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Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory
  • Author : Hari Nair,William Clarke
  • Publisher :Unknown
  • Release Date :2016-11-02
  • Total pages :304
  • ISBN : 9780128009925
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Summary : Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory
  • Author : Hari Nair
  • Publisher :Unknown
  • Release Date :2016-11-01
  • Total pages :300
  • ISBN : 0128008717
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Summary : "Mass Spectrometry for the Clinical Laboratory" is an accessible guide to mass spectrometry and the evaluation, validation, and trouble-shooting of the most common assays seen in clinical pathology labs. It offers readers a complete set of tools for the design of assay protocol, validation of experimental designs to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. The book provides appropriate statistical tools for validation, as well as guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Chapters have been written by expert users of the most common assays found in a clinical pathology laboratory (clinical chemists, toxicologists, and MD clinical pathologists practicing mass spectrometry). Introductory chapters lay out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The first half of the book covers what the practitioners have learned from a year or more of testing, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. Chapters in this section also include protocols for troubleshooting and for maintaining continuity in testing. The second half of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, lipids, amino acids, proteins, antibodies, etc.). Each chapter in this section has been written by an expert practitioner of an assay which is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labsExplains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline

Mass spectrometry in the clinical laboratory : general principles and guidance ; approved guideline
  • Author : Donald H. Chace
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :97
  • ISBN : 1562386484
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Summary :

Principles and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry
  • Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
  • Publisher :Unknown
  • Release Date :2018-06-26
  • Total pages :216
  • ISBN : 9780128160640
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Summary : Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Clinical Applications of Mass Spectrometry in Biomolecular Analysis

Clinical Applications of Mass Spectrometry in Biomolecular Analysis
  • Author : Uttam Garg
  • Publisher :Unknown
  • Release Date :2015-11-25
  • Total pages :333
  • ISBN : 1493931814
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Summary : This volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and no need for specialized reagents. The techniques described are a must for the measurement of many clinically relevant analytes in the fields of drug analysis, endocrinology, and inborn errors of metabolism. Each chapter provides a brief introduction about a specified analyte, followed by detailed instructions on the analytical protocol. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols is a great resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book
  • Author : Nigel Clarke,Andrew N. Hoofnagle
  • Publisher :Unknown
  • Release Date :2011-10-03
  • Total pages :104
  • ISBN : 9781455712014
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Summary : This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Clinical Applications of Mass Spectrometry

Clinical Applications of Mass Spectrometry
  • Author : Uttam Garg,Catherine A. Hammett-Stabler
  • Publisher :Unknown
  • Release Date :2009-12-14
  • Total pages :540
  • ISBN : 1607614588
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Summary : As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology
  • Author : Fernando Cobo
  • Publisher :Unknown
  • Release Date :2018-08-03
  • Total pages :298
  • ISBN : 9780128144527
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Summary : The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry
  • Author : Karoly Vekey,Andreas Telekes,Akos Vertes
  • Publisher :Unknown
  • Release Date :2011-08-11
  • Total pages :606
  • ISBN : 9780080554655
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Summary : Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Protein Analysis using Mass Spectrometry

Protein Analysis using Mass Spectrometry
  • Author : Mike S. Lee,Qin C. Ji
  • Publisher :Unknown
  • Release Date :2017-06-19
  • Total pages :288
  • ISBN : 9781118605196
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Summary : Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

Clinical Applications of Mass Spectrometry in Drug Analysis

Clinical Applications of Mass Spectrometry in Drug Analysis
  • Author : Uttam Garg
  • Publisher :Unknown
  • Release Date :2015-12-11
  • Total pages :272
  • ISBN : 1493932519
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Summary : This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of total Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. Each chapter contains a brief introduction to the topic, clinical utility of the analyte(s), and useful notes to help laboratorians easily reproduce the protocols discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, is a great resource for laboratorians who are already using mass spectrometry or thinking of introducing this technology to their laboratories.

GC/MS in Clinical Chemistry

GC/MS in Clinical Chemistry
  • Author : Petra Gerhards,Ulrich Bons,Jürgen Sawazki,Jörg Szigan,Albert Wertmann
  • Publisher :Unknown
  • Release Date :2008-07-11
  • Total pages :257
  • ISBN : 9783527614059
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Summary : This book enables the reader to gain a rapid understanding of GC/MS analysis through a basic knowledge of the fundamental principles, linking these with simple and practical applications in the field of industrial medicine and analysis of drugs. Additional information from other specialist fields is also provided with the aim of helping the analyst to understand their relevance to the interpretation of results. The book describes efficient methods of sample preparation and quality assurance and provides information on epidemiology and pharmacology, without which drug screening is impossible. This comprehensive overview is mainly written for the practical analyst in the clinical laboratory but it is equally suited for teaching purposes.

Advances in Clinical Chemistry

Advances in Clinical Chemistry
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2020-01-17
  • Total pages :340
  • ISBN : 9780128208021
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Summary : Advances in Clinical Chemistry, Volume 94, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest technologies relating to the field of clinical chemistry, with specific chapters in this new release covering Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome, Clotting factors - Clinical biochemistry and their roles as plasma enzymes, Myokines: The endocrine coupling of skeletal muscle and bone, Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance, and more. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory

Clinical Core Laboratory Testing

Clinical Core Laboratory Testing
  • Author : Ross Molinaro,Christopher R. McCudden,Marjorie Bonhomme,Amy Saenger
  • Publisher :Unknown
  • Release Date :2016-12-26
  • Total pages :105
  • ISBN : 9781489977946
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Summary : The clinical laboratory is often known as a “black box” to nurses, physicians, and surgeons, but this concise book removes the veil by covering all the pertinent aspects of the clinical laboratory. This book bridges between medicine and chemistry by offering an overview to a clinical laboratory’s structure and function, the importance of laboratory utilization and test ordering, as well as pre-analytical, analytical, and post-analytical issues of importance to recognize in any clinical laboratory. An interactive FAQ and a detailed index are also available.

