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Terpenes from Natural Products with Potential Anti-Inflammatory Activity

Terpenes from Natural Products with Potential Anti-Inflammatory Activity
  • Author : Roberto José Serrano
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :229
  • ISBN : OCLC:1154241413
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Summary : The development and progression of many diseases is related with an inflammatory process, which could affect different organs or tissues. Currently, many drugs are used to treat inflammation. However, some of these compounds induce severe side effects. For this reason, the search of new therapeutic options for the treatment of inflammation is very desirable. Medicinal plants have been an interesting source for obtaining new active compounds, including several terpenes and terpenoids with anti-inflammatory activity. This book chapter includes 62 sesquiterpenes, 34 diterpenes, and 22 triterpenes with anti-inflammatory activity. The anti-inflammatory effect was evaluated using in vitro, in vivo, and both models. These terpenes were obtained from 44 plant species belonging to 25 botanical families. Eight of theses species belong to the Asteraceae family and four to Lamiaceae family, respectively, and the other species belong to 13 different botanical families, one sesquiterpene was obtained from a sponge and two diterpenes were isolated from corals.

Research Focus on Natural Products and the Body's Immune and Inflammatory Systems

Research Focus on Natural Products and the Body's Immune and Inflammatory Systems
  • Author : Kyoungho Suk
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :313
  • ISBN : 1600217516
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Summary : The definition of 'natural' is 'produced or existing in nature.' Natural products refer to as any natural constituents, natural substances, or a group of the secondary metabolites that derive from plants, insects, marine plants and animals through their own metabolic pathways. Natural products are usually of high value and small quantity, and they have a variety of biological activities. Extensive research has been performed to understand the effects of natural products on the immune and inflammatory systems. However, the results have been published individually focusing on a particular aspect of immunity or inflammation. The readers in this field may benefit from a comprehensive review book that describes different aspects of immune/inflammatory responses together. This book provides an overview of how a variety of naturally occurring compounds may influence the body's immune and inflammatory systems with an emphasis on the actions of medicinal herbs. In this book, experts in each field present their recent data on the mechanisms by which natural products influence the immune and inflammatory responses. The experimental results that are described in this book are based on various in vitro as well as in vivo model systems. It is also discussed how such effects of natural products are related with their therapeutic applications for the treatment of immune and inflammatory diseases.

Inflammation and Natural Products

Inflammation and Natural Products
  • Author : Sreeraj Gopi,Augustine Amalraj,Ajaikumar B Kunnumakkara,Sabu Thomas
  • Publisher :Unknown
  • Release Date :2020-09-15
  • Total pages :435
  • ISBN : 0128192186
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Summary : Inflammation and Natural Products: Recent Development and Current Status brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries. Increases the knowledge of anti-inflammatory activities of natural products and their mechanism of action Provides a new perspective and forward-thinking ideas to researchers, the scientific community and industry Intensifies the understanding of synergistic action of biologically active naturally occurring molecules and their biological activities against inflammation

Inflammation, 4 Volume Set

Inflammation, 4 Volume Set
  • Author : Jean-Marc Cavaillon,Mervyn Singer
  • Publisher :Unknown
  • Release Date :2018-01-03
  • Total pages :1830
  • ISBN : 9783527338993
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Summary : The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Bioactive Natural Products Detection, Isolation, and Structural Determination

Bioactive Natural Products Detection, Isolation, and Structural Determination
  • Author : Steven M. Colegate,Russell J. Molyneux
  • Publisher :Unknown
  • Release Date :1993-09-29
  • Total pages :544
  • ISBN : 0849343720
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Summary : Bioactive Natural Products covers all the aspects of bioactive natural product research from ethnobotanical investigations to modern, technologically assisted isolation and structural determination of active compounds. An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers. The book is also excellent for upper division or post-graduate courses.

Discovery and Development of Anti-inflammatory Agents from Natural Products

Discovery and Development of Anti-inflammatory Agents from Natural Products
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2019-07-11
  • Total pages :332
  • ISBN : 9780128169933
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Summary : Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
  • Author : Atta-ur Rahman
  • Publisher :Unknown
  • Release Date :2020-08-21
  • Total pages :548
  • ISBN : 9780128194843
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Summary : Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Pharmaceutical and Bioactive Natural Products

