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Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Anna Gvozdjáková
  • Publisher :Unknown
  • Release Date :2008-02-01
  • Total pages :409
  • ISBN : 1402067143
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Summary : Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Pankaj Prasun
  • Publisher :Unknown
  • Release Date :2019-06-15
  • Total pages :364
  • ISBN : 0128170069
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Summary : Mitochondrial Medicine: A Primer for Healthcare Providers and Translational Researchers is an applied, holistic resource addressing the evolving and multidisciplinary area of mitochondrial disease. In twenty-six short, easily accessible chapters, Dr. Prasun Pankaj discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis, and treatment of mitochondrial diseases. Three all-inclusive sections examine the role of mitochondria in common medical conditions such as diabetes and heart failure, and the full range of inherited mitochondrial diseases, covering the genetic and biochemical basis of both mitochondrial DNA deletion syndromes and point mutation syndromes, their clinical presentation, treatment plans, genetic counseling, prenatal testing, and ongoing research of translational relevance. While providing a solid foundation in its topic area, each chapter in Mitochondrial Medicine is written in an accessible format with illustrative case studies, making for a quick reference at the patient's bedside or clinical laboratory. Includes a basic introduction to mitochondria and their misfunctions in human disease Presents current practice and research in mitochondrial medicine, with emphasis on clinical presentation, diagnosis, treatment, genetic counseling, and prenatal testing Features short, accessible chapters with illustrative case studies for quick reference at the patient's bedside or in the clinical laboratory Provides thorough coverage of inherited mitochondrial disorders, as well as the role of mitochondria in common medical conditions

Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Pankaj Prasun
  • Publisher :Unknown
  • Release Date :2019-05-18
  • Total pages :138
  • ISBN : 9780128170076
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Summary : Mitochondrial Medicine: A Primer for Health Care Providers and Translational Researchers is an applied, holistic resource that addresses the evolving and multidisciplinary area of mitochondrial disease. The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases. Three all-inclusive sections examine the role of mitochondria in common medical conditions, such as diabetes, heart failure and the full range of inherited mitochondrial diseases. Sections cover the genetic and biochemical basis of both mitochondrial DNA deletion syndromes and point mutation syndromes, their clinical presentation, treatment plans, genetic counseling, prenatal testing, and ongoing research. While providing a solid foundation in its topic area, each chapter in the book is written in an accessible format with illustrative case studies, thus making it a quick bedside or clinical laboratory reference. Includes a basic introduction to mitochondria and their misfunctions in human disease Presents current practice and research in mitochondrial medicine, with an emphasis on clinical presentation, diagnosis, treatment, genetic counseling and prenatal testing Features short, accessible chapters with illustrative case studies for quick reference Provides thorough coverage of inherited mitochondrial disorders, as well as the role of mitochondria in common medical conditions

Clinical Mitochondrial Medicine

Clinical Mitochondrial Medicine
  • Author : Patrick F. Chinnery,Michael Keogh
  • Publisher :Unknown
  • Release Date :2018-04-30
  • Total pages :226
  • ISBN : 9780521132985
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Summary : This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.

Advances in Mitochondrial Medicine

Advances in Mitochondrial Medicine
  • Author : Roberto Scatena,Patrizia Bottoni,Bruno Giardina
  • Publisher :Unknown
  • Release Date :2012-02-09
  • Total pages :461
  • ISBN : 9789400728684
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Summary : Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Salvatore DiMauro,Michio Hirano,Eric A. Schon
  • Publisher :Unknown
  • Release Date :2006-04-19
  • Total pages :368
  • ISBN : 0415386780
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Summary : Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Volkmar Weissig,Marvin Edeas
  • Publisher :Unknown
  • Release Date :2015-01-29
  • Total pages :480
  • ISBN : 1493922564
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Summary : This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

Mitochondria and the Future of Medicine

Mitochondria and the Future of Medicine
  • Author : Lee Know
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :272
  • ISBN : 9781603587679
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Summary : With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Mitochondrial Disease Genes Compendium

