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Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment

Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment
  • Author : Scott D Mendelson
  • Publisher :Unknown
  • Release Date :2007-12-19
  • Total pages :224
  • ISBN : 0080556523
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Summary : Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

Brain-Metabolic Crossroads in Severe Mental Disorders – Focus on Metabolic Syndrome

Brain-Metabolic Crossroads in Severe Mental Disorders – Focus on Metabolic Syndrome
  • Author : Virginio Salvi,Tomas Hajek
  • Publisher :Unknown
  • Release Date :2019-10-23
  • Total pages :97
  • ISBN : 9782889630790
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Summary :

The Metabolic Syndrome

The Metabolic Syndrome
  • Author : Christopher D. Byrne,Sarah H. Wild
  • Publisher :Unknown
  • Release Date :2011-08-08
  • Total pages :400
  • ISBN : 9781444347302
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Summary : The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

WHO Resource Book on Mental Health, Human Rights and Legislation

WHO Resource Book on Mental Health, Human Rights and Legislation
  • Author : Melvyn Freeman,Soumitra Pathare,World Health Organization
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :181
  • ISBN : 924156282X
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Summary : This publication highlights key issues and principles to be considered in the drafting, adoption and implementation of mental health legislation and best practice in mental health services. It contains examples of diverse experiences and practices, as well as extracts of laws and other legal documents from a range of different countries, and a checklist of key policy components. Three main elements of effective mental health legislation are identified, relating to context, content and process.

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
  • Author : Michael J. Zigmond,Joseph T. Coyle,Lewis P. Rowland
  • Publisher :Unknown
  • Release Date :2014-12-03
  • Total pages :824
  • ISBN : 9780123982803
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Summary : Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Schizophrenia Treatment Outcomes

Schizophrenia Treatment Outcomes
  • Author : Amresh Shrivastava,Avinash De Sousa
  • Publisher :Unknown
  • Release Date :2020-02-05
  • Total pages :350
  • ISBN : 9783030198473
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Summary : This book analyzes schizophrenia management in the context of recent clinical therapeutic advances that have transformed the measurements and outcomes landscape. Unlike any other resource, this volume carefully develops the social and clinical guidelines that affect the life of the patient and defines its role in schizophrenia treatment outcomes. The text begins by determining the concepts, development, neuroscience, and guidelines for positive outcomes before analyzing the gaps in the literature. The text addresses medical concerns in relation to outcomes in schizophrenic patients, including substance use, impact from antipsychotic medications, and medical comorbidities. The text also covers external determinants that may inhibit positive outcomes, including cultural factors, stigma, and environmental issues. Written by experts in schizophrenia care, this book compiles sound research, current clinical trends, and modern measurement markers into a well-organized compendium that delivers this data into a practical guide for measuring treatment outcomes in patients suffering from the disease. Schizophrenia Treatment Outcomes is the ultimate guide for psychiatrists, psychologists, nurses, social workers, and all medical practitioners interested in improving outcomes for schizophrenia patients.

Exercise, Health and Mental Health

Exercise, Health and Mental Health
  • Author : Guy E. J. Faulkner,Adrian H. Taylor
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :233
  • ISBN : 0415334314
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Summary : The first of its kind, this book is written by internationally acclaimed scientists and presents an introduction to the emerging field of exercise as a strategy for mental health promotion, providing a platform for future research and practice.

Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder
  • Author : Joao Quevedo,Andre Ferrer Carvalho,Eduard Vieta
  • Publisher :Unknown
  • Release Date :2020-11-25
  • Total pages :470
  • ISBN : 9780128191835
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Summary : The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Comorbidity of Mental and Physical Disorders

Comorbidity of Mental and Physical Disorders
  • Author : N. Sartorius,R.I.G. Holt,M. Maj
  • Publisher :Unknown
  • Release Date :2014-12-01
  • Total pages :200
  • ISBN : 9783318026047
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Summary : 0

Herbal Treatment of Major Depression: Scientific Basis and Practical Use

Herbal Treatment of Major Depression: Scientific Basis and Practical Use
  • Author : Scott D Mendelson
  • Publisher :Unknown
  • Release Date :2019-11-27
  • Total pages :422
  • ISBN : 9781000727463
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Summary : This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored. Key Features: Focuses on oxidative damage, inflammation, and metabolic syndrome. Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications. These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act. The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.

