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Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher :Unknown
  • Release Date :2011-04-28
  • Total pages :1075
  • ISBN : 0080460062
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Summary : The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Neurochemistry

Neurochemistry
  • Author : Thomas Heinbockel
  • Publisher :Unknown
  • Release Date :2014-04-23
  • Total pages :416
  • ISBN : 9789535112372
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Summary : Neurochemistry is a flourishing academic field that contributes to our understanding of molecular, cellular and medical neurobiology. As a scientific discipline, neurochemistry studies the role of chemicals that build the nervous system, it explores the function of neurons and glial cells in health and disease, it discovers aspects of cell metabolism and neurotransmission, and it reveals how degenerative processes are at work in the nervous system. Accordingly, this book contains chapters from a variety of topics that fall into the following broad sections: I. Neural Membranes and Intracellular Signaling, II. Neural Processing and Intercellular Signaling, III. Growth, Development and Differentiation, and IV. Neurodegenerative Diseases. The book presents comprehensive reviews in these different areas written by experts in their respective fields. Neurodegeneration and neuronal diseases are featured prominently and are a recurring theme throughout most chapters. This book will be a most valuable resource for neurochemists and other scientists alike. In addition, it will contribute to the training of current and future neurochemists and, hopefully, will lead us on the path to curing some of the biggest challenges in human health.

Neuronal Cytoskeleton; Morphogenesis, Transport and Synaptic Transmission

Neuronal Cytoskeleton; Morphogenesis, Transport and Synaptic Transmission
  • Author : 廣川信隆
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :335
  • ISBN : 4762277495
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Summary :

Dependence of Synaptic Plasticity and Memory Facilitation Upon Amyloid Precusor Protein Intracellular Domain

Dependence of Synaptic Plasticity and Memory Facilitation Upon Amyloid Precusor Protein Intracellular Domain
  • Author : Huifang Ma
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :362
  • ISBN : MINN:31951P01074144L
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Summary :

The Effect of Oxidative Stress and Sumoylation on APP Processing in Alzheimer's Disease

The Effect of Oxidative Stress and Sumoylation on APP Processing in Alzheimer's Disease
  • Author : Jared Evan Goldstine
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :254
  • ISBN : UCLA:L0096927678
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Summary :

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
  • Author : J. Robin Harris
  • Publisher :Unknown
  • Release Date :2012-12-09
  • Total pages :650
  • ISBN : 9789400754164
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Summary : This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :342
  • ISBN : 9780987073051
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Summary : The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Alzheimer's Disease

Alzheimer's Disease
  • Author : Jolanta Dorszewska,Wojciech Kozubski
  • Publisher :Unknown
  • Release Date :2018-07-18
  • Total pages :162
  • ISBN : 9781789234626
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Summary : Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.

Alzheimer's Disease

Alzheimer's Disease
  • Author : Inga Zerr
  • Publisher :Unknown
  • Release Date :2015-07-01
  • Total pages :372
  • ISBN : 9789535121374
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Summary : There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

The Biology of Alzheimer Disease

The Biology of Alzheimer Disease
  • Author : Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :511
  • ISBN : 1936113449
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Summary : Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses — accumulation of amyloid beta and neurofibrillary tangles — is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer Disease, is also an intense area of research.

Free Radicals, Antioxidants and Diseases

Free Radicals, Antioxidants and Diseases
  • Author : Rizwan Ahmad
  • Publisher :Unknown
  • Release Date :2018-08-01
  • Total pages :148
  • ISBN : 9781789235647
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Summary : The current book entitled Free Radicals, Antioxidants, and Diseases gives an idea of detecting free radicals in vivo by newer techniques and provides insights into the roles played by various antioxidants in combating diseases caused by oxidative stress. The chapters included in this volume showcase new investigation in this field by the research groups around the world.

Progress in Alzheimer’s and Parkinson’s Diseases

Progress in Alzheimer’s and Parkinson’s Diseases
  • Author : Abraham Fisher,Israel Hanin,Mitsuo Yoshinda
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :888
  • ISBN : 9781461553373
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Summary : This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Conference was attended by 550 participants from 28 countries, representing a broad spectrum of research interests; and included a well-balanced representation from aca demia, clinical institutions and pharmaceutical industry. The four-and-one-half day meeting served as an excellent medium for surveying the current preclinical and clinical develop ments in AD, PO, and other related disorders. The scientific program was divided into 24 oral sessions and daily poster sessions. The conference culminated in a round table discus sion. There were 122 talks and 161 posters. This book incorporates a combination of both.

Cellular Trafficking and Metabolism of the Alzheimer's Disease Amyloid Precursor Protein (APP) in the Secretory and Endocytic Pathways

Cellular Trafficking and Metabolism of the Alzheimer's Disease Amyloid Precursor Protein (APP) in the Secretory and Endocytic Pathways
  • Author : Michelle Leigh Steinhilb
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :229
  • ISBN : UOM:39015054296150
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Summary :

Brain Diseases and Metalloproteins

Brain Diseases and Metalloproteins
  • Author : David R. Brown
  • Publisher :Unknown
  • Release Date :2012-08-07
  • Total pages :300
  • ISBN : 9789814316019
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Summary : This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

Alzheimer Disease

Alzheimer Disease
  • Author : Sangram S. Sisodia,Robert Katzman
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :457
  • ISBN : UOM:39015047449270
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Summary : Examines every aspect of Alzheimer disease - clinical, epidemiological, structural, chemical, genetic, molecular and therapeutic. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with presentation of prion diseases, Pick's disease, front-temporal disorders, transgenic models, and biochemistry of presenilins. Treatment of symptoms with therapeutic drugs is discussed, along with outcomes of and problems inherent in clinical trails for AD.

The Journal of Cell Biology

The Journal of Cell Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :229
  • ISBN : UOM:39015060942466
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Summary : No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Apolipoprotein E and Alzheimer’s Disease

Apolipoprotein E and Alzheimer’s Disease
  • Author : A.D. Roses,K.H. Weisgraber,Y. Christen
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :188
  • ISBN : 9783642801099
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Summary : There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America
  • Author : National Academy of Sciences (U.S.)
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : WISC:89099178071
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Summary :

Memoirs of the Institute for Protein Research, Osaka University

Memoirs of the Institute for Protein Research, Osaka University
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : OSU:32435073235020
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Summary :

Brain Research

Brain Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1999-04
  • Total pages :229
  • ISBN : NWU:35558004252710
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Summary :

Astrocyte

Astrocyte
  • Author : Maria Teresa Gentile,Luca Colucci D’Amato
  • Publisher :Unknown
  • Release Date :2018-03-21
  • Total pages :242
  • ISBN : 9789535138853
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Summary : A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.