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In Vivo NMR Spectroscopy

In Vivo NMR Spectroscopy
  • Author : Robin A. de Graaf
  • Publisher :Unknown
  • Release Date :2019-03-11
  • Total pages :568
  • ISBN : 9781119382546
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Summary : Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.

Magnetic Resonance Spectroscopy

Magnetic Resonance Spectroscopy
  • Author : Charlotte Stagg,Douglas L. Rothman
  • Publisher :Unknown
  • Release Date :2013-11-11
  • Total pages :398
  • ISBN : 9780124016972
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Summary : Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations. Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective. Chapters written by world-leading experts in the field Fully illustrated Covers both proton and non-proton MRS Includes the background to novel MRS imaging approaches

Handbook of Magnetic Resonance Spectroscopy In Vivo

Handbook of Magnetic Resonance Spectroscopy In Vivo
  • Author : Paul A. Bottomley,John R. Griffiths
  • Publisher :Unknown
  • Release Date :2016-12-19
  • Total pages :1232
  • ISBN : 9781118997666
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Summary : This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms–including animal models and patients. Comprised of three parts: Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity. Reference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit the eMagRes Homepage

Nuclear Magnetic Resonance Spectroscopy

Nuclear Magnetic Resonance Spectroscopy
  • Author : Joseph B. Lambert,Eugene P. Mazzola,Clark D. Ridge
  • Publisher :Unknown
  • Release Date :2019-01-04
  • Total pages :480
  • ISBN : 9781119295235
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Summary : Combines clear and concise discussions of key NMR concepts with succinct and illustrative examples Designed to cover a full course in Nuclear Magnetic Resonance (NMR) Spectroscopy, this text offers complete coverage of classic (one-dimensional) NMR as well as up-to-date coverage of two-dimensional NMR and other modern methods. It contains practical advice, theory, illustrated applications, and classroom-tested problems; looks at such important ideas as relaxation, NOEs, phase cycling, and processing parameters; and provides brief, yet fully comprehensible, examples. It also uniquely lists all of the general parameters for many experiments including mixing times, number of scans, relaxation times, and more. Nuclear Magnetic Resonance Spectroscopy: An Introduction to Principles, Applications, and Experimental Methods, 2nd Edition begins by introducing readers to NMR spectroscopy - an analytical technique used in modern chemistry, biochemistry, and biology that allows identification and characterization of organic, and some inorganic, compounds. It offers chapters covering: Experimental Methods; The Chemical Shift; The Coupling Constant; Further Topics in One-Dimensional NMR Spectroscopy; Two-Dimensional NMR Spectroscopy; Advanced Experimental Methods; and Structural Elucidation. Features classical analysis of chemical shifts and coupling constants for both protons and other nuclei, as well as modern multi‐pulse and multi-dimensional methods Contains experimental procedures and practical advice relative to the execution of NMR experiments Includes a chapter-long, worked-out problem that illustrates the application of nearly all current methods Offers appendices containing the theoretical basis of NMR, including the most modern approach that uses product operators and coherence-level diagrams By offering a balance between volumes aimed at NMR specialists and the structure-determination-only books that focus on synthetic organic chemists, Nuclear Magnetic Resonance Spectroscopy: An Introduction to Principles, Applications, and Experimental Methods, 2nd Edition is an excellent text for students and post-graduate students working in analytical and bio-sciences, as well as scientists who use NMR spectroscopy as a primary tool in their work.

Clinical Applications of Magnetic Resonance Spectroscopy

Clinical Applications of Magnetic Resonance Spectroscopy
  • Author : Suresh K. Mukherji
  • Publisher :Unknown
  • Release Date :1998-04-28
  • Total pages :317
  • ISBN : 0471161780
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Summary : Clinical Applications of MR Spectroscopy Edited by Suresh K. Mukherji, M.D. Magnetic resonance spectroscopy (MRS) is a powerful diagnostic tool for a variety of brain disorders—from epilepsy and tumors to age-related degeneration and strokes. Unlike magnetic resonance imaging (MRI), which gives us a picture of anatomical and physiological conditions, MRS generates a frequency domain spectrum that provides information about biochemical and metabolic processes occurring within tissues. Clinical Applications of MR Spectroscopy presents a short, practical treatment of MRS today. Comprising contributions by leading authorities in the field, the book discusses MRS techniques used for diagnostic purposes and research, terminologies and examples drawn from clinical experience, and ways to correlate MRS results with other modalities to enhance our understanding of disease processes and the outcomes of particular treatments. Topics include: Basic principles of clinical proton magnetic resonance spectroscopy MRS in the evaluation of epilepsy Proton MRS of brain tumors Proton MRS in selected childhood disorders MRS and spectroscopic imaging for cerebrovascular disease MRS of degenerative brain disease in the elderly MRS of the head and neck Potential clinical applications of new techniques in MRS Correlation of functional brain imaging with MRS Clinical Applications of MR Spectroscopy provides 150 photographs and figures to illustrate the interpretation of MRS signals, as well as fully referenced chapters for those wishing to expand their knowledge of the underlying science. It is an essential guide to the state of the art for radiologists and neurologists using this technology to improve patient care.

