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Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases

Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases
  • Author : Seyed Moayed Alavian,Seyed Mohammad Nabavi,Seyed Fazel Nabavi,Ana Sanches Silva
  • Publisher :Unknown
  • Release Date :2020-12-01
  • Total pages :314
  • ISBN : 9780128175231
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Summary : Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases explores the role of plant-based natural compounds and the biological effects of these substances as they relate to liver disease, including the most prevalent - hepatitis, cancer and cirrhosis. Providing evidence-based knowledge on the effect of phytochemicals in liver diseases, this book includes extensive coverage of the mechanism of action of compounds, as well as the relation of structure and function of phytochemicals in hepatitis B and C, fatty liver disease, nonalcoholic fatty liver disease, liver cancer, biliary cirrhosis, and primary sclerosing cholangitis. The effect of phytochemicals in the hepatotoxicity of drugs is also addressed. Written for health professionals seeking reliable and up-to-date information on the beneficial or toxic effects of natural compounds on liver disease, this book is sure to be a welcomed resource for nutritionists, food chemists, natural product researchers, pharmacists, medical doctors, and pharmacognosists alike. Explores the benefits of phytonutrients, especially those due to their wide spectrum of biological activities Addresses various liver diseases, including hepatitis B, hepatitis C, alcoholic fatty liver disease, nonalcoholic fatty liver disease, liver cancer, biliary cirrhosis and primary sclerosing cholangitis Provides reliable, up-to-date information on the natural compounds that have protective or toxic effects on liver diseases

Bioactive Foods and Extracts

Bioactive Foods and Extracts
  • Author : Ronald Ross Watson,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2010-11-11
  • Total pages :663
  • ISBN : 1439816212
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Summary : Though there is considerable historical and anecdotal record for the use and efficacy of the cancer preventative properties of vegetables, fruits, and herbs, modern healthcare professionals require scientific evidence and verifiable results to make defensible decisions on the benefits, risks, and value of botanicals and their extracts in the prevention and treatment of cancers. Presenting research-based evidence of the role of herbs and bioactive foods in the prevention and treatment of cancer, Bioactive Foods and Extracts: Cancer Treatment and Prevention provides the scientific basis for millennia of empirical evidence. Divided into four sections, the book begins with a look at herbal medicines and bioactive foods in cancer prevention in general including the benefits of Greco-Arabic and Islamic herbal medicine, Indian vegetarian diet, and a range of culinary spices. The second section considers specific bioactive foods in cancer prevention. Chapters include in-depth discussions of phytochemicals and their therapeutic action within the body, curcumin-mediated cellular response, and the mechanism and use of prunes and plums, mushrooms, and tomato-based products. The third section takes a focused look at certain cancers such as colon, prostate, breast, and lung cancer. Substances analyzed include ginseng, pentacyclic triterpenes from olives, cruciferous vegetables, and fruit phenolics, as well as alcohol and its associated risks. The final section investigates non-botanical supplements including vitamin D, calcium, selenium, and probiotics. Providing an important scientific and evidence-based record on an increasingly popular branch of modern healthcare, this indispensible reference brings together the analytical research of modern science and the wisdom of herbal and food based medicine and puts them at your fingertips.

Fruit and Vegetable Phytochemicals

Fruit and Vegetable Phytochemicals
  • Author : Elhadi M. Yahia
  • Publisher :Unknown
  • Release Date :2017-08-25
  • Total pages :1488
  • ISBN : 9781119157977
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Summary : Now in two volumes and containing more than seventy chapters, the second edition of Fruit and Vegetable Phytochemicals: Chemistry, Nutritional Value and Stability has been greatly revised and expanded. Written by hundreds of experts from across the world, the chapters cover diverse aspects of chemistry and biological functions, the influence of postharvest technologies, analysis methods and important phytochemicals in more than thirty fruits and vegetables. Providing readers with a comprehensive and cutting-edge description of the metabolism and molecular mechanisms associated with the beneficial effects of phytochemicals for human health, this is the perfect resource not only for students and teachers but also researchers, physicians and the public in general.

