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Life-Threatening Effects of Antipsychotic Drugs

Life-Threatening Effects of Antipsychotic Drugs
  • Author : Peter Manu,Robert J. Flanagan,Kathlyn J. Ronaldson
  • Publisher :Unknown
  • Release Date :2016-08-16
  • Total pages :394
  • ISBN : 9780128033906
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Summary : Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects. Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations

Neuroleptic-induced Movement Disorders

Neuroleptic-induced Movement Disorders
  • Author : Ramzy Yassa,N. P. V. Nair,Dilip V. Jeste
  • Publisher :Unknown
  • Release Date :2007-02-01
  • Total pages :516
  • ISBN : 0521033527
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Summary : Neuroleptics, the most widely prescribed group of psychotropic drugs, are indispensable in the management of a majority of patients with schizophrenia, as well as other psychoses, yet they have not proved to be an unmixed blessing. They are associated with troublesome adverse effects, of which movement disorders are the most serious in terms of frequency, persistence and overall impact on the well-being of patients and care-givers. This book was prepared with the aim of improving understanding and clinical management of these iatrogenic conditions. It deals with historical, clinical and neurobiological aspects of tardive dyskinesia and related movement disorders such as parkinsonism, dystonia and akathisia. Sections are also devoted to the measurement of tardive dyskinesia, to geographical and ethnic differences, and to management with novel neuroleptic agents and biofeedback. With authoritative contributions and an international perspective, this book will be valuable to clinicians and researchers alike in psychiatry, neurology and related disciplines.

Pharmacological Treatment of Mental Disorders in Primary Health Care

Pharmacological Treatment of Mental Disorders in Primary Health Care
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :68
  • ISBN : 9789241547697
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Summary : This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.

The American Psychiatric Association Practice Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients With Dementia

The American Psychiatric Association Practice Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients With Dementia
  • Author : American Psychiatric Association
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :218
  • ISBN : 9780890426777
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Summary : Dementia is associated with a sizeable public health burden that is growing rapidly as the population ages. In addition to cognitive impairments, individuals with dementia often come to clinical attention because of symptoms of a behavioral disturbance (e.g., irritability, agitation, aggression) or psychosis. The burden on caregivers is substantial and is increased when dementia is associated with behavioral and psychological symptoms, and particularly with agitation or aggression. Treatment of psychotic symptoms and agitation in individuals with dementia has often involved use of antipsychotic medications. In recent years, the risks associated with use of these agents in the older adult population have become apparent. There has been a growing need to develop guidelines for appropriate use of antipsychotic medications in dementia. The American Psychiatric Association Practice Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients With Dementia seeks to fulfill this need to improve the care of patients with dementia who are exhibiting agitation or psychosis. The guideline focuses on the judicious use of antipsychotic medications when agitation or psychosis occurs in association with dementia. It is intended to apply to individuals with dementia in all settings of care as well as to care delivered by generalist and specialist clinicians. The guideline offers clear, concise, and actionable recommendation statements to help clinicians to incorporate recommendations into clinical practice, with the goal of improving quality of care. Each recommendation is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms. Findings from an expert opinion survey have also been taken into consideration in making recommendations or suggestions. In addition to reviewing the available evidence on use of antipsychotics in treating agitation or psychosis in patients with dementia, the guideline provides guidance to clinicians on implementing these recommendations to enhance patient care.

The Maudsley 2005-2006 Prescribing Guidelines

The Maudsley 2005-2006 Prescribing Guidelines
  • Author : David Taylor,Carol Paton,Robert Kerwin
  • Publisher :Unknown
  • Release Date :2005-05-12
  • Total pages :384
  • ISBN : 1841845000
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Summary : Now in its eighth edition, The Maudsley Prescribing Guidelines is the most widely used guide to psychiatric prescribing in the UK. Fully updated throughout, this new edition presents sections on topics of current interest such as antipsychotics and hyperlipidaemia, antipsychotic-induced hyponatraemia, borderline personality disorder, depression in multiple sclerosis, and melatonin for the treatment of insomnia in children and adolescents. Providing practically useful advice for common clinical situations, this is an essential text for prescribers, nursing staff, pharmacists, GPs, and those in related professions.

Stahl's Essential Psychopharmacology

Stahl's Essential Psychopharmacology
  • Author : Stephen M. Stahl
  • Publisher :Unknown
  • Release Date :2013-04-11
  • Total pages :608
  • ISBN : 9781107025981
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Summary : The single most readily readable source of information on psychopharmacology, covering disease and drug mechanisms in one highly illustrated volume.

Clinical Drug Therapy

Clinical Drug Therapy
  • Author : Anne Collins Abrams
  • Publisher :Unknown
  • Release Date :2010-05-14
  • Total pages :1360
  • ISBN : 1451108761
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Summary : This popular core nursing pharmacology textbook provides unique coverage of nursing interventions for drug therapy with related rationales. Highly praised for its organized and readable presentation, the text explains the "why" behind each nursing action and emphasizes how drugs work differently in different patients. New to the Ninth Edition is an Evidence-Based Nursing feature that builds on the previous edition's Research Briefs and highlights the nursing implications of current research. Chapter openers now include key terms with definitions. Other highlights include a comprehensive glossary, a revised art program, and thoroughly revised end-of-chapter NCLEX-style questions.

