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Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
  • Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
  • Publisher :Unknown
  • Release Date :2017-06-14
  • Total pages :1178
  • ISBN : 9780128040676
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Summary : Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
  • Author : Asla Pitkänen,Philip A. Schwartzkroin,Solomon L. Moshé
  • Publisher :Unknown
  • Release Date :2005-10-04
  • Total pages :712
  • ISBN : 0080457029
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Summary : An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. The first comprehensive description of animal models of epilepsy since the early 1970's Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research World expert opinions on the clinical relevance of each model

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
  • Author : Asla Pitkänen,Solomon L. Mosh,Aristea S. Galanopoulou
  • Publisher :Unknown
  • Release Date :2017-06-16
  • Total pages :1178
  • ISBN : 0128040661
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Summary : Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Epileptic Seizures and the EEG

Epileptic Seizures and the EEG
  • Author : Andrea Varsavsky,Iven Mareels,Mark Cook
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :370
  • ISBN : 9781439812044
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Summary : A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Animal Models of Epilepsy

Animal Models of Epilepsy
  • Author : Scott C. Baraban
  • Publisher :Unknown
  • Release Date :2009-05-29
  • Total pages :276
  • ISBN : 1603272623
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Summary : In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

Encyclopedia of Basic Epilepsy Research

Encyclopedia of Basic Epilepsy Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009-05-27
  • Total pages :1832
  • ISBN : 9780123739612
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Summary : As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies
  • Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
  • Publisher :Unknown
  • Release Date :2012-06-01
  • Total pages :1264
  • ISBN : 9780199842599
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Summary : H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Computational Neuroscience in Epilepsy

Computational Neuroscience in Epilepsy
  • Author : Ivan Soltesz,Kevin Staley
  • Publisher :Unknown
  • Release Date :2011-09-02
  • Total pages :624
  • ISBN : 0080559530
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Summary : Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher :Unknown
  • Release Date :2016-07-05
  • Total pages :394
  • ISBN : 9780128026243
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Summary : Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
  • Author : Daniel Laskowitz,Gerald Grant
  • Publisher :Unknown
  • Release Date :2015-12-01
  • Total pages :412
  • ISBN : 9781498766579
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Summary : Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

New Antiepileptic Drugs

New Antiepileptic Drugs
  • Author : Francesco Pisani
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :196
  • ISBN : UOM:39015024821962
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Summary : The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.