Stem Cells and Cancer in Hepatology

Stem Cells and Cancer in Hepatology
  • Author : Yun-Wen Zheng
  • Publisher :Unknown
  • Release Date :2018-05-18
  • Total pages :382
  • ISBN : 9780128123027
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Summary : Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge. Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation

Principles of Nutrigenetics and Nutrigenomics

Principles of Nutrigenetics and Nutrigenomics
  • Author : Raffaele De Caterina,J. Alfredo Martinez,Martin Kohlmeier
  • Publisher :Unknown
  • Release Date :2019-09-22
  • Total pages :586
  • ISBN : 9780128045879
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Summary : Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book

Nonvitamin and Nonmineral Nutritional Supplements

Nonvitamin and Nonmineral Nutritional Supplements
  • Author : Seyed Mohammad Nabavi,Ana Sanches Silva
  • Publisher :Unknown
  • Release Date :2018-09-28
  • Total pages :583
  • ISBN : 9780128125632
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Summary : Nonvitamin and Nonmineral Nutritional Supplements compiles comprehensive information and recent findings on supplements found in today’s market. The book focuses on non-essential nutrients, animal extracts, yeast and fungi extracts, and plant and algae extracts used as supplements. Readers will find valuable insights on the impact of dietary supplementation on human health, along with an understanding of the positive and negative aspects of each supplement. Provides reliable information on available supplements to inform nutritional practices Presents each supplement’s sources, availability, health benefits, drawbacks, and possible interactions with other supplements, food or drugs Serves as a guide to non-essential nutrients, plant and algae extracts, animal extracts, including bee products and shark cartilage, and supplements from yeast and fungi

Marine Bioactive Compounds

Marine Bioactive Compounds
  • Author : Maria Hayes
  • Publisher :Unknown
  • Release Date :2011-11-19
  • Total pages :232
  • ISBN : 1461412471
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Summary : The aim and scope of this book is to highlight the sources, isolation, characterization and applications of bioactive compounds from the marine environment and to discuss how marine bioactive compounds represent a major market application in food and other industries. It discusses sustainable marine resources of macroalgal origin and gives examples of bioactive compounds isolated from these and other resources, including marine by-product and fisheries waste streams. In addition, it looks at the importance of correct taxonomic characterization.

Stellate Cells in Health and Disease

Stellate Cells in Health and Disease
  • Author : Chandrashekhar Gandhi,Massimo Pinzani
  • Publisher :Unknown
  • Release Date :2015-04-10
  • Total pages :336
  • ISBN : 9780128005446
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Summary : Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Antioxidants in Foods and Its Applications

Antioxidants in Foods and Its Applications
  • Author : Emad Shalaby,Ghada Mostafa Azzam
  • Publisher :Unknown
  • Release Date :2018-07-11
  • Total pages :178
  • ISBN : 9781789233780
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Summary : Free radicals are atoms or molecules containing unpaired electrons. Damage occurs when the free radical encounters another molecule and seeks to find another electron to pair its unpaired electron. Free radicals can cause mutation in different biological compounds such as protein, nucleic acids, and lipids, and the damage caused by the free radicals lead to various diseases (cancer, cardiovascular disease, aging, etc.). Antioxidants are helpful in reducing and preventing damage from free radical reactions because of their ability to donate electrons, which neutralize the radical without forming another. Ascorbic acid, for example, can lose an electron to a free radical and remain stable itself by passing its unstable electron around the antioxidant molecule. Unfortunately, new data indicate that the synthetic antioxidants used in the industry could have carcinogenic effects on human cells, thus fueling an intense search for new, natural, and efficient antioxidants. Therefore, the current book discusses the role and source of antioxidant compounds in nutrition and diets. Also, the current book includes nine chapters contributed by experts around the world, and the chapters are categorized into two sections: "Antioxidant Compounds and Biological Activities" and "Natural Antioxidants and Applications."

