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• Author : Helder A. Santos,Dongfei Liu,Hongbo Zhang
• Publisher :Unknown
• Release Date :2018-10-12
• Total pages :495
• ISBN : 9780128126608

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Summary : Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications. Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness Includes a variety of case studies that explain principles Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world

• Author : Frank A. Gomez
• Publisher :Unknown
• Release Date :2008-02-15
• Total pages :517
• ISBN : 9780470074831

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Summary : Microfluidics-today's applications and tomorrow's potential Microfluidics has facilitated major biochemical application advancements in point-of-care diagnostics, bioterrorism detection, and drug discovery. There are numerous potential applications in biotechnology, pharmaceuticals, the life sciences, defense, public health, and agriculture. Microfluidic lab-on-a-chip (LOC) technologies represent a revolution in laboratory experimentation, bringing the benefits of miniaturization, integration, and automation to many research-based industries. Biological Applications of Microfluidics details recent advances in the biological applications of microfluidics, including cell sorting, DNA sequencing on a chip, microchip capillary electrophoresis, and synthesis on a microfluidic format. After an overview of microfluidics highlighting recent seminal works, it includes multiple chapters on: * Cell analysis on microfluidic devices * Chemical (enzymatic and non-enzymatic) reactions on microchips * Separations on microchips * Biomedical applications of microfluidics * Microfluidic fabrication * Hybrid microfluidic applications Microfluidics has incredible potential in a variety of areas. This book covers many recent advances, including microfabricated LOC technologies, advanced microfluidic tools, microfluidic culture platforms for stem cell and neuroscience research, a novel application of microfluidic LOC devices that facilitates fundamental research in proteomics that cannot be performed without miniaturization, the nano fountain pen, and more. With contributions from leading experts in chemistry, physics, bioengineering, material science, biomedicine, and other fields plus references at the end of each chapter to facilitate further study, this is an all-in-one, hands-on resource for analytical chemists and researchers. It is also an excellent resource for students studying analytical chemistry or biotechnology.

• Author : Wei-Cheng Tian,Erin Finehout
• Publisher :Unknown
• Release Date :2010-10-12
• Total pages :416
• ISBN : 1441934847

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Summary : Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.

• Author : Xiao-Ying Yu
• Publisher :Unknown
• Release Date :2016-11-23
• Total pages :422
• ISBN : 9789535127857

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Summary : Increasing innovations and applications make microfluidics a versatile choice for researchers in many disciplines. This book consists of multiple review chapters that aim to cover recent advances and new applications of microfluidics in biology, electronics, energy, and materials sciences. It provides comprehensive views of various aspects of microfluidics ranging from fundamentals of fabrication, flow control, and droplet manipulation to the most recent exploration in emerging areas such as material synthesis, imaging and novel spectroscopy, and marriage with electronics. The chapters have many illustrations showcasing exciting results. This book should be useful for those who are eager to learn more about microfluidics as well as researchers who want to pick up new concepts and developments in this fast-growing field.

• Author : Eric Chappel
• Publisher :Unknown
• Release Date :2020-11-07
• Total pages :678
• ISBN : 9780128198391

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Summary : Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. Provides essential information on the most recent drug delivery systems available Explains current technology and its applications to drug delivery Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers

• Author : Michael R. Hamblin,Mahdi Karimi
• Publisher :Unknown
• Release Date :2020-11-12
• Total pages :350
• ISBN : 9780128187920

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Summary : Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

• Author : Ali Khademhosseini,Utkan Demirci,Robert Langer
• Publisher :Unknown
• Release Date :2012
• Total pages :478
• ISBN : 9789814405515

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Summary : Ch. 1. A microscale bioinspired cochlear-like sensor / Robert D. White, Robert Littrell, and Karl Grosh -- ch. 2. Systematic evaluation of the efficiencies of proteins and chemicals in pharmaceutical applications / Morgan Hamon and Jong Wook Hong -- ch. 3. Microfluidic glucose sensors / Jithesh V. Veetil ... [et al.] -- ch. 4. Applications of microfabrication and microfluidic techniques in mesenchymal stem cell research / Abhijit Majumder ... [et al.] -- ch. 5. Patient-specific modeling of low-density lipoprotein transport in coronary arteries / Ufuk Olgac -- ch. 6. Point-of-care microdevices for global health diagnostics of infectious diseases / Sau Yin Chin ... [et al.] -- ch. 7. Integrated microfluidic sample preparation for chip-based molecular diagnostics / Jane Y. Zhang ... [et al.] -- ch. 8. Microfluidic devices for cellular proteomic studies / Yihong Zhan and Chang Lu -- ch. 9. Microfluidics for neuroscience: novel tools and future implications / Vivian M. Hernandez and P. Hande Ozdinler -- ch. 10. Microfluidics: on-chip platforms as in vitro disease models / Shan Gao, Erkin Seker, and Martin L. Yarmush -- ch. 11. Application of microfluidics in stem cell and tissue engineering / Sasha H. Bakhru, Christopher Highley, and Stefan Zappe -- ch. 12. Microfluidic "on-the-fly" fabrication of microstructures for biomedical applications / Edward Kang, Sau Fung Wong, and Sang-Hoon Lee -- ch. 13. Microfluidics as a promising tool toward distributed viral detection / Elodie Sollier and Dino Di Carlo -- ch. 14. Electrophoresis and dielectrophoresis for lab-on-a-chip (LOC) analyses / Yagmur Demircan, Gurkan Yilmaz, and Haluk Kulah -- ch. 15. Ultrasonic embossing of carbon nanotubes for the fabrication of polymer microfluidic chips for DNA sample purification / Puttachat Khuntontong, Min Gong, and Zhiping Wang -- ch. 16. Ferrofluidics / A. Rezzan Kose and Hur Koser -- ch. 17. Antibody-based blood bioparticle capture and separation using microfluidics for global health / ZhengYuan Luo ... [et al.] -- ch. 18. Applications of quantum dots for fluorescence imaging in biomedical research / ShuQi Wang ... [et al.]

