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Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine
  • Author : Claudio Cobelli,Ewart Carson
  • Publisher :Unknown
  • Release Date :2019-08-01
  • Total pages :384
  • ISBN : 0128158050
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Summary : Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning

Modelling Methodology for Physiology and Medicine

Modelling Methodology for Physiology and Medicine
  • Author : Ewart Carson,Claudio Cobelli
  • Publisher :Unknown
  • Release Date :2013-12-05
  • Total pages :588
  • ISBN : 0124095259
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Summary : Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Introduction to Biomedical Engineering

Introduction to Biomedical Engineering
  • Author : John Enderle, Ph.D.,Joseph Bronzino,Susan M. Blanchard
  • Publisher :Unknown
  • Release Date :2005-04-20
  • Total pages :1118
  • ISBN : 0122386620
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Summary : Since publication in 1999, the first edition of Introduction to Biomedical Engineering has dominated the market of biomedical engineering texts. Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field. Both Enderle and Blanchard are on the Accreditation Board for Engineering and Technology (ABET), the body that sets the standard for US-based engineering programs. These standards have been used as a guideline for examples and pedagogy. New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics. · 60% update from first edition to reflect the developing field of biomedical engineering. · Pioneer title in the Academic Press Series in Biomedical Engineering · Over 4,000 units of first edition sold · MatLab examples included in every chapter

Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine
  • Author : Claudio Cobelli,Ewart Carson
  • Publisher :Unknown
  • Release Date :2008-02-06
  • Total pages :328
  • ISBN : 9780080559988
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Summary : This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology

Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology
  • Author : Willem van Meurs
  • Publisher :Unknown
  • Release Date :2011-08-07
  • Total pages :224
  • ISBN : 0071714464
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Summary : THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation. A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications. Coverage includes: Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators “Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014 “This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.

Similarity and Modeling in Science and Engineering

Similarity and Modeling in Science and Engineering
  • Author : Josef Kuneš
  • Publisher :Unknown
  • Release Date :2012-04-05
  • Total pages :442
  • ISBN : 1907343784
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Summary : The present text sets itself in relief to other titles on the subject in that it addresses the means and methodologies versus a narrow specific-task oriented approach. Concepts and their developments which evolved to meet the changing needs of applications are addressed. This approach provides the reader with a general tool-box to apply to their specific needs. Two important tools are presented: dimensional analysis and the similarity analysis methods. The fundamental point of view, enabling one to sort all models, is that of information flux between a model and an original expressed by the similarity and abstraction Each chapter includes original examples and applications. In this respect, the models can be divided into several groups. The following models are dealt with separately by chapter; mathematical and physical models, physical analogues, deterministic, stochastic, and cybernetic computer models. The mathematical models are divided into asymptotic and phenomenological models. The phenomenological models, which can also be called experimental, are usually the result of an experiment on an complex object or process. The variable dimensionless quantities contain information about the real state of boundary conditions, parameter (non-linearity) changes, and other factors. With satisfactory measurement accuracy and experimental strategy, such models are highly credible and can be used, for example in control systems.

An Introduction to Mathematical Physiology and Biology

An Introduction to Mathematical Physiology and Biology
  • Author : J. Mazumdar
  • Publisher :Unknown
  • Release Date :1999-08-19
  • Total pages :226
  • ISBN : 9780521646758
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Summary : A textbook about the mathematical modelling of biological and physiological phenomena for mathematically sophisticated students.