Recent Advances in Predicting and Preventing Epileptic Seizures

Recent Advances in Predicting and Preventing Epileptic Seizures
  • Author : Ronald Tetzlaff,Christian E Elger,Klaus Lehnertz
  • Publisher :Unknown
  • Release Date :2013-08-28
  • Total pages :304
  • ISBN : 9789814525367
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Summary : This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational models of seizures and epilepsy. Furthermore the book covers recent developments of international databases and of parallel computing structures based on Cellular Nonlinear Networks that can play an important role in the realization of a portable seizure warning device. Contents:Epileptic Networks and Their Role for Seizure Prediction and Seizure Control:Transition Into and Out of a Focal Seizure (M de Curtis)Neuronal and Network Dynamics Preceding Experimental Seizures (P Jiruska, F Mormann and J G R Jefferys)Interictal EEG and Its Relevance for Seizure Prediction (A Schulze-Bonhage)Invasive Brain Stimulation in the Treatment of Epilepsy (M Sprengers, R Raedt, A Meurs, E Carrette, D van Roost, P Boon and K Vonck)Computational Models of Seizures and Epilepsy:Patient-Specific Neural Mass Modeling — Stochastic and Deterministic Methods (D R Freestone, L Kuhlmann, M S Chong, D Nesic and D B Grayden)Computational Modelling of Microseizures and Focal Seizure Onset (Y Wang, M Goodfellow, P N Taylor, D J Garry and G Baier)Predictability of Seizure-Like Events in a Complex Network Model of Integrate-and-Fire Neurons (A Rothkegel and K Lehnertz)Bursting and Synchrony in Networks of Model Neurons (C Geier, A Rothkegel and K Lehnertz)Advances in Analysis and Measurement Techniques:Signal Processing of the EEG: Approaches Tailored to Epilepsy (B Schelter, M Thiel, M Mader and W Mader)From Time Series to Complex Networks: An Overview (S Bialonski and K Lehnertz)Visualizing and Quantifying EEG Complexity on the Base of Ordinal Pattern Distributions (K Keller)Dynamics of Linear and Nonlinear Interrelation Networks in Peri-Ictal Intracranial EEG: Seizure Onset and Termination (C Rummel, M Müller, M Hauf, R Wiest and K Schindler)On the Centrality of the Focus in Human Epileptic Brain Networks (C Geier, M-T Kuhnert, C E Elger and K Lehnertz)Pre-Seizure States in Epileptic Brain Nnetworks: A Surrogate-Assisted, Weighted Network Analysis (G Ansmann, M-T Kuhnert, C E Elger and K Lehnertz)Network Analysis of Generalized Epileptic Discharges (P Ossenblok, P van Houdt, A Lüttjohann and G van Luijtelaar)Signal Processing Platform Based on Cellular Nonlinear Networks (J Müller, J Müller, R Becker and R Tetzlaff)Seizure Prediction by Cellular Nonlinear Networks? (V Senger and R Tetzlaff)Measuring Directed Interactions Using Cellular Neural Networks with Complex Connection Topologies (H Dickten, C E Elger and K Lehnertz)Seizure Prediction Using Optical Measurements of Blood Flow and Oxygenation (M Zhao, H Ma and T H Schwartz)Observing the Sleep-Wake Regulatory System to Improve Prediction of Seizures (M Sedigh-Sarvestani and B J Gluckman)The World's Largest Epilepsy Database: Content and Structure (M Ihle, B Schelter, J Timmer and A Schulze-Bonhage) Readership: Graduate students and professionals in the field of epileptology, neurosurgery and neuroscience. Keywords:Epileptic Networks;Seizure Prediction;Seizure Control;Computational Models;EpilepsyKey Features:Provides latest findings in the field of epilepsy research

Epilepsy

Epilepsy
  • Author : Jerome Engel,Timothy A. Pedley,Jean Aicardi
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :3056
  • ISBN : 0781757770
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Summary : Written and edited by world-renowned authorities, this three-volume work is, to quote a reviewer, "the definitive textbook about seizures and epilepsy". This Second Edition is thoroughly updated and gives you a complete print and multimedia package: the three-volume set plus access to an integrated content Website. More than 300 chapters cover the spectrum of biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Included are detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; psychiatric and medical comorbidity; conditions that could be mistaken for epilepsy; and an increasing range of pharmacologic, surgical, and alternative therapies, including vagus nerve stimulation and deep brain stimulation. This edition describes many new antiepileptic drugs, major advances in surgical treatment, and state-of-the-art neuroimaging, EEG, and other technologies for diagnosis and seizure prediction. A companion Website offers instant access to the complete, fully searchable text, plus an image bank of additional figures, video footage, and annual updates to selected chapters.

Seizures and Epilepsy

Seizures and Epilepsy
  • Author : Jerome Engel
  • Publisher :Unknown
  • Release Date :2013-01-31
  • Total pages :706
  • ISBN : 9780195328547
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Summary : This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology.

Epilepsy Topics

Epilepsy Topics
  • Author : Mark D. Holmes
  • Publisher :Unknown
  • Release Date :2014-07-16
  • Total pages :272
  • ISBN : 9789535116301
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Summary : An international group of recognised experts has contributed to this volume to discuss a variety of topics on epilepsy. The subject matter is diverse, including new concepts in brain circuitry involved in seizure generation, a discussion on reflex epilepsy, reviews and updates on juvenile myoclonic epilepsy, the role of EEG in epilepsy evaluation, the novel possibility of employing scalp EEG for seizure prediction, the roles of vagus nerve stimulation and other neuromodulatory therapies, non-epileptic seizures, and, no less important, some of the psychosocial issues that confront the patient and his or her family. This volume is not a comprehensive overview of the entire field of epilepsy, but each discussion is focused and will be valuable to both investigators and practitioners.

