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Mechanobiology

Mechanobiology
  • Author : Simon Rawlinson
  • Publisher :Unknown
  • Release Date :2017-02-06
  • Total pages :432
  • ISBN : 9781118966143
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Summary : An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

Mechanobiology

Mechanobiology
  • Author : Glen L. Niebur
  • Publisher :Unknown
  • Release Date :2019-12-01
  • Total pages :254
  • ISBN : 9780128179321
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Summary : Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
  • Author : Stefaan Verbruggen
  • Publisher :Unknown
  • Release Date :2018-08-09
  • Total pages :527
  • ISBN : 9780128129531
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Summary : Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Mechanobiology Handbook, Second Edition

Mechanobiology Handbook, Second Edition
  • Author : Jiro Nagatomi,Eno Essien Ebong
  • Publisher :Unknown
  • Release Date :2018-12-07
  • Total pages :682
  • ISBN : 9780429816734
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Summary : This will be a substantial revision of a former reference work that willl now be developed as a primary text for emerging courses in mechanobiology/cell mechanics being offered in a growing number of biomedical engineering and chemical engineering departments worldwide. It will also serve as a professional reference book for engineers, scientisits and clinicians who are interested in mechanobiology, which is the study of the effects of mechanical environments on the biological processess of cells. The readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluide mechanics, and molecular analysis techniques.

Introduction to Cell Mechanics and Mechanobiology

Introduction to Cell Mechanics and Mechanobiology
  • Author : Christopher R. Jacobs,Hayden Huang,Ronald Y. Kwon
  • Publisher :Unknown
  • Release Date :2012-11-16
  • Total pages :350
  • ISBN : 9781135042653
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Summary : Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope

Modern Mechanobiology

Modern Mechanobiology
  • Author : Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai
  • Publisher :Unknown
  • Release Date :2021-02-25
  • Total pages :250
  • ISBN : 9781000021264
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Summary : Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Mechanobiology of the Endothelium

Mechanobiology of the Endothelium
  • Author : Helim Aranda-Espinoza
  • Publisher :Unknown
  • Release Date :2015-02-25
  • Total pages :280
  • ISBN : 9781482207255
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Summary : The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.

Mechanobiology of Cell-Cell and Cell-Matrix Interactions

Mechanobiology of Cell-Cell and Cell-Matrix Interactions
  • Author : A. Wagoner Johnson,Brendan Harley
  • Publisher :Unknown
  • Release Date :2011-02-21
  • Total pages :319
  • ISBN : 1441980830
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Summary : Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Mechanobiology

Mechanobiology
  • Author : J. F. Stoltz
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :448
  • ISBN : 1586034367
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Summary : Mechanobiology is now a vigorous branch of biomechanics and biorheology which is mainly concerned with the study of the influence of mechanical forces on cells and tissues and their clinical or therapeutical applications. As we are now at the age of proteomics and genomics and of cell micromechanical approaches, using methods like laser tweezers or confocal microscopy, mechanobiology brings new challenges. With these new researches, mechanobiology is the promise of new diagnostic and therapeutic approaches. The most recent work shows that the incidence of mechanical forces is specific to the system under scrutiny and that stresses are implicated in tissue physiology (for example by the production of the extracellular matrix), secretions (i.e. production of NO and prostaglandins by endothelial cells), or for the induction of specific functions via intercellular communication; hence the interest from pharmacology in studies on new molecules. Moreover, these new findings have led to the development of tissue engineering, which is the concept of substitute tissue developed in vitro, from bioresorbable or non-bioresorbable scaffolds and from cells harvested in a physiologic mechanical environment such as from cartilage, bone and vessels. At the same time, the problem of cell grafting in tissue repair and especially the use of stem cells have led to new therapeutic fields.

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology
  • Author : Shu Chien,Adam J. Engler,Peter Yingxiao Wang
  • Publisher :Unknown
  • Release Date :2016-08-10
  • Total pages :302
  • ISBN : 9781493956173
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Summary : This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Multi-scale Extracellular Matrix Mechanics and Mechanobiology
  • Author : Yanhang Zhang
  • Publisher :Unknown
  • Release Date :2019-07-12
  • Total pages :392
  • ISBN : 9783030201821
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Summary : This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Cellular and Biomolecular Mechanics and Mechanobiology

Cellular and Biomolecular Mechanics and Mechanobiology
  • Author : Amit Gefen
  • Publisher :Unknown
  • Release Date :2010-12-02
  • Total pages :562
  • ISBN : 3642142184
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Summary : This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Integrative Mechanobiology

Integrative Mechanobiology
  • Author : Yu Sun,Deok-Ho Kim,Craig A. Simmons
  • Publisher :Unknown
  • Release Date :2015-11-12
  • Total pages :371
  • ISBN : 9781107078390
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Summary : Experts describe state-of-the-art micro-nano techniques for cell mechanobiology and introduce the most recent advances in the field.

The Mechanobiology of Obesity and Related Diseases

The Mechanobiology of Obesity and Related Diseases
  • Author : Amit Gefen,Dafna Benayahu
  • Publisher :Unknown
  • Release Date :2014-10-18
  • Total pages :296
  • ISBN : 9783319093369
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Summary : This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

Mechanobiology Handbook

Mechanobiology Handbook
  • Author : Jiro Nagatomi
  • Publisher :Unknown
  • Release Date :2011-03-15
  • Total pages :564
  • ISBN : 9781420091229
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Summary : Mechanobiology-the study of the effects of mechanical environments on the biological processes of cells-has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanob

Multiscale Modeling in Biomechanics and Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology
  • Author : Suvranu De,Wonmuk Hwang,Ellen Kuhl
  • Publisher :Unknown
  • Release Date :2014-10-10
  • Total pages :286
  • ISBN : 9781447165996
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Summary : Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Exam Prep for: Mechanobiology

Exam Prep for: Mechanobiology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 1230987654XX
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Summary :

Exam Prep for: Mechanobiology Handbook, Second Edition

Exam Prep for: Mechanobiology Handbook, Second Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 1230987654XX
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Summary :

The Mechanobiology and Mechanophysiology of Military-Related Injuries

The Mechanobiology and Mechanophysiology of Military-Related Injuries
  • Author : Amit Gefen,Yoram Epstein
  • Publisher :Unknown
  • Release Date :2016-03-31
  • Total pages :333
  • ISBN : 9783319330129
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Summary : This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.

Mechanics of Biological Systems

Mechanics of Biological Systems
  • Author : Seungman Park,Yun Chen
  • Publisher :Unknown
  • Release Date :2019-11-06
  • Total pages :134
  • ISBN : 9781643273921
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Summary : This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Skeletal Aging and Osteoporosis

Skeletal Aging and Osteoporosis
  • Author : Matthew J. Silva
  • Publisher :Unknown
  • Release Date :2012-08-30
  • Total pages :260
  • ISBN : 9783642180538
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Summary : The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.