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Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
  • Author : Christopher Jackson,Michael Lim
  • Publisher :Unknown
  • Release Date :2021-08-15
  • Total pages :250
  • ISBN : 0128197552
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Summary : Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Glioma

Glioma
  • Author : ryuya yamanaka
  • Publisher :Unknown
  • Release Date :2012-05-27
  • Total pages :232
  • ISBN : 9781461431466
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Summary : Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery. Despite major advances in our understanding of the pathomechanism, diagnosis by imaging and the availability of powerful therapeutic tools, the life expectancy of patients with glioblastoma has only been slightly prolonged and a cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image-guided surgery, can enable the detection and removal of all of the tumor tissue. In recent years, however, the landscape has been changing immeasurably, and molecular studies over the past two decades have identified a variety of genetic aberrations that are specifically associated with individual types of gliomas. In addition, certain molecular abnormalities have been linked to therapy responses, thereby establishing clinical biomarkers and molecular targets, and the use of novel agents is being investigated. These agents have been specifically engineered to exert specific cytotoxicity against gliomas, either on their own as single agents or in combination with other modalities. Moreover, there has been an enormous surge of interest in the area of immunology and immunotherapy, which has been facilitated by our understanding of the molecular basis of gliomas. Although several kinds of immunotherapeutic trials have been undertaken, we still await a great breakthrough in terms of clinical efficacy to prolong the survival time of glioma patients.

Brain Tumor Immunotherapy

Brain Tumor Immunotherapy
  • Author : Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
  • Publisher :Unknown
  • Release Date :2000-11-10
  • Total pages :374
  • ISBN : 9781592590353
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Summary : An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Glioblastoma:

Glioblastoma:
  • Author : Swapan K. Ray
  • Publisher :Unknown
  • Release Date :2009-10-31
  • Total pages :431
  • ISBN : 1441904107
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Summary : Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

The Duke Glioma Handbook

The Duke Glioma Handbook
  • Author : Allan H. Friedman
  • Publisher :Unknown
  • Release Date :2016-03-31
  • Total pages :220
  • ISBN : 9781107065970
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Summary : Provides a summary of glioma biology, genetics and management, based on the world-leading Duke University Preston Robert Tisch Brain Tumor Center program.

Impact of Immunotherapy in the Treatment of Glioblastoma

Impact of Immunotherapy in the Treatment of Glioblastoma
  • Author : Jessica Silva
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :229
  • ISBN : OCLC:1154234821
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Summary : Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite the efforts developed in the respective treatment, consisting of maximal surgical resection followed by adjuvant radiotherapy and chemotherapy, the prognosis remains very poor. This may be partly related to the resistance of GBM cells and their infiltrative and invasive nature into the surrounding brain tissue. Therefore, newer and challenging alternative approaches for the treatment have emerged, including immunotherapy. This anticancer therapy, based on the stimulation of the host's immune system, has been currently investigated and several advances in the clinical trial stage have already been reached. Immunotherapeutic strategies comprise a set of modalities, including vaccines (cell-free and cell-based), chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint inhibitors, monoclonal antibodies (mAbs), and oncolytic viruses (OVs). In this chapter, we will review the principal concepts and the recent progress in immunotherapy for GBM.

New Techniques for Management of ‘Inoperable’ Gliomas

New Techniques for Management of ‘Inoperable’ Gliomas
  • Author : Michael E. Sughrue,Isaac Yang
  • Publisher :Unknown
  • Release Date :2019-08-03
  • Total pages :256
  • ISBN : 9780128136348
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Summary : New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients. Provides the first comprehensive book to discuss techniques for removing gliomas that are traditionally deemed ‘inoperable’ Presents a great reference tool that challenges stereotypical thinking by offering techniques by innovative surgeons Includes chapters that are organized by different glioma types and surgery/techniques

Gliomas

Gliomas
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2016-03-02
  • Total pages :464
  • ISBN : 9780128030073
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Summary : Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care. Synthesizes widely dispersed information on the management of gliomas into one comprehensive resource Chapters written by international authors who are preeminent researchers in the field Fully explores the therapeutic options for patient care, from chemotherapy to radiotherapy to personalized approaches

Glioma

Glioma
  • Author : Ibrahim Omerhodzic,Kenan Arnautovic
  • Publisher :Unknown
  • Release Date :2019-01-16
  • Total pages :258
  • ISBN : 9781789849530
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Summary : The past three decades have been marked with huge enthusiasm from scientists and professionals in an effort to find a cure for glioma disease. Methods to confirm the kinds and grades of glioma have taken a path from classical macro- to microscopic pathohystological confirmation of tumors, through morphological-histological, molecular, and genetic diagnosis. Surgically, progress was made possible with the development and use of technological aids, for example neuronavigation, cortical mapping, electrocorticography, neuromonitoring, functional and intraoperative MRI, magnetoencephalography, etc. Great hope was placed on the extension of tumor resection and popular supratotal resection. Significant progress has been made generally in glioma treatment with the use of modern radiotherapy and new chemotherapeutics. What do we want to see for the future? By way of stem cells, a specific medicine will be produced, individualized for the particular patient, and by using a microcapsule it will be implanted into the brain zone affected by the tumor by way of robot surgery and injection needle. This is not at all an unrealistic expectation in the next decade or two.

