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Molecular Biology of B Cells

Molecular Biology of B Cells
  • Author : Tasuku Honjo,Michael Reth,Andreas Radbruch,Frederick Alt
  • Publisher :Unknown
  • Release Date :2014-10-09
  • Total pages :600
  • ISBN : 9780123984906
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Summary : Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

Molecular Biology of B-Cell and T-Cell Development

Molecular Biology of B-Cell and T-Cell Development
  • Author : John G. Monroe,Ellen Rothenberg
  • Publisher :Unknown
  • Release Date :2013-03-14
  • Total pages :587
  • ISBN : 9781475727784
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Summary : Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.

B Cell Biology in Autoimmunity

B Cell Biology in Autoimmunity
  • Author : David Ahmad Nemazee
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :272
  • ISBN : 9783805574549
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Summary : B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.

B Cell Protocols

B Cell Protocols
  • Author : Hua Gu (PhD.),K. Rajewsky
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :289
  • ISBN : 9781592597963
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Summary : A diverse collection of protocols ranging from the latest inventions and applications to some classic, but still frequently used, methods for studying B-lymphocyte development and function in higher animals. These readily reproducible protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Readily reproducible techniques for studying B-lymphocyte development and function Comprehensive collection of classic and cutting-edge methods Step-by-step instructions that ensure experimental success.

Regulatory B Cells

Regulatory B Cells
  • Author : Gaetano Vitale,Francesca Mion
  • Publisher :Unknown
  • Release Date :2014-07-14
  • Total pages :292
  • ISBN : 1493911600
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Summary : Regulatory B Cells: Methods and Protocols present the current experimental set-ups and methodologies useful for the identification and characterization of B cells with suppressive functions and for the study of their biological and immunological properties. Organized into four sections, this detailed volume covers the basic methods for the isolation and immunophenotypical characterization of specific B cell subsets from mouse and human tissues, methods for the investigation of the mechanisms of immune suppression operated by B cells, several experimental approaches for the ex vivo generation/expansion of IL-10-producing B cells, as well as procedures for the study of the immune suppressive function of B cells in specific pathological settings. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Regulatory B Cells: Methods and Protocols serves as an ideal guide for immunologists as well as for cell and molecular biologists interested in the intricacies of B cell biology.

B Cells

B Cells
  • Author : Robert L. Montes,Leo Reyes
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :119
  • ISBN : 1628085428
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Summary : B cells belong to a group of white blood cells known as lymphocytes, making them a vital part of the immune system. The human body makes millions of different types of B cells each day that circulate in the blood and lymphatic system performing the role of immune surveillance. They do not produce antibodies until they become fully activated. In this book, the authors present current research in the study of the molecular biology, developmental origin and impact on the immune system of B cells. Topics discussed include the role of B cells in intracellular bacterial pathogen infections; dynamic clustering of BCR-lipid rafts in antigen affinity discrimination by B cells; and B cells as a key player in the pathogenesis of multiple sclerosis.

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
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Summary :

Immunoglobulin Genes

Immunoglobulin Genes
  • Author : Tasuku Honjo,Frederick W. Alt
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :443
  • ISBN : 9780080984483
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Summary : Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells.

Molecular Biology of the Cell 6E - The Problems Book

Molecular Biology of the Cell 6E - The Problems Book
  • Author : John Wilson,Tim Hunt
  • Publisher :Unknown
  • Release Date :2014-11-21
  • Total pages :984
  • ISBN : 9781317497271
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Summary : The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be

T and B Lymphocytes: Recognition and Function

T and B Lymphocytes: Recognition and Function
  • Author : Fritz Bach
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :736
  • ISBN : 9780323142847
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Summary : T and B Lymphocytes: Recognition and Function is the 16th volume of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology. This book is organized into seven sections, encompassing 74 chapters that summarize molecular level progress in the field of immunobiology. It emphasizes cell membrane, techniques developed for its analysis, and varied products of the major histocompatibility complex, as well as other receptors on cells of the immune system. The book starts by describing two approaches for molecular association evaluation. First is the use of artificial membranes or lipid vesicles for the incorporation of antigens for recognition by T-lymphocytes both at the afferent and efferent levels. Second is the chemical crosslinking of cell surface components with a variety of different crosslinking reagents. This is followed by a discussion on the molecular nature of a T-cell receptor that provides insights of the target(s) recognized by T-lymphocytes. Several chapters discuss data dealing with the issue of the apparent differential recognition by T- and B-cells while both use the same VH genes. Antiidiotypic sera, together with the activity of ""regulator"" T-cells, are also discussed, with regard to their role in networks of regulation of the immune response. This book presents works demonstrating that human T-lymphocytes can also be cloned and both noncytotoxic proliferating T-lymphocytes and Tc can be so obtained. This is along with the continuing studies regarding heterogenity of B-lymphocytes as well as macrophages. Part V focuses on the interaction between lymphocyte and virus and molecular modifications of viral-infected cells. The subsequent section deals with recognition, reactivities, and function of T- and B-lymphocytes. Considerable chapters in this section discuss T-cell cytotoxicity, dichotomy of MHC control over anti H-Y cytotoxic T-cell responses, mouse alloantibodies, and mixed lymphocyte reactions. The concluding part describes immunological tools, such as synthetic membranes and cloned T-cells with biological function.