Bioengineering Approaches to Pulmonary Physiology and Medicine

Bioengineering Approaches to Pulmonary Physiology and Medicine
  • Author : M.C.K. Khoo
  • Publisher :Unknown
  • Release Date :2007-08-20
  • Total pages :256
  • ISBN : 0585349649
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Summary : As the current millennium steams towards a close, one cannot help but look with amazement at the incredible amount of progress that has been achieved in medicine in just the last few decades. A key contributing factor to this success has been the importation and blending of ideas and techniques from disciplines outside the traditional borders of medical science. In recent years, the most well-known example is the cross-pollination between molecular biology and medicine. Advances driven by this potent combination have spawned the vision of a future where cures based on gene therapy become commonplace. Yet, as we continue our search for "magic bullets" in the quest to eradicate disease, it important to recognize the value of other less-heralded interdisciplinary efforts that have laid a large part of the foundation of present-day medicine. In pulmonary medicine, the contribution from the bioengineers (a diverse collection of individuals cross-bred to various degrees in mathematical modeling and experimental physiology) has been larger and more sustained than in many other medical specialties. It is easy to point to the vast array of ventilators, blood-gas analyzers, oximeters, pulmonary function devices, and respiration monitors that are present in any modern clinical setting as solid evidence of the successful synergy between engineering science and pulmonary medicine. However, one must not forget the less tangible, but perhaps more important, contributions that have been derived from mathematical modeling and computer simulation, without which many of these modern instruments would not have come into existence.

An Introduction to Mathematical Modeling in Physiology, Cell Biology, and Immunology

An Introduction to Mathematical Modeling in Physiology, Cell Biology, and Immunology
  • Author : James Sneyd,American Mathematical Society
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :177
  • ISBN : 9780821867648
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Summary : In many respects, biology is the new frontier for applied mathematicians. This book demonstrates the important role mathematics plays in the study of some biological problems. It introduces mathematicians to the biological sciences and provides enough mathematics for bioscientists to appreciate the utility of the modelling approach. The book presents a number of diverse topics, such as neurophysiology, cell biology, immunology, and human genetics. It examines how research is done,what mathematics is used, what the outstanding questions are, and how to enter the field. Also given is a brief historical survey of each topic, putting current research into perspective. The book is suitable for mathematicians and biologists interested in mathematical methods in biology.

Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic

Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic
  • Author : Julius Guccione,Ghassan S. Kassab
  • Publisher :Unknown
  • Release Date :2020-01-13
  • Total pages :229
  • ISBN : 2889633233
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Summary :

Nonlinear Dynamic Modeling of Physiological Systems

Nonlinear Dynamic Modeling of Physiological Systems
  • Author : Professor Vasilis Z. Marmarelis
  • Publisher :Unknown
  • Release Date :2004-09-03
  • Total pages :541
  • ISBN : 9780471469605
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Summary : The study of nonlinearities in physiology has been hindered by the lack of effective ways to obtain nonlinear dynamic models from stimulus-response data in a practical context. A considerable body of knowledge has accumulated over the last thirty years in this area of research. This book summarizes that progress, and details the most recent methodologies that offer practical solutions to this daunting problem. Implementation and application are discussed, and examples are provided using both synthetic and actual experimental data. This essential study of nonlinearities in physiology apprises researchers and students of the latest findings and techniques in the field.

Physiology and Medicine

Physiology and Medicine
  • Author : Ivan Y. Torshin
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :302
  • ISBN : 9781600217524
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Summary : Several years have passed since the sequencing of the human genome and what might be called "the post-genomic era" has begun. Of course, there are many different genomes and the term "post-genomic" does not necessarily imply the human genome. However, it is the data encoded in the human genome that hold the promise to be of practical importance in a wide range of biomedical applications. The sequencing and preliminary annotations of the human genome provided an incredible amount of the raw, largely unprocessed information. Coupled with the millions of publications on human physiology already available in public databases, it is clear that certain informational strategies should be adopted for the retrieval, analysis and representation of these data. Among biological sciences, bioinformatics is a specific branch that deals with managing complexities in the biological information. However, the bioinformatics is in no way restricted to the compilation of large databases or elaboration of sophisticated software. The methods of bioinformatics can greatly assist the generation of productive hypotheses that allow subsequent experimental testing followed by confirmation or disapproval. The main idea behind the present volume is not worrying about the steadily growing amounts of biomedical information or about the relative quality of it. This volume, as well as the entire book series, is based on the purpose-oriented attitude: how to make a good use of this information in particular research projects.

