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Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : UOM:39015068688129
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Summary :

Pluripotent Stem Cells

Pluripotent Stem Cells
  • Author : Deepa Bhartiya,Nibedita Lenka
  • Publisher :Unknown
  • Release Date :2013-08-28
  • Total pages :640
  • ISBN : 9789535111924
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Summary : Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Fundamentals of the Stem Cell Debate

Fundamentals of the Stem Cell Debate
  • Author : Kristen Renwick Monroe,Ronald Miller,Jerome Tobis
  • Publisher :Unknown
  • Release Date :2007-12-11
  • Total pages :226
  • ISBN : 9780520940994
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Summary : Few recent advances in science have generated as much excitement and controversy as human embryonic stem cells. The potential of these cells to replace diseased or damaged cells in virtually every tissue of the body heralds the advent of an extraordinary new field of medicine. Controversy arises, however, because current techniques required to harvest stem cells involve the destruction of the human blastocyst. This even-handed, lucidly written volume is an essential tool for understanding the complex issues—scientific, religious, ethical, and political—that currently fuel public debate about stem cell research. One of the few books to provide a comprehensive overview for a wide audience, the volume brings together leading scientists, ethicists, political scientists, and doctors to explain this new scientific development and explore its ramifications.

Stem Cell Regulators

Stem Cell Regulators
  • Author : Gerald Litwack
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :490
  • ISBN : 9780123860156
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Summary : First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on stem cell regulators. Longest running series published by Academic Press Contributions by leading international authorities

Stem Cell Biology and Tissue Engineering in Dental Sciences

Stem Cell Biology and Tissue Engineering in Dental Sciences
  • Author : Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam
  • Publisher :Unknown
  • Release Date :2014-11-05
  • Total pages :932
  • ISBN : 9780123977786
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Summary : Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color

Stem Cell Research – State of Art, Revised Concepts and Perspectives

Stem Cell Research – State of Art, Revised Concepts and Perspectives
  • Author : Katiucia Batista Silva Paiva,Valerie Kouskoff,Atsushi Asakura
  • Publisher :Unknown
  • Release Date :2020-08-21
  • Total pages :229
  • ISBN : 9782889635276
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Summary :

Stem Cells

Stem Cells
  • Author : Mary Clarke,Jonathan Frampton
  • Publisher :Unknown
  • Release Date :2020-07-27
  • Total pages :450
  • ISBN : 9781000062656
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Summary : Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

Principles of Tissue Engineering

Principles of Tissue Engineering
  • Author : Robert Lanza,Robert Langer,Joseph P. Vacanti
  • Publisher :Unknown
  • Release Date :2000-05-16
  • Total pages :995
  • ISBN : 9780080539676
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Summary : The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features * Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves * Essential to anyone working in the field * Educates and directs both the novice and advanced researcher * Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves * Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell * Considered the definitive reference in the field * List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others

Human Embryonic Stem Cells

Human Embryonic Stem Cells
  • Author : Arlene Chiu,Mahendra S. Rao
  • Publisher :Unknown
  • Release Date :2003-08-01
  • Total pages :461
  • ISBN : 9781592594238
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Summary : A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

Regulatory Networks in Stem Cells

Regulatory Networks in Stem Cells
  • Author : Vinagolu K. Rajasekhar
  • Publisher :Unknown
  • Release Date :2009-03-04
  • Total pages :601
  • ISBN : 1603272275
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Summary : Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals of developmental biology.

Genetics Abstracts

Genetics Abstracts
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :229
  • ISBN : UOM:39015053938455
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Summary :

Adult Stem Cell Niches

Adult Stem Cell Niches
  • Author : Sabine Wislet
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :330
  • ISBN : 9789535117186
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Summary : Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Essentials of Stem Cell Biology

Essentials of Stem Cell Biology
  • Author : Robert Lanza,John Gearhart,Brigid Hogan,Douglas Melton,Roger Pedersen,E. Donnall Thomas,James A. Thomson,Michael West
  • Publisher :Unknown
  • Release Date :2005-11-22
  • Total pages :584
  • ISBN : 9780080456553
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Summary : This abridged version of the bestselling reference Handbook of Stem Cells, Two-Volume Set attempts to incorporate all the essential subject matter of the original two-volume edition in a single volume. The material has been reworked in an accessible format suitable for students and general readers interested in following the latest advances in stem cells, including full color presentation throughout. Although some extra language and chapters have been deleted, rigorous effort has been made to retain from the original two-volume set the material pertinent to the understanding of this exciting area of biology. The organization of the book remains largely unchanged, combining the prerequisites for a general understanding of adult and embryonic stem cells; the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations; as well as a presentation by the world's experts of what is currently known about each specific organ system. * Full-color presentation througout * Each chapter begins with 3-5 defined glossary terms, and all of the terms are collected in a comprehensive list within the book * References have been eliminated - now there are about 10 bibliographic entries per chapter

Goodman's Medical Cell Biology

Goodman's Medical Cell Biology
  • Author : Steven R. Goodman
  • Publisher :Unknown
  • Release Date :2020-06-11
  • Total pages :442
  • ISBN : 9780128179284
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Summary : Goodman’s Medical Cell Biology, Fourth Edition, has been student tested and approved for decades. This updated edition of this essential textbook provides a concise focus on eukaryotic cell biology (with a discussion of the microbiome) as it relates to human and animal disease. This is accomplished by explaining general cell biology principles in the context of organ systems and disease. This new edition is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. This is a classic reference for moving forward into advanced study. Includes five new chapters: Mitochondria and Disease, The Cell Biology of the Immune System, Stem Cells and Regenerative Medicine, Omics, Informatics, and Personalized Medicine, and The Microbiome and Disease Contains over 150 new illustrations, along with revised and updated illustrations Maintains the same vision as the prior editions, teaching cell biology in a medically relevant manner in a concise, focused textbook

