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Molecular Diagnostics

Molecular Diagnostics
  • Author : George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
  • Publisher :Unknown
  • Release Date :2016-10-27
  • Total pages :520
  • ISBN : 0128029889
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Summary : Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Molecular Diagnostics

Molecular Diagnostics
  • Author : Wayne W. Grody,Robert M. Nakamura,Frederick L. Kiechle,Charles Strom
  • Publisher :Unknown
  • Release Date :2009-11-06
  • Total pages :736
  • ISBN : 9780080919041
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Summary : Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. Serves as the definitivereference for molecular pathologists worldwide Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science

Molecular Diagnostics

Molecular Diagnostics
  • Author : William B. Coleman,Gregory J. Tsongalis
  • Publisher :Unknown
  • Release Date :2007-10-28
  • Total pages :567
  • ISBN : 1592599281
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Summary : Accompanying CD-ROM contains ... "a companion eBook version of Molecular diagnostics : for the clinical laboratorian, Second edition ... for downloading and use in the reader's PC or PDA." -- p. [4] of cover.

Molecular Diagnostics

Molecular Diagnostics
  • Author : W. Edward Highsmith, Jr.
  • Publisher :Unknown
  • Release Date :2013-09-20
  • Total pages :257
  • ISBN : 1461481279
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Summary : Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.

Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics - E-Book

Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics - E-Book
  • Author : Carl A. Burtis,David E. Bruns
  • Publisher :Unknown
  • Release Date :2014-08-14
  • Total pages :1104
  • ISBN : 0323292062
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Summary : A condensed, easier-to-understand student version of the acclaimed Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th Edition uses a laboratory perspective in providing the clinical chemistry fundamentals you need to work in a real-world, clinical lab. Coverage ranges from laboratory principles to analytical techniques and instrumentation, analytes, pathophysiology, and more. New content keeps you current with the latest developments in molecular diagnostics. From highly respected clinical chemistry experts Carl Burtis and David Bruns, this textbook shows how to select and perform diagnostic lab tests, and accurately evaluate results. Authoritative, respected author team consists of two well-known experts in the clinical chemistry world. Coverage of analytical techniques and instrumentation includes optical techniques, electrochemistry, electrophoresis, chromatography, mass spectrometry, enzymology, immunochemical techniques, microchips, automation, and point of care testing. Learning objectives begin each chapter, providing measurable outcomes to achieve after completing the material. Key words are listed and defined at the beginning of each chapter, and bolded in the text. A glossary at the end of the book makes it quick and easy to look up definitions of key terms. More than 500 illustrations plus easy-to-read tables help you understand and remember key concepts. New chapters on molecular diagnostics include the principles of molecular biology, nucleic acid techniques and applications, and genomes and nucleic acid alterations, reflecting the changes in this rapidly evolving field. New content on clinical evaluation of methods, kidney function tests, and diabetes is added to this edition. NEW multiple-choice review questions at the end of each chapter allow you to measure your comprehension of the material. NEW case studies on the Evolve companion website use real-life scenarios to reinforce concepts.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book
  • Author : Carl A. Burtis,Edward R. Ashwood,David E. Bruns
  • Publisher :Unknown
  • Release Date :2012-10-14
  • Total pages :2256
  • ISBN : 1455759422
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Summary : As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

Molecular Diagnostics

Molecular Diagnostics
  • Author : Jan Trost Jorgensen,Henrik Winther
  • Publisher :Unknown
  • Release Date :2019-07-17
  • Total pages :351
  • ISBN : 0429533691
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Summary : This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

Molecular Diagnostics

Molecular Diagnostics
  • Author : Lela Buckingham
  • Publisher :Unknown
  • Release Date :2019-02-22
  • Total pages :576
  • ISBN : 0803699549
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Summary : Meet the challenges of this rapidly expanding field with a solid understanding of the fundamentals of nucleic acid biochemistry as well as the advanced concepts integral to practice in today’s laboratories. With a focus on the application of molecular concepts to the diagnosis of disease, the 3rd Edition of this popular resource encompasses microbiology, virology, genetics, oncology, and human identification.