Magnetic Resonance Spectroscopy Diagnosis of Neurological Diseases

Magnetic Resonance Spectroscopy Diagnosis of Neurological Diseases
  • Author : Else Rubaek Danielsen,Brian Ross
  • Publisher :Unknown
  • Release Date :1999-02-16
  • Total pages :344
  • ISBN : 9781482270105
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Summary : Demonstrates how MRS offers a useful tool for the noninvasive biochemical analysis of the brain. The book covers over 70 clinical cases and more than 100 spectra that enhance skills at interpreting MRS, including minimizing errors, highlighting artifacts, and expanding the clinical usefulness of this diagnostic modality.

Molecular Imaging

Molecular Imaging
  • Author : Bernhard Schaller
  • Publisher :Unknown
  • Release Date :2012-03-16
  • Total pages :402
  • ISBN : 9789535103592
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Summary : The present book gives an exceptional overview of molecular imaging. Practical approach represents the red thread through the whole book, covering at the same time detailed background information that goes very deep into molecular as well as cellular level. Ideas how molecular imaging will develop in the near future present a special delicacy. This should be of special interest as the contributors are members of leading research groups from all over the world.

Development of Dynamic in Vivo Carbon-13 Magnetic Resonance Spectroscopy for Rat Brain Imaging at 7-Tesla

Development of Dynamic in Vivo Carbon-13 Magnetic Resonance Spectroscopy for Rat Brain Imaging at 7-Tesla
  • Author : Chathura Kumaragamage
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :229
  • ISBN : OCLC:1112735173
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Summary : "The overarching objective of this thesis is to develop novel methods for dynamic in vivo carbon-13 (13C) Magnetic Resonance Spectroscopy (MRS) for rodent brain imaging. Dynamic 13C MRS is a powerful technique that provides non-invasive means to quantify neurotransmitter cycling rates and cell-specific neuroenergetics in the brain, following the infusion of a 13C labeled substrate. Proton observed carbon edited (POCE) MRS is a popularly used indirect 13C MRS technique, typically implemented with a surface coil transceiver on the proton channel to benefit from surface coil sensitivity gains. POCE MRS implementations for a surface coil transceiver benefit from the use of relatively long and power intensive adiabatic radiofrequency (RF) pulses to minimize nutation angle errors, signal losses, and artifacts due to the spatially varying magnetic field (B1+). The first goal of this work was thus to develop an RF coil platform with homogeneous B1+, in addition to providing receive sensitivity gains of a surface coil. This was achieved by combining a proton volumetric resonator, and detunable surface coil for proton signal reception, in addition to a surface coil on the 13C channel. A point resolved spectroscopy (PRESS) localized POCE MRS sequence with a 12.6-ms echo time (TE) was implemented with short conventional pulses, enabling uniform nutation, two-shot edited POCE MRS, combined with a short TE; a feat that cannot be achieved with all-surface coil based approaches described in the literature.An extension to the above goal was to improve the PRESS-POCE sequence by reducing the sequence TE and minimize T2 and homonuclear J-evolution related losses. To that end, a novel PRESS localized POCE sequence that utilizes simultaneous editing and localization pulses (SEAL-PRESS) allowing the TE to be reduced to a theoretically optimal value of 8.1-ms was implemented. The SEAL-PRESS sequence was validated in phantom and in an in vivo rat preparation. Carbon editing efficiency of the SEAL-PRESS sequence was >95%, and provided a >17% improvement of 13C labeled metabolites relative to the previously described PRESS-POCE sequence. The final goal of this thesis was to investigate the feasibility of sequentially acquiring indirect and direct 13C MRS during a dynamic in vivo 13C MRS session, to harvest the benefits of indirect and direct 13C methods, with the ultimate goal of improving metabolic modeling. Modifications to the RF chain were necessary to extend the developed coil platform to be capable of both direct and indirect 13C MRS. A PRESS-localized semi-adiabatic distortionless enhancement by polarization transfer (DEPT) sequence was designed and evaluated in phantom, and the SEAL-PRESS sequence was used for indirect 13C MRS. Phantom data showed that measurements made with the two sequences were in reasonable agreement. Finally a dynamic in vivo 13C MRS study in rat brain was conducted while sequentially acquiring data with both sequences. Time-resolved indirect 13C spectra were obtained as expected, however due to much poorer sensitivity of direct 13C signal acquisition; no meaningful time-resolved spectra were recorded. Avenues for SNR degradation along the RF chain were investigated, and considerations for the next iteration coil setup are discussed. " --

