Summary : The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Host Response to Biomaterials

Host Response to Biomaterials
  • Author : Stephen F Badylak
  • Publisher :Unknown
  • Release Date :2015-05-08
  • Total pages :460
  • ISBN : 9780128005002
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Summary : Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
  • Author : Nihal Vrana,Helena Knopf-Marques,Julien Barthes
  • Publisher :Unknown
  • Release Date :2020-03-20
  • Total pages :846
  • ISBN : 9780081029077
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Summary : Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair
  • Author : Mario Barbosa,M Cristina L Martins
  • Publisher :Unknown
  • Release Date :2017-09-25
  • Total pages :390
  • ISBN : 9780081008522
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Summary : Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy

Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy
  • Author : Anubhab Mukherjee,Vijay Sagar Madamsetty,Sudip Mukherjee
  • Publisher :Unknown
  • Release Date :2021-04-06
  • Total pages :84
  • ISBN : 9781636391052
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Summary : Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.

Characterizing the Macrophage Response to Immunomodulatory Biomaterials Through Gene Set Analyses

Characterizing the Macrophage Response to Immunomodulatory Biomaterials Through Gene Set Analyses
  • Author : Sarah E. Blatt
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :88
  • ISBN : OCLC:1240365047
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Summary : Abstract

Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and In Vitro Models for Biomaterial Testing

Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and In Vitro Models for Biomaterial Testing
  • Author : Nihal Engin Vrana,Amir M. Ghaemmaghami,Pinar Zorlutuna
  • Publisher :Unknown
  • Release Date :2019-05-15
  • Total pages :137
  • ISBN : 9782889458226
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Summary : Adverse immune reactions to biomaterials are important bottlenecks for translation of novel biomaterials for clinical use. Moreover, recent advances in highthrough-put biomaterial discovery and synthetic biology, while providing exciting new veues, also significantly increases potential risks related to the in vivo reactions to these new materials. For example, the novel materials might have unintended biological activities due to their natural building blocks. In this perspective, biomaterial field needs i) better understanding of cell/biomaterial interactions at systems level; ii) development of new analysis and testing tools for advanced risk assessment iii) tools and technologies for modulating reactions to biomaterials and iv) advanced in vitro models for understanding and testing of reactions to biomaterials. In the following collection of articles you will find examples of such systems,together with comprehensive reviews of current developments in in vitro model systems. The collection also contains articles that elucidate the immune reaction to biomaterials in vitro and in vitro.

Bioactive Materials for Bone Regeneration

Bioactive Materials for Bone Regeneration
  • Author : Jiang Chang,Xingdong Zhang,Kerong Dai
  • Publisher :Unknown
  • Release Date :2020-02-28
  • Total pages :248
  • ISBN : 9780128135044
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Summary : Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments

Immunomodulation of Innate Immune Cells

Immunomodulation of Innate Immune Cells
  • Author : Catarina R. Almeida,Barbara Bottazzi,Kate E. Lawlor,Dominic De Nardo
  • Publisher :Unknown
  • Release Date :2020-03-23
  • Total pages :229
  • ISBN : 9782889635740
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Summary :

Biomimetic Medical Materials

Biomimetic Medical Materials
  • Author : Insup Noh
  • Publisher :Unknown
  • Release Date :2018-11-23
  • Total pages :399
  • ISBN : 9789811304453
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Summary : This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

An Introduction to Biomaterials, Second Edition

An Introduction to Biomaterials, Second Edition
  • Author : Jeffrey O. Hollinger
  • Publisher :Unknown
  • Release Date :2011-11-28
  • Total pages :644
  • ISBN : 9781439812570
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Summary : A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property. Divided into four sections (Biology, Biomechanics, Biomaterials Interactions; Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property; Biomaterials Compositions; and Biomaterials Applications), this dramatically revised edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cell-cell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, new U.S. FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure. With nine completely new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data, this comprehensive introduction discusses 13 important classes of biomaterials, their fundamental and applied research, practical applications, performance properties, synthesis and testing, potential future applications, and commonly matched clinical applications. The authors include extensive references, to create a comprehensive, yet manageable didactic work that is an invaluable desk references and instructional text for undergraduates and working professionals alike.