Pharmaceutical and Bioactive Natural Products
  • Author : David H. Attaway,Oskar R. Zaborsky
  • Publisher :Unknown
  • Release Date :1993-03-31
  • Total pages :500
  • ISBN : 0306441748
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Summary : Biotechnology may be defined as the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services (Bullet al. , 1982, p. 21) or as any technique that uses living organisms (or parts of organisms) to make or modify products, to improve plants or animals, or to develop microorganisms for specific use (OTC, 1988). In line with these broad definitions we can consider marine biotechnology as the use of marine organisms or their constituents for useful purposes in a controlled fashion. This series will explore a range of scientific advances in support of marine biotechnology. It will provide information on advances in three categories: (1) basic knowledge, (2) ap plied research and development, and (3) commercial and institutional issues. We hope the presentation of the topics will generate interest and interaction among readers in the academic world, government, and industry. This first volume examines chemical and biological properties of some natural products that are useful or potentially useful in research and in the chemical and pharmaceutical industries. One chapter describes a system for producing such substances on a large scale. Biotechnology incorporates molecular biology in order to go beyond tradi tional biochemical technology such as the production of antibiotic drugs from bacterial cultures in bioreactors. Development of the technology for production of antibiotics in this way resulted from fundamental advances in chemistry, phar macology, microbiology, and biochemical engineering.

Natural Products and Drug Discovery

Natural Products and Drug Discovery
  • Author : Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
  • Publisher :Unknown
  • Release Date :2018-02-16
  • Total pages :776
  • ISBN : 9780081021040
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Summary : Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Natural Products Targeting Clinically Relevant Enzymes

Natural Products Targeting Clinically Relevant Enzymes
  • Author : Paula B. Andrade,Patrícia Valentão,David M. Pereira
  • Publisher :Unknown
  • Release Date :2017-08-30
  • Total pages :250
  • ISBN : 9783527805914
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Summary : The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases
  • Author : Ronald Ross Watson,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2019-01-26
  • Total pages :628
  • ISBN : 9780128138212
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Summary : Bioactive Food as Dietary Interventions for Arthritis and Inflammatory Diseases, Second Edition is a valuable scientific resource that focuses on the latest advances in bioactive food research and the potential benefit of bioactive food choice on arthritis. Written by experts from around the world, the book presents important information that can help improve the health of those at risk for arthritis and related conditions using food selection as its foundation. Serves as a starting point for in-depth discussions in academic settings Offers detailed, well-documented reviews outlining the ability of bioactive foods to improve and treat arthritis Includes updated research on the global epidemic of diabetes Updated with current research on antioxidant flavonoids, anti-Inflammatory natural foods, ginger and the effects of beef on inflammation Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases that share common etiological pathways

Lectures on Surgical Pathology, Delivered at the Royal College of Surgeons of England

Lectures on Surgical Pathology, Delivered at the Royal College of Surgeons of England
  • Author : Sir James Paget
  • Publisher :Unknown
  • Release Date :1854
  • Total pages :699
  • ISBN : PRNC:32101023475393
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Summary :

Inflammation: Natural Resources and Its Applications

Inflammation: Natural Resources and Its Applications
  • Author : Parag Jain,Ravindra Pandey,Shiv Shankar Shukla
  • Publisher :Unknown
  • Release Date :2014-12-04
  • Total pages :156
  • ISBN : 9788132221630
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Summary : Inflammation is the very natural process of our body; it does its work immediately and smoothly along with lots of helpers. Inflammation is linked to immune system as acute inflammatory or pro-inflammatory phase through macrophage activation. This book is for researchers and scholars in the field of life sciences and medical sciences. The book contains all inflammatory sources around the world. It emphasizes on anti-inflammatory sources along with its active inflammatory constituents and other medicinal uses with authentic references. Anti-inflammation is a kind of activity with is found in nearly all of the natural sources used for major biological activities. So, the book helps them to correlate their activity of interest with anti-inflammatory source. The present work deals with illustrative representation of inflammation, causes of inflammation, inflammatory mediators, anti-inflammatory sources other uses and inflammation and lifestyle. It mainly provides the researchers the updated information from the ancient to the most recent ongoing research on inflammation. This book imparts pace to their idea of thinking, assist to make clear predictions before proceeding to research. The introduction includes natural sources of inflammation and its benefits; the sources are from plant, animal and marine. The book tells how these sources are useful for us to cure several diseases and opens new path for further research. Inflammation part of the book is well presented along with its phases, types and other diseases interrelated with inflammation. Inflammatory mediators, the foremost player of inflammation are defined in a very pleasant and convenient manner. The chapter includes both cell- derived and plasma - derived mediators illustratively with their synthesis and action. Natural source of anti-inflammation is the heart chapter of this book which contains all anti-inflammation sources from plants, marine and animals. This chapter also contains short description of most of the sources, its availability and uses. The authors have also added inflammatory models for assessment of biological activities of natural sources both in vitro and in vivo. Inflammation free lifestyle is described very nicely in the book. The contents are very specific and relevant to its topic; all the data provided is unique and useful. The anti-inflammatory table includes sources, plant parts used, active constituents and other uses. This data provides ample information regarding anti-inflammatory research and innovation. The highlights of this book shall be: -Describes almost all anti-inflammatory sources around the globe at one place in a more convenient tabulated form -Illustrative representation makes the book more attractive and interactive