Comparative Physiology, Natural Animal Models and Clinical Medicine

Comparative Physiology, Natural Animal Models and Clinical Medicine
  • Author : Michael A Singer
  • Publisher :Unknown
  • Release Date :2007-07-27
  • Total pages :292
  • ISBN : 1908979305
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Summary : This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the “research” that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection. Contents:IntroductionDiabetes MellitusChronic Renal FailureAtherosclerotic Vascular DiseaseDisuse Osteoporosis and Disuse Muscle AtrophyAmmonia ToxicityHypoxia/IschemiaEpilogue Readership: Advanced undergraduate and graduate students in biology, medical scientists, comparative physiologists and biologists. Keywords:Comparative;Physiology;Models;Clinical Medicine;NaturalKey Features:Discusses in detail for each of six clinical disorders the current understanding of the pathogenesis of the disorder and how the natural animal model has solved that particular problemSuggests potential research questions based upon what is known and not known about the natural animal modelClearly illustrates that natural animal models not only provide a different perspective from traditional animal models, but also prove that biological solutions currently exist for different human diseasesHighlights the power of a comparative physiological approach to the development of treatments for human diseasesReviews:“This is an interesting and important book … A few of these questions about natural models for disease have been raised before by comparative physiologists, but they have largely been ignored by those involved in medical research. Dr Singer hopes that a presentation by a clinician will correct this situation. I sincerely hope that he is correct for I agree with his basic thesis.”Professor Emeritus William H Dantzler University of Arizona “Michael Singer has produced a marvellous volume of thought provoking observations … This volume presents a tour de force of integrative and comparative physiology to consider the possible answers to such questions … For many reasons, I cannot recommend this splendid book highly enough.”Troels Ring Aalborg Hospital, Denmark “The style is easily readable, with a logical progression from a clinical setting in the Introduction, through a number of common disease entities … There is a satisfying combination of science and art, and a call for further research in each area … The book is suitable for medical professionals of all levels of training and interests, from the Basic Scientist in the laboratory to the Clinician at the bedside.”Professor A R Morton Queen's University, Ontario

Nonlinear Dynamics in Physiology and Medicine

Nonlinear Dynamics in Physiology and Medicine
  • Author : Anne Beuter,Leon Glass,Michael C. Mackey,Michele S. Titcombe
  • Publisher :Unknown
  • Release Date :2013-06-05
  • Total pages :436
  • ISBN : 0387216405
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Summary : Introduces concepts from nonlinear dynamics using an almost exclusively biological setting for motivation, and includes examples of how these concepts are used in experimental investigations of biological and physiological systems. One novel feature of the book is the inclusion of classroom-tested computer exercises. This book will appeal to students and researchers working in the natural and physical sciences wanting to learn about physiological systems from a mathematical perspective.

Physiology, Biophysics, and Biomedical Engineering

Physiology, Biophysics, and Biomedical Engineering
  • Author : Andrew W Wood
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :782
  • ISBN : 1466552794
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Summary : Physiology, Biophysics and Biomedical Engineering provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It covers the physical phenomena of electricity, pressure, and flow along with the adaptation of the physics of the phenomena to the special conditions and constraints of biological systems. While the text focuses on human biological systems, some of the principles also apply to plants, bacteria, and other animals. The first section of the book presents a general introduction to physiological systems and describes specialized methods used to record electrical events from biological tissue. The next part examines molecules involved in cell transport and signaling as well as the proteins relevant in cells’ ability to contract and generate tension. The text goes on to cover the properties of the heart, blood, and circulation and the monitoring of cardiac and circulatory function. It then discusses the importance of the interrelationship of pressures and flows in organ systems, such as the lungs and kidneys, and details the organization and function of the nervous system. After focusing on the systems used to monitor signals, the book explores modeling, biomechanics, and emerging technologies, including the progressive miniaturization of sensors and actuators in biomedical engineering. Developed from the authors’ courses in medical biophysics and biomedical instrumentation, this book shows how biophysics and biomedical engineering have advanced modern medicine. It brings together the physical principles underlying human physiological processes and the physical methods used to monitor these processes. Requiring only basic mathematical knowledge, the text supplements mathematical formulae with qualitative explanations and illustrations to encourage an intuitive grasp on the processes discussed.