The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults, Third Edition

The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults, Third Edition
  • Author : American Psychiatric Association
  • Publisher :Unknown
  • Release Date :2015-07-29
  • Total pages :170
  • ISBN : 9780890424650
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Summary : Since the publication of the Institute of Medicine (IOM) report Clinical Practice Guidelines We Can Trust in 2011, there has been an increasing emphasis on assuring that clinical practice guidelines are trustworthy, developed in a transparent fashion, and based on a systematic review of the available research evidence. To align with the IOM recommendations and to meet the new requirements for inclusion of a guideline in the National Guidelines Clearinghouse of the Agency for Healthcare Research and Quality (AHRQ), American Psychiatric Association (APA) has adopted a new process for practice guideline development. Under this new process APA's practice guidelines also seek to provide better clinical utility and usability. Rather than a broad overview of treatment for a disorder, new practice guidelines focus on a set of discrete clinical questions of relevance to an overarching subject area. A systematic review of evidence is conducted to address these clinical questions and involves a detailed assessment of individual studies. The quality of the overall body of evidence is also rated and is summarized in the practice guideline. With the new process, recommendations are determined by weighing potential benefits and harms of an intervention in a specific clinical context. Clear, concise, and actionable recommendation statements help clinicians to incorporate recommendations into clinical practice, with the goal of improving quality of care. The new practice guideline format is also designed to be more user friendly by dividing information into modules on specific clinical questions. Each module has a consistent organization, which will assist users in finding clinically useful and relevant information quickly and easily. This new edition of the practice guidelines on psychiatric evaluation for adults is the first set of the APA's guidelines developed under the new guideline development process. These guidelines address the following nine topics, in the context of an initial psychiatric evaluation: review of psychiatric symptoms, trauma history, and treatment history; substance use assessment; assessment of suicide risk; assessment for risk of aggressive behaviors; assessment of cultural factors; assessment of medical health; quantitative assessment; involvement of the patient in treatment decision making; and documentation of the psychiatric evaluation. Each guideline recommends or suggests topics to include during an initial psychiatric evaluation. Findings from an expert opinion survey have also been taken into consideration in making recommendations or suggestions. In addition to reviewing the available evidence on psychiatry evaluation, each guideline also provides guidance to clinicians on implementing these recommendations to enhance patient care.

The Organic Psychoses

The Organic Psychoses
  • Author : John G. Dewan,William B. Spaulding
  • Publisher :Unknown
  • Release Date :1958-12-15
  • Total pages :229
  • ISBN : 9781442638211
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Summary : Psychoses due to physical disturbances involving the brain are common and can complicate a bewildering variety of illnesses. Patients with such disorders may be encountered in general practice, emergency wards, medical services, on the surgical ward, post-operatively as well as in psychiatric clinics and of course in mental hospitals. A specialist in psychiatry and a specialist in internal medicine have collaborated to fill an important gap in medical literature of practical value to the physician. Throughout the book the needs of doctors who are responsible for such patients has been kept in mind. In this well-organized, concise monograph the organic psychoses are classified in a comprehensive manner which can be easily applied to clinical cases. The chief diagnostic features of the various organic syndromes have been presented, together with full references to the clinical literature. The diagnostic approach to the various clinical problems has been considered and illustrated by a group of case histories. As teachers, the authors have become aware of the need for a clarification of this complicated area of medicine in order that the practitioner, postgraduate physician, interne, and undergraduate student may have a ready guide to aid him in the diagnosis of these complicated disorders. Many doctors in a number of branches of medical practice will find this a handy, useful book to own.

Physical Illness and Schizophrenia

Physical Illness and Schizophrenia
  • Author : Stefan Leucht
  • Publisher :Unknown
  • Release Date :2007-11-22
  • Total pages :208
  • ISBN : 9780521882644
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Summary : Provides a comprehensive review of research evidence on physical diseases in people with schizophrenia.

