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Gene Knockout Protocols

Gene Knockout Protocols
  • Author : Martin J. Tymms,Ismail Kola
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :431
  • ISBN : 9781592592203
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Summary : As the major task of sequencing the human genome nears completion and the full complement of human genes are catalogued, the task of understanding the normal biological functions of genes and how their alteration leads to diseased states becomes more imperative. In Gene Knockout Protocols, highly skilled investigators with extensive experience in gene targeting and mouse genetics describe their best techniques for the design of targeting constructs and for genetic phenotype analysis. These proven methods contain step-by-step instructions, as well as notes on pitfalls to avoid, and emphasize techniques that are relevant to researchers carrying out gene targeting work. These include embryo transplantation, in vitro embryonic stem cell differentiation, creation of aggregation chimeras, mouse pathology, embryo cryopreservation, and transplantation. Issues such as the use of existing mouse mutation resources and the influence of genetic background and epigenetic effects upon phenotype are also covered. State-of-the-art and highly practical, Gene Knockout Protocols not only constitutes an invaluable source of readily reproducible techniques for those just entering the field of gene targeting, but also a key reference for all genetic researchers today.

Knockout

Knockout
  • Author : Mia Kang
  • Publisher :Unknown
  • Release Date :2020-10-20
  • Total pages :288
  • ISBN : 9781647000165
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Summary : An intimate and unflinching memoir exploring Mia Kang’s journey from self-loathing to self-love Mia Kang is many things: a sought-after model, an immigrant, an eating disorder survivor, and a Muay Thai ï¬?ghter. Her ï¬?rst book, Knockout, is the story of how she eschewed normative body standards and learned to use martial arts to redeï¬?ne her sense of self-worth. In a charming, ï¬?erce, and intimate voice, Kang invites readers into her world. She once lived and died by her weight, but she is now deï¬?ned by her conï¬?dence in being a woman who lives outside the mold of what we’re taught is “feminine.” After dealing with bullying, addiction, body dysmorphia, anxiety, depression, and even suicidal thoughts, Mia acknowledges that she is lucky to still be alive to tell readers what she’s learned: to not let anyone else dictate who you are supposed to be.

Transgenic and Knockout Models of Neuropsychiatric Disorders

Transgenic and Knockout Models of Neuropsychiatric Disorders
  • Author : Gene S. Fisch,Jonathan Flint
  • Publisher :Unknown
  • Release Date :2007-11-06
  • Total pages :296
  • ISBN : 9781597450584
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Summary : In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Knockout

Knockout
  • Author : Suzanne Somers
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :337
  • ISBN : 9780307587596
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Summary : Draws on the expertise of eight doctors whose cutting-edge methods are enabling unprecedented cures, sharing the celebrity author's personal experiences as well as the survival stories of other cancer patients while identifying lifestyle strategies and challenging mainstream practices. By the best-selling author of Ageless. Reprint. A #1 best-seller. 150,000 first printing.

Study of Light Neutron-Rich Nuclei Via One-Neutron Knockout Reactions.

Study of Light Neutron-Rich Nuclei Via One-Neutron Knockout Reactions.
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 1230987654XX
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Summary :

Knockout Entrepreneur

Knockout Entrepreneur
  • Author : George Foreman
  • Publisher :Unknown
  • Release Date :2010-12-13
  • Total pages :240
  • ISBN : 9781418577414
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Summary : As true for boxing as business: Champions in business are not born. They are made. In an era of bankruptcy and bailouts, two-time Heavyweight Champion of the World and record-busting businessman George Foreman steps into the ring to challenge prevailing conceptions of success and achievement and lays out a new way of doing business—the way of the Knockout Entrepreneur. The Knockout Entrepreneur: Is focused on smart growth, fearlessly seizing opportunity, and building an organization of significance. Is an idea wrangler and visionary who uses God-given imagination; who never gives up, gives in, or backs down from the hard work necessary to make it. Is an encourager, risk-taker, mentor, and giver in a world that often reflects the opposite. Is defined by integrity and generosity rather than title and possessions. Amasses wisdom over wealth and knows that when all is said and done, the greatest ROI is found in faith, family, and community. Foreman equips you with principles and strategies to help you come out swinging and backs them up with personal stories, contemporary accounts of success, timeless wisdom, and leading questions—all of which are geared to help you put your Knockout plan into action and achieve extraordinary levels of success.