Janeway's Immunobiology

Janeway's Immunobiology
  • Author : Murphy, Kenneth M.,Weaver, Casey
  • Publisher :Unknown
  • Release Date :2016-03-22
  • Total pages :904
  • ISBN : 9780815345510
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Summary : Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

B Lymphocytes

B Lymphocytes
  • Author : G. G. B. Klaus
  • Publisher :Unknown
  • Release Date :1990
  • Total pages :71
  • ISBN : UOM:39015021997989
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Summary : This book provides a timely review of our current knowledge of the cellular and molecular biology of B lymphocytes. These cells play a key role in the immune system. B cells recognize antigens by means of specific cell surface antibody molecules, and in recent years there has been rapid progress in our understanding of these responses. Considerable advances have also been made in unravelling the regulation of B cell activation by T cells and the cytokines they produce, and how microenvironmental factors determine whether B cells become antibody-producing cell or memory cells. Intended for undergraduates and graduate students in biology and medicine, this work covers new topics and ideas not adequately covered in existing textbooks. It provides in-depth knowledge in an easy-to-read format, with two-color diagrams for increased clarity.

Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers

Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers
  • Author : Robert B. Northrop,Anne N. Connor
  • Publisher :Unknown
  • Release Date :2008-10-28
  • Total pages :480
  • ISBN : 9781420061215
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Summary : Illustrates the Complex Biochemical Relations that Permit Life to Exist It can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to their chosen profession. Introduction to Molecular Biology, Genomics, and Proteomics for Biomedical Engineers hones in on the specialized organic molecules in living organisms and how they interact and react. The book’s sound approach to this intricately complex field makes it an exceptional resource for further exploration into the biochemistry, molecular biology, and genomics fields. It is also beneficial for electrical, chemical, and civil engineers as well as biophysicists with an interest in modeling living systems. This seminal reference includes many helpful tools for self study, including— 143 illustrations, 32 in color, to bolster understanding of complex biochemical relations 20 tables for quick access to precise data 100 key equations Challenging self-study problems within each chapter Conveys Human Progress in the Manipulation of Genomes at the Molecular Level In response to growing global interest in biotechnology, this valuable text sheds light on the evolutionary theories and future trends in genetic medicine and stem cell research. It provides a broader knowledge base on life-permitting complexities, illustrates how to model them quantitatively, and demonstrates how to manipulate them in genomic-based medicine and genetic engineering. Consequently, this book allows for a greater appreciation among of the incredible complexity of the biochemical systems required to sustain life in its many forms. A solutions manual is available for instructors wishing to convert this reference to classroom use.

Lymphocytes

Lymphocytes
  • Author : Erman Salih Istifli,Hasan Basri İla
  • Publisher :Unknown
  • Release Date :2019-01-16
  • Total pages :124
  • ISBN : 9781789849196
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Summary : Although all the features of the immune system have not been fully resolved yet, the knowledge we have gained from studies on lymphocytes, the basic elements of the immune system, is quite lucid. For this reason, the significance of lymphocytes (the cells that are the source of most of the information we have obtained about the human genome, the negative effects of drugs on the genetic system, the development and behavior of immune system, antigen-antibody association, cytotoxic adaptive immunity, antibody-driven adaptive immunity, cancer and autoimmune diseases) is clear. Studies on lymphocytes will not only help us develop tools to combat human diseases more effectively in the future, but will also help us understand how evolution shapes the immune system in living organisms.

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
  • Author : Fumiaki Uchiumi
  • Publisher :Unknown
  • Release Date :2018-02-21
  • Total pages :334
  • ISBN : 9789535138556
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Summary : "Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

Lymphocyte Activation and Differentiation

Lymphocyte Activation and Differentiation
  • Author : J. C. Mani,J. Dornand
  • Publisher :Unknown
  • Release Date :2019-08-07
  • Total pages :981
  • ISBN : 9783110850253
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Summary :

Lymphocyte Updates

Lymphocyte Updates
  • Author : Gheorghita Isvoranu
  • Publisher :Unknown
  • Release Date :2017-07-12
  • Total pages :192
  • ISBN : 9789535133438
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Summary : This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Cell and Molecular Biology of Breast Cancer

Cell and Molecular Biology of Breast Cancer
  • Author : Heide Schatten
  • Publisher :Unknown
  • Release Date :2013-09-27
  • Total pages :383
  • ISBN : 9781627036344
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Summary : Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

Concepts of Biology

Concepts of Biology
  • Author : Samantha Fowler,Rebecca Roush,James Wise
  • Publisher :Unknown
  • Release Date :2018-01-07
  • Total pages :618
  • ISBN : 9888407457
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Summary : Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Biomedical Index to PHS-supported Research

Biomedical Index to PHS-supported Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :229
  • ISBN : UOM:39015015076972
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Summary :

Molecular Biology Techniques

Molecular Biology Techniques
  • Author : Sue Carson,Susan Carson,Heather Miller,D. Scott Witherow
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :200
  • ISBN : 9780123855442
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Summary : This manual is an indispensable tool for introducing advanced undergraduates and beginning graduate students to the techniques of recombinant DNA technology, or gene cloning and expression. The techniques used in basic research and biotechnology laboratories are covered in detail. Students gain hands-on experience from start to finish in subcloning a gene into an expression vector, through purification of the recombinant protein. The third edition has been completely re-written, with new laboratory exercises and all new illustrations and text, designed for a typical 15-week semester, rather than a 4-week intensive course. The "project" approach to experiments was maintained: students still follow a cloning project through to completion, culminating in the purification of recombinant protein. It takes advantage of the enhanced green fluorescent protein - students can actually visualize positive clones following IPTG induction. Cover basic concepts and techniques used in molecular biology research labs Student-tested labs proven successful in a real classroom laboratories Exercises simulate a cloning project that would be performed in a real research lab "Project" approach to experiments gives students an overview of the entire process Prep-list appendix contains necessary recipes and catalog numbers, providing staff with detailed instructions