The American Psychiatric Association Practice Guideline for the Treatment of Patients with Schizophrenia, Third Edition

The American Psychiatric Association Practice Guideline for the Treatment of Patients with Schizophrenia, Third Edition
  • Author : American Psychiatric Association
  • Publisher :Unknown
  • Release Date :2020-09-04
  • Total pages :336
  • ISBN : 9780890424698
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Summary : "The goal of this practice guideline is to improve the quality of care and treatment outcomes for patients with schizophrenia. The guideline aims to help clinicians optimize care for their patients by providing evidence-based statements that are intended to enhance knowledge and increase the appropriate use of evidence-based pharmacological and nonpharmacological treatments for schizophrenia. In addition, it includes statements related to assessment and treatment planning, which are an integral part of patient-centered care"--

Chemotherapy in Psychiatry

Chemotherapy in Psychiatry
  • Author : Ross J. Baldessarini
  • Publisher :Unknown
  • Release Date :2012-09-28
  • Total pages :272
  • ISBN : 9781461437093
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Summary : Use of psychotropic drugs has come to dominate clinical practice in psychiatry worldwide—perhaps owing largely to perceived simplicity, ease of use, and apparent efficiency, as well as apparent cost-effectiveness of such treatments. Nevertheless, medicinal treatments for patients with psychiatric disorders are but one component of comprehensive clinical care of complex human problems. Extensively updated since its second edition in 1985, Chemotherapy in Psychiatry, Third Edition, again addresses basic aspects of modern psychopharmacology and clinical applications of drugs used in the treatment of major psychiatric disorders, with major emphasis on psychotic, bipolar, and depressive disorders. The presentation covers descriptions of the main classes of psychotropic drugs, selected information concerning their known action mechanisms and metabolic disposition, and their clinical applications for acute illnesses and to prevent recurrences and long-term morbidity. Also covered are limitations and adverse effects of each type of agent, with emphasis on the fact that all psychotropic medicines have adverse effects that range from annoying to potentially lethal. Chemotherapy in Psychiatry, Third Edition, outlines the need to balance benefits and risks at the level of individual persons. Authoritative, and an important contribution to the literature, Chemotherapy in Psychiatry, Third Edition is an invaluable resource for physicians, scientists, trainees, and policymakers.

The Skeptical Professional’s Guide to Psychiatry

The Skeptical Professional’s Guide to Psychiatry
  • Author : Charles E. Dean
  • Publisher :Unknown
  • Release Date :2020-11-23
  • Total pages :338
  • ISBN : 9781000245622
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Summary : This text critically examines the shortcomings of psychiatry; the flawed development of the diagnostic system, including the DSM-5; and the failure to advance the effectiveness of antipsychotics and antidepressants. Starting with an overview of the evolution of psychiatry, Dean explores the creation, use, and misuse of medications, a process largely driven by drug companies. Other chapters describe the benefits and risks of medications, the problems associated with rational prescribing, and the embrace of so-called novel therapies including hallucinogenic drugs and opioids. Chapters end with a set of clinical notes that provide specific recommendations to clinicians, families, patients, and other providers, emphasizing the risks and benefits of treatment with medications but also stressing alternative approaches. This book will challenge clinicians to think critically about the DSM-5 and the current systems of diagnosis and treatment of mental illnesses in the hopes of ultimately improving the lives of people with mental illnesses.

Biomarkers and Mental Illness

Biomarkers and Mental Illness
  • Author : Paul C. Guest
  • Publisher :Unknown
  • Release Date :2016-12-02
  • Total pages :203
  • ISBN : 9783319460888
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Summary : Employing accessible language throughout, this book covers the history of psychiatric research, the current state-of-the art in psychiatric practice, the physiological systems affected by psychiatric illnesses, the whole-body nature of these diseases and the impact that this aspect has on emerging biomarker discoveries. Further, it provides descriptions of the major specific psychiatric disorders and the special challenges regarding the diagnosis and treatment of each. The book concludes with insights into the latest developments in hand-held biomarker test devices, which can provide diagnostic information in less than 15 minutes in point-of-care settings. This book investigates the emerging use of biomarkers in the study of psychiatric diseases, a topic of considerable importance for a broad range of people including researchers, clinicians, psychiatrists, university students and even those whose lives are affected in some way by a psychiatric illness. The last category is hardly trivial, since a staggering one in three people worldwide show the criteria for at least one psychiatric disorder at some point in their lifetime.

