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Introduction to Nuclear Mechanics and Genome Regulation

Introduction to Nuclear Mechanics and Genome Regulation
  • Author : G.V. Shivashankar
  • Publisher :Unknown
  • Release Date :2019-06-01
  • Total pages :200
  • ISBN : 9780128125496
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Summary : Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study. Contains applied case studies and full color images that support concept illustration Features a diverse range of chapters that cover the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNA Introduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures

Exam Prep for: Introduction to Nuclear Mechanics and Genome ...

Exam Prep for: Introduction to Nuclear Mechanics and Genome ...
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 1230987654XX
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Summary :

Nuclear Mechanics and Genome Regulation

Nuclear Mechanics and Genome Regulation
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010-10-12
  • Total pages :392
  • ISBN : 0123810108
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Summary : In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

Mechanisms of Gene Regulation: How Science Works

Mechanisms of Gene Regulation: How Science Works
  • Author : Carsten Carlberg
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9783030523213
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Summary :

Cancer Biology and the Nuclear Envelope

Cancer Biology and the Nuclear Envelope
  • Author : Eric C. Schirmer,Jose I. de las Heras
  • Publisher :Unknown
  • Release Date :2014-02-22
  • Total pages :611
  • ISBN : 9781489980328
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Summary : "Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Cell Mechanics

Cell Mechanics
  • Author : Yu-Li Wang,Dennis E. Discher
  • Publisher :Unknown
  • Release Date :2007-07-05
  • Total pages :632
  • ISBN : 0080548709
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Summary : Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells

Genome Organization And Function In The Cell Nucleus

Genome Organization And Function In The Cell Nucleus
  • Author : Karsten Rippe
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :594
  • ISBN : 9783527640003
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Summary : By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.

Structural Materials for Generation IV Nuclear Reactors

Structural Materials for Generation IV Nuclear Reactors
  • Author : Pascal Yvon
  • Publisher :Unknown
  • Release Date :2016-08-27
  • Total pages :684
  • ISBN : 9780081009123
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Summary : Operating at a high level of fuel efficiency, safety, proliferation-resistance, sustainability and cost, generation IV nuclear reactors promise enhanced features to an energy resource which is already seen as an outstanding source of reliable base load power. The performance and reliability of materials when subjected to the higher neutron doses and extremely corrosive higher temperature environments that will be found in generation IV nuclear reactors are essential areas of study, as key considerations for the successful development of generation IV reactors are suitable structural materials for both in-core and out-of-core applications. Structural Materials for Generation IV Nuclear Reactors explores the current state-of-the art in these areas. Part One reviews the materials, requirements and challenges in generation IV systems. Part Two presents the core materials with chapters on irradiation resistant austenitic steels, ODS/FM steels and refractory metals amongst others. Part Three looks at out-of-core materials. Structural Materials for Generation IV Nuclear Reactors is an essential reference text for professional scientists, engineers and postgraduate researchers involved in the development of generation IV nuclear reactors. Introduces the higher neutron doses and extremely corrosive higher temperature environments that will be found in generation IV nuclear reactors and implications for structural materials Contains chapters on the key core and out-of-core materials, from steels to advanced micro-laminates Written by an expert in that particular area

RNA-Based Regulation in Human Health and Disease

RNA-Based Regulation in Human Health and Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2020-08-15
  • Total pages :444
  • ISBN : 9780128171943
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Summary : RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

A Personal History of Nuclear Medicine

A Personal History of Nuclear Medicine
  • Author : Henry N. Wagner
  • Publisher :Unknown
  • Release Date :2007-12-23
  • Total pages :299
  • ISBN : 9781846280726
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Summary : A Personal History of Nuclear Medicine is an account of how nuclear medicine developed, and its basic philosophy in the past, present and future. The book outlines the history of the development of nuclear medicine as experienced by the author and describes the hurdles that nuclear medicine has had to face, in view of the perception of risk of radiation. It also explains how nuclear medicine solves medical problems in clinical practice and how it has contributed to a new definition of disease. The book concludes with future projections of the likely developments in this area in the next 50 years. Target market: nuclear medicine professionals as well non-nuclear medicine physicians and the public

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher :Unknown
  • Release Date :2016-09-03
  • Total pages :712
  • ISBN : 9780128033456
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Summary : Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability and its effect on human diseases Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Materials Science & Engineering

Materials Science & Engineering
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : STANFORD:36105115204567
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Summary :

Chromatin

Chromatin
  • Author : Ralf Blossey
  • Publisher :Unknown
  • Release Date :2017-08-04
  • Total pages :172
  • ISBN : 9781498729383
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Summary : An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

Post-Transcriptional Gene Regulation

Post-Transcriptional Gene Regulation
  • Author : Jane Wu
  • Publisher :Unknown
  • Release Date :2013-04-24
  • Total pages :280
  • ISBN : 9783527665419
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Summary : Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.