• Author : Yujun Song,Daojian Cheng,Liang Zhao
• Publisher :Unknown
• Release Date :2018-01-04
• Total pages :544
• ISBN : 9783527800650

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Summary : The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.

• Author : Andreas Dietzel
• Publisher :Unknown
• Release Date :2016-01-22
• Total pages :348
• ISBN : 9783319269207

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Summary : This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

• Author : João Pedro Martins,Hélder A. Santos
• Publisher :Unknown
• Release Date :2020-07-30
• Total pages :534
• ISBN : 9780128180396

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Summary : Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research

• Author : Abhay Andar,Benjamin Adelstein,Michael Adelstein
• Publisher :Unknown
• Release Date :2020-09-29
• Total pages :400
• ISBN : 3110636158

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Summary : This book covers the impact of microfluidics on the field of Biotechnology, including biologics manufacturing, biosensors, macromolecule purification, nucleotide sequencing, organs-on-a-chip, and stem cell manufacturing. The authors, coming from both academia and industry, provide an in-depth look into the economics, manufacturing, scale-up, regulatory affairs and future outlook for microfluidic technologies.

• Author : Alexandru Mihai Grumezescu
• Publisher :Unknown
• Release Date :2019-03-20
• Total pages :720
• ISBN : 9780128172612

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Summary : Nanoarchitectonics in Biomedicine describes this new area of nanoscience that has emerged as a major branch of nanoscience. The book brings together recent applications and discusses the advantages and disadvantages of each process, offering international perspectives on the technologies based on these findings. It offers new insights for nanoarchitectonics, starting with the currently used methods of synthesis and characterization of such materials, along with their biomedical applications. Authored by a wide range of international scientists, this volume shows how nanoarchitectonics is being used to create more efficient medical treatment solutions. Users will find this to be an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science. Explores how design aspects, smart materials and personalized materials are used in biomedicine today Offers global perspectives on how nanoarchitectonics is used in different regions Presents an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science

• Author : Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
• Publisher :Unknown
• Release Date :2012-12-31
• Total pages :452
• ISBN : 9781437734607

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Summary : The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering

• Author : Sebastian Seiffert,Julian Thiele
• Publisher :Unknown
• Release Date :2019-12-02
• Total pages :295
• ISBN : 9783110487848

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Summary : Microfluidics introduces the theory and practice of fluid flow on small scales. The exquisite control of such flow at low Reynolds numbers allows liquids to be processed in either a well-defined co-flow or a well-defined segmented-flow fashion. Both lays a ground for high-throughput analytics and advanced materials design. With that, this book is ideal for research scientists and Ph.D. students in the fields of chemistry, chemical engineering, biotechnology, and materials science.

• Author : Xiujun James Li,Yu Zhou
• Publisher :Unknown
• Release Date :2013-10-31
• Total pages :676
• ISBN : 9780857097040

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Summary : Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

• Author : Michael R. Hamblin,Mahdi Karimi
• Publisher :Unknown
• Release Date :2020-11-12
• Total pages :350
• ISBN : 9780128187920

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Summary : Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

• Author : Leena Peltonen
• Publisher :Unknown
• Release Date :2021-01-11
• Total pages :416
• ISBN : 9781119414049

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Summary : Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.

• Author : Alexandru Mihai Grumezescu
• Publisher :Unknown
• Release Date :2017-12-12
• Total pages :766
• ISBN : 9780128136287

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Summary : Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

• Author : Nam-Trung Nguyen
• Publisher :Unknown
• Release Date :2011-09-17
• Total pages :368
• ISBN : 9781437735215

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Summary : The ability to mix minute quantities of fluids is critical in a range of recent and emerging techniques in engineering, chemistry and life sciences, with applications as diverse as inkjet printing, pharmaceutical manufacturing, specialty and hazardous chemical manufacturing, DNA analysis and disease diagnosis. The multidisciplinary nature of this field – intersecting engineering, physics, chemistry, biology, microtechnology and biotechnology – means that the community of engineers and scientists now engaged in developing microfluidic devices has entered the field from a variety of different backgrounds. Micromixers is uniquely comprehensive, in that it deals not only with the problems that are directly related to fluidics as a discipline (aspects such as mass transport, molecular diffusion, electrokinetic phenomena, flow instabilities, etc.) but also with the practical issues of fabricating micomixers and building them into microsystems and lab-on-chip assemblies.With practical applications to the design of systems vital in modern communications, medicine and industry this book has already established itself as a key reference in an emerging and important field. The 2e includes coverage of a broader range of fabrication techniques, additional examples of fully realized devices for each type of micromixer and a substantially extended section on industrial applications, including recent and emerging applications. Introduces the design and applications of micromixers for a broad audience across chemical engineering, electronics and the life sciences, and applications as diverse as lab-on-a-chip, ink jet printing, pharmaceutical manufacturing and DNA analysis Helps engineers and scientists to unlock the potential of micromixers by explaining both the scientific (microfluidics) aspects and the engineering involved in building and using successful microscale systems and devices with micromixers The author's applied approach combines experience-based discussion of the challenges and pitfalls of using micromixers, with proposals for how to overcome them

• Author : Emmanuel Delamarche,Govind V. Kaigala
• Publisher :Unknown
• Release Date :2018-01-18
• Total pages :450
• ISBN : 9783527696796

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Summary : Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.

• Author : Dongshin Kim
• Publisher :Unknown
• Release Date :2006
• Total pages :142
• ISBN : WISC:89101061315

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Summary :