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Motor Neuron Disorders

Motor Neuron Disorders
  • Author : Pamela J. Shaw,Michael J. Strong
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :569
  • ISBN : UOM:39015060031468
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Summary : This book includes state-of-the-art discussions of the pathogenesis of amyotrophic lateral sclerosis; new information on the genetic basis and clinical management of spinal muscular atrophy; current understanding of Kennedy's disease; and recent findings on hereditary spastic paraparesis. This book will deliver the guidance the reader needs to accurately diagnose any type of motor neuron disorder and manage it using effective methods.

Motor Neuron Disease in Adults

Motor Neuron Disease in Adults
  • Author : Mark B. Bromberg
  • Publisher :Unknown
  • Release Date :2014-10-28
  • Total pages :336
  • ISBN : 9780199783113
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Summary : Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on genetics and frontotemporal lobe involvement. Allied health providers will find useful information for their discipline. Patients will also find both specific and general information to help understand what they are experiencing and how to help manage their symptoms.

Motor Neuron Disorders and Related Diseases

Motor Neuron Disorders and Related Diseases
  • Author : Andrew Eisen,Pamela J. Shaw, MD
  • Publisher :Unknown
  • Release Date :2007-01-19
  • Total pages :464
  • ISBN : 9780444518941
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Summary : This volume provides a comprehensive and scholarly accounting of motor neuron disorders, a group of diseases that are both clinically and genetically diverse. Clinicians and neuroscientists alike will find invaluable research and information on recent advancements that have occurred in the understanding of these disorders. From specific discussions of their underlying molecular pathogenesis, to advancements in therapies and diagnosis, users will find a resource that presents a comprehensive understanding of the general clinical features and management of these devastating disorders. In addition, new tactics that can be used to enhance patient care are also presented and discussed. Specific chapters within the volume include discussions pertaining to the historical aspects of motor neuron diseases, comparative anatomy, physiology, and development of the corticospinal system, and discussions of spinal muscular atrophies, amongst others. In addition, symptomatic therapy and the palliative aspects of clinical patient care are also presented. * A scholarly accounting of new research in motor neuron disorders and their associated diseases * The intricate relationships that exist between different motor neuron related disorders * A comprehensive resource that provides a guide to the diagnosis and treatment of motor neuron disorders, along with new approaches to patient care

Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases
  • Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
  • Publisher :Unknown
  • Release Date :2017-01-18
  • Total pages :336
  • ISBN : 9780128025246
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Summary : Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Motor Neuron Diseases

Motor Neuron Diseases
  • Author : Bradley J. Turner
  • Publisher :Unknown
  • Release Date :2014-01-01
  • Total pages :244
  • ISBN : 1631173421
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Summary : Motor neuron disease (MND), also commonly known as amyotrophic lateral sclerosis (ALS), is a chronic neurodegenerative disorder of the motor system in adults, characterized by the loss of motor neurons in the cortex, brain stem and spinal cord. This book presents current research from across the globe in the study of the causes, classification and treatments of MND, including membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS; motorneuron specific calcium dysregulation and perturbed cellular calcium homeostasis in ALS; stem cells and their application in ALS treatment; excitotoxicity and selective motor neuron degeneration and therapeutic invervention and assistive technology treatments. (Imprint: Nova Biomedical)

Current Advances in Amyotrophic Lateral Sclerosis

Current Advances in Amyotrophic Lateral Sclerosis
  • Author : Alvaro Estévez
  • Publisher :Unknown
  • Release Date :2013-09-11
  • Total pages :266
  • ISBN : 9789535111955
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Summary : Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.

Clinical Neurophysiology of Motor Neuron Diseases

Clinical Neurophysiology of Motor Neuron Diseases
  • Author : Andrew Eisen
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :724
  • ISBN : 0444513590
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Summary : The volume summarizes the most recent knowledge in the field of motor system (upper and lower motor neuron) physiology and pathophysiology as related to diseases of this system. It covers the various aspects of motor system disorders from the motor cortex to the spinal anterior horn cell. Emphasis is placed on clinical disorders as they affect the human motor system and includes critical discussion of advances in techniques for diagnosing and understanding the pathophysiology of disorders affecting the motor system, describing approaches to characterization of disease type, location, severity and prognosis. There is discussion of the specificity and sensitivity of methodological techniques used in diagnosis, with comparison among the various methods.