Cancer Biology and the Nuclear Envelope

Cancer Biology and the Nuclear Envelope
  • Author : Eric C. Schirmer,Jose I. de las Heras
  • Publisher :Unknown
  • Release Date :2014-02-22
  • Total pages :611
  • ISBN : 9781489980328
GET BOOK HERE

Summary : "Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Nuclear Engineering Handbook, Second Edition

Nuclear Engineering Handbook, Second Edition
  • Author : Kenneth D. Kok
  • Publisher :Unknown
  • Release Date :2016-10-03
  • Total pages :978
  • ISBN : 9781315356303
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Summary : Building upon the success of the first edition, the Nuclear Engineering Handbook, Second Edition, provides a comprehensive, up-to-date overview of nuclear power engineering. Consisting of chapters written by leading experts, this volume spans a wide range of topics in the areas of nuclear power reactor design and operation, nuclear fuel cycles, and radiation detection. Plant safety issues are addressed, and the economics of nuclear power generation in the 21st century are presented. The Second Edition also includes full coverage of Generation IV reactor designs, and new information on MRS technologies, small modular reactors, and fast reactors.

A Classical Introduction to Cryptography Exercise Book

A Classical Introduction to Cryptography Exercise Book
  • Author : Thomas Baigneres,Pascal Junod,Yi Lu,Jean Monnerat,Serge Vaudenay
  • Publisher :Unknown
  • Release Date :2007-08-06
  • Total pages :254
  • ISBN : 9780387288352
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Summary : TO CRYPTOGRAPHY EXERCISE BOOK Thomas Baignkres EPFL, Switzerland Pascal Junod EPFL, Switzerland Yi Lu EPFL, Switzerland Jean Monnerat EPFL, Switzerland Serge Vaudenay EPFL, Switzerland Springer - Thomas Baignbres Pascal Junod EPFL - I&C - LASEC Lausanne, Switzerland Lausanne, Switzerland Yi Lu Jean Monnerat EPFL - I&C - LASEC EPFL-I&C-LASEC Lausanne, Switzerland Lausanne, Switzerland Serge Vaudenay Lausanne, Switzerland Library of Congress Cataloging-in-Publication Data A C.I.P. Catalogue record for this book is available from the Library of Congress. A CLASSICAL INTRODUCTION TO CRYPTOGRAPHY EXERCISE BOOK by Thomas Baignkres, Palcal Junod, Yi Lu, Jean Monnerat and Serge Vaudenay ISBN- 10: 0-387-27934-2 e-ISBN-10: 0-387-28835-X ISBN- 13: 978-0-387-27934-3 e-ISBN- 13: 978-0-387-28835-2 Printed on acid-free paper. O 2006 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now know or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if the are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America.

Concerning the Origin of Malignant Tumours

Concerning the Origin of Malignant Tumours
  • Author : Theodor Boveri
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :89
  • ISBN : STANFORD:36105131699378
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Summary : An English translation of Boveri's famous monograph which was first published in Germany in 1914. Written almost a hundred years ago, Theodor Boveri's Zur Frage der Entstehung maligner Tumoren has had a momentous impact on cancer research. In it he argues that malignancy arises as a consequence of chromosomal abnormalities and that multiplication is an inherent property of cells. With astonishing prescience, Boveri predicts in this monograph the existence of tumor suppressor mechanisms and is perhaps the first to suggest that hereditary factors (genes) are linearly arranged along chromosomes. This new translation by Sir Henry Harris, Regius Professor of Medicine Emeritus at Oxford University and former Editor-in-Chief of Journal of Cell Science, includes extensive annotations in which he discusses the relevance of Boveri's views today. It is essential reading for all cancer researchers, as well as those interested in the history of cytogenetics and cell biology.

Human Genome Editing

Human Genome Editing
  • Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
  • Publisher :Unknown
  • Release Date :2017-08-13
  • Total pages :328
  • ISBN : 9780309452885
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Summary : Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Anatomy of Gene Regulation

Anatomy of Gene Regulation
  • Author : Panagiotis A. Tsonis
  • Publisher :Unknown
  • Release Date :2003-01-13
  • Total pages :282
  • ISBN : 0521804744
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Summary : Table of contents

Structural and Dynamic Characterization of Eukaryotic Gene Regulatory Protein Domains in Solution

Structural and Dynamic Characterization of Eukaryotic Gene Regulatory Protein Domains in Solution
  • Author : Andrew Loyd Lee
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :500
  • ISBN : UCAL:C3390191
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Summary :