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Inhaled Medicines

Inhaled Medicines
  • Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
  • Publisher :Unknown
  • Release Date :2021-01-20
  • Total pages :438
  • ISBN : 9780128149751
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Summary : Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ● Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ● Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ● Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ● Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Inhaled Medicines

Inhaled Medicines
  • Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
  • Publisher :Unknown
  • Release Date :2021-02-05
  • Total pages :438
  • ISBN : 9780128149744
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Summary : Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Inhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives
  • Author : Anthony J. Hickey
  • Publisher :Unknown
  • Release Date :2017-11-23
  • Total pages :110
  • ISBN : 9780128123362
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Summary : Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

EPA's Particulate Matter and Ozone Rulemaking

EPA's Particulate Matter and Ozone Rulemaking
  • Author : United States,United States. Congress. House. Committee on Government Reform and Oversight. Subcommittee on National Economic Growth, Natural Resources, and Regulatory Affairs
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :499
  • ISBN : PURD:32754067967129
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Summary :

Pharmaceutical Inhalation Aerosol Technology, Third Edition

Pharmaceutical Inhalation Aerosol Technology, Third Edition
  • Author : Anthony J. Hickey,Sandro R. da Rocha
  • Publisher :Unknown
  • Release Date :2019-03-26
  • Total pages :730
  • ISBN : 9780429619564
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Summary : This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

FDA Consumer

FDA Consumer
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :229
  • ISBN : STANFORD:36105113704360
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Summary :

Pharmacology and Medicines Management for Nurses

Pharmacology and Medicines Management for Nurses
  • Author : George Downie (MSc.),Jean Mackenzie (RGN.),Arthur Williams (MPS.),Caroline Hind
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :568
  • ISBN : CHI:82082953
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Summary : This edition has been fully updated and now includes self-assessment exercises with answers.

American Journal of Respiratory and Critical Care Medicine

American Journal of Respiratory and Critical Care Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :229
  • ISBN : NWU:35558005287863
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Summary :

Emergency Medicine

Emergency Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1986
  • Total pages :229
  • ISBN : UCLA:31158011511762
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Summary :

Inhalation Drug Delivery

Inhalation Drug Delivery
  • Author : Paolo Colombo,Daniela Traini,Francesca Buttini
  • Publisher :Unknown
  • Release Date :2013-02-11
  • Total pages :214
  • ISBN : 9781118354124
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Summary : There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.

Hospital Medicine

Hospital Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1986-05
  • Total pages :229
  • ISBN : NWU:35558001027776
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Summary :

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols
  • Author : Warren H. Finlay
  • Publisher :Unknown
  • Release Date :2019-06-01
  • Total pages :302
  • ISBN : 9780081027868
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Summary : The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Encyclopedia of Respiratory Medicine

Encyclopedia of Respiratory Medicine
  • Author : Geoffrey J. Laurent,Steven D Shapiro
  • Publisher :Unknown
  • Release Date :2006-05-30
  • Total pages :2576
  • ISBN : UCLA:L0089634265
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Summary : An impressive four-volume work that provides an authoritative and comprehensive coverage of the complete field of respiratory medicine. It provides a vital interface between the pure and clinical science environments covering all aspects of respiratory medicine from the relevant molecular biology to the treatment of diseases that affect the respiratory system. It includes comprehensive coverage of lung cells, the structural components of the lung and key molecules that regulate lung function as well as all the major respiratory diseases. Students, researchers and professionals alike will find this an authoritative source of information on all aspects of respiratory medicine. Also available online via ScienceDirect (2006) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. Includes diagrams of uniformly high quality and references to enable readers to access the wider literature Highly structured through the use of chapter templates Key four-color illustrations that will be invaluable teaching tools

Zoey and the Zones

Zoey and the Zones
  • Author : Shawn McCormick,Ginny Trevino
  • Publisher :Unknown
  • Release Date :2002-02
  • Total pages :108
  • ISBN : 0971812012
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Summary : Parents workbook for families of children with Asthma

One Minute Asthma

One Minute Asthma
  • Author : Thomas F. Plaut
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :61
  • ISBN : 0914625241
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Summary :

Journal of the American Pharmaceutical Association

Journal of the American Pharmaceutical Association
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :229
  • ISBN : UCLA:L0081974925
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Summary :

Understanding Canadian Prescription Drugs : a Consumer's Guide to Correct Use

Understanding Canadian Prescription Drugs : a Consumer's Guide to Correct Use
  • Author : Dorothy L. Smith,Association pharmaceutique canadienne
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :389
  • ISBN : 155013129X
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Summary :

Asthma Information for Teens

Asthma Information for Teens
  • Author : Karen Bellenir
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :386
  • ISBN : 0780807707
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Summary : Including Facts about Asthma Causes, Triggers, Symptoms, Diagnosis, and Treatment.

Nanoparticles in medicine and environment

Nanoparticles in medicine and environment
  • Author : J.C. Marijnissen,Leon Gradon
  • Publisher :Unknown
  • Release Date :2009-12-01
  • Total pages :287
  • ISBN : 9048126320
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Summary : A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system. Three main themes are discussed: Nanoparticle sources and production Nanoparticle inhalation and deposition Toxicological and medical consequences of nanoparticles Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.

Caregiver Education Guide for Children with Developmental Disabilities

Caregiver Education Guide for Children with Developmental Disabilities
  • Author : Sara N. Di Lima,Suzanne Niemeyer,Jennifer R. Carson
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :598
  • ISBN : CORNELL:31924074252994
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Summary : This comprehensive reference addresses the need for specific, hands-on instructions and guidelines for the parents and caregivers of children with special needs. The book includes charts, guidelines, instructions, tools, and educational handouts designed to be copied and distributed by the health professional to enhance patient care and compliance with treatment programs.

Consumer Drug Reference 2005

Consumer Drug Reference 2005
  • Author : Thompson Healt Micromedex
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :1736
  • ISBN : 0890439931
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Summary : Accompanied by a color chart that helps identify the most common pills and tablets, a comprehensive and practical reference to more than eleven thousand prescription drugs, non-prescription medicines, and nutritional supplements covers side effects, indications, proper usage, interactions with other food and other drugs, dosage information, and much more. 25,000 first printing.