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Gene Editing

Gene Editing
  • Author : Yuan-Chuan Chen,Shiu-Jau Chen
  • Publisher :Unknown
  • Release Date :2019-05-29
  • Total pages :108
  • ISBN : 9781789845082
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Summary : Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.

Cardiovascular Disease

Cardiovascular Disease
  • Author : Qing Wang
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :400
  • ISBN : 9781597452137
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Summary : The two volumes of Cardiovascular Disease: Methods and Protocols provide comprehensive coverage of both basic and advanced approaches to the study and characterization of cardiovascular disease. In Volume 1: Genetics and Volume 2: Molecular Medicine, highly experienced cardiovascular researchers describe in detail the most important techniques in molecular medicine that are employed in genetic, molecular, cellular, structural, and physiological studies of cardiovascular disease.

Advances in Animal Genomics

Advances in Animal Genomics
  • Author : Sukanta Mondal,Ram Lakhan Singh
  • Publisher :Unknown
  • Release Date :2020-11-25
  • Total pages :328
  • ISBN : 9780128206126
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Summary : Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. Integrates basic and advanced concepts of animal biotechnology and presents future developments Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion

Targeted Genome Editing Using Site-Specific Nucleases

Targeted Genome Editing Using Site-Specific Nucleases
  • Author : Takashi Yamamoto
  • Publisher :Unknown
  • Release Date :2015-01-05
  • Total pages :205
  • ISBN : 9784431552277
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Summary : This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

Animal Biotechnology 2

Animal Biotechnology 2
  • Author : Heiner Niemann,Christine Wrenzycki
  • Publisher :Unknown
  • Release Date :2018-08-01
  • Total pages :303
  • ISBN : 9783319923482
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Summary : This two-volume textbook provides a comprehensive overview on the broad field of Animal Biotechnology with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and animal biotechnology. This second volume is dedicated to genetic tools in animal biotechnology such as somatic cloning, transgenic technologies and the application of stem cells in livestock breeding. Also, ethics and legal aspects are discussed.

Genome Editing in Animals

Genome Editing in Animals
  • Author : Izuho Hatada
  • Publisher :Unknown
  • Release Date :2017-06-23
  • Total pages :256
  • ISBN : 1493971271
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Summary : This volume details protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Genome Editing in Animals: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries

Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries
  • Author : Yashpal Singh Malik,Debmalya Barh,Vasco Azevedo,S.M. Paul Khurana
  • Publisher :Unknown
  • Release Date :2019-09-14
  • Total pages :564
  • ISBN : 9780128163535
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Summary : Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries is a comprehensive reference for animal biotechnologists, veterinary clinicians, fishery scientists, and anyone who needs to understand the latest advances in the field of next generation sequencing and genomic editing in animals and fish. This essential reference provides information on genomics and the advanced technologies used to enhance the production and management of farm and pet animals, commercial and non-commercial birds, and aquatic animals used for food and research purposes. This resource will help the animal biotechnology research community understand the latest knowledge and trends in this field. Presents biological applications of cattle, poultry, marine and animal pathogen genomics Discusses the relevance of biomarkers to improve farm animals and fishery Includes recent approaches in cloning and transgenic cattle, poultry and fish production

Science and Governance

Science and Governance
  • Author : Group Expert
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :168
  • ISBN : 9788895145259
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Summary : IPOC Italian Paths of Culture is proud to offer a new printing of this excellent study, unsurpassed in its depth and significance. The building of a "knowledge-based society" necessarily implicates analysis and criticism of the relationship between society and techno-scientific innovation. If we maintain that the function of such innovation ought to be the general enrichment of human existence and not solely the profit of a few, then relevant discourse cannot be limited to scientists or politicians. The difficulty, in fact, lies not in discovery but in discovery's application. What are the ramifications of a discovery or innovation? What benefits does it bring with it? What world do we seek to build? The ability to make responsible choices for our planet and for future generations requires us to construct new forms of democratic debate in which all components of society have a voice. This study examines these issues and their implications.