Natural Bioactive Compounds

Natural Bioactive Compounds
  • Author : Rajeshwar P. Sinha,h.c. Donat-P. Häder
  • Publisher :Unknown
  • Release Date :2020-10-15
  • Total pages :502
  • ISBN : 9780128206591
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Summary : Natural Bioactive Compounds: Technological Advancements deals with the latest breakthroughs in the field of screening, characterization and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, viruses, cyanobacteria, algae, fungi, bryophytes, higher plants, sponges, corals and fishes. Written by some of the most reputed scientists in the field, this book introduces the reader to strategies and methods in the search for bioactive natural products. It is an essential read for researchers and students interested in bioactive natural products, their biological and pharmacological properties, their possible use as chemopreventive or chemotherapeutic agents, and other future potential applications. Explores natural sources of bioactive compounds, including cyanobacteria, bacteria, viruses, fungi and higher plants Discusses the potential applications of biological products, such as their use in medicine (antibiotics, cancer research, immunology), as food additives, supplements and technological substances Analyzes the contributions of emerging or developing technologies for the study of bioactive natural compounds (characterization and purification)

Dietary Interventions in Liver Disease

Dietary Interventions in Liver Disease
  • Author : Ronald Ross Watson,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2019-01-10
  • Total pages :428
  • ISBN : 9780128144671
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Summary : Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. Provides information on agents that affect metabolism and other health-related conditions in the liver Explores the impact of composition, including differences based on country of origin and processing techniques Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function

Nutritional Composition and Antioxidant Properties of Fruits and Vegetables

Nutritional Composition and Antioxidant Properties of Fruits and Vegetables
  • Author : Amit K. Jaiswal
  • Publisher :Unknown
  • Release Date :2020-07-30
  • Total pages :766
  • ISBN : 9780128127810
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Summary : Nutritional Composition and Antioxidant Properties of Fruits and Vegetables provides an overview of the nutritional and anti-nutritional composition, antioxidant potential, and health benefits of a wide range of commonly consumed fruits and vegetables. The book presents a comprehensive overview on a variety of topics, including inflorescence, flowers and flower buds (broccoli, cauliflower, cabbage), bulb, stem and stalk (onion, celery, asparagus, celery), leaves (watercress, lettuce, spinach), fruit and seed (peppers, squash, tomato, eggplant, green beans), roots and tubers (red beet, carrots, radish), and fruits, such as citrus (orange, lemon, grapefruit), berries (blackberry, strawberry, lingonberry, bayberry, blueberry), melons (pumpkin, watermelon), and more. Each chapter, contributed by an international expert in the field, also discusses the factors influencing antioxidant content, such as genotype, environmental variation and agronomic conditions. Contains detailed information on nutritional and anti-nutritional composition for commonly consumed fruits and vegetables Presents recent epidemiological information on the health benefits of fresh produce Provides in-depth information about the antioxidant properties of a range of fruits and vegetables

Grape and Wine Biotechnology

Grape and Wine Biotechnology
  • Author : Antonio Morata,Iris Loira
  • Publisher :Unknown
  • Release Date :2016-10-19
  • Total pages :470
  • ISBN : 9789535126928
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Summary : Grape and Wine Biotechnology is a collective volume divided into 21 chapters focused on recent advances in vine pathology and pests, molecular tools to control them, genetic engineering and functional analysis, wine biotechnology including molecular techniques to study Saccharomyces and non-Saccharomyces yeast in enology, new fermentative applications of nonconventional yeasts in wine fermentation, biological aging on lees and wine stabilization, advanced instrumental techniques to detect wine origin and frauds, and many other current applications useful for researchers, lecturers, and vine or wine professionals. The chapters have been written by experts from different universities and research centers of 13 countries being representative of the knowledge, research, and know-how of many wine regions worldwide.

Liver Pathophysiology

Liver Pathophysiology
  • Author : Pablo Muriel
  • Publisher :Unknown
  • Release Date :2017-03-02
  • Total pages :914
  • ISBN : 9780128043219
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Summary : Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Illustrated Toxicology