Mitochondrial Disease Genes Compendium
  • Author : Marni J. Falk
  • Publisher :Unknown
  • Release Date :2020-04-28
  • Total pages :548
  • ISBN : 9780128200308
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Summary : The field of Mitochondrial Medicine has been dominated by symptom constellation-based diagnostic categorization since the first clinical syndrome was described three decades ago. Now, as rapidly expanding knowledge has revealed that mitochondrial diseases may result from several hundred distinct gene disorders with extensive clinical and mutation heterogeneity, the most useful guide for clinical care and research embraces a gene-centric approach to each individual’s disorder. Together with international colleagues, Dr. Marni Falk has developed the Mitochondrial Disease Sequence Data Resource (MSeqDR), an online, community curated, centralized data resource of mitochondrial disease data from a genomic perspective. MSeqDR provides tens of thousands of users with interactive access to mitochondrial disease feature descriptions in a defined human phenotype ontology, mitochondrial proteome-based gene and variant curation, and a suite of easily accessible tools to facilitate analysis of complex genomic datasets in nuclear and mitochondrial genomes as well as accurate interpretation of mitochondrial disease genes, variants, and diseases. Here, in the Mitochondrial Disease Genes Compendium, Dr. Marni Falk and a team of international experts have built off their work on MSeqDR to provide an all-in-one, readily accessible, and easy-to-use at point of care reference on mitochondrial disease from a gene-based perspective. In this book, clinicians and researchers will find a complete overview of mitochondrial disease genes relevant across all specialties, cataloging and building context around clinical features and the genetic basis of each condition. Within, each "gene page" offers an in-depth, referenced view of the relevant clinical disease spectrum, including gene and protein descriptions, year discovered, inheritance pattern(s), age ranges affected, major clinical features and severity range, clinical pearls, known therapies, available support groups, animal models, and gene-specific basic, translational, or clinical research activities now underway. Links provided on each gene page direct readers to MSeqDR for new findings, up-to-date genomic variant data, and user friendly informatics tools accessible to general clinicians and sophisticated geneticists or bioinformaticians alike, ensuring access to updated information on each condition. Covering 256 mitochondrial disease genes that have been expert-curated to assure they cause human diseases and have known mitochondrial localization or impact mitochondrial function, the Mitochondrial Disease Genes Compendium is directed at clinicians and researchers, facilitating bedside access to high-level, curated knowledge on mitochondrial disease genetics that rapidly enables patient diagnosis, counseling, management, treatment, and research. Provides a readily intelligible, all-in-one reference of known mitochondrial disease genes and their associated conditions Features live links to Mitochondrial Disease Sequence Data Resource (MSeqDR) pages with regularly updated genetic variant data and bioinformatics tools Covers the inheritance patterns, age spectrum affected, major clinical features, therapeutics, support groups, and research currently under way for over 250 mitochondrial diseases

Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Salvatore DiMauro,Michio Hirano,Eric A. Schon
  • Publisher :Unknown
  • Release Date :2019-11-29
  • Total pages :16
  • ISBN : 0367446367
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Summary : Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

Diagnosis and Management of Mitochondrial Disorders

Diagnosis and Management of Mitochondrial Disorders
  • Author : Michelangelo Mancuso,Thomas Klopstock
  • Publisher :Unknown
  • Release Date :2019-05-03
  • Total pages :382
  • ISBN : 9783030055172
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Summary : This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Mitochondrial Medicine

Mitochondrial Medicine
  • Author : Volkmar Weissig,Marvin Edeas
  • Publisher :Unknown
  • Release Date :2021-02-19
  • Total pages :405
  • ISBN : 1071612697
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Summary : This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Horizons in Medicine 18

