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Managing Health in the Genomic Era

Managing Health in the Genomic Era
  • Author : Vincent Henrich,Lori A. Orlando,Brian H. Shirts
  • Publisher :Unknown
  • Release Date :2020-06-27
  • Total pages :238
  • ISBN : 9780128160169
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Summary : In Managing Health in the Genomic Era: A Guide to Family Health History and Disease Risk, Drs. Vincent C. Henrich, Lori A. Orlando, and Brian H. Shirts discuss the practical considerations surrounding the use of genomic and genetic tests to manage patient health, to provide adult disease risk assessment, to improve diagnosis, and to support effective interventions and treatment. In 10 chapters, evidence-based information and case studies are described and examine the central place of family health history (FHH) in genomic medicine, tools and strategies for compiling and analyzing family health history, how to identify existing and novel genetic markers, how to identify lineage specific (or rare) variants within families, and how to find effective interventions based on genetic testing results and FHH. Factors that influence clinical practice, including gene-environment interactions, FHH social networking, direct to consumer (DTC) genetic testing and data sharing, algorithms for analyzing genetic data, and patient counseling are discussed from the standpoint of clinical practice. Here, frontline healthcare providers will discover succinct commentary and key examples to assist with their local needs. Relevant principles of genetic biology and inheritance are explored and guidance on available support networks and online resources is also provided Presents a practical, accessible resource for primary care providers, allied health professionals, pharmacologists, public health professionals, students and clinical researchers Addresses genetic and genomic approaches in managing patient health, conducting and analyzing family health histories, and assessing adult disease risk Features an expert author team with direct experience integrating genetics and genomics in primary care and family medicine settings Examines the attributes and limitations of family health history, genetic testing, and genomic testing in clinical practice Includes detailed explanations following practice-based examples

Plant Disease Management in the Post-Genomic Era: From Functional Genomics to Genome Editing

Plant Disease Management in the Post-Genomic Era: From Functional Genomics to Genome Editing
  • Author : Sabrina Sarrocco,Alfredo Herrera-Estrella,David B. Collinge
  • Publisher :Unknown
  • Release Date :2020-03-16
  • Total pages :229
  • ISBN : 9782889635603
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Summary :

Medical and Health Genomics

Medical and Health Genomics
  • Author : Dhavendra Kumar,Stylianos Antonarakis
  • Publisher :Unknown
  • Release Date :2016-06-04
  • Total pages :358
  • ISBN : 9780127999227
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Summary : Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems

Genomic management of animal genetic diversity

Genomic management of animal genetic diversity
  • Author : J.K. Oldenbroek
  • Publisher :Unknown
  • Release Date :2017-03-23
  • Total pages :232
  • ISBN : 9789086868506
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Summary : Recently developed genomic tools, like SNP-genotyping and whole genome sequencing, and their analysis, offer great opportunities for the conservation and utilisation of animal genetic diversity, both among and within breeds. These genomic tools can be used to detect potentially valuable rare alleles and haplotypes. They are important parts of the genetic diversity we need to conserve now for possible utilisation in the future. This book describes the use of genomic technology to define breeds, to measure diversity and to assess important features in the history of breeds affecting the present genetic diversity. The management of genetic diversity with genomic tools is outlined both in vivo: small populations of rare breeds or large populations with small effective population sizes and in vitro: genebanks. Special attention is given to the genomic management of populations of animals with high incidences of genetic defects. This book is intended for MSc and PhD students, scientists working with small populations in animal breeding and in conservation programmes for rare breeds.