Fundamentals of Molecular Diagnostics

Fundamentals of Molecular Diagnostics
  • Author : David E. Bruns,Edward R. Ashwood,Carl A. Burtis
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :267
  • ISBN : 1416037373
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Summary : This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.

Molecular Diagnostics

Molecular Diagnostics
  • Author : Juluri R. Rao,Colin Craig Fleming,John Edmund Moore
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :379
  • ISBN : 190493319X
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Summary : Molecular techniques are being harnessed for the detection of organisms in a wide range of circumstances. Global trade has introduced new pests of crops and plants; simultaneously, there is universal concern from disease outbreaks such as BSE, Foot & Mouth and the bird-flu virus. Molecular diagnostic applications for the detection of foodborne bacterial pathogens and genetically modified organisms in food are also becoming increasingly important. This book provides a critical assessment of the various molecular methods in medical and veterinary science, forensics, biodefense, plant science, food safety and quarantine sciences. Aimed at graduates, postdoctoral research scientists, established researchers and specialist scientists, the book describes and evaluates molecular techniques and applications in this increasingly important area. Topics include the molecular methods for the direct detection of pathogens such as E. coli O157: H7, MRSA and other important bacterial infections, medical viruses, medical parasites, dental plaque bacteria and haematological malignancies. Also covered is the molecular recognition and detection of catastrophic bio-threat agents as a consequence of global terrorism.

Molecular Diagnostics: Promises and Possibilities

Molecular Diagnostics: Promises and Possibilities
  • Author : Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
  • Publisher :Unknown
  • Release Date :2010-01-29
  • Total pages :520
  • ISBN : 9789048132614
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Summary : A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Molecular Diagnostics of Infectious Diseases

Molecular Diagnostics of Infectious Diseases
  • Author : Harald H. Kessler
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :193
  • ISBN : 3110214857
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Summary : In a unique way, the laboratory specialist's knowledge about molecular diagnostics of infectious diseases is connected with the clinician's practical experience. The first part of this book focuses on general questions including correct specimen collection, ordering adequate tests, choice of molecular techniques, quality control, and correct interpretation of results. In the second part, pathogens are discussed according to different body systems and specific symptoms. Up-to-date diagnostics of infectious diseases Tables, flow charts, take-home messages

Molecular Diagnostics

Molecular Diagnostics
  • Author : Gregory J. Tsongalis,William B. Coleman
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :364
  • ISBN : 9781890883768
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Summary :

Congenital Heart Disease

Congenital Heart Disease
  • Author : Mary Kearns-Jonker
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :278
  • ISBN : 159745088X
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Summary : Prominent researchers and clinicians describe in detail all the latest laboratory techniques currently used to define the molecular genetic basis for congenital malformations of the heart, cardiomyopathies, cardiac tumors, and arrythmias in human patients. In particular, the methods can be used to identify in clinical samples those genetic mutations responsible for such congenital abnormalities as Marfan syndrome, Williams-Beuren Syndrome, Alagille syndrome, Noonan syndrome, and Friedreich ataxia. The authors also discuss the limitations of identifying patients with congenital heart disease using these techniques during both pre- and postnatal periods.

Molecular Diagnostics in Dermatology and Dermatopathology

Molecular Diagnostics in Dermatology and Dermatopathology
  • Author : Michael J. Murphy
  • Publisher :Unknown
  • Release Date :2011-03-24
  • Total pages :478
  • ISBN : 9781607611714
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Summary : Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with ‘traditional’ histologic approaches, and discussions of regulatory, ethical, legal, economic issues and ‘newer’ technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.

