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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
  • Author : Venkataramana K Sidhaye,Michael Koval
  • Publisher :Unknown
  • Release Date :2017-03-09
  • Total pages :276
  • ISBN : 9780128038819
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Summary : Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Comparative Biology of the Normal Lung

Comparative Biology of the Normal Lung
  • Author : Richard A. Parent
  • Publisher :Unknown
  • Release Date :2015-03-13
  • Total pages :834
  • ISBN : 9780124047266
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Summary : Comparative Biology of the Normal Lung, 2nd Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system

Pulmonary Biology in Health and Disease

Pulmonary Biology in Health and Disease
  • Author : Edward E. Bittar
  • Publisher :Unknown
  • Release Date :2002-09-10
  • Total pages :428
  • ISBN : 9780387952154
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Summary : This new book provides an accessible review of the field of lung biology and disease aimed at the graduate or medical student and biomedical researcher. The book starts by considering the anatomy and ultrastructure of the lung and the tracheal and bronchial system, the control of respiration as well as the fundamentals of pulmonary physiology, gas exchange and circulation. This is followed by discussion of the regulation of acid-base balance, high altitude physiology and pathophysiology as well as exercise and the pulmonary system. Chapters follow on the immunology of the lung, lung injury, asthma and emphysema, granulomatous lung disease, inhalation of toxic substances as well as diseases of the small airways. The final chapter considers current research into lung transplantation.

Oxidative Stress in Lung Diseases

Oxidative Stress in Lung Diseases
  • Author : Sajal Chakraborti,Tapati Chakraborti,Salil Kumar Das,Dhrubajyoti Chattopadhyay
  • Publisher :Unknown
  • Release Date :2019-08-31
  • Total pages :491
  • ISBN : 9789811384134
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Summary : This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.

Molecular Pathology of Lung Diseases

Molecular Pathology of Lung Diseases
  • Author : Dani S. Zander,Helmut Popper,Jaishree Jagirdar,Abida Haque,Roberto Barrios
  • Publisher :Unknown
  • Release Date :2010-05-26
  • Total pages :682
  • ISBN : 0387724303
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Summary : This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.

Proteases in Tissue Remodelling of Lung and Heart

Proteases in Tissue Remodelling of Lung and Heart
  • Author : Uwe Lendeckel,Nigel M. Hooper
  • Publisher :Unknown
  • Release Date :2003-09-30
  • Total pages :237
  • ISBN : 0306479109
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Summary : Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. Thus, the book should be a valuable source for both clinicians and researchers interested in protease function and/or diseases of lung and heart. Proteases in Tissue Remodelling of Lung and Heart: *is devoted to proteases in lung and heart specifically and extensively, *covers major diseases of the lung and heart, *extensively introduces individual proteases (or families thereof), *presents up-to-date patient-derived and experimental data, *covers most aspects of protease function in disease.

Human Respiratory Viral Infections

Human Respiratory Viral Infections
  • Author : Sunit K. Singh
  • Publisher :Unknown
  • Release Date :2014-06-23
  • Total pages :698
  • ISBN : 9780429586453
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Summary : Using a multidisciplinary approach, Human Respiratory Viral Infections is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic sciences of epidemiology, virology, molecular biology, and immunology to cover clinical diagnos

The Paracellular Channel

The Paracellular Channel
  • Author : Jianghui Hou
  • Publisher :Unknown
  • Release Date :2018-06-08
  • Total pages :248
  • ISBN : 9780128146361
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Summary : The Paracellular Channel: Biology, Physiology and Disease serves as the first volume to offer a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues. This new class of ion channel utilizes a completely different mechanism to create ion passage pathways across the cell junction. This volume outlines common principles that govern the organization and regulation of these diverse cellular structures, describes the methodology of study, and highlights the pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases. Coverage includes biochemical, biophysical, structural, physiologic analyses of the paracellular channel, and new technologies for recording and characterization. Offers integrated coverage of all key aspects of the paracellular channel, an understudied field that may hold key insights into some of the most mysterious aspects of physiology Targets different levels of expertise, spanning from graduate students, interns and clinical fellows, to seasoned researchers that study functions, regulation and dysfunctions of different tissue barriers Provides a cohesive and unifying picture that describes the critical functions of paracellular channels (tight junctions) in different tissues