Managing biomedical research to prevent and cure disease in the 21st century

Managing biomedical research to prevent and cure disease in the 21st century
  • Author : United States. Congress. House. Committee on Energy and Commerce
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :260
  • ISBN : UOM:39015089026515
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Summary :

Genomic and Personalized Medicine

Genomic and Personalized Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-10-30
  • Total pages :1350
  • ISBN : 9780123822284
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Summary : Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Nursing Care in the Genomic Era

Nursing Care in the Genomic Era
  • Author : Jean F. Jenkins,Dale Halsey Lea
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :411
  • ISBN : 0763733253
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Summary : Increasingly, genomic-based approaches and resources are redefining our categorization of disease, leading to new approaches to prevention and therapy. As nurses traditionally practice patient-oriented care, they will undoubtedly play a key role in both developing and applying the aspects of genomic health care. Nursing Care in the Genomic Era: A Case Based Approach is designed to provide nurses with up-to-date and accessible information on this powerful new approach to understanding, preventing, and treating disease.The framework for each chapter consists of core competencies in genetics, interwoven with stories that highlight a particular condition and the related biological, personal, and psychosocial issues. The chapters then go on to address the knowledge, skills, and attitudes necessary for nurses and health professionals as recommended by the National Coalition for Health Professional Education in Genetics (NCHPEG). The text presents the genetic components of common diseases such as cancer, diabetes, heart disease, and Alzheimer's, and the innovative technologies used to detect them.Understanding genomic issues and how they affect individuals and families is the first step for nurses hoping to make a difference when providing nursing care in the genomic era.

Renaissance of Sickle Cell Disease Research in the Genome Era

Renaissance of Sickle Cell Disease Research in the Genome Era
  • Author : Betty Pace
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :357
  • ISBN : 9781860946455
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Summary : The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook.

Aspergillus in the genomic era

Aspergillus in the genomic era
  • Author : János Varga,Robert A. Samson
  • Publisher :Unknown
  • Release Date :2008-01-11
  • Total pages :334
  • ISBN : 9789086860654
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Summary : Aspergillus is among the economically most important fungal genera. Aspergillus species are used in the fermentation industry for the production of various enzymes, organic acids and pharmaceutically important compounds, and in Oriental food fermentations. At the same time, Aspergilli can cause opportunistic infections, and produce a range of secondary metabolites also known as mycotoxins which are harmful to humans and animals. Due to its importance in biotechnology, medicine and foods, Aspergilli are in the forefront of studies dealing with various aspects of fungi. This is well illustrated by the fact that projects aiming at sequencing the genomes of nine species are in progress. In this book, some aspects of the biology of this genus are covered, including the biotechnological importance of Aspergilli, their role in mycotoxin contamination of food products including grapes and coffee products, and implications of biodiversity of Aspergillus populations for agriculture. Among the clinical aspects, the role of Aspergilli in eye infections, the mechanisms of antifungal drug resistance and their molecular identification in the clinical setting are covered. Several chapters deal with the genomic aspects of Aspergilli, including the genomics of pigment biosynthesis, extracellular enzyme production, aflatoxin biosynthesis and the identification of genes taking part in sexual processes. Additional chapters cover the variability and inheritance of mycoviruses in Aspergilli and multilocus approaches are given to clarify the evolutionary history of the genus. Finally, a new taxonomic classification of the various Aspergillus sections is given based on multilocus sequence data.

The National Institutes of Health-decoding our federal investment in genomic research

The National Institutes of Health-decoding our federal investment in genomic research
  • Author : United States,United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :49
  • ISBN : UOM:39015089026416
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Summary :

Microbial Diversity in the Genomic Era

Microbial Diversity in the Genomic Era
  • Author : Surajit Das,Hirak Ranjan Dash
  • Publisher :Unknown
  • Release Date :2018-09-20
  • Total pages :710
  • ISBN : 9780128148501
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Summary : Microbial Diversity in the Genomic Era presents insights on the techniques used for microbial taxonomy and phylogeny, along with their applications and respective pros and cons. Though many advanced techniques for the identification of any unknown bacterium are available in the genomics era, a far fewer number of the total microbial species have been discovered and identified to date. The assessment of microbial taxonomy and biosystematics techniques discovered and practiced in the current genomics era with suitable recommendations is the prime focus of this book. Discusses the techniques used for microbial taxonomy and phylogeny with their applications and respective pros and cons Reviews the evolving field of bacterial typing and the genomic technologies that enable comparative analysis of multiple genomes and the metagenomes of complex microbial environments Provides a uniform, standard methodology for species designation

