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Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs

Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs
  • Author : Bojan Čalija
  • Publisher :Unknown
  • Release Date :2017-01-03
  • Total pages :284
  • ISBN : 9780128040805
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Summary : Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin. This book presents the latest research on advances and limitations of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that are intended for oral, dermal, and transdermal administration of NSAIDs. In addition, functionality of these materials as potential excipients for microsized and nanosized carriers is discussed and debated. Practical solutions for improving effectiveness of these drugs are included throughout the book, making this an important resource for graduate students, professors, and researchers in the pharmaceutical sciences. Covers a wide range of microsized and nanosized carriers in one resource, including particulate carriers (microparticles, nanoparticles, and zeolites) and the soft colloidal carriers, such as micro-emulsions and nano-emulsions Presents the reader with various formulation approaches dependent on the characteristics of the material, model drug, and desired route of administration Approaches are based on the latest research in the area and formulation strategies may have broader applications to the encapsulation of other active pharmaceutical ingredients

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering
  • Author : Lisa C. du Toit,Pradeep Kumar,Yahya E. Choonara,Viness Pillay
  • Publisher :Unknown
  • Release Date :2020-03-08
  • Total pages :316
  • ISBN : 9780128184721
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Summary : Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient Explores the current generation of nanostructured 3D printed medical devices Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals

Materials for Biomedical Engineering: Inorganic Micro- and Nanostructures

Materials for Biomedical Engineering: Inorganic Micro- and Nanostructures
  • Author : Alexandru Grumezescu,Valentina Grumezescu
  • Publisher :Unknown
  • Release Date :2019-03-01
  • Total pages :450
  • ISBN : 9780128172537
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Summary : Materials for Biomedical Engineering

Modified Clay and Zeolite Nanocomposite Materials

Modified Clay and Zeolite Nanocomposite Materials
  • Author : Mariano Mercurio,Binoy Sarkar,Alessio Langella
  • Publisher :Unknown
  • Release Date :2018-11-29
  • Total pages :362
  • ISBN : 9780128146187
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Summary : Modified Clay and Zeolite Nanocomposite Materials: Environmental and Pharmaceutical Applications retraces the most important knowledge gaps that the scientific community is facing, including a drawback of real-world applications. This valuable resource explores the novel applications of this group of nanomaterials that can be suitably surface-modified to obtain properties that can be applied in environmental and pharmaceutical fields. For example, modification with surfactants has given new motivation to the study of these materials by producing an inversion in the ion exchange behavior from cationic to anionic. This strategy has paved the way for new uses highlighted in this timely resource. Explores the combination of both minerals (clay and zeolite) together, with their application in two broad areas of emerging research Explains better utilization and applications for modified clay and zeolite through detailed comparative studies Consolidates information on the modification and tuning of clay and zeolite materials for novelty applications Helps users in the selection of materials, surface features, and other functionalization for diverse applications

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement
  • Author : Nina Dragicevic,Howard I. Maibach
  • Publisher :Unknown
  • Release Date :2016-01-05
  • Total pages :384
  • ISBN : 9783662478622
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Summary : Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.​

Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy

Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy
  • Author : Challa S.S.R. Kumar
  • Publisher :Unknown
  • Release Date :2019-11-22
  • Total pages :464
  • ISBN : 9783662595961
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Summary : Ninth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.