Schizophrenia Bulletin

Schizophrenia Bulletin
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : OSU:32435056634074
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Summary :

The Myth of the Chemical Cure

The Myth of the Chemical Cure
  • Author : J. Moncrieff
  • Publisher :Unknown
  • Release Date :2016-04-13
  • Total pages :278
  • ISBN : 9780230589445
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Summary : This book overturns the idea that psychiatric drugs work by correcting chemical imbalance and analyzes the professional, commercial and political vested interests that have shaped this view. It provides a comprehensive critique of research on drugs including antidepressants, antipsychotics and mood stabilizers.

Antipsychotic Drugs and Their Side-effects

Antipsychotic Drugs and Their Side-effects
  • Author : Thomas R. E. Barnes
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :287
  • ISBN : UOM:39015032908215
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Summary : Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including movement disorders like parkinsonism and akathisia; although, in many cases, these can be minimised by titration to the minimum effective dose.

Current Antipsychotics

Current Antipsychotics
  • Author : Gerhard Gross,Mark A. Geyer
  • Publisher :Unknown
  • Release Date :2012-11-05
  • Total pages :418
  • ISBN : 9783642257612
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Summary : Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into the pathophysiology of psychotic disorders, especially the role of glutamatergic mechanisms in schizophrenia, are now under development, and further principles are on the horizon. This situation, in many respects similar to that when the initial second-generation antipsychotics became available, can be rewarding for all. Preclinical and clinical researchers now have the opportunity to confirm their hypotheses and the pharmaceutical industry may be able to develop really novel classes of therapeutics. When we were approached by the publishers of the Handbook of Experimental Pharmacology to prepare a new volume on antipsychotics, our intention was to capture both, the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We thank the editorial board and the publishers for supporting our decision to prepare two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume. We hope these collective contributions will facilitate the development of improved treatments for the full range of symptomatology seen in the group of schizophrenias and other major psychotic disorders. Gerhard Gross, Ludwigshafen, Germany Mark A. Geyer, La Jolla, CA This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.

Cardiac Repolarization

Cardiac Repolarization
  • Author : Ihor Gussak,Charles Antzelevitch,Stephen C. Hammill,Win K. Shen,Preben Bjerregaard
  • Publisher :Unknown
  • Release Date :2003-03-13
  • Total pages :548
  • ISBN : 9781592593620
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Summary : A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Dystonia

Dystonia
  • Author : Tamer Rizk
  • Publisher :Unknown
  • Release Date :2018-11-07
  • Total pages :112
  • ISBN : 9781789844146
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Summary : The book contains four chapters discussing dystonia from a new perspective. Dystonia may result from either diffuse or localized pathology of the cerebral cortex, brain stem, or spinal cord. Management of dystonia is challenging, and specific goals should be identified. Dystonia is considered one of the most disabling conditions in the pediatric age group, which may remain until adulthood; treatment is usually unsatisfactory. Meige's syndrome, or "oromandibular dystonia," may be misdiagnosed as temporomandibular joint or psychogenic disorder, which will alter management and delay proper treatment. Dystonia with non-motor disorders includes sleep, cognitive, pain, sensory, and psychiatric disorders, and their pathophysiological and biochemical mechanisms and specific treatment are discussed. This book will be of interest to GPs, neurologists, family physicians, and internal medicine specialists.

Risk of Arrhythmia and Sudden Death

Risk of Arrhythmia and Sudden Death
  • Author : Marek Malik
  • Publisher :Unknown
  • Release Date :2000-12-19
  • Total pages :432
  • ISBN : 0727915819
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Summary : Suden cardiac death is one of the major challenges of modern cardiac cardiology. This book explains the modern risk stratification procedures which are aimed at idenfitifcation of patients who are at increased risk of malignant arrhythmias and sudden cardiac death. In addition to the description of the individual procedures and stratification tests, the book proposes strategies of using these tests in different clinically defined groups of patients.

Physical Illness and Schizophrenia

Physical Illness and Schizophrenia
  • Author : Stefan Leucht
  • Publisher :Unknown
  • Release Date :2007-11-22
  • Total pages :208
  • ISBN : 9780521882644
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Summary : Provides a comprehensive review of research evidence on physical diseases in people with schizophrenia.