Molecular Diagnostics

Molecular Diagnostics
  • Author : Harald Seitz,Sarah Schumacher
  • Publisher :Unknown
  • Release Date :2014-07-08
  • Total pages :170
  • ISBN : 3642376916
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Summary : Integration in Bioanalysis: Technologies for Point-of-Care Testing, by Frank F. Bier, Soeren Schumacher Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine, by Babette Regierer, Valeria Zazzu, Ralf Sudbrak, Alexander Kühn and Hans Lehrach A Highly Versatile Microscope Imaging Technology Platform for the Multiplex Real-Time Detection of Biomolecules and Autoimmune Antibodies, by Stefan Rödiger, Peter Schierack, Alexander Böhm, Jörg Nitschke, Ingo Berger, Ulrike Frömmel, Carsten Schmidt, Mirko Ruhland, Ingolf Schimke, Dirk Roggenbuck, Werner Lehmann, Christian Schröder Platform Technologies for Molecular Diagnostics near the Patient’s Bedside, by Soeren Schumacher, Christine Lüdecke, Eva Ehrentreich-Förster, Frank F. Bier Microfluidic Technology for Molecular Diagnostics, by Tom Robinson, Petra S. Dittrich Biosensors for Diagnostic Applications, by Friederike J. Gruhl, Bastian E. Rapp, Kerstin Länge Planar Protein Arrays in Microtiter Plates: Development of a New Format Towards Accurate, Automation-Friendly and Affordable (A3) Diagnostics, by Holger Eickhoff, Arif Malik

Nucleic Acids as Molecular Diagnostics

Nucleic Acids as Molecular Diagnostics
  • Author : Andreas Keller,Eckart Meese
  • Publisher :Unknown
  • Release Date :2015-01-12
  • Total pages :392
  • ISBN : 3527335560
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Summary : By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.

Molecular Diagnostics for Dermatology

Molecular Diagnostics for Dermatology
  • Author : Gregory A. Hosler,Kathleen M. Murphy
  • Publisher :Unknown
  • Release Date :2014-04-30
  • Total pages :356
  • ISBN : 364254066X
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Summary : Molecular diagnostics is an exploding field, and recent advances in our understanding of the molecular basis of disease have provided a platform for the development of new diagnostic tests as well as tests to predict tumor behavior and potential response to targeted therapy. This textbook provides a reference and practical guide to molecular diagnostics for dermatologists and dermatopathologists. It outlines our current understanding of the molecular underpinnings of dermatologic disease, describes the appropriate use of currently available molecular tests, and explains the interpretation of these tests in the context of diagnosis and management. Tests relating to various disorders are covered, including but not confined to melanoma, genodermatoses, and infectious disease. Pitfalls are highlighted and user-friendly algorithmic approaches, presented.

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
  • Author : Dongfeng Tan,Henry T. Lynch
  • Publisher :Unknown
  • Release Date :2012-12-07
  • Total pages :992
  • ISBN : 1469820641
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Summary : The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Molecular Diagnostics of Solar and Stellar Magnetic Fields

Molecular Diagnostics of Solar and Stellar Magnetic Fields
  • Author : Nadine Afram
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :132
  • ISBN : 386727763X
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Summary :

Early, rapid and sensitive veterinary molecular diagnostics - real time PCR applications

Early, rapid and sensitive veterinary molecular diagnostics - real time PCR applications
  • Author : Erika Pestana,Sandor Belak,Adama Diallo,John R. Crowther,Gerrit J. Viljoen
  • Publisher :Unknown
  • Release Date :2010-01-18
  • Total pages :310
  • ISBN : 9048131324
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Summary : This book gives a comprehensive account of the practical aspects of Real time PCR and its application to veterinary diagnostic laboratories. The optimisation of assays to help diagnose livestock diseases is stressed and exemplified through assembling standard operating procedures from many laboratory sources. Theoretical aspects of PCR are dealt with as well as quality control features necessary to maintain an assured testing system. The book will be helpful to all scientists involved in diagnostic applications of molecular techniques, but is designed primarily to offer developing country scientists a collection of working methods in a single source. The book is an adjunct to the Molecular Diagnostic PCR Handbook published in 2005.