McLean EMG Guide, Second Edition

McLean EMG Guide, Second Edition
  • Author : Christopher J. Visco, MD
  • Publisher :Unknown
  • Release Date :2019-04-10
  • Total pages :280
  • ISBN : 9780826172136
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Summary : Revised, updated, and expanded second edition of the premier learning guide for residents, McLean EMG Guide emphasizes skills and concepts required for success in mastering basic electrodiagnostic techniques. This step-by-step approach to performing and interpreting EMG and nerve conduction studies will prepare trainees, fellows, and attendings to meet the challenges encountered in daily practice with confidence. The book is broken into short formatted chapters covering instrumentation, basic nerve conduction and needle EMG techniques, interpretation, applications for common clinical problems, and a new chapter on ultrasound. The procedures are laid out as illustrated tables with specifics for lead placement, stimulation, sample waveforms, and photographs to guide electrodiagnostic set-ups. Clinical presentation, anatomy, recommended studies, normal values, pearls and tips, and key findings are presented throughout in bulleted text for a thorough, more focused guidebook. Multiple choice questions and answers with rationales reinforce learning for those wishing to review concepts through self-guided assessment. Key Features Updates to all chapters with new figures and diagrams and more multiple-choice questions with answers Brand new chapter on the use of ultrasound with electrodiagnosis Checklists with key steps and takeaways for each study Clear, easy-to-understand tables and photos illustrate each set-up and study Codifies what you need to know to make a diagnosis in the EMG laboratory Print purchase includes on-line access to the full contents for mobile or desktop use

Neurodegeneration

Neurodegeneration
  • Author : Ted M. Dawson
  • Publisher :Unknown
  • Release Date :2017-04-24
  • Total pages :344
  • ISBN : 9780470672686
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Summary : This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

Update on Amyotrophic Lateral Sclerosis

Update on Amyotrophic Lateral Sclerosis
  • Author : Humberto Foyaca Sibat,Lourdes de Fátima Ibañez-Valdés
  • Publisher :Unknown
  • Release Date :2016-09-14
  • Total pages :280
  • ISBN : 9789535126003
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Summary : This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.

Clinical and Molecular Aspects of Motor Neuron Disease

Clinical and Molecular Aspects of Motor Neuron Disease
  • Author : Johnathan Cooper-Knock,Thomas Jenkins,Pamela J. Shaw
  • Publisher :Unknown
  • Release Date :2013-09-01
  • Total pages :60
  • ISBN : 9781615044290
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Summary : In this e-book, motor neuron disease (MND) shall refer to amyotrophic lateral sclerosis (ALS), the most common neurodegenerative disorder affecting both the upper and lower motor neurons. With the discovery of C9ORF72 expansions in approximately 10% of all MND cases, in certain populations, we stand at the brink of a new era of MND research and hopefully treatment facilitated by the ability to associate a relatively large group of patients with a similar disease mechanism. This review will summarise both current clinical management of MND and our present understanding of the molecular pathogenesis of MND. Study of C9ORF72-MND has the potential to rapidly advance both of these aspects in the coming years.

Motor Neuron Disease, An Issue of Neurologic Clinics,

Motor Neuron Disease, An Issue of Neurologic Clinics,
  • Author : Richard J. Barohn
  • Publisher :Unknown
  • Release Date :2016-01-07
  • Total pages :229
  • ISBN : 9780323413459
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Summary : Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS; Potential environmental factors in ALS; Neuropathology; Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS; Symptoms management and end of life care; Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data; Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?; Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.

Practical Guide to Neurogenetics E-Book

Practical Guide to Neurogenetics E-Book
  • Author : Thomas T. Warner,Simon R. Hammans
  • Publisher :Unknown
  • Release Date :2008-11-04
  • Total pages :344
  • ISBN : 9780702038457
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Summary : This simple guide to neurogenetics demystifies the overwhelming amount of information on the subject so you can identify key clinical features and understand your management options. Reach relevant differential diagnoses and provide appropriate counseling to your patients using the symptom-based approach. By integrating genetic and neurological approaches to diagnoses, this book ensures that the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis are clear and explicit. Concise and portable, this book is ideal for easy reference in clinical use. Details the underlying basic science and clinical features of genetic disorders by taking a symptom-based approach to provide you with a comprehensive understanding of the field. Focuses on the clinical application of neurogenetics to be of practical use to you in the clinic. Clarifies the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis by integrating genetic and neurological approaches to diagnoses. Discusses and evaluates necessary investigations so you know when to use them and when to refer. Highlights diagnostic and therapeutic tips so you can learn new concepts or refine your skills in practice. Refers to online sources, such as Online Mendelian Inheritance in Man (OMIM) and others, to help you supplement your knowledge.