Getting Started with Knockout.js for .NET Developers

Getting Started with Knockout.js for .NET Developers
  • Author : Andrey Akinshin
  • Publisher :Unknown
  • Release Date :2015-05-27
  • Total pages :188
  • ISBN : 9781783984015
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Summary : This book is intended for .NET developers who want to use the MVVM design pattern to create powerful client-side JavaScript linked to server-side C# logic. Basic experience with ASP.NET, Razor, and creating web applications is needed.

Knockout Mice

Knockout Mice
  • Author : J M Fulgham
  • Publisher :Unknown
  • Release Date :2008-02
  • Total pages :176
  • ISBN : 9780595471812
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Summary : Dr. Jonathan Goodman is desperate to cure his son Daniel's cancer. His wife, Lilith, becomes pregnant with another child, a sibling whose DNA can potentially cure Daniel. Their hopes are dashed when a genetic disorder is detected in their unborn child. When Daniel dies and their unborn child miscarries, grief and devastation splinter the couple's bond. Under emotional duress but driven to honor Daniel's memory, Jonathan, a brilliant medical researcher, makes a major breakthrough using genetically modified laboratory mice. He develops a novel treatment for several disease clusters, including cancer. Bypassing all protocols to push his findings forward, Goodman unethically secures approval and funding for a human clinical trial. With enough funding for four participants, Goodman carefully chooses those upon whom he'll experiment. Each participant faces a terminal illness, and Dr. Goodman's exploratory treatment is their last hope for survival. Despite his noble intentions, Goodman is motivated to exorcise the demons that haunt him. Those spirits, however, also besiege each member of the clinical trial. Lives will be forever changed-and possibly lost. Saving those whom Goodman has put in harm's way and saving what is left of his family and career presents an almost insurmountable challenge.

Knockout

Knockout
  • Author : Rebecca Sjonger
  • Publisher :Unknown
  • Release Date :2011-09-26
  • Total pages :229
  • ISBN : 9781552779088
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Summary : Noah Brusso was small in size, but feisty. After winning a bare-knuckle boxing tournament at age ten, he found his way out of poverty. Noah changed his name to Tommy Burns, a tough Irish fighting name, and boxed his way to the top. In 1906, he won both the World Heavyweight Boxing Championship and the fame he longed for. At a time when few other boxers dared to do the same, Tommy Burns was willing to defend his title against boxers of all races and nationalities, forever changing the sport. Rebecca Sjonger details both Burns' unbelievable rise and his spectacular fall. [Fry Reading Level - 3.8]

Knockout

Knockout
  • Author : Louis La Russo
  • Publisher :Unknown
  • Release Date :1980
  • Total pages :66
  • ISBN : 0573611297
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Summary :

Knockout Games

Knockout Games
  • Author : G. Neri
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :304
  • ISBN : 9781467765930
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Summary : For Kalvin Barnes, the only thing that comes close to the rush of playing the knockout game is watching videos of the knockout game. Kalvin's crew always takes videos of their KOs, but Kalvin wants more—something better. He thinks if someone could really see the game for what it was, could appreciate it, could capture the essence of it—that would be a video for all time. The world would have to notice. That's where Erica comes in. She's new in town. Awkward. Shy. White. But she's got a good camera and a filmmaker's eye. She could learn. Kalvin could open her eyes to the power he sees in the knockout game; he could make her see things his way. But first she'll have to close her eyes to everything else. For a while, Kalvin's knockouts are strangers. For a while, Erica can ignore their suffering in the rush of creativity and Kalvin's attention. Then comes the KO that forces her eyes open, that makes her see what's really happening. No one wins the knockout game. Coretta Scott King Award honoree G. Neri captures the notorious and terrifying knockout game and its players in an unflinching novel that's hard to read and impossible to put down.

