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Introduction to Nuclear Mechanics and Genome Regulation

Introduction to Nuclear Mechanics and Genome Regulation
  • Author : G.V. Shivashankar
  • Publisher :Unknown
  • Release Date :2019-06-15
  • Total pages :200
  • ISBN : 0128123451
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Summary : Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study. Contains applied case studies and full color images that support concept illustration Features a diverse range of chapters that cover the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNA Introduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures

Nuclear Mechanics and Genome Regulation

Nuclear Mechanics and Genome Regulation
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010-10-12
  • Total pages :392
  • ISBN : 0123810108
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Summary : In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

RNA-Based Regulation in Human Health and Disease

RNA-Based Regulation in Human Health and Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2020-08-15
  • Total pages :444
  • ISBN : 9780128171943
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Summary : RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Mosby's Medical Dictionary

Mosby's Medical Dictionary
  • Author : Mosby
  • Publisher :Unknown
  • Release Date :2016-05-06
  • Total pages :1984
  • ISBN : 0323414257
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Summary :

The Cytoskeleton

The Cytoskeleton
  • Author : Thomas Pollard,Robert Goldman
  • Publisher :Unknown
  • Release Date :2016-12-31
  • Total pages :600
  • ISBN : 1621820165
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Summary : The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

Structural and Dynamic Characterization of Eukaryotic Gene Regulatory Protein Domains in Solution

Structural and Dynamic Characterization of Eukaryotic Gene Regulatory Protein Domains in Solution
  • Author : Andrew Loyd Lee
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :500
  • ISBN : UCAL:C3390191
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Summary :

25 Years of p53 Research

25 Years of p53 Research
  • Author : Pierre Hainaut,Klas G. Wiman
  • Publisher :Unknown
  • Release Date :2007-10-26
  • Total pages :446
  • ISBN : 1402065647
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Summary : p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.

Cancer Biology and the Nuclear Envelope

Cancer Biology and the Nuclear Envelope
  • Author : Eric C. Schirmer,Jose I. de las Heras
  • Publisher :Unknown
  • Release Date :2014-02-22
  • Total pages :611
  • ISBN : 9781489980328
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Summary : "Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Nuclear Structure and Function

Nuclear Structure and Function
  • Author : J.R. Harris,I.B. Zbarsky
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :504
  • ISBN : 9781461306672
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Summary : This collection of 101 short communications, submitted by some of the participants at the 11th Nuclear Workshop held in Suzdal, USSR, 18-23 September, 1989, provides a representative survey of the material presented at the Workshop. Articles have been submitted by both those who delivered lectures and those who had poster presentations. The order of presentation at the Nuclear Workshop is roughly maintained within this proceedings book, but the session titles within the scientific program have not been utilized as discrete subdivisions within the book, because of the considerable overlap of subject matter. The overall sequence is as follows: Genome structure, Gene Structure and Expression, Nucleolar Genes, Structure and Proteins, Chromatin and Nuclear Granules, Nuclear Matrix and Nuclear Proteins, Replication and Transcription and finally Nuclear Envelope and Nuclear Cytoplasmic Transport. Several articles on Nuclear Lipids are also included, stemming from an evening round-table discussion on lipids. The third Wilhelm Bernhard Lecture was delivered in Suzdal by Professor Harris Busch, who can be seen in the photograph above (on the left) in the presence of Professor Ilya B. Zbarsky, President of the organizing committee for the 11th Nuclear Workshop. (Previous Wilhelm Bernhard lecturers have been Ronald H. Reeder, in Krakow, Poland, 1985 and Oscar L. Miller, Jr. , in Stevensbeek, The Netherlands, in 1987).

Structural Materials for Generation IV Nuclear Reactors

Structural Materials for Generation IV Nuclear Reactors
  • Author : Pascal Yvon
  • Publisher :Unknown
  • Release Date :2016-08-27
  • Total pages :684
  • ISBN : 9780081009123
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Summary : Operating at a high level of fuel efficiency, safety, proliferation-resistance, sustainability and cost, generation IV nuclear reactors promise enhanced features to an energy resource which is already seen as an outstanding source of reliable base load power. The performance and reliability of materials when subjected to the higher neutron doses and extremely corrosive higher temperature environments that will be found in generation IV nuclear reactors are essential areas of study, as key considerations for the successful development of generation IV reactors are suitable structural materials for both in-core and out-of-core applications. Structural Materials for Generation IV Nuclear Reactors explores the current state-of-the art in these areas. Part One reviews the materials, requirements and challenges in generation IV systems. Part Two presents the core materials with chapters on irradiation resistant austenitic steels, ODS/FM steels and refractory metals amongst others. Part Three looks at out-of-core materials. Structural Materials for Generation IV Nuclear Reactors is an essential reference text for professional scientists, engineers and postgraduate researchers involved in the development of generation IV nuclear reactors. Introduces the higher neutron doses and extremely corrosive higher temperature environments that will be found in generation IV nuclear reactors and implications for structural materials Contains chapters on the key core and out-of-core materials, from steels to advanced micro-laminates Written by an expert in that particular area

Genome Organization And Function In The Cell Nucleus

Genome Organization And Function In The Cell Nucleus
  • Author : Karsten Rippe
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :594
  • ISBN : 9783527640003
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Summary : By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.