Horizons in Medicine 18
  • Author : Jonathan M. Rhodes
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :311
  • ISBN : 1860162924
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Summary : The papers included in this volume provide a fascinating review of contemporary pathology, diagnostic techniques, management approaches and pharmacological interventions. They are based on the popular Advanced Medicine conference organised annually by the Royal College of Physicians which aims to present 'the latest cutting edge advances in clinical medicine, supported by improved understanding of disease mechanisms'. Each chapter, by an eminent physician from one of a variety of specialties included, is followed by self-assessment questions, which allow the reader to ensure they have fully absorbed and correctly understood the chapter's key messages. Whether the reader's specific interest lies in, for example, 'Attacking the disease spiral in COPD', New drugs for diabetes' or Advances in Parkinson's disease' - to name but a few of the topics covered - the remainder of the book will provide them with an informative summary of advances in other fields of medicine.

Mitochondrial Replacement Techniques

Mitochondrial Replacement Techniques
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases
  • Publisher :Unknown
  • Release Date :2016-03-17
  • Total pages :200
  • ISBN : 9780309388733
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Summary : Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.

The Encyclopaedia of Sports Medicine, Genetic and Molecular Aspects of Sports Performance

The Encyclopaedia of Sports Medicine, Genetic and Molecular Aspects of Sports Performance
  • Author : Claude Bouchard,Eric P. Hoffman
  • Publisher :Unknown
  • Release Date :2011-08-02
  • Total pages :424
  • ISBN : 9781444348293
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Summary : This is the latest volume in the IOC Encyclopaedia of Sports Medicine series, summarizing the evidence from all relevant sources on the genetic and molecular basis of sports and other human physical performance. The initial chapters address the basic science of genomics and genetics and the regulation of gene expression. Additional chapters provide authoritative information on the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons. A final section addresses the issue of the contribution of specific genes and molecular markers as related to endurance, strength and power, and responsiveness to specific conditioning programs. This latest volume in the Encyclopaedia of Sports Medicine Series from the Medical Commission of the International Olympic Committee is a must for sports and exercise scientists who require a thorough guide to the most cutting edge science in this expanding field.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
  • Author : Yvonne Will,James A. Dykens
  • Publisher :Unknown
  • Release Date :2018-03-23
  • Total pages :816
  • ISBN : 9781119329749
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Summary : Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dynamics in Cardiovascular Medicine

Mitochondrial Dynamics in Cardiovascular Medicine
  • Author : Gaetano Santulli
  • Publisher :Unknown
  • Release Date :2017-05-25
  • Total pages :646
  • ISBN : 9783319553306
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Summary : This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Chemical Biology

Chemical Biology
  • Author : Natanya Civjan
  • Publisher :Unknown
  • Release Date :2012-08-07
  • Total pages :524
  • ISBN : 9781118434505
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Summary : An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

User's Guide to Nutritional Supplements

User's Guide to Nutritional Supplements
  • Author : Jack Challem
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :327
  • ISBN : 1591200679
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Summary : The User's Guide to Nutritional Supplements focuses on the most popular nutritional supplements, those that consistently attract the most attention - and are the ones most likely to benefit the majority of people. In describing the most popular nutritional supplements, this book explains: * Vitamin E can reduce the risk of heart disease - and the best types to take. * Selenium can slash the chances of developing some types of cancer. * Ginkgo can improve memory and recall. * Chromium can help oromote weigth loss and lower the risk of diabetes. * Glucosamine and chondroitin can prevent osteoarthritis. * Calcium and magnesium work together to build strong bones. * Coenzyme Q10 can boost your energy levels and strengthenyour heart. * Ginseng and other supplements boost your exercise stamina.

Mitochondrial Function and Biogenesis

Mitochondrial Function and Biogenesis
  • Author : Carla Koehler,Matthias F. Bauer
  • Publisher :Unknown
  • Release Date :2004-05-13
  • Total pages :333
  • ISBN : 3540214895
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Summary : This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. (Cover)

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction
  • Author : James A. Dykens,Yvonne Will
  • Publisher :Unknown
  • Release Date :2008-09-11
  • Total pages :652
  • ISBN : 9780470372524
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Summary : This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.