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor
  • Author : Terry Lichtor
  • Publisher :Unknown
  • Release Date :2015-03-25
  • Total pages :434
  • ISBN : 9789535120315
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Summary : A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Cancer Vaccines

Cancer Vaccines
  • Author : Adrian Bot,Mihail Obrocea,Francesco M. Marincola
  • Publisher :Unknown
  • Release Date :2015-05-06
  • Total pages :280
  • ISBN : 9781841848303
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Summary : Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
  • Author : Herbert B. Newton
  • Publisher :Unknown
  • Release Date :2018-03-28
  • Total pages :848
  • ISBN : 9780128121016
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Summary : Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Re-Irradiation: New Frontiers

Re-Irradiation: New Frontiers
  • Author : Carsten Nieder,Johannes Langendijk
  • Publisher :Unknown
  • Release Date :2016-10-25
  • Total pages :364
  • ISBN : 9783319418254
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Summary : This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Brain Tumors

Brain Tumors
  • Author : Amit Agrawal,Luis Rafael Moscote-Salazar
  • Publisher :Unknown
  • Release Date :2018-08-22
  • Total pages :248
  • ISBN : 9781789235562
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Summary : We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book "Brain Tumor - An Update" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book.

Brain Tumor Therapy

Brain Tumor Therapy
  • Author : Mark L. Rosenblum,Charles B. Wilson
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :288
  • ISBN : 3805536992
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Summary :

Neuroblastoma

Neuroblastoma
  • Author : Swapan K. Ray
  • Publisher :Unknown
  • Release Date :2019-01-11
  • Total pages :334
  • ISBN : 9780128120040
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Summary : Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions. Comprehensively covers the histopathological characterization, molecular mechanisms, and most recent therapeutic interventions in neuroblastoma Includes recent developments and therapeutic interventions for neuroblastoma, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy Presents a broad scope that provides basic researchers, practitioners and students with the most current overview of recent advances

Trigeminocardiac Reflex

Trigeminocardiac Reflex
  • Author : Tumul Chowdhury,Bernhard J. Schaller
  • Publisher :Unknown
  • Release Date :2015-05-29
  • Total pages :256
  • ISBN : 9780128005934
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Summary : Trigeminocardiac Reflex is a comprehensive tutorial reference to the science, diagnosis, and possible treatment of the trigeminocardiac reflex (TCR) that is usually initiated when the trigeminal nerve is disturbed during intercranial surgery. Since first reported in 1999 by co-Editor Bernhard Schaller, the research focused on TCR is expanding. While its instance is rare, new discoveries are not only increasing diagnosis, but also providing more effective treatment protocols. This text is ideal as a reference for clinical and research neurologists, as a general introduction for clinical presentation, and as a foundation for new research. Represents the first tutorial reference focused on the Trigeminocardiac Reflex (TCR) Content organized by two of the leading scientists in the area, Dr. Tumul Chowdhury (University of Manitoba) and Prof. Bernhard Schaller (University of Southampton) Defines TCR, its onset, and possible treatments Establishes a knowledge base for the future study of the TCR and treatment protocols

Neurooncology

Neurooncology
  • Author : Amit Agrawal
  • Publisher :Unknown
  • Release Date :2016-07-13
  • Total pages :488
  • ISBN : 9789535124252
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Summary : The book contains the information of various aspects of newer developments and recent advances in the field of central nervous system (CNS) tumor molecular biology, tumor progression, clinical presentation, imaging and management. The authors from different reputed institutions shared their knowledge on this open access platform to disseminate their knowledge at global level. As it is obvious in the current text, the field of neurooncology is heterogeneous and under continuous development with addition of new knowledge and information on regular basis. The collective contributions from experts attempt to provide updates regarding ongoing research and developments pertaining to CNS tumor genetics and molecular aspects and their applied aspect in reference to patient management.

Precision Medicine in Oncology

Precision Medicine in Oncology
  • Author : Bulent Aydogan,James A. Radosevich
  • Publisher :Unknown
  • Release Date :2020-08-11
  • Total pages :288
  • ISBN : 9781119432494
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Summary : A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Immunopathology and Immunomodulation

Immunopathology and Immunomodulation
  • Author : Krassimir Metodiev
  • Publisher :Unknown
  • Release Date :2015-11-18
  • Total pages :312
  • ISBN : 9789535122104
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Summary : This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors.

Intracranial Gliomas Part III - Innovative Treatment Modalities

Intracranial Gliomas Part III - Innovative Treatment Modalities
  • Author : M.F. Chernov,Y. Muragaki,S. Kesari,I.E. McCutcheon
  • Publisher :Unknown
  • Release Date :2018-07-10
  • Total pages :222
  • ISBN : 9783318060638
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Summary : At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.