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Metastatic Disease of the Nervous System

Metastatic Disease of the Nervous System
  • Author : David Schiff,M J Van den Bent
  • Publisher :Unknown
  • Release Date :2018-01-04
  • Total pages :304
  • ISBN : 9780444638793
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Summary : Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail. Covers all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy Presents a multidisciplinary review of the evidence regarding accuracy of diagnostic testing and evidence-based reviews of therapies Addresses metastatic diseases of the nervous system for residents, fellows and clinicians in neurology and oncology

Central Nervous System Metastases

Central Nervous System Metastases
  • Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
  • Publisher :Unknown
  • Release Date :2019-11-05
  • Total pages :421
  • ISBN : 9783030234171
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Summary : This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Central Nervous System Metastases

Central Nervous System Metastases
  • Author : Rohan Ramakrishna
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9783030429584
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Summary :

Metastatic Tumors of the Central Nervous System

Metastatic Tumors of the Central Nervous System
  • Author : Kintomo Takakura
  • Publisher :Unknown
  • Release Date :1982
  • Total pages :346
  • ISBN : UOM:39015002435439
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Summary :

New Approaches to the Management of Primary and Secondary CNS Tumors

New Approaches to the Management of Primary and Secondary CNS Tumors
  • Author : Lee Roy Morgan
  • Publisher :Unknown
  • Release Date :2017-03-23
  • Total pages :214
  • ISBN : 9789535130512
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Summary : Several new concepts are reviewed and discussed in this book and allude to the transport of drugs bound to red blood cells into the vascular blood-brain barrier and into cancer cells. Such a transport system is novel and of potential therapeutic potential. It is the goal of this book to provide information and data that will be useful for others to develop new approaches for the management of CNS malignancies.

Central Nervous System Metastases in Lung Cancer Patients: From Prevention to Diagnosis and Treatment

Central Nervous System Metastases in Lung Cancer Patients: From Prevention to Diagnosis and Treatment
  • Author : Lizza E.L Hendriks,Deepa S. Subramaniam,Anne-Marie C. Dingemans
  • Publisher :Unknown
  • Release Date :2019-01-21
  • Total pages :94
  • ISBN : 9782889457076
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Summary : Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.

Brain Metastases

Brain Metastases
  • Author : Jeffrey Raizer,Lauren E. Abrey
  • Publisher :Unknown
  • Release Date :2007-10-03
  • Total pages :239
  • ISBN : 9780387692210
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Summary : Brain metastases are the most dreaded complication of systemic cancer, affecting some 170,000 people a year, a far greater incidence than primary brain tumors. This book presents current information on the presentation and management of patients with brain metastases, providing available data, giving guidelines that can be applied in day to day practice, updated information for neurosurgeons, radiation oncologists, medical oncologists, and neuron-oncologists, and as an overview for physicians in training.

HER2-Positive Breast Cancer

HER2-Positive Breast Cancer
  • Author : Sara Hurvitz,Kelly McCann
  • Publisher :Unknown
  • Release Date :2018-07-26
  • Total pages :264
  • ISBN : 9780323581233
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Summary : Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.

Metastatic Disease of the Nervous System

Metastatic Disease of the Nervous System
  • Author : David Schiff,M J Van den Bent
  • Publisher :Unknown
  • Release Date :2018-01-04
  • Total pages :304
  • ISBN : 9780444638793
GET BOOK HERE

Summary : Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail. Covers all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy Presents a multidisciplinary review of the evidence regarding accuracy of diagnostic testing and evidence-based reviews of therapies Addresses metastatic diseases of the nervous system for residents, fellows and clinicians in neurology and oncology

Primary Central Nervous System Tumors

Primary Central Nervous System Tumors
  • Author : Andrew D. Norden,David A. Reardon,Patrick C. Y. Wen
  • Publisher :Unknown
  • Release Date :2010-12-16
  • Total pages :570
  • ISBN : 160761166X
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Summary : This comprehensive, yet practical, text is a ready collection of the most up-to-date information on primary CNS tumors. Authored by a carefully selected group of the world’s leading clinicians and scientists, the book is divided into three sections. The opening chapters cover general principles, including epidemiology, pathogenesis, tumor stem cells, supportive care, complications of therapy, and quality of life. The remaining two sections are comprised of treatment-oriented chapters covering the spectrum of gliomas and rarer tumor types. Each of these chapters presents multi-disciplinary therapeutic approaches and addresses specific disease concerns. Throughout, the authors incorporate the cutting-edge advances in molecular biology and genomics that are revolutionizing neuro-oncology. The result is an important clinical resource which provides evidence-based data and interpretation essential to intelligent therapeutic decision making.