Principles and Practice of Psychiatric Nursing

Principles and Practice of Psychiatric Nursing
  • Author : Gail Wiscarz Stuart,Michele T. Laraia
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :915
  • ISBN : UOM:49015002766526
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Summary : PRINCIPLES AND PRACTICE OF PSYCHIATRIC NURSING has long been one of the leading psychiatric nursing texts for undergraduate students. This popularity is due to its comprehensive coverage of important nursing and medical concepts, the widely used stress-adaptation framework, and a biopsychosocial approach that stresses the mental health continuum and strong, current coverage of psychobiology and psychopharmacology reflecting the contemporary biological emphasis in psychiatry. The seventh edition offers a new, dynamic four-color text. The basic structure and award-winning approach of the book will be retained in the revision, accentuated by a new theoretic emphasis on evidence-based practice, which strives to decrease the knowledge gap between clinical research and everyday practice. Integrating this cutting-edge information will make Stuart & Laraia's approach unique in the psychiatric nursing market. (Includes a FREE MERLIN website at:www.harcourthealth.com/MERLIN/Stuart/)

Treatment–Refractory Schizophrenia

Treatment–Refractory Schizophrenia
  • Author : Peter F. Buckley,Fiona Gaughran
  • Publisher :Unknown
  • Release Date :2014-03-18
  • Total pages :230
  • ISBN : 9783642452574
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Summary : Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.

Toxicology Studies

Toxicology Studies
  • Author : Ana Cristina Andreazza,Gustavo Scola
  • Publisher :Unknown
  • Release Date :2015-07-08
  • Total pages :244
  • ISBN : 9789535121404
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Summary : The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed. Since the bioactivation of many toxins and toxicants and its consequences on human health are not clearly known, this book offers a quick overview of cellular toxicology through the cell, drug and environmental toxicity. This book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. The book is divided into three main sections,; the first one discusses the role of mitochondrial dysfunction, oxidative stress and mitochondrial drug development. The second and third sections bring light to forensic toxicology and drug poisoning followed by environmental toxicity.

Seminars in Clinical Psychopharmacology

Seminars in Clinical Psychopharmacology
  • Author : Peter M. Haddad,David J. Nutt
  • Publisher :Unknown
  • Release Date :2020-03-31
  • Total pages :229
  • ISBN : 9781108850902
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Summary : This greatly expanded third edition provides a comprehensive overview of clinical psychopharmacology, incorporating the major advances in the field since the previous edition's publication. Renowned experts from psychiatry, pharmacy, and nursing have integrated basic science, psychopharmacology, and clinical practice throughout the book in order to provide a thorough basis for prescribing. It covers all key psychiatric drugs and disorders and includes the latest data on efficacy, safety and tolerability. Adopting a pragmatic approach to drug nomenclature, both Neuroscience-based Nomenclature (NbN) and older generic terminology are included in the text reflecting that clinicians are likely to use both systems. Many chapters refer to current National Institute of Health and Care Excellence (NICE) guidelines, making this a crucial resource. Edited by leading authorities in the field, Professor Peter M. Haddad and Professor David J. Nutt, Seminars in Clinical Psychopharmacology emphasises evidence-based prescribing with the aim of achieving better clinical outcomes for patients.

Behavioral and Psychological Symptoms of Dementia

Behavioral and Psychological Symptoms of Dementia
  • Author : Art Walaszek, M.D.
  • Publisher :Unknown
  • Release Date :2019-08-28
  • Total pages :284
  • ISBN : 9781615371686
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Summary : The number of geriatric psychiatrists, specialty fellowships, and practices has been declining relative to the increase in the number of older adults in the United States; critical shortages in care are the new norm. Behavioral and Psychological Symptoms of Dementia was designed to address this predicament by enabling primary care providers to access a solid knowledge base and the clinical experience required to meet the needs of their patients with dementia. The author has written a concise yet comprehensive book that covers the full range of behavioral and psychological symptoms of dementia (BPSD) encountered by patients, families, caregivers, and primary care providers. In addition, the book provides the necessary foundation for distinguishing the different types of dementia, critical elements of patient history needed to develop an appropriate treatment approach, and the basic medical examinations and lab work that should be performed. Each chapter begins with a brief précis; well-written descriptions of the major topic follow. The chapters explore the common types of behavioral and emotional symptoms and the important associated system issues relevant to dementia care, including elder abuse reporting, creation of advance directives and power of attorney arrangements, safety planning, and caregiver support.The book's strengths are many * Carefully chosen, realistic case examples bring the material to life in a vivid, compelling way.* An up-to-date review of the literature is presented, striking an appropriate balance between new and promising findings and current standard-of-care practices. The book also identifies significant gaps in the literature.* Standard-of-care pharmacological and psychosocial approaches in the management of BPSD are offered with a realistic understanding of the benefits and difficulties of implementing each.* Relevant information on complementary medicine is included, and the book covers personality, cultural, and spiritual domains so that the reader is cognizant of the whole-person approach in delivering dementia care.* Each chapter includes key points for quick and easy reference and resources to share with patients, families, and caregivers -- a boon to the busy clinician. * Although intended as a practical guide for clinicians in a variety of fields, those in academia who specialize in geriatric medicine or psychiatry will find the book a useful way to organize and teach this material to students, residents, and fellows. Pragmatic and clinically oriented, Behavioral and Psychological Symptoms of Dementia will help primary care practitioners provide informed, compassionate care to older adults at risk for, or exhibiting, BPSD.

BMJ

BMJ
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : UCLA:L0076230762
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Summary :