Knockout

Knockout
  • Author : Leger Grindon
  • Publisher :Unknown
  • Release Date :2011-05-10
  • Total pages :320
  • ISBN : 1604739894
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Summary : Knockout: The Boxer and Boxing in American Cinema is the first book-length study of the Hollywood boxing film, a popular movie entertainment since the 1930s, that includes such classics as Million Dollar Baby, Rocky, and Raging Bull. The boxer stands alongside the cowboy, the gangster, and the detective as a character that shaped America's ideas of manhood. Leger Grindon relates the Hollywood boxing film to the literature of Jack London, Ernest Hemingway, and Clifford Odets; the influence of ring champions, particularly Joe Louis and Muhammad Ali; and controversies surrounding masculinity, race, and sports. Knockout breaks new ground in film genre study by focusing on the fundamental dramatic conflicts uniting both documentary and fictional films with compelling social concerns. The boxing film portrays more than the rise and fall of a champion; it exposes the body in order to reveal the spirit. Not simply a brute, the screen boxer dramatizes conflicts and aspirations central to an American audience's experience. This book features chapters on the conventions of the boxing film, the history of the genre and its relationship to famous ring champions, and self-contained treatments of thirty-two individual films including a chapter devoted to Raging Bull.

KnockOut

KnockOut
  • Author : Catherine Coulter
  • Publisher :Unknown
  • Release Date :2009-06-16
  • Total pages :512
  • ISBN : 1101101385
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Summary : After witnessing her relatives burying a pile of dead bodies in the middle of the night, a seven-year-old uses her telepathic powers to call a man she's seen only on television: FBI Agent Dillon Savich. Now Savich and his wife and partner, Agent Lacey Sherlock, face their most elusive foes to keep the child out of harm's way-before it's too late.

ASP.NET MVC 5 with Bootstrap and Knockout.js

ASP.NET MVC 5 with Bootstrap and Knockout.js
  • Author : Jamie Munro
  • Publisher :Unknown
  • Release Date :2015-05-18
  • Total pages :278
  • ISBN : 9781491914403
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Summary : Bring dynamic server-side web content and responsive web design together to build websites that work and display well on any resolution, desktop or mobile. With this practical book, you’ll learn how by combining the ASP.NET MVC server-side language, the Bootstrap front-end framework, and Knockout.js—the JavaScript implementation of the Model-View-ViewModel pattern. Author Jamie Munro introduces these and other related technologies by having you work with sophisticated web forms. At the end of the book, experienced and aspiring web developers alike will learn how to build a complete shopping cart that demonstrates how these technologies interact with each other in a sleek, dynamic, and responsive web application. Build well-organized, easy-to-maintain web applications by letting ASP.NET MVC 5, Bootstrap, and Knockout.js do the heavy lifting Use ASP.NET MVC 5 to build server-side web applications, interact with a database, and dynamically render HTML Create responsive views with Bootstrap that render on a variety of modern devices; you may never code with CSS again Add Knockout.js to enhance responsive web design with snappy client-side interactions driven by your server-side web application

Total Knockout Fitness

Total Knockout Fitness
  • Author : Martin McKenzie,Stefanie Kirchner
  • Publisher :Unknown
  • Release Date :2014-01-28
  • Total pages :216
  • ISBN : 9780736094344
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Summary : Total Knockout Fitness incorporates a blend of boxing, cardio, and cross-training to produce the ultimate total-body workout. Featuring full-color photos, step-by-step descriptions of exercises and fundamental boxing skills, and a DVD depicting workouts, variations, and training tips, this special package contains everything you need in order to burn calories, increase power and strength, sculpt muscles, and transform your body.

Knockout.js

Knockout.js
  • Author : Jamie Munro
  • Publisher :Unknown
  • Release Date :2014-12-09
  • Total pages :102
  • ISBN : 9781491914335
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Summary : Use Knockout.js to design and build dynamic client-side web applications that are extremely responsive and easy to maintain. This example-driven book shows you how to use this lightweight JavaScript framework and its Model-View-ViewModel (MVVM) pattern. You’ll learn how to build your own data bindings, extend the framework with reusable functions, and work with a server to enhance your client-side application with persistence. In the final chapter, you’ll build a shopping cart to see how everything fits together. If you’re a web developer with experience in JavaScript, HTML, and CSS, you’re ready for Knockout. Learn how to create a ViewModel Bind HTML data and attributes, and CSS classes and styles Understand data binding in Knockout’s context hierarchy Use properties that change dynamically through user interaction Work with forms by using several different bindings Bind multiple ViewModels on a single page Extend or attach custom functions to observables Perform server-side interactions with jQuery Map a JavaScript object or apply JSON data to a new object