Tumors of the Nervous System

Tumors of the Nervous System
  • Author : H. Gunter Seydel
  • Publisher :Unknown
  • Release Date :1975
  • Total pages :193
  • ISBN : UOM:39015003795757
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Summary :

Adult CNS Radiation Oncology

Adult CNS Radiation Oncology
  • Author : Eric L. Chang,Paul D. Brown,Simon S. Lo,Arjun Sahgal,John H. Suh
  • Publisher :Unknown
  • Release Date :2018-07-27
  • Total pages :766
  • ISBN : 9783319428789
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Summary : This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

Comparative Oncology

Comparative Oncology
  • Author : Alecsandru Ioan Baba,Cornel Cătoi
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :787
  • ISBN : 9732714573
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Summary :

Management of Metastatic Disease to the Musculoskeletal System

Management of Metastatic Disease to the Musculoskeletal System
  • Author : John P Heiner,Timothy J Kinsella,Thomas Zdeblick
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :595
  • ISBN : UOM:39015054277754
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Summary : Metastatic Disease to the Musculoskeletal Systemis a comprehensive text designed for use by clinicians from multiple disciplines. As approximately 70% of people who die of cancer have metastatic musculoskeletal system, it has become a common problem seen by oncologists, orthopedic surgeons, radiation therapists and internists. However, to date, no text has been available that has provided a solid multidisciplinary approach to these conditions. This book has contributors from many disciplines who offer their insight and experience in treating these devastating and complicated problems.

Neurologic Complications of Cancer

Neurologic Complications of Cancer
  • Author : Lisa M. DeAngelis,Jerome B. Posner
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :634
  • ISBN : 9780195366747
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Summary : The final section addresses several nonmetastatic complications of cancer and includes sections on vascular disease, infections, metabolic and nutritional disorders, side effects of chemotherapy and radiation, and other diagnostic and therapeutic procedures and concludes with a discussion on paraneoplastic syndromes."

Central Nervous System Cancers

Central Nervous System Cancers
  • Author : Oncology Nursing Society
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :151
  • ISBN : 189050498X
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Summary : Considered one of the most devastating and frightening of all cancers, cancers of the central nervous system (CNS) attack the complex organs that control not only the CNS but also the peripheral nervous system and many of the voluntary and involuntary body systems, with 20% to 40% of CNS cancers metastasizing to the brain. Site-Specific Cancer Series: Central Nervous System Cancers, a new volume in the Series edited by Deborah Hutchinson Allen and Laurie L. Rice, details the cancers of the brain and spinal cord. Chapters examine issues such as anatomy and physiology of the brain and spine, patient assessment, pathology, histology, and molecular markers of primary brain tumors, and adult and pediatric cancers of the brain and spinal cord. Other issues include treatment modalities (surgical treatments, chemotherapy, and radiotherapy), as well as pediatric therapeutic modalities, symptom management and psychological issues, and the current state of evidence-based practice. You can use this new volume as a guide to treating your patients and to providing sensitive and realistic care that optimizes the quality of life and permits a sense of hopefulness to prevail when many patients with type of cancer feel only pain and fear.

Aminoff's Neurology and General Medicine

Aminoff's Neurology and General Medicine
  • Author : Michael J. Aminoff,S. Andrew Josephson
  • Publisher :Unknown
  • Release Date :2021-01-29
  • Total pages :1230
  • ISBN : 9780128193075
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Summary : Aminoff’s Neurology and General Medicine, Sixth Edition is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering neurologic complications of immunotherapies, headache and general medical disorders, back and neck pain in general medical disorders, swallowing and speech disorders, and neurological changes in the elderly, this new edition will again be the go-to reference for both neurologists and general practitioners. The standard authoritative reference detailing the relationship between neurology and general medicine 100% revised and updated with several new chapters including Neurologic Complications of Immunotherapies, Headache and General Medical Disorders, and Neurological Changes in the Elderly Well-illustrated, with most illustrations in full color

Neuroblastoma

Neuroblastoma
  • Author : Chandrika Gowda
  • Publisher :Unknown
  • Release Date :2017-10-25
  • Total pages :168
  • ISBN : 9789535135838
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Summary : Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma.

Report of the Division of Cancer Treatment, NCI.

Report of the Division of Cancer Treatment, NCI.
  • Author : National Cancer Institute (U.S.). Division of Cancer Treatment
  • Publisher :Unknown
  • Release Date :1976
  • Total pages :229
  • ISBN : STANFORD:36105214598596
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Summary :

Journal of the National Cancer Institute

Journal of the National Cancer Institute
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1979-11
  • Total pages :229
  • ISBN : UCR:31210002452926
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Summary :

Metastatic Cancer: Clinical and Biological Perspectives

Metastatic Cancer: Clinical and Biological Perspectives
  • Author : Rahul Jandial
  • Publisher :Unknown
  • Release Date :2013-08-08
  • Total pages :312
  • ISBN : 1587066599
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Summary : Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.