Signal Processing for Magnetic Resonance Imaging and Spectroscopy

Signal Processing for Magnetic Resonance Imaging and Spectroscopy
  • Author : Hong Yan
  • Publisher :Unknown
  • Release Date :2002-02-20
  • Total pages :672
  • ISBN : 0203908783
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Summary : This reference/text contains the latest signal processing techniques in magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for more efficient clinical diagnoses-providing ready-to-use algorithms for image segmentation and analysis, reconstruction and visualization, and removal of distortions and artifacts for increased detec

Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry

Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry
  • Author : Lloyd Miles Jackman,S. Sternhell
  • Publisher :Unknown
  • Release Date :1978
  • Total pages :456
  • ISBN : 0080229530
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Summary : Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, Second Edition focuses on the applications of nuclear magnetic resonance spectroscopy to problems in organic chemistry and the theories involved in this kind of spectroscopy. The book first discusses the theory of nuclear magnetic resonance, including dynamic and magnetic properties of atomic nuclei, nuclear resonance, and relaxation process. The manuscript also examines the experimental method. Topics include experimental factors that influence resolution and the shapes of absorption lines; measurement of line posit...

Nuclear Magnetic Resonance Spectroscopy in Solids

Nuclear Magnetic Resonance Spectroscopy in Solids
  • Author : Rex Richards,K. J. Packer
  • Publisher :Unknown
  • Release Date :1981
  • Total pages :210
  • ISBN : 085403160X
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Summary :

MR Spectroscopy of Pediatric Brain Disorders

MR Spectroscopy of Pediatric Brain Disorders
  • Author : Stefan Blüml,Ashok Panigrahy
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :402
  • ISBN : 9781441958648
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Summary : Magnetic resonance spectroscopy (MRS) is a modality available on most clinical MR scanners and readily integrated with standard MR imaging (MRI). For the brain in particular, MRS has been a powerful research tool providing additional clinically relevant information for several disease families such as brain tumors, metabolic disorders, and systemic diseases. The most widely-available MRS method, proton (1H; hydrogen) spectroscopy, is FDA approved for general use in the US and can be ordered by clinicians for patient studies if indicated. There are several books available that describe applications of MRS in adults. However, to the best of our knowledge there is currently no book available that focuses exclusively on applications in pediatrics. MR spectroscopy in the pediatric population is different from adults for two main reasons. Particularly in the newborn phase the brain undergoes biochemical maturation with dramatic changes of the "normal" biochemical fingerprint. Secondly, brain diseases in the pediatric population are different from adult disorders. For example, brain tumors, which are mostly gliomas in the adults, often originate from different cell types and are also more diverse even within the same type and grade of tumor. This diversity of diseases and its implications for MR spectroscopy has not been addressed sufficiently in the literature, we believe. The target audience for "MR Spectroscopy of Pediatric Brain Disorders" are thus both clinicians and researchers involved with pediatric brain disorders. This includes radiologists, neurologists, neurooncologists, neurosurgeons, and more broadly the neuroscience and neurobiology community. This book will provide the necessary background information to understand the basics of MR spectroscopy. This will be followed by a detailed discussion of the normal biochemical maturation which will highlight the metabolic differences between the pediatric and adult brain. Thereafter, in SECTION I individual chapters will address various pediatric brain disease families. Of particular importance for pediatrics are case studies. For that reason, SECTION II will contain a large number of case studies. This will be particularly important for clinicians who may want to see examples of MRS for various conditions. A standardized format will be used for case reports that allow the reader to quickly understand the history of each case presented and the significance of the findings. The case reports will also include information from other imaging modalities to point out any added value of MRS in addition to conventional studies and clinical information. This section is necessary because the format of providing more complete information about individual patients is not practical for the chapters in SECTION I.

Clinical MR Spectroscopy

Clinical MR Spectroscopy
  • Author : Peter B. Barker,Alberto Bizzi,Nicola De Stefano,Doris D. M. Lin
  • Publisher :Unknown
  • Release Date :2009-11-12
  • Total pages :264
  • ISBN : 9780521868983
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Summary : Covers all MR spectroscopy techniques and their clinical applications in neurological disorders, malignancies and musculoskeletal diseases.