Biomaterial-Mediated Control Over Macrophage Behavior for Tissue Regeneration

Biomaterial-Mediated Control Over Macrophage Behavior for Tissue Regeneration
  • Author : Claire Elizabeth Witherel
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :528
  • ISBN : OCLC:1147971476
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Summary : Macrophages, the primary cell of the immune response, and fibroblasts, the major producers of extracellular matrix (ECM), have significant roles in wound healing and the foreign body response to implanted biomaterials. Macrophages are known to exhibit a spectrum of unique phenotypes in response to their environment; M1 macrophages, are associated with increased inflammation and initiating angiogenesis, while M2a macrophages have been associated with anti-inflammatory behavior and extracellular matrix deposition. Temporal control of macrophage phenotype from M1 to M2a has been shown to be critical in normal wound healing. On the other hand, dysregulated macrophage behavior has been associated with detrimental pathologies including chronic wounds and fibrosis. Therefore, the development of immunomodulatory biomaterials that can harness the natural immune response for repair and healing, hold significant promise for future of regenerative medicine. While it's appreciated that macrophages may hold the key to aberrant healing outcomes, it is not well understood how they direct pro-healing outcomes, especially within the context of a biomaterial implant. Therefore, the overall goals of this work were to 1. thoroughly characterize macrophage-biomaterial interactions and macrophage-fibroblast interactions further our understanding of how these cells may influence functional tissue regeneration, and 2. Utilize a model drug-eluting biomaterial to directly assess the role of M2a macrophages in tissue regeneration. To accomplish these goals, I investigated how macrophages change their behavior in response to 'successful', commercially- available wound matrices in vitro. Collectively, these studies showed that four commercially-available wound matrices evaluated pro-inflammatory macrophage behavior (more M1-like) and that direct contact (as opposed to soluble factors) of macrophages with a bioactive (i.e. containing cells and proteins) wound matrix was critical for reducing inflammation in pro-inflammatory macrophages. Next, I investigated the effects of macrophage-secreted signals on fibroblast behavior and matrix formation in vitro and employed model drug-eluting biomaterials to develop an M2a-promoting hydrogel to directly assess the role of M2a macrophages in the foreign body response in vivo. Together, these studies illustrated that M1 and M2a macrophage-derived signals significantly reduced the fiber diameter of fibroblast-derived deposition in vitro relative to other macrophage phenotypes. While clinically relevant macrophage-derived signals (M1+M2a and M1->M2a) returned fibroblast matrix fiber diameter to the in vitro baseline. IL4+IL13-releasing hydrogel resulted in a significant reduction in leukocyte recruitment 21 days relative to the Blank hydrogel control, suggesting an increased presence of other key ECM-producing cells. Alternatively, these results may also imply that IL4+IL13 hydrogels may change the quality and composition of ECM surrounding a biomaterial or at the tissue-biomaterial interface. Interestingly and in contrast to pilot data, the IL4+IL13 hydrogel yielded minimal differences in gene expression and histological outcomes compared the Blank control. Collectively, these preliminary and somewhat inconclusive in vivo results are likely due to technical challenges there were discovered in the in vivo experimental design. A final validation study showed that the IL4+IL13 hydrogels that were originally implanted within the same mouse as the Blank controls were likely releasing enough drug to have an impact on the outcomes of the Blank controls. Preliminary data from the validation study yielded a robust response of the IL4+IL13 hydrogel relative to the Blank control at the Day 3 time point. Future work will focus on elucidating the long-term effects of these IL4+IL13 hydrogels on ECM deposition. This work is critical for understanding how transient control of macrophage behavior is directly linked to tissue repair and regeneration outcomes. Due to the importance of macrophage behavior in all tissues, this project has the potential to translate into a myriad of other fields, especially those in which abnormal inflammation prevent tissue repair or regeneration.

Cellular Response to Biomaterials

Cellular Response to Biomaterials
  • Author : Lucy Di Silvio
  • Publisher :Unknown
  • Release Date :2008-12-22
  • Total pages :648
  • ISBN : 9781845695477
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Summary : The response of cells to biomaterials is critical in medical devices. Traditionally inert biomaterials were used to minimise the reaction in cells in contact with the material. However, it has been realised that specific cell responses may be beneficial in such areas as encouraging adhesion, healing or cell multiplication. Cellular response to biomaterials discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. Part one discusses cell responses to a variety of polymers and ceramics with chapters on such topics as degradable polymers and biocompatibility. Part two covers cell responses and regenerative medicine with coverage of themes such as vascular grafts, nerve repair and Bioglass®. Part three examines the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion and surface modification of titanium implants. With its distinguished editor and team of international contributors, Cellular response to biomaterials is an essential read for those researching or studying medical devices in industry and academia. Examines the response of cells to a wide range of biomaterials targeted at specific medical applications Discusses cell responses and regenerative medicine with specific chapters on vascular grafts and nerve repair Assesses the effect of surfaces and proteins on cell response including the influence of plasma proteins on cell adhesion and surface modification of titanium implants

Cells and Biomaterials in Regenerative Medicine

Cells and Biomaterials in Regenerative Medicine
  • Author : Daniel Eberli
  • Publisher :Unknown
  • Release Date :2014-11-26
  • Total pages :384
  • ISBN : 9789535117315
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Summary : This book serves as a good starting point for anyone interested in the application of tissue engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications. The first part covers the use of adult stem cells and their applications. The following chapters offer an insight into the development of a tailored biomaterial for organ replacement and highlight the importance of cell-biomaterial interaction. In summary, this book offers insights into a wide variety of cells, biomaterials, interfaces and applications of the next generation biotechnology, which is tissue engineering.

Biomaterials in Regenerative Medicine

Biomaterials in Regenerative Medicine
  • Author : Leszek A. Dobrzański
  • Publisher :Unknown
  • Release Date :2018-02-14
  • Total pages :448
  • ISBN : 9789535137764
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Summary : The book Biomaterials in Regenerative Medicine is addressed to the engineers and mainly medical practitioners as well as scientists and PhD degree students. The book indicates the progress in research and in the implementation of the ever-new biomaterials for the application of the advanced types of prosthesis, implants, scaffolds and implant-scaffolds including personalised ones. The book presents a theoretical approach to the synergy of technical, biological and medical sciences concerning materials and technologies used for medical and dental implantable devices and on metallic biomaterials. The essential contents of the book are 16 case studies provided in each of the chapters, comprehensively describing the authors' accomplishments of numerous teams from different countries across the world in advanced research areas relating to the biomaterials applied in regenerative medicine and dentistry. The detailed information collected in the book, mainly deriving from own and original research and R