The Gene Knockout Factsbook, Two-Volume Set

The Gene Knockout Factsbook, Two-Volume Set
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1998-10-26
  • Total pages :1140
  • ISBN : 0080532365
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Summary : The FactsBooks Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today, and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format and drawing from meticulous research, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. The Gene Knockout FactsBook contains entries, grouped into subject disciplines, covering immunology, neurobiology, development, cancer, and other knockouts. It describes more than 600 gene knockouts described and listed in alphabetical order for easy reference. Key Features * Entries provide information on: * general description of the protein and its function * gene symbol and database accession number * knockout construct * mouse phenotype * key references

Knockout Tournament Design

Knockout Tournament Design
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :229
  • ISBN : STANFORD:qk299yx6689
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Summary : Knockout tournaments constitute a very common and important form of social institution. They are perhaps best known in sporting competitions, but also play a key role in other social and commercial settings as they model a specific type of election scheme (namely, sequential pairwise elimination election). In such tournaments the organizer controls the shape of the tournament (a binary tree) and the seeding of the players (their assignment to the tree leaves). A tournament can involve millions of people and billions of dollars, and yet there is no consensus on how it should be organized. It is usually dependent on arbitrary decisions of the organizers, and it remains unclear why one design receives precedence over another. The question turns out to be surprisingly subtle. It depends among other things on (a) the objective, (b) the model of the players, (c) the constraints on the structure of the tournament, and (d) whether one considers only ordinal solutions or also cardinal ones. We investigate the problem of finding a good or optimal tournament design across various settings. We first focus on the problem of tournament schedule control, i.e., designing a tournament that maximizes the winning probability of a target player. While the complexity of the general problem is still unknown, various constraints -- all naturally occurring in practice -- serve to push the problem to one side or the other: easy (polynomial) or hard (NP-complete). We then address the question of how to find a fair tournament. We consider two alternative fairness criteria, adapted from the literature: envy-freeness and order preservation. For each setting, we provide either impossibility results or algorithms (either exact or heuristic) to find such a fair tournament. We show through experiments that our heuristics are both efficient and effective. Finally, using a combination of analytic and experimental tools we investigate the optimality of ordinal solutions for three objective functions: maximizing the predictive power, maximizing the expected value of the winner, and maximizing the revenue of the tournament. The analysis relies on innovative upper bounds that allow us to evaluate the optimality of any seeding, even when the number of possible seedings is extremely large.

Knockout Mouse

Knockout Mouse
  • Author : James Calder
  • Publisher :Unknown
  • Release Date :2010-07-01
  • Total pages :272
  • ISBN : 0811870626
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Summary : Knockout Mouse is the gripping debut of a mystery series, set in the high-stakes world of biotechnology. When a dinner guest dies suddenly of an allergic reaction to a food she hasn't eaten, dot-com casualty Bill Damen goes from suspect to sleuth, embroiled in a murder with far-reaching consequences. He follows a trail that leads from cancer research to genetic engineering to secret rogue experiments, as he uncovers motives, means, and characters that could only exist in state-of-the-art Silicon Valley.

Knockout Fitness

Knockout Fitness
  • Author : Andy Dumas,Jamie Dumas
  • Publisher :Unknown
  • Release Date :2009-01-01
  • Total pages :178
  • ISBN : 9781602392991
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Summary : Two certified boxing trainers show you how to use boxing in order to get in outstanding shape.

Knockout Knits

Knockout Knits
  • Author : Laura Nelkin
  • Publisher :Unknown
  • Release Date :2014-09-02
  • Total pages :144
  • ISBN : 9780385345798
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Summary : An abundance of knitted luxuries--summery lace shawls, warm and wooly hats, a trio of cool knitted bracelets, and stunning beaded gloves--designed to grow your skills. Who doesn't love to knit accessories? They're fast, often require only a skein or two of yarn, and make amazingly versatile gifts for friends and family. Small knits are also the perfect way to try something new--an unusual stitch pattern, wild multi-colored yarn, or even a touch of sparkle. Laura Nelkin is well-known for designing these fun-to-knit little projects introducing her students and fans to advanced techniques with her signature "You can do it!" enthusiasm. In her first book, she shares her 3 favorite types of knitting using wrapped stitches, lacework, and beads. Each chapter begins with a quick knitted cuff to lay the foundations, then gradually ramps up to more complicated designs. The result is an all-new collection of wearable, feminine knits with a slightly rustic aesthetic. Give them as gifts, stockpile for a chilly day, or dress up a casual outfit--these are knockout projects to enjoy knitting again and again. From the Trade Paperback edition.