Avian and Reptilian Developmental Biology

Avian and Reptilian Developmental Biology
  • Author : Guojun Sheng
  • Publisher :Unknown
  • Release Date :2017
  • Total pages :365
  • ISBN : 1493972162
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Summary : This volume discusses recent advances in avian and reptilian biology that have caused this diverse field to re-emerge. The chapters in this book are divided into 4 parts: genomics and transcriptomics, genetic manipulation, stem cells, and new model systems. Part I details how to perform genomic and transcriptomic analyses in birds and reptiles; Part II highlights technological advancements in avian genetic manipulation; Part III focuses on methods to handle pluripotent cells; and part IV looks at the emerging models in avian and reptilian developmental biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Avian and Reptilian Developmental Biology: Methods and Protocols explores a variety of approaches and different sauropsid models that will help facilitate communication and collaboration among researchers, which in turn will progress this field forward.

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
  • Author : Fredric P. Manfredsson,Matthew J. Benskey
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :328
  • ISBN : 1493990659
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Summary : This volume discusses protocols, ranging from vector production to delivery methods, used to execute gene therapy applications. Chapters are divided into four parts, and cover topics such as design, construction, and application of transcription activation-like effectors; multi-modal production of adeno-associated virus; construction of oncolytic herpes simplex virus; AAV-mediated gene delivery to the mouse liver; and intrathecal delivery of gene therapeutics by direct lumbar puncture in mice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Viral Vectors for Gene Therapy: Methods and Protocols is a valuable resource for researchers, clinicians, and students looking to utilize viral vectors in gene therapy experiments.

Animal Genomics

Animal Genomics
  • Author : Bhanu P. Chowdhary
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :366
  • ISBN : STANFORD:36105114281491
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Summary : This publication provides an update on the current status of gene maps in different livestock and pet/companion animal species. The findings summarized in species specific commentaries and original articles testify the rapid advances made in the field of animal genomics. Of significant interest is the fact that current investigations are providing headways for two important and exciting research fronts: targeted high-resolution mapping leading to the application of genomic information in addressing questions of economic and biological significance in animals, and the initiation of whole genome sequencing projects for some of the animal species. Like in humans and mice, this will set the stage for a new level of research and real time complex analysis of the genomes of these species. Animal Genomics signifies the beginning of a new era in this field and celebrates the achievements of the past 20 years of genomics research. It will be of special interest to researchers involved in genome analysis - both gross chromosomal as well as molecular - in various animal species, and to comparative and evolutionary geneticists.

Advances in Breeding of Dairy Cattle

Advances in Breeding of Dairy Cattle
  • Author : Julius Van der Werf
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :659
  • ISBN : 1786762986
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Summary :

Pests and vector-borne diseases in the livestock industry

Pests and vector-borne diseases in the livestock industry
  • Author : Claire Garros,Jérémy Bouyer,Willem Takken,Renate C. Smallegange
  • Publisher :Unknown
  • Release Date :2018-08-30
  • Total pages :611
  • ISBN : 9789086868636
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Summary : How to control economically important vector-borne diseases? What are the best strategies to protect livestock from vector-borne diseases in a changing environment? How to evaluate and assess the acceptability, cost efficiency and cost benefit of the control and surveillance methods? The information in this book will help to answer these questions. It aims at presenting the latest information on vector-borne diseases affecting livestock worldwide, from state-of-the art interventions to the assessment of the impact of these control measures. This book is a valuable tool for entomologists and all those involved in pest and vector control.

Food futures: ethics, science and culture

Food futures: ethics, science and culture
  • Author : I. Anna S. Olsson,Sofia M. Araújo,M. Fátima Vieira
  • Publisher :Unknown
  • Release Date :2016-09-28
  • Total pages :618
  • ISBN : 9789086868346
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Summary : Food is at the centre of human existence. We eat every day, not only to satisfy our physical needs but also as part of cultural and social interaction. Food choices and markets shape the agricultural landscape and the cities we live in. Whereas what we choose to eat and feed our family is part of who we are, a growing number of actors compete to influence our food habits, through marketing strategies and nutritional advice. And ethical considerations are coupled with every choice over food - whether related to production, distribution, consumption, food waste, policy in general, marketing or advice. Given the variety of implications the ‘food problem’ entails, the construction of an inclusive society must redirect the concerns about food in the present to the imagination of future alternatives. The search for innovative solutions calls for multidisciplinary critical enquiry - and utopian thinking will be instrumental in that regard. This book brings together work by scholars in a wide range of disciplines addressing many different topics related to food futures. Topics covered include food and literature, food waste, food communication, food policy, corporate social responsibility and public procurement in food supply, responsible research and innovation in food production as well as sustainability and animal ethics and welfare.

