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Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry

Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry
  • Author : Bindesh Shrestha
  • Publisher :Unknown
  • Release Date :2021-05-07
  • Total pages :270
  • ISBN : 9780128189993
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Summary : Imaging mass spectrometry (MS) techniques are often utilized without an understanding of their underlying principles, making it difficult for scientists to determine when and how they can exploit MS to visualize their biomolecules of interest. Introduction to Spatial Mapping of Biomolecules by Imaging Mass Spectrometry is an essential reference to help scientists determine the status and strategies of biomolecule analysis, describing its many applications for diverse classes of biomolecules. The book builds a foundation of imaging MS knowledge by introducing ionization sources, sample preparation, visualization guidelines, molecule identification, quantification, data analysis, etc. The second section contains chapters focused on case studies on analyzing a biomolecule class of molecules. Case studies include an introduction/background, and a summary of successful imaging MS studies with illustrative figures and future directions. Provides the introductory foundations of imaging mass spectrometry for those new to the technique Organized by topic to facilitate a quick deep dive, allowing researchers to immediately apply the imaging MS techniques to their work Includes case studies summarizing the imaging MS techniques developed for the class of molecules

Biocomputing 2007

Biocomputing 2007
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2006-12-11
  • Total pages :507
  • ISBN : 9789812704177
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Summary : The Pacific Symposium on Biocomputing (PSB) 2007 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2007 will be held January 3-7, 2007 at the Grand Wailea, Maui. Tutorials will be offered prior to the start of the conference.PSB 2007 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Applications of Mass Spectrometry Imaging to Cancer

Applications of Mass Spectrometry Imaging to Cancer
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2017-01-19
  • Total pages :312
  • ISBN : 9780128054406
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Summary : Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Pacific Symposium on Biocomputing

Pacific Symposium on Biocomputing
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : UOM:39015069292194
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Summary :

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
  • Author : Haleem J. Issaq,Timothy D. Veenstra
  • Publisher :Unknown
  • Release Date :2019-10-24
  • Total pages :504
  • ISBN : 9780128197882
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Summary : Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

Imaging Mass Spectrometry

Imaging Mass Spectrometry
  • Author : Mitsutoshi Setou
  • Publisher :Unknown
  • Release Date :2010-01-29
  • Total pages :272
  • ISBN : 4431094253
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Summary : Addressing the widespread need for a practical guide to imaging mass spectrometry (IMS), this book presents the protocols of IMS technology. As that technology expands, research groups around the world continue its development. Pharmaceutical companies are using IMS for drug analyses to study pharmacokinetics and medical properties of drugs. Drug research and disease-related biomarker screening are experiencing greater use of this technology, with a concurrent increase in the number of researchers in academia and industry interested in wider applications of IMS. Intended for beginners or those with limited experience with IMS technology, this book provides practical details and instructions needed for immediate know-how, including the preparation of animal tissue samples, the application of a matrix, instrumental operations, and data analysis, among others. By describing the foundations of IMS, this volume contributes to the ongoing development of the field and to progress in human health.

Lipid Analysis

Lipid Analysis
  • Author : W. W. Christie,X Han
  • Publisher :Unknown
  • Release Date :2010-01-10
  • Total pages :448
  • ISBN : 9780857097866
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Summary : This well-known and highly successful book was first published in 1973 and has been completely re-written in subsequent editions (published in 1982 and 2003). This new Fourth Edition has become necessary because of the pace of developments in mass spectrometry of intact lipids, which has given recognition of lipid analysis and ‘lipidomics’ as a distinct science. To bring the book up to date with these developments, author William W. Christie is joined by co-author Xianlin Han. Although devoting considerable space to mass spectrometry and lipidomics, Lipid analysis remains a practical guide, in one volume, to the complexities of the analysis of lipids. As in past editions, it is designed to act as a primary source, of value at the laboratory bench rather than residing on a library shelf. Lipid analysis deals with the isolation, separation, identification and structural analysis of glycerolipids, including triacylglycerols, phospholipids, sphingolipids, and the various hydrolysis products of these. The chapters follow a logical sequence from the extraction of lipids to the isolation and characterization of particular lipid classes and of molecular species of each, and to the mass spectrometric analysis of lipids and lipidomics. The new influence of mass spectrometry is due mainly to the development of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). Most emphasis in this book is placed on ESI, which is enabling structural characterization of different lipid classes and the identification of novel lipids and their molecular species.

Peptidomics

Peptidomics
  • Author : Mikhail Soloviev,Per Andrén,Chris Shaw
  • Publisher :Unknown
  • Release Date :2007-12-21
  • Total pages :424
  • ISBN : 0470196491
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Summary : The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Molecular Technologies for Detection of Chemical and Biological Agents

Molecular Technologies for Detection of Chemical and Biological Agents
  • Author : Joseph H. Banoub,Richard M. Caprioli
  • Publisher :Unknown
  • Release Date :2017-07-05
  • Total pages :306
  • ISBN : 9789402411133
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Summary : This book describes the latest molecular insights needed to understand the chemical and biological (CB) agents and their associated biotechnologies. Its primary focus is to present and discuss molecular technologies such as mass spectrometry, chemical and biological sensors, chromatographic and electrophoretic separation, and comparisons of spectroscopic, immunological and molecular analyses of chemicals used for the detection of chemical and biological agents and to prevent terrorism. This NATO-ASI book also contributes to the critical assessment of existing knowledge on new and important detection technologies. It helps to identify directions for future research and to promote closer working relationships between scientists from different professional fields.

Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry

Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry
  • Author : Rainer Cramer
  • Publisher :Unknown
  • Release Date :2015-11-09
  • Total pages :286
  • ISBN : 9783319048192
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Summary : This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

Mass Spectrometry Imaging of Small Molecules

Mass Spectrometry Imaging of Small Molecules
  • Author : Lin He
  • Publisher :Unknown
  • Release Date :2014-11-01
  • Total pages :213
  • ISBN : 1493913565
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Summary : Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules: Methods and Protocols aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.

Ambient Ionization Mass Spectrometry

Ambient Ionization Mass Spectrometry
  • Author : Marek Domin,Robert Cody
  • Publisher :Unknown
  • Release Date :2014-11-25
  • Total pages :508
  • ISBN : 9781849739269
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Summary : Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

MALDI MS

MALDI MS
  • Author : Franz Hillenkamp,Jasna Peter-Katalinic
  • Publisher :Unknown
  • Release Date :2013-10-08
  • Total pages :480
  • ISBN : 9783527673742
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Summary : This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

Secondary Ion Mass Spectrometry: SIMS VII

Secondary Ion Mass Spectrometry: SIMS VII
  • Author : A. Benninghoven,C. A. Evans,K. D. McKeegan,H. A. Storms,H. W. Werner
  • Publisher :Unknown
  • Release Date :1990-06-28
  • Total pages :992
  • ISBN : UOM:39015019844250
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Summary : Based on the proceedings of the Seventh International Conference on Secondary Ion Mass Spectrometry, held in Monterey, California, September 3-8, 1989. Covers fundamental, complementary and enhancement techniques, comparative SIMS, geology, biology, polymers, metallurgy, profiling and semiconductors. Describes a valuable methodology (SIMS) for characterizing solid surfaces and presents numerous analytical applications.

Metabolomics: From Fundamentals to Clinical Applications

Metabolomics: From Fundamentals to Clinical Applications
  • Author : Alessandra Sussulini
  • Publisher :Unknown
  • Release Date :2017-01-28
  • Total pages :350
  • ISBN : 9783319476568
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Summary : This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Visualizing Chemistry

Visualizing Chemistry
  • Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Revealing Chemistry through Advanced Chemical Imaging
  • Publisher :Unknown
  • Release Date :2006-06-01
  • Total pages :222
  • ISBN : 030916463X
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Summary : Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imaging—the ability to visualize molecular structures and chemical composition in time and space as actual events unfold—from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology
  • Author : Fernando Cobo
  • Publisher :Unknown
  • Release Date :2018-08-03
  • Total pages :298
  • ISBN : 9780128144527
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Summary : The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers

Chemical Biology

Chemical Biology
  • Author : Banafshe Larijani,Colin A. Rosser,Rudiger Woscholski
  • Publisher :Unknown
  • Release Date :2006-08-04
  • Total pages :272
  • ISBN : 9780470090664
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Summary : Written by a team of international researchers and teachers at the cutting edge of chemical biology research, this book provides an exciting, comprehensive introduction to a wide range of chemical and physical techniques with applications in areas as diverse as molecular biology, signal transduction, drug discovery and medicine. Techniques include: Cryo-electron microscopy, atomic force microscopy, differential scanning calorimetry in the study of lipid structures, membrane potentials and membrane probes, identification and quantification of lipids using mass spectroscopy, liquid state NMR, solid state NMR in biomembranes, molecular dynamics, two dimensional infra-red studies of biomolecules, single and two-photon fluorescence, optical tweezers, PET imaging and chemical genetics. KEY FEATURES: a unique guide to the rapidly evolving, interdisciplinary field of chemical biology. adopts a molecular structure for maximum flexibility. addresses relevant, topical chemical biological questions throughout. includes stunning illustrations. associates website with PowerPoint slides of figures within the book. Chemical Biology: Techniques and Applications provides an invaluable resource for final year undergraduate and post graduate bioscience and biomedical students and pharmaceutical researchers with an interest in this fascinating, and ever changing field.

Imaging Mass Spectrometry

Imaging Mass Spectrometry
  • Author : Ron M. A. Heeren,Mitsutoshi Setou
  • Publisher :Unknown
  • Release Date :2014-07-31
  • Total pages :250
  • ISBN : 1849736294
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Summary : This title describes the current state-of-the-art in analytical mass spectrometry, providing the reader with a solid understanding of the unique complex surface analysis capabilities of the molecular imaging method.

ToF-SIMS

ToF-SIMS
  • Author : J. C. Vickerman,David Briggs
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :732
  • ISBN : 9781906715175
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Summary : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is the most versatile of the surface analysis techniques that have been developed during the last 30 years. This is the Second Edition of the first book ToF-SIMS: Surface analysis by Mass Spectrometry to be dedicated to the subject and the treatment is comprehensive

Data Analysis for Omic Sciences: Methods and Applications

Data Analysis for Omic Sciences: Methods and Applications
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-09-22
  • Total pages :730
  • ISBN : 9780444640451
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Summary : Data Analysis for Omic Sciences: Methods and Applications, Volume 82, shows how these types of challenging datasets can be analyzed. Examples of applications in real environmental, clinical and food analysis cases help readers disseminate these approaches. Chapters of note include an Introduction to Data Analysis Relevance in the Omics Era, Omics Experimental Design and Data Acquisition, Microarrays Data, Analysis of High-Throughput RNA Sequencing Data, Analysis of High-Throughput DNA Bisulfite Sequencing Data, Data Quality Assessment in Untargeted LC-MS Metabolomic, Data Normalization and Scaling, Metabolomics Data Preprocessing, and more. Presents the best reference book for omics data analysis Provides a review of the latest trends in transcriptomics and metabolomics data analysis tools Includes examples of applications in research fields, such as environmental, biomedical and food analysis