Research Grants Index

Research Grants Index
  • Author : National Institutes of Health (U.S.). Division of Research Grants
  • Publisher :Unknown
  • Release Date :1972
  • Total pages :229
  • ISBN : MINN:31951D03457586Q
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Summary :

Proteases in Human Diseases

Proteases in Human Diseases
  • Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
  • Publisher :Unknown
  • Release Date :2017-07-13
  • Total pages :513
  • ISBN : 9789811031625
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Summary : This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Stem Cell-Based Therapy for Lung Disease

Stem Cell-Based Therapy for Lung Disease
  • Author : Janette K. Burgess,Irene H. Heijink
  • Publisher :Unknown
  • Release Date :2019-11-23
  • Total pages :259
  • ISBN : 9783030294038
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Summary : This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

Seminars in Dysphagia

Seminars in Dysphagia
  • Author : Renee Speyer,Hans Bogaardt
  • Publisher :Unknown
  • Release Date :2015-09-02
  • Total pages :248
  • ISBN : 9789535121510
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Summary : Seminars in Dysphagia provides a comprehensive overview of contemporary issues in the field of dysphagia assessment, treatment and management in diverse subject populations. Expert views are shared by international clinical experts from different medical and allied health fields. This book contains an introductory chapter on the anatomical structures and physiology processes that underpin dysphagia and discusses the effects of polypharmacy and ageing on deglutition. Contemporary practices of functional assessment of swallowing and the endoscopic assessment for both oropharyngeal and esophageal dysphagia are reviewed. Both the nutritional support and decision making in oral route are described and the impact of dysphagia on carers and family when managing dysphagia. Several chapters are dedicated to outlining the manifestation and consequences of dysphagia in specific populations, including persons with Parkinsons disease, dystonia, chronic obstructive pulmonary disease and mixed connective tissue disease.

Stem Cells in the Respiratory System

Stem Cells in the Respiratory System
  • Author : Mauricio Rojas
  • Publisher :Unknown
  • Release Date :2010-08-05
  • Total pages :170
  • ISBN : 1607617757
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Summary : In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant—and recent—ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung’s alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung’s relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.

Inventory of Federal Energy-related Environment and Safety Research for ...

Inventory of Federal Energy-related Environment and Safety Research for ...
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :229
  • ISBN : UOM:39015095045236
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Summary :

Inventory of Federal Energy-related Environment and Safety Research for FY 1978

Inventory of Federal Energy-related Environment and Safety Research for FY 1978
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :229
  • ISBN : STANFORD:36105211307652
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Summary :

Research Awards Index

Research Awards Index
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1978
  • Total pages :229
  • ISBN : MINN:30000008789962
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Summary :

The Nose and Sinuses in Respiratory Disorders

The Nose and Sinuses in Respiratory Disorders
  • Author : Claus Bachert,Arnaud Bourdin,Pascal Chanez
  • Publisher :Unknown
  • Release Date :2017-06-01
  • Total pages :224
  • ISBN : 9781849840866
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Summary :

American Journal of Respiratory Cell and Molecular Biology

American Journal of Respiratory Cell and Molecular Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :229
  • ISBN : NWU:35558003469026
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Summary :

Lung Stem Cells in the Epithelium and Vasculature

Lung Stem Cells in the Epithelium and Vasculature
  • Author : Amy Firth,Jason X.-J. Yuan
  • Publisher :Unknown
  • Release Date :2015-05-23
  • Total pages :345
  • ISBN : 9783319162324
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Summary : This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Role of Neutrophils in Disease Pathogenesis

Role of Neutrophils in Disease Pathogenesis
  • Author : Maitham Khajah
  • Publisher :Unknown
  • Release Date :2017-06-07
  • Total pages :180
  • ISBN : 9789535131953
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Summary : This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.

Hypoxia and Human Diseases

Hypoxia and Human Diseases
  • Author : Jing Zheng,Chi Zhou
  • Publisher :Unknown
  • Release Date :2017-02-01
  • Total pages :454
  • ISBN : 9789535128953
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Summary : This book contains a total of 21 chapters, each of which was written by experts in the corresponding field. The objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions in the detection, recognition, and management of hypoxia-related disorders. This collection of articles provides a clear update in the area of hypoxia research for biomedical researchers, medical students, nurse practitioners, and practicing clinicians in the fields of high altitude biology, cardiovascular biology and medicine, tumor oncology, obstetrics, pediatrics, and orthodontics and for others who may be interested in hypoxia.