Human Genome Editing

Human Genome Editing
  • Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
  • Publisher :Unknown
  • Release Date :2017-08-13
  • Total pages :328
  • ISBN : 9780309452885
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Summary : Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Quantitative Trait Loci Analysis in Animals

Quantitative Trait Loci Analysis in Animals
  • Author : Joel Ira Weller
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :272
  • ISBN : 9781845937348
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Summary : Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.

A Crack in Creation

A Crack in Creation
  • Author : Jennifer A. Doudna,Samuel H. Sternberg
  • Publisher :Unknown
  • Release Date :2017-06-13
  • Total pages :320
  • ISBN : 9780544716964
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Summary : BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “Required reading for every concerned citizen.” — New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “An invaluable account . . . We owe Doudna several times over.” — Guardian

Genomes 4

Genomes 4
  • Author : T. A. Brown
  • Publisher :Unknown
  • Release Date :2018-12-07
  • Total pages :520
  • ISBN : 9781351851299
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Summary : Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.

RNAi and Small Regulatory RNAs in Stem Cells

RNAi and Small Regulatory RNAs in Stem Cells
  • Author : Baohong Zhang
  • Publisher :Unknown
  • Release Date :2017
  • Total pages :311
  • ISBN : 1493971085
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Summary : This detailed collection provides an accessible compendium of up-to-date methods focused on the study of RNAi and small regulatory miRNAs in stem cells. Beginning with a brief introductory section, the volume continues by exploring methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, recently developed methods for miRNA expression and functional analysis, as well as usage of CRISPR/Cas 9 to knockout an individual gene for functional studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, RNAi and Small Regulatory RNAs in Stem Cells: Methods and Protocols aims to accelerate progress in this crucial field by reducing the time required to decipher and put into practice procedures published in the literature.

Redesigning Life

Redesigning Life
  • Author : John Parrington
  • Publisher :Unknown
  • Release Date :2016-08-25
  • Total pages :320
  • ISBN : 9780198766827
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Summary : Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximize agricultural production and cater to our tastes in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering. In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. 'Mutation chain reaction' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch. These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring - and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.

Principles of Cloning

Principles of Cloning
  • Author : Jose Cibelli,Ian Sir Wilmut,Rudolf Jaenisch,John Gurdon,Robert Lanza,Michael West,Keith H.S. Campbell
  • Publisher :Unknown
  • Release Date :2013-09-24
  • Total pages :572
  • ISBN : 9780123865427
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Summary : Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species—including mice, sheep, cattle, and non-mammals—is considered as well. The Editors have been involved in a number of breakthroughs using cloning technique, including the first demonstration that cloning works in differentiated cells done by the Recipient of the 2012 Nobel Prize for Physiology or Medicine – Dr John Gurdon; the cloning of the first mammal from a somatic cell – Drs Keith Campbell and Ian Wilmut; the demonstration that cloning can reset the biological clock - Drs Michael West and Robert Lanza; the demonstration that a terminally differentiated cell can give rise to a whole new individual – Dr Rudolf Jaenisch and the cloning of the first transgenic bovine from a differentiated cell – Dr Jose Cibelli. The majority of the contributing authors are the principal investigators on each of the animal species cloned to date and are expertly qualified to present the state-of-the-art information in their respective areas. First and most comprehensive book on animal cloning, 100% revised Describes an in-depth analysis of current limitations of the technology and research areas to explore Offers cloning applications on basic biology, agriculture, biotechnology, and medicine