Handbook of Pharmaceutical Biotechnology

Handbook of Pharmaceutical Biotechnology
  • Author : Shayne C. Gad
  • Publisher :Unknown
  • Release Date :2007-06-11
  • Total pages :1659
  • ISBN : UOM:39015064951935
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Summary : Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Plant Biotechnology: Progress in Genomic Era

Plant Biotechnology: Progress in Genomic Era
  • Author : S. M. Paul Khurana,Rajarshi Kumar Gaur
  • Publisher :Unknown
  • Release Date :2020-11-27
  • Total pages :670
  • ISBN : 9811385017
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Summary : Refinement in sequencing technologies and potential of genomic research resulted in meteoric growth of biological information such as sequences of DNA, RNA and protein requiring databases for efficient storage, management and retrieval of the biological information. Also, computational algorithms for analysis of these colossal data became a vital aspect of biological sciences. The work aims to show the process of turning bioscience innovation into companies and products, covering the basic science, the translation of science into technology. Due to rapid developments, there seems to be no basic difference between the pharmaceutical industry and the biotechnological industry. However, approved products in the pipeline and renewed public confidence make it one of the most promising areas of economic growth in the near future. India offers a huge market for the products as well as cheap manufacturing base for export. The book is a sincere work of compilation of new and recent advances in the topic of concern through various innovative researches and scientific opinion therefrom. The book is dedicated to the readers who will definitely find it interesting and knowledgeable in carrying out their respective researches in different aspects of applied microbiology and biotechnology.

Bioinformatics in the Post-genomic Era

Bioinformatics in the Post-genomic Era
  • Author : Jeffrey Augen
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :388
  • ISBN : STANFORD:36105114316099
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Summary : A comprehensive treatment of the role of bioinformatics in the emerging world of molecular medicine, for anyone involved in this new field

Genetic Governance

Genetic Governance
  • Author : Robin Bunton,Alan R. Petersen
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :215
  • ISBN : 0415354072
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Summary : Ethical and practical issues around genetic research are of major international concern, both in academia and in the public domain. This text looks at how the 'new' genetics and healthcare and health policy arising from it can or should be governed and regulated.

Human Genome Informatics

Human Genome Informatics
  • Author : Christophe Lambert,Darrol Baker,George P. Patrinos
  • Publisher :Unknown
  • Release Date :2018-08-02
  • Total pages :314
  • ISBN : 9780128134313
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Summary : Human Genome Informatics: Translating Genes into Health examines the most commonly used electronic tools for translating genomic information into clinically meaningful formats. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented. With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics. It is also ideal for workers in the bioinformatics industry who are interested in recent developments in the field. Provides an overview of the most commonly used electronic tools to translate genomic information Brings an update on the existing human genomic databases that directly impact genome interpretation Summarizes and comparatively analyzes interpretation methods of whole genome data and their application in genomic medicine

Essentials of Genomic and Personalized Medicine

Essentials of Genomic and Personalized Medicine
  • Author : Geoffrey S. Ginsburg,Huntington F Willard
  • Publisher :Unknown
  • Release Date :2009-10-02
  • Total pages :850
  • ISBN : 0080958117
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Summary : Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Plant Genomics

Plant Genomics
  • Author : Ibrokhim Y. Abdurakhmonov
  • Publisher :Unknown
  • Release Date :2016-07-14
  • Total pages :310
  • ISBN : 9789535124559
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Summary : Plant genomics aims to sequence, characterize, and study the genetic compositions, structures, organizations, functions, and interactions/networks of an entire plant genome. Its development and advances are tightly interconnected with proteomics, metabolomics, metagenomics, transgenomics, genomic selection, bioinformatics, epigenomics, phenomics, system biology, modern instrumentation, and robotics sciences. Plant genomics has significantly advanced over the past three decades in the land of inexpensive, high-throughput sequencing technologies and fully sequenced over 100 plant genomes. These advances have broad implications in every aspect of plant biology and breeding, powered with novel genomic selection and manipulation tools while generating many grand challenges and tasks ahead. This Plant genomics provides some updated discussions on current advances, challenges, and future perspectives of plant genome studies and applications.