Medical Device Data and Modeling for Clinical Decision Making

Medical Device Data and Modeling for Clinical Decision Making
  • Author : John R. Zaleski
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :356
  • ISBN : 1608070956
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Summary : This cutting-edge volume is the first book that provides you with practical guidance on the use of medical device data for bioinformatics modeling purposes. You learn how to develop original methods for communicating with medical devices within healthcare enterprises and assisting with bedside clinical decision making. The book guides in the implementation and use of clinical decision support methods within the context of electronic health records in the hospital environment.This highly valuable reference also teaches budding biomedical engineers and bioinformaticists the practical benefits of using medical device data. Supported with over 100 illustrations, this all-in-one resource discusses key concepts in detail and then presents clear implementation examples to give you a complete understanding of how to use this knowledge in the field.

Nonlinear Dynamics in Physiology and Medicine

Nonlinear Dynamics in Physiology and Medicine
  • Author : Anne Beuter,Leon Glass,Michael C. Mackey,Michele S. Titcombe
  • Publisher :Unknown
  • Release Date :2003-09-12
  • Total pages :436
  • ISBN : 9780387004495
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Summary : Introduces concepts from nonlinear dynamics using an almost exclusively biological setting for motivation, and includes examples of how these concepts are used in experimental investigations of biological and physiological systems. One novel feature of the book is the inclusion of classroom-tested computer exercises. This book will appeal to students and researchers working in the natural and physical sciences wanting to learn about physiological systems from a mathematical perspective.

Allostasis, Homeostasis, and the Costs of Physiological Adaptation

Allostasis, Homeostasis, and the Costs of Physiological Adaptation
  • Author : Jay Schulkin,Research Professor of Physiology and Biophysics Jay Schulkin
  • Publisher :Unknown
  • Release Date :2004-10-25
  • Total pages :372
  • ISBN : 9780521811415
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Applied Mathematical Models in Human Physiology

Applied Mathematical Models in Human Physiology
  • Author : Johnny T. Ottesen,Mette S. Olufsen,Jesper K. Larsen
  • Publisher :Unknown
  • Release Date :2004-01-01
  • Total pages :298
  • ISBN : 9780898718287
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Summary : This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors focus on models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation.

Biomechanics and Exercise Physiology

Biomechanics and Exercise Physiology
  • Author : Arthur T. Johnson
  • Publisher :Unknown
  • Release Date :2007-03-09
  • Total pages :688
  • ISBN : 1420019074
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Summary : Whether you are a bioengineer designing prosthetics, an aerospace scientist involved in life support, a kinesiologist training athletes, or an occupational physician prescribing an exercise regimen, you need the latest edition of Biomechanics and Exercise Physiology: Quantitative Modeling. Using numerous worked examples to demonstrate what and when to calculate, this book covers more than the fundamentals of exercise physiology and shows you how to calculate responses magnitudes. The second edition improves upon the first edition with inclusion of numerical examples, homework problems, margin notes, and updated material. The five sections cover the energetics of exercise, biomechanics, circulation, respiration, and thermoregulation. The author explains physiological models, demonstrating the conversion of physiology into quantitative form. Tables of values, diagrams, and figures make this book helpful for estimating magnitudes, determining trends, and illustrating concepts. The book emphasizes quantitative mathematical models if possible and conceptual models when mathematical models are not available. Covering a broad scope of material, the author emphasizes quantitative description as much as possible. The book demonstrates the vast amount of physiological material that can be quantitatively predicted and how to translate this information into applications.

Mathematical and Computer Modeling of Physiological Systems

Mathematical and Computer Modeling of Physiological Systems
  • Author : Vincent C. Rideout
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :261
  • ISBN : 09876543XX
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Summary :