Lectures on Surgical Pathology

Lectures on Surgical Pathology
  • Author : Sir James Paget
  • Publisher :Unknown
  • Release Date :1860
  • Total pages :700
  • ISBN : UOM:39015076978256
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Summary : Copy 1: Signed on title page S.N. Benham, M.D.; copy 2: 1978. Gift of Drs. Berry, Askins, and Suggs of Marion, S.C; copy 3: 1999, Gift of Forde A. McIver, M.D.

Bioactive Natural Products

Bioactive Natural Products
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2015-01-20
  • Total pages :544
  • ISBN : 9783527684427
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Summary : Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

British and Foreign Medico-chirurgical Review

British and Foreign Medico-chirurgical Review
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1851
  • Total pages :229
  • ISBN : HARVARD:32044103050878
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Summary :

The British and Foreign Medico-chirurgical Review Or Quarterly Journal of Practical Medicine and Surgery

The British and Foreign Medico-chirurgical Review Or Quarterly Journal of Practical Medicine and Surgery
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1855
  • Total pages :229
  • ISBN : BSB:BSB10085959
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Summary :

Mode of Action and Target Identification of Anti-inflammatory Natural Products

Mode of Action and Target Identification of Anti-inflammatory Natural Products
  • Author : Stefanie König
  • Publisher :Unknown
  • Release Date :2019*
  • Total pages :229
  • ISBN : OCLC:1176266202
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Summary : In the present thesis, the mode of action of three different natural secondary metabolites was clarified in human cancer cells and primary immune cells. The investigated compounds of this work were (I) the mycotoxin gliotoxin from Aspergillus fumigatus targeting leukotriene A4 hydrolase (LTA4H) resulting in a reduction of the biosynthesis of the neutrophil chemoattractant leukotriene B4 (LTB4) in vivo and in vitro. Furthermore, gliotoxin caused a reduced neutrophil infiltration into the peritoneal cavity. Interestingly, gliotoxin suppressed solely LTB4 formation without compromising other eicosanoids identifying thereby the cause of neutropenia during invasive aspergillosis (IA). However, gliotoxin failed to impede LTA4H activity in non-cellular systems but pre-incubation with GSH enables inhibition of LTA4H activity by gliotoxin indicating that reducing conditions were crucial to cleave the intramolecular disulfide bond. The formed free thiol groups chelated the zinc ion in the active epoxide hydrolase center of LTA4H. Second (II), the melleolide dehydroarmillylorsellinate (DAO) exhibiting, on the one hand, anti-inflammatory features by abrogating 5-lipoxygenase (5-LOX) product formation due to an interaction with surface cysteines especially C159 located at the entrance to the active center of 5-LOX hampering the interaction between 5-LOX and the 5-LOX activating protein (FLAP), and on the other hand, manipulate monocyte functions by covalent binding of the cellular membrane constituent phosphatidylethanolamine (PE). And finally (III), myxochelin A biosynthesized by Pyxidicoccus fallax hampering 5-LOX activity due to iron chelation by the catechol basic structure. Over the last decades, the link between inflammation and cancer gains relevance. Hence, it is important to investigate new anti-inflammatory drugs to prevent chronic diseases, and to elucidate the mechanism of action of cytotoxic compounds to develop new strategies of action for anti-cancer drugs.

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2016-10-11
  • Total pages :332
  • ISBN : 9780128096925
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Summary : Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Obesity, Inflammation and Cancer

Obesity, Inflammation and Cancer
  • Author : Andrew J. Dannenberg,Nathan A. Berger
  • Publisher :Unknown
  • Release Date :2013-05-21
  • Total pages :433
  • ISBN : 9781461468196
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Summary : In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.

The Half-yearly Abstract of the Medical Sciences

The Half-yearly Abstract of the Medical Sciences
  • Author : William Harcourt Ranking,Charles Bland Radcliffe,William Dommett Stone
  • Publisher :Unknown
  • Release Date :1850
  • Total pages :229
  • ISBN : UOM:39015076551822
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Summary :