Febrile Seizures

Febrile Seizures
  • Author : Tallie Z. Baram,Shlomo Shinnar
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :337
  • ISBN : 0120781417
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Summary : Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following: New imaging tools and emerging data, visualizing effects of febrile seizures on the brain; New genetic methodologies; The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure. First book on febrile seizures in over 20 years! Broad spectrum of approaches, from genetic and epidemiological to bench research using animal models and in vitro single-cell patch-clamp methods Comprehensive update of the topic, written by world leaders in the field Novel and newly discovered information based on up-to the minute methods Engaging style, accessible to the clinician, researcher, and educated parent

Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research
  • Author : Steven L. Peterson,Timothy E. Albertson
  • Publisher :Unknown
  • Release Date :2019-05-07
  • Total pages :272
  • ISBN : 9781420048889
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Summary : There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

Drugs for the Control of Epilepsy

Drugs for the Control of Epilepsy
  • Author : Carl L. Faingold,Gerhard H. Fromm
  • Publisher :Unknown
  • Release Date :2019-06-04
  • Total pages :560
  • ISBN : 9780429553226
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Summary : Originally published in 1991. This book brings together the ideas of an international group of experts on clinical and experimental epilepsy. These authors consider how antiepileptic drugs may act on elements of neuronal networks to reduce seizure incidence and severity. The book addresses such topics as the four general classes of anticonvulsant drug mechanisms, major epilepsy models, the proposed mechanisms of action of major antiepileptic drugs, and the clinical use of antiepileptic drugs in the treatment of various forms of human epilepsy. This volume is special for its focus on the neuronal network approach to epilepsy, as well as for its comprehensive review and integration of human and animal data. Neurologists, pharmacologists, psychiatrists, and other investigators actively working on epilepsy research will find this book to be a useful, thought-provoking reference volume.

Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition

Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition
  • Author : Bureau Michelle,Genton Pierre,Dravet Charlotte
  • Publisher :Unknown
  • Release Date :2012-11-12
  • Total pages :600
  • ISBN : 9782742008292
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Summary : The ultimate reference book : the 5th updated edition of the famous “blue guide”. Incluided : A DVD with new sequences completes each chapter! Epileptology changes. The syndromic approach is completed by an etiological approach, based on the major advances in genetics and functional genetics. New entities have found their place, and a purely descriptive, “electroclinical” approach is no longer adapted in many circumstances. The 5th edition of the Blue Guide includes the most recent advances. It was necessary to justify the physiological, epidemiologic, genetic and therapeutic approaches and to consider them in the light of the new classification efforts, which are still in the making. Nevertheless, the description of epileptic syndromes, both classical and recent, remains at the core of this book.

Epilepsy

Epilepsy
  • Author : Jong Rho,Raman Sankar,Carl E. Stafstrom
  • Publisher :Unknown
  • Release Date :2010-06-18
  • Total pages :684
  • ISBN : 9781420085600
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Summary : Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo

Atlas of Epilepsies

Atlas of Epilepsies
  • Author : S.R. Benbadis,R.G. Beran,A.T. Berg,J. Engel, Jr.,A.S. Galanopoulou,P.W. Kaplan,M. Koutroumanidis,S.L. Moshe,D.R. Nordli, Jr.,J.M. Serratosa,S.M. Sisodiya,W.O. Tatum,T. Valeta,A. Wilner
  • Publisher :Unknown
  • Release Date :2010-09-20
  • Total pages :2000
  • ISBN : 9781848821279
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Summary : Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.