Illustrated Toxicology
  • Author : PK Gupta
  • Publisher :Unknown
  • Release Date :2018-04-04
  • Total pages :630
  • ISBN : 9780128132142
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Summary : Illustrated Toxicology: With Study Questions is an essential, practical resource for self-study and guidance catering to a broad spectrum of students. This book covers a range of core toxicological areas, including pesticides, radioactive materials and poisonous plants, also presenting a section on veterinary toxicology. Across 16 chapters, the book presents key concepts with the aid of over 250 detailed, full-color illustrations. Each section is supplemented with practical exercises to support active learning. This combination of clear illustrations and sample testing will help readers gain a deeper understanding of toxicology. This book is useful for toxicology, pharmacy, medical and veterinary students, and also serves as a refresher for academics and professionals in the field, including clinical pharmacists, forensic toxicologists, environmentalists and veterinarians. Includes comprehensive coverage of key toxicological concepts for study and revision Provides a visual learning aid with over 250 full-color illustrations Enhances understanding and memory retention of core concepts with the use of practical exercises

The SAGE Encyclopedia of Cancer and Society

The SAGE Encyclopedia of Cancer and Society
  • Author : Graham A. Colditz
  • Publisher :Unknown
  • Release Date :2015-08-12
  • Total pages :1632
  • ISBN : 9781506301266
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Summary : The first edition of the Encyclopedia of Cancer and Society was published in 2007 and received a 2008 Editors’ Choice Award from Booklist. It served as a general, non-technical resource focusing on cancer from the perspective of the social and behavioral sciences, exploring social and economic impacts, the “business” of cancer, advertising of drugs and treatment centers, how behavior change could offer great potential for cancer prevention, environmental risks, food additives and regulation, the relation between race and ethnicity and cancer risk, socioeconomic status, controversies—both scientific and political—in cancer treatment and research, country-by-country entries on cancer around the world, and more. Given various developments in the field including new drug treatments, political controversies over use of the vaccines Gardasil and Cervarix with young girls to prevent cervical cancer, and unexpected upticks in the prevalence of adult smoking within the U.S. following decades of decline, the SAGE Encyclopedia of Cancer and Society, Second Edition serves as an updated and more current encyclopedia that addresses concerns pertaining to this topic. Key Features: · Approximately half of the 700 first-edition articles revised and updated · 30+ new entries covering new developments since 2006 · Signed entries with cross-references · Further Readings accompanied by pedagogical elements · New Reader’s Guide · Updated Chronology, Resource Guide, Glossary, and through new Index The SAGE Encyclopedia of Cancer and Society, Second Edition serves as a reliable and precise source for students and researchers with an interest in social and behavioral sciences and seeks to better understand the continuously evolving subject matter of cancer and society.

Handbook on Natural Pigments in Food and Beverages

Handbook on Natural Pigments in Food and Beverages
  • Author : Reinhold Carle,Ralf Schweiggert
  • Publisher :Unknown
  • Release Date :2016-04-20
  • Total pages :538
  • ISBN : 9780081003923
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Summary : Handbook on Natural Pigments: Industrial Applications for Improving Food Colour is unique in its approach to the improvement of food colors. The book is written with industrial applications in mind, with each chapter focusing on a color solution for a specific commodity that will provide food scientists with a one-stop, comprehensive reference on how to improve the color of a particular food product. The first section of the book looks at the legal frameworks which underpin natural food colorings, also investigating the consumer expectations of food color. The second section of the book focuses on specific industrial applications of natural colorants with chapters covering the use of natural colorants in aqueous food products, cereal-based foods, and meat products, amongst many other topics. The various pigments which can be used to effectively color these commodities are presented with information on safety and testing included throughout. The final section in the book looks at recent developments and future perspectives in natural food colorings. There are chapters which cover the health benefits of natural pigments, the use of novel fruits and vegetables in pigments, and stable natural solutions for blue colorings. Presents recent advances in consumer demand and worldwide legislation regarding natural food colorants Discusses the use of natural food colorants for one specific product category per chapter rather than one pigment class per chapter – this makes the book extremely useable for industrialists working in a specific sector Contains a comprehensive array of product-specific coloration approaches, from using pigment-enriched feed additives to the direct addition of color formulations