Myoblast Transfer Therapy

Myoblast Transfer Therapy
  • Author : Robert C. Griggs,George Karpati
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :330
  • ISBN : 9781468458657
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Summary : I am pleased to introduce this volume on Myoblast Transfer Therapy on behalf of the Muscular Dystrophy Association and all of its Advisory Committees. The international conference which led to this volume brought together leading basic scientists and clinical investigators for the purpose of coordinating the development of this new field in the fight against muscular dystrophy. The Muscular Dystrophy Association is the nation's most rapidly growing voluntary health agency in terms of its programs of patient care, research, and professional and public education. Success is attributable to its National Chairman, Jerry Lewis, to its effective corporate membership, and to the many physicians and scientists who give their time freely to advise on policies, to review grant applications, and to participate in meetings such as this. I should like to acknowledge a large number of other individuals to whom we are indebted: the broad segment of the American public which continually and generously supports our spectrum of services. The Muscular Dystrophy Association, next year, should raise in excess of $115,000,000. These contributions are derived from more than 10 million American families. These families are not only pledging their money but expressing their hopes that we will find answers to the tragic problem of neuromuscular disease. We are confident that the fruits of this meeting will move the frontier of research forward toward that goal.

Stem Cell Biology in Normal Life and Diseases

Stem Cell Biology in Normal Life and Diseases
  • Author : Kamran Alimoghaddam
  • Publisher :Unknown
  • Release Date :2013-05-08
  • Total pages :196
  • ISBN : 9789535111078
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Summary : Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).

Stem Cells in Marine Organisms

Stem Cells in Marine Organisms
  • Author : Baruch Rinkevich,Valeria Matranga
  • Publisher :Unknown
  • Release Date :2009-10-03
  • Total pages :371
  • ISBN : 904812767X
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Summary : Do real stem cells and stem cell lineages exist in lower organisms? Can stem cells from one organism parasitize the soma and/or the germ line of conspecifics? Can differentiated cells in marine organisms be re-programmed to regenerate tissues, organs and appendages through novel de-differentiation, transdifferentiation, or re-differentiation processes, leading to virtually all three germ layers, including the germline? The positive answers to above questions open a new avenue in stem cell research: the biology of stem cells in marine organisms. It is therefore unfortunate that while the literature on stem cell from terrestrial organisms is rich and expanding at an exponential rate, investigations on marine organisms’ stem cells are very limited and scarce. By presenting theoretical chapters, overview essays and specific research results, this book summarises the knowledge and the hypotheses on stem cells in marine organisms through major phyla and specific model organisms. The study on stem cells from marine invertebrates may shed lights on mechanisms promoting immunity, developmental biology, regeneration and budding processes in marine invertebrates, body maintenance, aging and senescence. It aims in encouraging a larger scientific community to follow and study the novel phenomena of stem cells behaviours as depicted from the few currently studied marine invertebrates.

Oxford Textbook of Medicine

Oxford Textbook of Medicine
  • Author : D. J. Weatherall,J. G. G. Ledingham,D. A. Warrell
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :4546
  • ISBN : UOM:49015003037976
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Summary :

Of Flies, Mice, and Men

Of Flies, Mice, and Men
  • Author : François Jacob
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :158
  • ISBN : 0674631110
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Summary : Collects seven essays in which 1965 Nobel Laureate in genetics reviews critical findings in biology and reveals his views on art and science, beauty and truth, good and evil, and mankind's quest for knowledge

Molecular and Cell Biology of Cancer

Molecular and Cell Biology of Cancer
  • Author : Rita Fior,Rita Zilhão
  • Publisher :Unknown
  • Release Date :2019-06-27
  • Total pages :216
  • ISBN : 9783030118129
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Summary : This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease

Non-Protein Coding RNAs

Non-Protein Coding RNAs
  • Author : Nils Walter,Sarah A. Woodson,Robert T. Batey
  • Publisher :Unknown
  • Release Date :2008-11-18
  • Total pages :398
  • ISBN : 9783540708407
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Summary : The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, Andrew Fire and Craig Mello. This prize, which follows “RNA” Nobels for splicing and RNA catalysis, highlights just one class of recently discovered non-protein coding RNAs. Remarkably, non-coding RNAs are thought to outnumber protein coding genes in mammals by perhaps as much as four-fold. In fact, it appears that the complexity of an organism correlates with the fraction of its genome devoted to non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic tra- posons, higher-level organization of eukaryotic chromosomes, and gene expression are found to be largely directed by non-protein coding RNAs. Currently, bioinformatic, high-throughput sequencing, and biochemical approaches are identifying an increasing number of these RNAs. Unfortunately, our ability to characterize the molecular details of these RNAs is significantly lacking. The biophysical study of these RNAs is an emergent field that is unraveling the molecular underpinnings of how RNA fulfills its multitude of roles in sustaining cellular life. The resulting understanding of the physical and chemical processes at the molecular level is critical to our ability to harness RNA for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.