Nursing Calculations E-Book

Nursing Calculations E-Book
  • Author : John D. Gatford,Nicole Phillips,Julie Martyn,Mathew Carey
  • Publisher :Unknown
  • Release Date :2016-05-18
  • Total pages :176
  • ISBN : 9780702063350
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Summary : This internationally renowned guide to basic arithmetic for nursing students has been completely revised and updated for a new generation of readers. Now entering its ninth edition, Nursing Calculations comes with a quick-reference card fits in the pocket to remind readers of essential formulae and AN ON-LINE PROGRAM TO ALLOW FURTHER SELF-TESTING VIA THE USE OF COMPUTERS AND MOBILE DEVICES. Over 200,000 copies sold since publication! Initial self-testing chapter allows readers to identify and address areas of difficulty before moving onto practical examples ‘Important Boxes’ highlight potential pitfalls for the reader Special section on paediatrics covers medication calculations relating to body weight and body surface area Contains glossary and useful abbreviations Brings together basic math skills and clinical examples to prepare readers for real life drug calculations Quick-reference card fits in the pocket and remind readers of essential formulae Questions have been revised and updated when necessary to reflect current practice New material includes the use of medication charts in questions that involve medication labels Additional worked examples facilitate understanding of the 24-hour clock Contains a new revision chapter to help consolidate learning NOW COMES WITH AN ON-LINE PROGRAM TO ALLOW FURTHER SELF-TESTING VIA THE USE OF MOBILE DEVICES!

Handbook of Harnessing Biomaterials in Nanomedicine

Handbook of Harnessing Biomaterials in Nanomedicine
  • Author : Dan Peer
  • Publisher :Unknown
  • Release Date :2012-01-12
  • Total pages :424
  • ISBN : 9789814364270
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Summary : This book concentrates on the use of biomaterials in nanomedicine. The areas of focus include drug delivery by polymers, lipids, and carbohydrates for the delivery of small molecules, RNA interference, and proteins; the use of nano-proteins such as antibodies and peptides as targeting agents for therapeutics and diagnosis; the use of nanocarrier-based biomaterials for manipulation of stem cells; different aspects of toxicity of nanocarriers (the immune response, liver toxicity, and many more); and success stories of biomaterials that have reached the clinics. The book covers theoretical and experimental analysis of various biomaterials that are used in nanomedicine, research methods and preparation techniques, and several promising applications.

Nanotechnologies for Environmental Remediation

Nanotechnologies for Environmental Remediation
  • Author : Giusy Lofrano,Giovanni Libralato,Jeanette Brown
  • Publisher :Unknown
  • Release Date :2017-03-02
  • Total pages :325
  • ISBN : 9783319531625
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Summary : In this book discussing the principles of green chemistry and green engineering an international team of investigators present significant recent developments in applying nanoscience, nanoengineering, and nanotechnology to the area of environmental remediation. The opening chapters introduce candidate nanomaterials, properties, mechanisms that enable the applications, the advantages and limitations compared to existing processes and commercial research requirements. It then explores the detection and application of nanomaterials in photocatalytic processes and as adsorbents, and also covers the effect of nanoparticles in the activated sludge process. Later chapters focus on the effects of nanoparticles on crops, the risks associated with the presence of nanoparticles in the environment, and lastly the environmental effects of nanoscale zero-valent iron (nZVI) on land remediation. This timely, multi-author contributed volume is aimed at students, technicians, and academics interested in the role, risks and benefits of nanotechnology in modern environmental contexts.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans,Eric Delpire
  • Publisher :Unknown
  • Release Date :2009-08-22
  • Total pages :630
  • ISBN : 0080922031
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Summary : The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Pharmacology of Pain

Pharmacology of Pain
  • Author : Pierre Beaulieu,David Lussier,Frank Porreca,Anthony Dickenson
  • Publisher :Unknown
  • Release Date :2015-06-01
  • Total pages :622
  • ISBN : 9781496331915
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Summary : Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees

Pocket Companion to Brenner and Rector's The Kidney E-Book

Pocket Companion to Brenner and Rector's The Kidney E-Book
  • Author : Michael R. Clarkson,Barry M. Brenner,Ciara Magee
  • Publisher :Unknown
  • Release Date :2010-02-22
  • Total pages :928
  • ISBN : 9781455703784
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Summary : Pocket Companion to Brenner and Rector’s The Kidney distills the essential clinical information from the latest edition of the seminal text on kidney diseases and their management. Michael R. Clarkson, Ciara Magee, and Barry M. Brenner detail the key pathophysiologic, diagnostic, and treatment issues in clinical nephrology, including interventional nephrology, endocrine aspects of kidney disease, and plasmapheresis. Diagnose, treat, and manage both common and uncommon disorders. Find clinical knowledge quickly and easily thanks to convenient tables throughout the text. Choose the best option of the many techniques available through discussions of indications for laboratory tests and imaging studies. Enhance your clinical acumen with coverage of new topics such as risk factors and kidney disease, nephron endowment, interventional nephrology, plasmapheresis, xenotransplantation, stem cells in renal biology and medicine, and more. Stay current thanks to two new sections—Epidemiology and Risk Factors in Kidney Disease and Frontiers in Kidney Disease—that include topics such as stem cell and genomics.

