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Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
  • Author : Wilma Wasco,Rudolph Tanzi
  • Publisher :Unknown
  • Release Date :1996-11-01
  • Total pages :312
  • ISBN : 1592594719
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Summary : The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
  • Author : Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2019-04-15
  • Total pages :386
  • ISBN : 0128167319
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Summary : Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia

Neurodegeneration

Neurodegeneration
  • Author : Dennis Dickson,Roy O. Weller
  • Publisher :Unknown
  • Release Date :2011-09-09
  • Total pages :432
  • ISBN : 1444341235
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Summary : Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer's Disease and Frontotemporal Dementia

Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer's Disease and Frontotemporal Dementia
  • Author : Nicolae-Daniel Pirici
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :215
  • ISBN : 9786061129188
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Summary :

Molecular Mechanism of Alzheimer's Disease

Molecular Mechanism of Alzheimer's Disease
  • Author : Ian Macreadie
  • Publisher :Unknown
  • Release Date :2019-10-25
  • Total pages :228
  • ISBN : 3039214071
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Summary : Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
  • Author : Marie-Francoise Chesselet
  • Publisher :Unknown
  • Release Date :2000-10-19
  • Total pages :410
  • ISBN : 1592590063
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Summary : With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
  • Author : Michael S. Wolfe
  • Publisher :Unknown
  • Release Date :2018-03-29
  • Total pages :560
  • ISBN : 0128113057
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Summary : The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Alzheimer's Disease

Alzheimer's Disease
  • Author : Benedetto Corain,Khalid Iqbal,Marino Nicolini,Bengt Winblad,Henry M. Wisniewski,Paolo F. Zatta
  • Publisher :Unknown
  • Release Date :1993-05-24
  • Total pages :633
  • ISBN : 09876543XX
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Summary : Charts the considerable progress made toward understanding the basic molecular mechanisms of this disorder and toward developing diagnostic and therapeutic strategies. Articles by leading scientists in the field cover such areas as neuroimaging, brain energy metabolism, biomarkers, brain amyloidosis, environmental and metabolic factors, similarities and differences between transmissible dementias and Alzheimer's disease.

Type 2 Diabetes and Dementia

Type 2 Diabetes and Dementia
  • Author : Velandai Srikanth,Zoe Arvanitakis
  • Publisher :Unknown
  • Release Date :2018-02-09
  • Total pages :320
  • ISBN : 0128096942
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Summary : Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications

The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease
  • Author : Patrick A. Lewis,Jennifer E. Spillane
  • Publisher :Unknown
  • Release Date :2018-11-16
  • Total pages :274
  • ISBN : 0128110708
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Summary : The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Genes, Environment and Alzheimer's Disease

Genes, Environment and Alzheimer's Disease
  • Author : Orly Lazarov,Giuseppina Tesco
  • Publisher :Unknown
  • Release Date :2016-02-25
  • Total pages :448
  • ISBN : 0128028858
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Summary : Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Diet and Nutrition in Dementia and Cognitive Decline

Diet and Nutrition in Dementia and Cognitive Decline
  • Author : Colin R. Martin,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2014-12-30
  • Total pages :1260
  • ISBN : 0124079393
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Summary : Diet and Nutrition in Dementia and Cognitive Decline offers researchers and clinicians a single authoritative source which outlines the complex interrelationships between cognitive decline, dementia and the way diet can be modified to improve outcomes. In a cross-disciplinary field like dementia research and practice, clinicians and researchers need a comprehensive resource which will quickly help them identify a range of nutritional components and how they affect cognitive decline and the development of dementia. While the focus is on clinical applications, the book also features landmark and innovative preclinical studies that have served as the foundation of rigorous trials. Chapters explore the evidence of how nutritional components, either in the diet or supplements, can either impede the development to, or progression from, the onset of dementia. Authors investigate how conditions and processes overlap between defined conditions and present studies which show that dietary components may be equally effective in a number of conditions characterized by declining cognition or dementia. This book represents essential reading for researchers and practicing clinicians in nutrition, dietetics, geriatrics, nursing, neurology, and psychology, as well as researchers, such as neuroscientists, molecular and cellular biochemists, interested in dementia. Explores the complex interrelationships between cognitive decline, dementia and the way diet can be modified to improve outcomes Focuses on both clinical nutrition applications and the innovative preclinical studies that serve as the foundation for rigorous trials Covers specific conditions and mechanisms in dementias, as well as general aspects, risk factors, lifestyle and guidelines for practitioners Organizes chapter content in terms of the molecular, mechanistic, epidemiologic, and practical, so that correlations can be observed across conditions

Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher :Unknown
  • Release Date :2016-09-28
  • Total pages :558
  • ISBN : 9535126547
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Summary : The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Animal Models of Dementia

Animal Models of Dementia
  • Author : Peter Paul De Deyn,Debby Van Dam
  • Publisher :Unknown
  • Release Date :2011-04-06
  • Total pages :732
  • ISBN : 9781607618997
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Summary : With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Brain Protein Aging and Dementia Control

Brain Protein Aging and Dementia Control
  • Author : Gen Sobue,Naruhiko Sahara
  • Publisher :Unknown
  • Release Date :2019-06-28
  • Total pages :229
  • ISBN : 2889458725
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Summary :

Vascular Cognitive Impairment

Vascular Cognitive Impairment
  • Author : John V. Bowler,Vladimir Hachinski
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :350
  • ISBN : 9780192632678
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Summary : Vascular dementia, caused by multiple small strokes, is the second commonest cause of dementia behind Alzheimer's disease. In recent years there has been a radical reappraisal of the concept of vascular dementia and a move away from an Alzheimer-based diagnostic paradigm towards one more appropriately tailored for vascular disease. Vascular Cognitive Impairment presents a new definition for this class of cerebrovascular process with an emphasis on early detection, prompt treatment and the prevention of disease progression. Vascular Cognitive Impairment: Preventable Dementia presents an overview of the current state of our knowledge in this field. It reviews the historical background, prevalence, risk factors and economic consequences of the condition. In addition, the book summarises our knowledge of the pathological process, describing insight derived from genetic and imaging studies, before examining opportunities for early diagnosis, prevention and the options for management, both now, and as a result of ongoing clinical trials. With contributions from an expert team of international contributors, this book provides a comprehensive summary of the state-of-the-art in this field, providing a framework for a new understanding of a complex, disabling but Preventable condition.

Frontiers of the Mechanisms of Memory and Dementia

Frontiers of the Mechanisms of Memory and Dementia
  • Author : Takeshi Kato
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :217
  • ISBN : 09876543XX
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Summary : Hardbound. This volume contains presentations of the 16th Yokohama 21st Century Forum on Brain Sciences in the Coming Century, entitled Frontiers of the Mechanisms of Memory and Dementia held in Japan in November 1999. The symposium included 19 invited speakers and 53 poster presentations. Over 150 scientists from around the world attended the meeting.Main features of this monograph cover the molecular mechanisms of long-term potentiation, the mechanisms of cell death and apoptosis and the recent research on memory and dementia. Multiple mechanisms have been proposed to mediate memory and learning encompassing molecular, neurochemical, neuronal, synaptic, network, neural systems and behavioral processes. The purpose of this volume is to review the state of knowledge in the topics of memory, cell death, neuroprotection, animal models of memory impairment, neuropathology and neuroimaging of dementing illness and

Neurobiology of Dementia

Neurobiology of Dementia
  • Author : Alireza Minagar
  • Publisher :Unknown
  • Release Date :2009-06-04
  • Total pages :360
  • ISBN : 9780080888781
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Summary : With recent advances of modern medicine, more people reach the “elderly age around the globe, and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians’ and neuroscientists’ interest to carry out more research projects into the pathogenesis of this devastating group of diseases.

Neuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer's Disease
  • Author : Illana Gozes
  • Publisher :Unknown
  • Release Date :2016-12-30
  • Total pages :342
  • ISBN : 0128037121
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Summary : Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Molecular Mechanisms of Synaptogenesis

Molecular Mechanisms of Synaptogenesis
  • Author : Alexander Dityatev,Alaa El-Husseini
  • Publisher :Unknown
  • Release Date :2006-11-24
  • Total pages :497
  • ISBN : 038732562X
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Summary : This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.

Cyclin Dependent Kinase 5 (Cdk5)

Cyclin Dependent Kinase 5 (Cdk5)
  • Author : Nancy Y. Ip,Li-Huei Tsai
  • Publisher :Unknown
  • Release Date :2009-02-28
  • Total pages :313
  • ISBN : 9780387788876
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Summary : Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.