Lipid Droplets

Lipid Droplets
  • Author : H. Robert Yang,Peng Li
  • Publisher :Unknown
  • Release Date :2013-10-04
  • Total pages :270
  • ISBN : 9780124095212
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Summary : This new volume of Methods in Cell Biology looks at lipid droplets LDs, covering sections on analyses of LDs in model systems, cell/tissue-specific analyses of LDs and imaging and in vitro analyses of LD biogenesis and growth. Chapters are written by experts in the field. With cutting-edge material, this comprehensive collection is intended to guide researchers of LDs for years to come. Covers sections on analyses of lipid droplets (LDs) in model systems, cell/tissue-specific analyses of LDs and imaging, and in vitro analyses of LD biogenesis and growth Chapters are written by experts in the field Cutting-edge material

The Zebrafish: Cellular and Developmental Biology

The Zebrafish: Cellular and Developmental Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010-12-24
  • Total pages :366
  • ISBN : 0123848938
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Summary : This volume of Methods in Cell Biology, the first of 3 parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This first volume provides state-of-the-art descriptions of novel cellular imaging technologies and methods for culture of zebrafish stem cells, summarizes protocols for analyzingthe development of major organ systems including the central nervous system (CNS), and introduces the use of the zebrafish as a model system for human diseases. Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls Summarizes the Zebrafish Genome Project

Receptor-Receptor Interactions

Receptor-Receptor Interactions
  • Author : P. Michael Conn
  • Publisher :Unknown
  • Release Date :2013-10-18
  • Total pages :538
  • ISBN : 9780124104709
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Summary : This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come. Covers sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes Chapters are written by experts in the field Cutting-edge material

The LINC Complex

The LINC Complex
  • Author : Gregg G. Gundersen,Howard J. Worman
  • Publisher :Unknown
  • Release Date :2019-09-07
  • Total pages :338
  • ISBN : 1493993674
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Summary : This volume describes research methodologies and approaches used to study the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex and its cellular functions. Chapters detail structural and biochemical analysis of LINC complexes, mechanical aspects of the LINC complex, analysis of the LINC complex in model systems and development, and LINC complex in mammalian tissue, organs, and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The LINC Complex: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Cell Mechanics

Cell Mechanics
  • Author : Yu-Li Wang,Dennis E. Discher
  • Publisher :Unknown
  • Release Date :2007-07-05
  • Total pages :632
  • ISBN : 0080548709
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Summary : Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells

Molecular Biology and Genetic Engineering

Molecular Biology and Genetic Engineering
  • Author : P. K. Gupta
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :613
  • ISBN : 8171337198
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Summary : PART I Molecular Biology 1. Molecular Biology and Genetic Engineering Definition, History and Scope 2. Chemistry of the Cell: 1. Micromolecules (Sugars, Fatty Acids, Amino Acids, Nucleotides and Lipids) Sugars (Carbohydrates) 3. Chemistry of the Cell . 2. Macromolecules (Nucleic Acids; Proteins and Polysaccharides) Covalent and Weak Non-covalent Bonds 4. Chemistry of the Gene: Synthesis, Modification and Repair of DNA DNA Replication: General Features 5. Organisation of Genetic Material 1. Packaging of DNA as Nucleosomes in Eukaryotes Techniques Leading to Nucleosome Discovery 6. Organization of Genetic Material 2. Repetitive and Unique DNA Sequences 7. Organization of Genetic Material: 3. Split Genes, Overlapping Genes, Pseudogenes and Cryptic Genes Split Genes or .Interrupted Genes 8. Multigene Families in Eukaryotes 9. Organization of Mitochondrial and Chloroplast Genomes 10. The Genetic Code 11. Protein Synthesis Apparatus Ribosome, Transfer RNA and Aminoacyl-tRNA Synthetases Ribosome 12. Expression of Gene . Protein Synthesis 1. Transcription in Prokaryotes and Eukaryotes 13. Expression of Gene: Protein Synthesis: 2. RNA Processing (RNA Splicing, RNA Editing and Ribozymes) Polyadenylation of mRNA in Prokaryotes Addition of Cap (m7G) and Tail (Poly A) for mRNA in Eukaryotes 14. Expression of Gene: Protein Synthesis: 3. Synthesis and Transport of Proteins (Prokaryotes and Eukaryotes) Formation of Aminoacyl tRNA 15. Regulation of Gene Expression: 1. Operon Circuits in Bacteria and Other Prokaryotes 16. Regulation of Gene Expression . 2. Circuits for Lytic Cycle and Lysogeny in Bacteriophages 17. Regulation of Gene Expression 3. A Variety of Mechanisms in Eukaryotes (Including Cell Receptors and Cell Signalling) PART II Genetic Engineering 18. Recombinant DNA and Gene Cloning 1. Cloning and Expression Vectors 19. Recombinant DNA and Gene Cloning 2. Chimeric DNA, Molecular Probes and Gene Libraries 20. Polymerase Chain Reaction (PCR) and Gene Amplification 21. Isolation, Sequencing and Synthesis of Genes 22. Proteins: Separation, Purification and Identification 23. Immunotechnology 1. B-Cells, Antibodies, Interferons and Vaccines 24. Immunotechnology 2. T-Cell Receptors and MHC Restriction 25. Immunotechnology 3. Hybridoma and Monoclonal Antibodies (mAbs) Hybridoma Technology and the Production of Monoclonal Antibodies 26. Transfection Methods and Transgenic Animals 27. Animal and Human Genomics: Molecular Maps and Genome Sequences Molecular Markers 28. Biotechnology in Medicine: l.Vaccines, Diagnostics and Forensics Animal and Human Health Care 29. Biotechnology in Medicine 2. Gene Therapy Human Diseases Targeted for Gene Therapy Vectors and Other Delivery Systems for Gene Therapy 30. Biotechnology in Medicine: 3. Pharmacogenetics / Pharmacogenomics and Personalized Medicine Phannacogenetics and Personalized 31. Plant Cell and Tissue Culture' Production and Uses of Haploids 32. Gene Transfer Methods in Plants 33. Transgenic Plants . Genetically Modified (GM) Crops and Floricultural Plants 34. Plant Genomics: 35. Genetically Engineered Microbes (GEMs) and Microbial Genomics References

Anatomy of Gene Regulation

Anatomy of Gene Regulation
  • Author : Panagiotis A. Tsonis
  • Publisher :Unknown
  • Release Date :2003-01-13
  • Total pages :282
  • ISBN : 0521804744
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Summary : Table of contents

Plant Growth and Regulation

Plant Growth and Regulation
  • Author : Diah Ratnadewi,Dr. Hamim
  • Publisher :Unknown
  • Release Date :2018-12-05
  • Total pages :114
  • ISBN : 9781789842852
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Summary : Plant Growth and Regulation - Alterations to Sustain Unfavorable Conditions consists of five chapters written by scientists from different parts of the world, who are experts in their respective focuses of research. The topics cover the physical growth and physiological and genetic alterations in plants, particularly under environmental stress conditions. The storyline of this book starts from the plant community, followed by cellular and ultrastructural phenomenes occurring within the plant in its interaction with the environment, and ends with elucidation of chloroplast's DNAs, their transfer to the nucleus, and the genetic engineering technology applicable for plant adaptation to changing environmental conditions. This book is aimed at attracting the attention of students, teachers, as well as scientists who have a similar focus of study or interest. It contains advanced studies in the respective chapters.

Classical Dynamics

Classical Dynamics
  • Author : Jorge V. José,Eugene J. Saletan
  • Publisher :Unknown
  • Release Date :1998-08-13
  • Total pages :229
  • ISBN : 9781139643399
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Summary : Advances in the study of dynamical systems have revolutionized the way that classical mechanics is taught and understood. Classical Dynamics, first published in 1998, is a comprehensive textbook that provides a complete description of this fundamental branch of physics. The authors cover all the material that one would expect to find in a standard graduate course: Lagrangian and Hamiltonian dynamics, canonical transformations, the Hamilton-Jacobi equation, perturbation methods, and rigid bodies. They also deal with more advanced topics such as the relativistic Kepler problem, Liouville and Darboux theorems, and inverse and chaotic scattering. A key feature of the book is the early introduction of geometric (differential manifold) ideas, as well as detailed treatment of topics in nonlinear dynamics (such as the KAM theorem) and continuum dynamics (including solitons). The book contains many worked examples and over 200 homework exercises. It will be an ideal textbook for graduate students of physics, applied mathematics, theoretical chemistry, and engineering, as well as a useful reference for researchers in these fields. A solutions manual is available exclusively for instructors.

DNA and Cell Biology

DNA and Cell Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :229
  • ISBN : UOM:39015053936947
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Summary :