Formulating Poorly Water Soluble Drugs

Formulating Poorly Water Soluble Drugs
  • Author : Robert O. Williams III,Alan B. Watts,Dave A. Miller
  • Publisher :Unknown
  • Release Date :2011-12-04
  • Total pages :648
  • ISBN : 1461411440
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Summary : This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.

Nano-Biomaterials For Ophthalmic Drug Delivery

Nano-Biomaterials For Ophthalmic Drug Delivery
  • Author : Yashwant Pathak,Vijaykumar Sutariya,Anjali A. Hirani
  • Publisher :Unknown
  • Release Date :2016-11-12
  • Total pages :627
  • ISBN : 9783319293462
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Summary : This consolidated reference book addresses the various aspects of nano biomaterials used in ophthalmic drug delivery, including their characterization, interactions with ophthalmic system and applications in treatments of the ophthalmic diseases and disorders. In the last decade, a significant growth in polymer sciences, nanotechnology and biotechnology has resulted in the development of new nano- and bioengineered nano-bio-materials. These are extensively explored as drug delivery carriers as well as for implantable devices and scaffolds. At the interface between nanomaterials and biological systems, the organic and synthetic worlds merge into a new science concerned with the safe use of nanotechnology and nano material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions. While it is impossible to describe with certainty all the bio physicochemical interactions at play at the interface, we are at a point where the pockets of assembled knowledge are providing a conceptual framework to guide this exploration, and review the impact on future product development. The book is intended as a valuable resource for academics and pharmaceutical scientists working in the field of polymers, polymers materials for drug delivery, drug delivery systems and ophthalmic drug delivery systems, in addition to medical and health care professionals in these areas.

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

Chemically-Induced DNA Damage, Mutagenesis, and Cancer
  • Author : Ashis K. Basu, Takehiko Nohmi
  • Publisher :Unknown
  • Release Date :2018-08-27
  • Total pages :274
  • ISBN : 9783038971290
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Summary : This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

Photocarcinogenesis & Photoprotection

Photocarcinogenesis & Photoprotection
  • Author : Ratan Singh Ray,Chandana Haldar,Ashish Dwivedi,Neeraj Agarwal,Jyoti Singh
  • Publisher :Unknown
  • Release Date :2018-11-30
  • Total pages :177
  • ISBN : 9789811054938
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Summary : This book highlights the problem of UV-R-induced photocarcinogenesis and its molecular mechanism. It covers different photosensitive xenobiotics (drugs, cosmetics, and environmental pollutants) and their photosensitization mechanisms under ambient UV-R exposure. It also summarizes the role of nanotechnology in skin cancer remedies. It provides a brief overview of the various novel nanocarriers for cosmeceuticals like nanoemulsions, liposomes, solid lipid nanoparticles (SLNs), dendrimers, inorganic nanoparticles, nanocrystals, etc., nanotechnology-based cosmeceutical products which are available in the market. It highlights the possible health hazards caused by nanoparticles on exposure of nano-based cosmetics and describes the recent regulatory rules applied to avoid the nanotoxicity.