The Clinical Practice of Neurological and Neurosurgical Nursing

The Clinical Practice of Neurological and Neurosurgical Nursing
  • Author : Joanne V. Hickey
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :768
  • ISBN : UCSD:31822037165628
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Summary : The new Sixth Edition of this award-winning classic prepares its users for delivering expert care in this most challenging nursing specialty. It addresses neuroanatomy, assessment, diagnostic evaluation, and management of the complete range of neurological disorders for which nurses provide patient care, including trauma, stroke, tumors, seizures, headache, aneurysms, infections, degenerative disorders, and peripheral neuropathies. This edition has been thoroughly revised to reflect standards of care based on evidence-based practice. It now includes case studies, community nursing sections throughout, and increased coverage of normal pressure hydrocephalus, inflammatory demyelinating polyneuropathy, and Creutzfeld-Jacob disease.

The Oxford Handbook of Public Health Ethics

The Oxford Handbook of Public Health Ethics
  • Author : Anna C. Mastroianni,Jeffrey P. Kahn,Nancy E. Kass
  • Publisher :Unknown
  • Release Date :2019-07-23
  • Total pages :992
  • ISBN : 9780190933197
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Summary : Natural disasters and cholera outbreaks. Ebola, SARS, and concerns over pandemic flu. HIV and AIDS. E. coli outbreaks from contaminated produce and fast foods. Threats of bioterrorism. Contamination of compounded drugs. Vaccination refusals and outbreaks of preventable diseases. These are just some of the headlines from the last 30-plus years highlighting the essential roles and responsibilities of public health, all of which come with ethical issues and the responsibilities they create. Public health has achieved extraordinary successes. And yet these successes also bring with them ethical tension. Not all public health successes are equally distributed in the population; extraordinary health disparities between rich and poor still exist. The most successful public health programs sometimes rely on policies that, while improving public health conditions, also limit individual rights. Public health practitioners and policymakers face these and other questions of ethics routinely in their work, and they must navigate their sometimes competing responsibilities to the health of the public with other important societal values such as privacy, autonomy, and prevailing cultural norms. This Oxford Handbook provides a sweeping and comprehensive review of the current state of public health ethics, addressing these and numerous other questions. Taking account of the wide range of topics under the umbrella of public health and the ethical issues raised by them, this volume is organized into fifteen sections. It begins with two sections that discuss the conceptual foundations, ethical tensions, and ethical frameworks of and for public health and how public health does its work. The thirteen sections that follow examine the application of public health ethics considerations and approaches across a broad range of public health topics. While chapters are organized into topical sections, each chapter is designed to serve as a standalone contribution. The book includes 73 chapters covering many topics from varying perspectives, a recognition of the diversity of the issues that define public health ethics in the U.S. and globally. This Handbook is an authoritative and indispensable guide to the state of public health ethics today.

Handbook of Clinical Adult Genetics and Genomics

Handbook of Clinical Adult Genetics and Genomics
  • Author : Shweta Dhar,Sandesh Sreenath Chakravarthy Nagamani,Tanya Eble
  • Publisher :Unknown
  • Release Date :2020-04-10
  • Total pages :534
  • ISBN : 9780128173459
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Summary : Handbook of Clinical Adult Genetics and Genomics: A Practice-Based Approach provides a thorough overview of genetic disorders that are commonly encountered in adult populations and supports the full translation of adult genetic and genomic modalities into clinical practice. Expert chapter authors supplement foundational knowledge with case-based strategies for the evaluation and management of genetic disorders in each organ system and specialty area. Topics discussed include employing genetic testing technologies, reporting test results, genetic counseling for adult patients, medical genetics referrals, issues of complex inheritance, gene therapy, and diagnostic and treatment criteria for developmental, cardiovascular, gastrointestinal, neuropsychiatric, pulmonary issues, and much more. Employs clinical case studies to demonstrate how to evaluate, diagnosis and treat adult patients with genetic disorders Offers a practical framework for establishing an adult genetics clinic, addressing infrastructure, billing, counseling, and challenges unique to adult clinical genetics Features chapter contributions from authors at leading adult genetics institutions in the US and abroad