Physician’s Guide to the Laboratory Diagnosis of Metabolic Diseases

Physician’s Guide to the Laboratory Diagnosis of Metabolic Diseases
  • Author : N. Blau,M. Duran,M.E. Blaskovics,K.M. Gibson
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :716
  • ISBN : 9783642558788
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Summary : This second edition of The Physician's Guide provides paediatricians and other physicians with a unique aid to help them select the correct diagnosis from a bewildering array of complex clinical and laboratory data. Delay and mistakes in the diagnosis of inherited metabolic diseases may have devastating consequences. The guide, which includes a CD-ROM, describes 298 disorders which have been grouped into 35 chapters according to the type of condition. Within each group of disorders, chapters provide tables of pertinent clinical findings as well as reference and pathological values for crucial metabolites. Relevant metabolic pathways and diagnostic flow charts are included. There are three indices to make the book as user-friendly as possible.

Toxicology Cases for the Clinical and Forensic Laboratory

Toxicology Cases for the Clinical and Forensic Laboratory
  • Author : Hema Ketha,Uttam Garg
  • Publisher :Unknown
  • Release Date :2020-06-20
  • Total pages :540
  • ISBN : 9780128163733
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Summary : Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both. Brings together expert cases encompassing analytical toxicology, clinical medicine and basic science in a consolidated format Presents unique and challenging cases in clinical laboratories contributed by experts in the field Consolidated format that make concepts in toxicology easy to learn and teach Key learning points highlighted with multiple choice questions

  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9780323548489
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Summary :

MALDI-TOF and Tandem MS for Clinical Microbiology

MALDI-TOF and Tandem MS for Clinical Microbiology
  • Author : Haroun N. Shah,Saheer E. Gharbia
  • Publisher :Unknown
  • Release Date :2017-03-31
  • Total pages :648
  • ISBN : 9781118960233
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Summary : This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry

A Practical Guide to Implementing Clinical Mass Spectrometry Systems

A Practical Guide to Implementing Clinical Mass Spectrometry Systems
  • Author : Neil Leaver
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :84
  • ISBN : 9781906799106
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Summary : Mass spectrometry is becoming increasingly popular in the field of therapeutic drug monitoring. The aim of this publication is to provide practical guidance for laboratories on the implementation of mass spectrometry into a clinical service where there might be limited expertise in the technique. This guidance is the author's personal recommendation based on over ten years' experience of clinical mass spectrometry. Throughout the text, examples are given to illustrate issues that a clinical laboratory might encounter. While some examples relate to the field of immunosuppressive drug monitoring, the issues are common and relevant to any clinical application. The guidance provided is also applicable to instrumentation made by any manufacturer. This practical guide covers instrument selection through business planning to installation, risk management and validation, and includes suggestions for future prospects for this developing field.

Analytical Techniques for Clinical Chemistry

Analytical Techniques for Clinical Chemistry
  • Author : Sergio Caroli,Gyula Záray
  • Publisher :Unknown
  • Release Date :2012-06-26
  • Total pages :830
  • ISBN : 9781118271841
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Summary : Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurements Metal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysis Use of X-ray techniques in medical research Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.

Applications of Mass Spectrometry in Microbiology

Applications of Mass Spectrometry in Microbiology
  • Author : Plamen Demirev,Todd R. Sandrin
  • Publisher :Unknown
  • Release Date :2016-01-12
  • Total pages :336
  • ISBN : 9783319260709
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Summary : In the last quarter century, advances in mass spectrometry (MS) have been at the forefront of efforts to map complex biological systems including the human metabolome, proteome, and microbiome. All of these developments have allowed MS to become a well-established molecular level technology for microorganism characterization. MS has demonstrated its considerable advantage as a rapid, accurate, and cost-effective method for microorganism identification, compared to conventional phenotypic techniques. In the last several years, applications of MS for microorganism characterization in research, clinical microbiology, counter-bioterrorism, food safety, and environmental monitoring have been documented in thousands of publications. Regulatory bodies in Europe, the US, and elsewhere have approved MS-based assays for infectious disease diagnostics. As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications. In twelve individual chapters, innovators, leaders and practitioners in the field from around the world have contributed to a comprehensive overview of current and next-generation approaches for MS-based microbial characterization at the subspecies and strain levels. Chapters include up-to-date reference lists as well as web-links to databases, recommended software, and other useful tools. The emergence of new, antibiotic-resistant strains of human or animal pathogens is of extraordinary concern not only to the scientific and medical communities, but to the general public as well. Developments of novel MS-based assays for rapid identification of strains of antibiotic-resistant microorganisms are reviewed in the book as well. Microbiologists, bioanalytical scientists, infectious disease specialists, clinical laboratory and public health practitioners as well as researchers in universities, hospitals, government labs, and the pharmaceutical and biotechnology industries will find this book to be a timely and valuable resource.