Drug Delivery Nanoparticles Formulation and Characterization

Drug Delivery Nanoparticles Formulation and Characterization
  • Author : Yashwant Pathak,Deepak Thassu
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :416
  • ISBN : 9781420078053
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Summary : Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na

Commonly Used Drugs

Commonly Used Drugs
  • Author : Rafik Karaman
  • Publisher :Unknown
  • Release Date :2015-04-01
  • Total pages :250
  • ISBN : 163463828X
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Summary : Drugs (medicines) are considered either the primary therapy or an adjunct to another modality. Physicians of all specialties prescribe drugs on a daily basis, and therefore they need to understand the mode and action by which drugs exert their therapeutic effects. Written records of the use of natural products as medicinal agents date back thousands of years. However, it was not until the early 1800s that the active principles from plants were isolated. Since then thousands of drugs have been introduced to the drugs market. With advances in drug design, molecular biology and genetics, the rate of developing new potent drugs is accelerated. Due to the vast progress in drug development and discovery, medical and pharmacy students, doctors, nurses and pharmacists in training need to learn the principles of therapeutics in order to follow up with the frequent changes in the therapeutics and adapt to them. With contributions from some of my colleagues, this book provides a clear and concise overview of the most important commonly used drugs with emphasis on the pharmacology aspects necessary for a basic understanding of the subject. It reviews the concepts, clinical applications, dosage forms, bioavailability, pharmacokinetics and side effects of a large number of drugs used to alleviate pain, lower cholesterol levels, and treat bacterial infections, diabetes, osteoporosis, bleeding, psoriasis and multiple Sclerosis. This book, with over 750 references, is an excellent pharmacology text for the student who is looking to broaden his/her strengths prior to the exam. The beauty of this text is that it includes essential pharmacology concepts in a compact book that can be quickly referenced and read multiple times during the course of a student's studies. In addition, this guide assists scientists trained in molecular biology, medicinal chemistry and related fields who need to know the basic theories, principles and practical applications of pharmacology. With the addition of pharmacokinetics coverage, ways to improve the bioavailability of commonly used drugs and sections on therapeutics that will help readers identify with diseases and drug treatments, this book provides better preparation of researchers in the basics of pharmacology.

Nanoparticulates as Drug Carriers

Nanoparticulates as Drug Carriers
  • Author : V. P. Torchilin
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :724
  • ISBN : 9781860949074
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Summary : Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."

Polymer Nanocomposites in Biomedical Engineering

Polymer Nanocomposites in Biomedical Engineering
  • Author : Kishor Kumar Sadasivuni,Deepalekshmi Ponnamma,Mariappan Rajan,Basheer Ahmed,Al-Maadeed Mariam Ali S A
  • Publisher :Unknown
  • Release Date :2019-03-18
  • Total pages :409
  • ISBN : 9783030047412
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Summary : This book presents a thorough discussion of the physics, biology, chemistry and medicinal science behind a new and important area of materials science and engineering: polymer nanocomposites. The tremendous opportunities of polymer nanocomposites in the biomedical field arise from their multitude of applications and their ability to satisfy the vastly different functional requirements for each of these applications. In the biomedical field, a polymer nanocomposite system must meet certain design and functional criteria, including biocompatibility, biodegradability, mechanical properties, and, in some cases, aesthetic demands. The content of this book builds on what has been learnt in elementary courses about synthesising polymers, different nanoparticles, polymer composites, biomedical requirements, uses of polymer nanocomposites in medicine as well as medical devices and the major mechanisms involved during each application. The impact of hybrid nanofillers and synergistic composite mixtures which are used extensively or show promising outcomes in the biomedical field are also discussed. These novel materials vary from inorganic/ceramic-reinforced nanocomposites for mechanical property improvement to peptide-based nanomaterials, with the chemistry designed to render the entire material biocompatible.

Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems

Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems
  • Author : Ashok Katdare,Mahesh Chaubal
  • Publisher :Unknown
  • Release Date :2006-07-28
  • Total pages :452
  • ISBN : 1420004131
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Summary : To facilitate the development of novel drug delivery systems and biotechnology-oriented drugs, the need for new excipients to be developed and approved continues to increase. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems serves as a comprehensive source to improve understanding of excipients and forge new avenues for regulatory review and allowance to use. This book presents detailed, up-to-date information on various aspects of excipient development, testing, and technological considerations for their use. It addresses specific details such as historical perspective, preclinical testing, safety, and toxicology evaluation, as well as regulatory, quality, and utility aspects. The text also describes best practices for use of various functional excipients and extensive literature references for all topics.