Cannabinoids in Neurologic and Mental Disease

Cannabinoids in Neurologic and Mental Disease
  • Author : Liana Fattore
  • Publisher :Unknown
  • Release Date :2015-01-23
  • Total pages :496
  • ISBN : 9780124171244
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Summary : The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neuroinflammatory disease. The neurologic application of cannabinoid therapy builds upon psychiatric and psychological use for the treatment of a variety of core mental disorders. This comprehensive reference on the known uses of cannabinoids will be useful for clinical neurologists, neuroscience and clinical neuroscience researchers, clinical psychologists and psychiatrists and the general medical community. A comprehensive reference on the clinical uses of cannabinoids for treating major neurologic and mental diseases Detailed coverage of cannabinoid use for neuroinflammatory and neurodegenerative disease including Multiple Sclerosis, Epilepsy, Huntington's disease, Parkinson's disease, and Alzheimer's disease Detailed coverage of cannabinoid use for major psychiatric and psychological diseases and disorders including schizophrenia, bipolar disorders, Tourette's syndrome, and post-traumatic stress disorder (PTSD)

Duty to Care

Duty to Care
  • Author : David Lawrence,Cashel D'Arcy James Holman,D'Arcy Holman,Assen Jablensky
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :117
  • ISBN : 1875912851
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Summary :

Textbook of Pediatric Psychosomatic Medicine

Textbook of Pediatric Psychosomatic Medicine
  • Author : Richard J. Shaw,David R. DeMaso
  • Publisher :Unknown
  • Release Date :2010-03-18
  • Total pages :551
  • ISBN : 9781585629305
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Summary : The Textbook of Pediatric Psychosomatic Medicine provides a comprehensive, empirically based knowledge of assessment and treatment issues in children and adolescents with physical illness. Scholarly, authoritative, and evidence based, it is the first volume of its kind and will help to define the field going forward. Addressing a very wide range of medical subspecialties, this volume is a first step for researchers who want to obtain a review of the psychiatric issues in their respective specialties. In addition, the book offers many special features, including An exceptionally strong section on psychopharmacology in the medical setting, which is complemented by a comprehensive set of reference tables on psychopharmacological agents, including doses, side effects, and indications for use in the physically ill child. Definitive chapters on less commonly reviewed topics that are of particular relevance for clinicians who treat physically ill children, including pediatric palliative care, Munchausen syndrome by proxy, and pediatric feeding disorders. Coverage of key legal and forensic issues in pediatric psychosomatic medicine. Presentation of material in graphical and tabular formats for maximal usefulness, including templates of specific questions for assessing common psychiatric symptoms and flowcharts illustrating step-by-step approaches to pain and somatoform disorders. Relevance to a broad range of professionals, including psychiatrists, pediatricians, psychologists, nurses, medical students, and social workers who work with children in medical settings. May be adopted as a textbook for psychology undergraduate classes, social work internships, and both general and child psychiatry residency training programs. The editors are recognized both nationally and internationally as being among the foremost experts for their respective fields, and they have assembled the leading practitioners of pediatric psychosomatic medicine to create this volume. The only complete text on pediatric psychosomatic medicine, this volume is destined to prove seminal in the field and indispensable in the clinician's library.

Mental Health and Illness of Women

Mental Health and Illness of Women
  • Author : Prabha Chandra,Helen Herrman,Jane Fisher,Anita Riecher-Rössler
  • Publisher :Unknown
  • Release Date :2020-02-28
  • Total pages :503
  • ISBN : 9811023670
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Summary : This book discusses psychiatric disorders among women in a manner that is relevant to clinical practice and keep cultural and social realities in perspective. The book is important in the face of rapidly changing conditions globally (including better education and more opportunities for work for women); challenges such as migration, war and violence and emerging areas such as newer reproductive technologies, Women's mental health cannot be divorced from social and cultural realities and while the book emphasises these areas, it also gives due importance to the current advances in neurobiology and psychopharmacology of psychiatric disorders among women. Chapters in the book are written by multiple authors, many of the chapters use the life stage approach, and have been written by authors from different parts of the world to ensure cultural relevance and diverse viewpoints.