Food Additives

Food Additives
  • Author : Desiree Nedra Karunaratne,Geethy Pamunuwa
  • Publisher :Unknown
  • Release Date :2017-09-06
  • Total pages :176
  • ISBN : 9789535134893
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Summary : Food additives is intended to provide the readers with knowledge on some very significant aspects of the food additives currently in use. Food additives have become essential in the food sector with the rising need for food processing and preservation. However, the use of food additives is regulated imposing strict rules as the impact of those additives on health cannot be neglected. The first chapter starts off with a general overview of food additives highlighting the novel trends that enhance the attributes of those additives. Thereafter, the chapters are devoted mainly to plant-derived food additives and microbially derived food additives. The main topics discussed under 'additives from plant origin' are the efficacy of beetroot formulations as a source of nitrate ions, plant-derived food preservatives and plant-derived food additives used in meat and meat-based products. The further chapters discuss 'additives from microbial origin' focusing on lactic acid bacteria and additives derived from lactic acid bacteria and food additives used in 'bread-making'. Overall, this manuscript emphasises the concept of 'clean labelling' and the importance of natural food additives.

Plant Secondary Metabolites for Human Health

Plant Secondary Metabolites for Human Health
  • Author : Megh R. Goyal,P. P. Joy,Hafiz Ansar Rasul Suleria
  • Publisher :Unknown
  • Release Date :2019-09-17
  • Total pages :308
  • ISBN : 9780429757655
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Summary : This new book deals with recent advanced research on natural products and health-promoting foods that work to reduce the risk of diseases while enhancing overall well-being. Plant-based functional foods are known to contain compounds (also referred to as phytochemicals) in the leaves, stems, flowers, and fruits of certain plants. These plant products are drawing the attention of researchers because of their demonstrated beneficial effects against disease, particularly diabetes, hypertension, cancer, neurodegenerative diseases, among others. The medicinal and nutritional use of plant secondary metabolites is a hot topic and has been receiving extensive attention from both health professionals and the public. This book presents new information on the extraction of bioactive compounds from plants, plant-based drugs, and the innovative use of plant-based drugs for human health.

Antioxidant-Antidiabetic Agents and Human Health

Antioxidant-Antidiabetic Agents and Human Health
  • Author : Oluwafemi Oguntibeju
  • Publisher :Unknown
  • Release Date :2014-02-05
  • Total pages :382
  • ISBN : 9789535112150
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Summary : The human system employs the use of endogenous enzymatic as well as non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress. Enzymatic antioxidants and non-enzymatic antioxidants work synergistically with each other, using different mechanisms against different free radicals and stages of oxidative stress. Dietary and lifestyle modifications are seen as the mainstay of treatment and management of chronic diseases such as diabetes mellitus. The major aims of dietary and lifestyle changes are to reduce weight, improve glycaemic control and reduce the risk of coronary heart disease, which accounts for 70- 80% of deaths among those with diabetes. It is also important to note that medicinal plants have been used as medicines since ancient time, and continue to play significant role even in modern medicine in management and treatment of chronic diseases. Impressive numbers of modern therapeutic agents have been developed from plants. Phytochemicals have been isolated and characterised from fruits such as grapes and apples, vegetables such as broccoli and onion, spices such as turmeric, beverages such as green tea and red wine, as well as many other sources. The WHO estimates that approximately 80% of the worlds inhabitants rely on traditional medicine for their primary health care and many medicinal plants have ethno-medical claims of usefulness in the treatment of diabetes and other chronic diseases globally, and have been employed empirically in antidiabetic, antihyperlipidemic, antihypertensive, antinflammatory and antiparasitic remedies. This book examines the role of antioxidant-rich natural products in management and treatment of diabetes and other chronic diseases.

Grain Legumes

Grain Legumes
  • Author : Aakash Goyal
  • Publisher :Unknown
  • Release Date :2016-10-19
  • Total pages :188
  • ISBN : 9789535127208
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Summary : Grain legumes are a main source of nitrogen-rich edible seeds and constitute a major source of dietary protein in the diets of human population especially for vegetarian diet. Legumes comprise the third largest family of flowering plants and provide important sources of food, fodder, oil, and fiber products. This book focuses on grain legumes production challenges, progress, and prospects. The book comprises a vast array of topics including diversity, biofortification, importance and antioxidant properties of pulse proteins, etc. This volume will serve as an excellent resource for students, researchers, and scientists interested and working in the area of sustainable crop production.