Clinical Magnetic Resonance Spectroscopy

Clinical Magnetic Resonance Spectroscopy
  • Author : E.B. Cady
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :290
  • ISBN : 9781468413335
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Summary : Nobody can know everything. For the successful application of techniques based on nuclear magnetic resonance to clinical problems, it is a vital necessity that individuals with widely different skills should learn a little of each others' trades by co-operation and communication. Ernest Cady has long proved himself a master of these arts to his colleagues at University College London, and by writing this excellent book he extends his experience to a wide circle of readers. Although the nuclear magnetic resonance (NMR) phenomenon had been predicted theoretically (and to some degree demonstrated experimentally) appreciably earlier, it required the advances in electronics that took place during World War II to turn NMR into a practical technique, as demonstrated independently in 1946 by Bloch and Purcell. Since then, NMR has been used extensively and increasingly by chemists and physicists. In the 1970s the first applications of NMR to animal organs yielded important advances in our knowledge of the biochemical and physiological processes as they occur in genuinely intact tissues. They showed incidentally that some conventional techniques introduce significant artifacts.

Proton Magnetic Resonance Spectroscopy of Carcinogenic Aromatic Hydrocarbons

Proton Magnetic Resonance Spectroscopy of Carcinogenic Aromatic Hydrocarbons
  • Author : Raymond Stanley Matthews
  • Publisher :Unknown
  • Release Date :1971
  • Total pages :229
  • ISBN : OCLC:1179522527
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Summary :

Spin Resonance Spectroscopy

Spin Resonance Spectroscopy
  • Author : Chandran Karunakaran
  • Publisher :Unknown
  • Release Date :2018-01-02
  • Total pages :378
  • ISBN : 9780128136096
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Summary : Spin Resonance Spectroscopy: Principles and Applications presents the principles, recent advancements and applications of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) in a single multi-disciplinary reference. Spin resonance spectroscopic techniques through NMR and EPR are widely used by chemists, physicists, biologists and medicinal chemists. This book addresses the need for new spin resonance spectroscopy content while also presenting the principles, recent advancements and applications of NMR and EPR simultaneously. Ideal for researchers and students alike, the book provides a single source of NMR and EPR applications using a dynamic, holistic and multi-disciplinary approach. Presents a highly interdisciplinary approach by including NMR and EPR applications in chemistry, physics, biology and biotechnology Addresses both NMR and EPR, making its concepts and applications implementable in multiple resonance environments and core scientific disciplines Features a broad range of methods, examples and illustrations for both NMR and EPR to aid in retention and underscore key concepts

Applications of Nuclear Magnetic Resonance Spectroscopy to the Study of Metal Complexes

Applications of Nuclear Magnetic Resonance Spectroscopy to the Study of Metal Complexes
  • Author : James David Thwaites
  • Publisher :Unknown
  • Release Date :1963
  • Total pages :229
  • ISBN : OCLC:1184534415
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Summary :

Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry

Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry
  • Author : L. M. Jackman,S. Sternhell
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :474
  • ISBN : 9781483280943
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Summary : Application of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, Second Edition covers the theoretical background necessary for the intelligent application of NMR spectroscopy to common problems encountered in organic chemistry. This book is composed of five parts, and begins with introduction to the theory and practice of nuclear magnetic resonance. The succeeding chapter deals with the theory of chemical effects in NMR spectroscopy. These topics are followed by a discussion on the application of chemical shift to organic compound analysis and the principles of the spin-spin coupling .The final chapter considers the applications of time- dependent phenomena in NMR spectroscopy. This book will prove useful to analytical chemists and researchers in the allied fields.

The Role of Magnetic Resonance Spectroscopy in the Diagnosis of Ring Enhancing Lesions

The Role of Magnetic Resonance Spectroscopy in the Diagnosis of Ring Enhancing Lesions
  • Author : Eftychia Kapsalaki
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :229
  • ISBN : OCLC:1154219979
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Summary : The Role of Magnetic Resonance Spectroscopy in the Diagnosis of Ring Enhancing Lesions.

Methodologies for Metabolomics

Methodologies for Metabolomics
  • Author : Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
  • Publisher :Unknown
  • Release Date :2013-01-21
  • Total pages :229
  • ISBN : 9781139619059
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Summary : Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Nuclear Magnetic Resonance Spectroscopy in Environmental Chemistry

Nuclear Magnetic Resonance Spectroscopy in Environmental Chemistry
  • Author : Mark A. Nanny,Roger A. Minear,Jerry A. Leenheer
  • Publisher :Unknown
  • Release Date :1997-04-03
  • Total pages :344
  • ISBN : 0198025807
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Summary : This book demonstrates the usefulness of NMR spectroscopy for a wide variety of applications in environmental science and technology. It contains a wealth of information relating to instrumentation, sample preparation, and data interpretation. The book is divided into three sections discussing contaminant interaction, solution and condensed-phase characterization, and nutrients and natural organic matter characterization. In addition to these in-depth chapters, an introductory overview provides the basic principles of solution and solid-state NMR spectroscopy. Each section also contains a discussion of advances in each area directly attributable to NMR spectroscopy. A final chapter suggests future directions for the deployment of this powerful technology in environmental science.