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis
  • Author : Ricardo Tapia
  • Publisher :Unknown
  • Release Date :2015-02-11
  • Total pages :229
  • ISBN : 9782889193769
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Summary : Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS), whereas there is no known cause of the sporadic form of ALS (SALS), which comprises >90% of cases. Both ALS types develop similar histopathological and clinical characteristics, and there is no treatment or prevention of the disease. Because effective treatments for ALS, as for other neurodegenerative diseases, can only result from the knowledge of their cellular and molecular pathophysiological mechanisms, research on such mechanisms is essential. Although progress in neurochemical, physiological and clinical investigations in the last decades has identified several mechanisms that seem to be involved in the cell death process, such as glutamate-mediated excitotoxicity, alterations of inhibitory circuits, inflammatory events, axonal transport deficits, oxidative stress, mitochondrial dysfunction and energy failure, the understanding of the origin and temporal progress of the disease is still incomplete and insufficient. Clearly, there is a need of further experimental models and approaches to discern the importance of such mechanisms and to discover the factors that determine the selective death of motor neurons characteristic of ALS, in contrast to other neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Whereas studies in vitro in cell cultures, tissue slices or organotypic preparations can give useful information regarding cellular and molecular mechanisms, the experiments in living animal models obviously reflect more closely the situation in the human disease, provided that the symptoms and their development during time mimics as close as possible those of the human disease. It is necessary to correlate the experimental findings in vitro with those in vivo, as well as those obtained in genetic models with those in non-genetic models, aiming at designing and testing therapeutic strategies based on the results obtained.

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
  • Author : Lewis P. Rowland
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :569
  • ISBN : UOM:39015020987445
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Summary : A collection of invited papers from a Muscular Dystrophy Association sponsored symposium which highlight findings and theories on the molecular genetics of these diseases, assess concepts on immune-mediated motor neuron destruction and examine the pathogenesis of motor neuron disease.

Motor Neuron Disease

Motor Neuron Disease
  • Author : P.N. Leigh,Michael Swash
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :468
  • ISBN : 9781447118718
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Summary : Here is the first book to provide a comprehensive overview of the clinical, pathological, and research aspects of motor neuron disease (MND). The text contains all essential features of the anatomy, physiology, pharmacology and toxicology of the motor system, a full description of MND and its variants, as well as historical developments and a review of the current concepts and controversies. This book comes at a time of increasing interest in neurodegenerative disorders and MND in particular. It will prove a key reference book with an integrated overview of the field, and will be indispensable to practicing neurologists, researchers, and all those with an interest in MND.

Motor Neuron Disease

Motor Neuron Disease
  • Author : Kevin Talbot,Rachael Marsden,Rachel Botell
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :214
  • ISBN : 9780199547364
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Summary : Written and designed to provide comprehensive, easily accessible advice for all healthcare professionals involved in the care of patients with this challenging condition, this book addresses the entire care pathway from presentation to diagnosis to symptom management and end of life issues.

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
  • Author : Muralidhar L. Hegde
  • Publisher :Unknown
  • Release Date :2020-08-26
  • Total pages :160
  • ISBN : 9781838805807
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Summary : A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.

Spinal Muscular Atrophy

Spinal Muscular Atrophy
  • Author : Charlotte J Sumner,Sergey Paushkin,Chien-Ping Ko
  • Publisher :Unknown
  • Release Date :2016-10-24
  • Total pages :506
  • ISBN : 9780128036860
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Summary : Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Textbook of Neural Repair and Rehabilitation

Textbook of Neural Repair and Rehabilitation
  • Author : Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller
  • Publisher :Unknown
  • Release Date :2014-04-24
  • Total pages :760
  • ISBN : 9781107011687
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Summary : Volume 2 of the Textbook of Neural Repair and Rehabilitation stands alone as a clinical handbook for neurorehabilitation.

The Management of Depression

The Management of Depression
  • Author : Stuart Checkley
  • Publisher :Unknown
  • Release Date :1998-04-15
  • Total pages :488
  • ISBN : 0865429871
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Summary : With a prevalence of 3% to 5% in the general population, depression is the most common mental disorder. Ranging from the almost universal 'blues' to very severe psychotic states in which a patient suffers delusions, hallucinations and paranoia, depression is consequently managed by a wide variety of health-care groups, including GPs, social workers, psychologists, psychiatrists, nurses and counsellors. This book attempts to produce a synthesis of all relevant facts about this range of affective disorders and to make sense of the many different ways they present and are treated by health-care workers. The aims of this book are to describe the social, psychological and physical treatments of depression; to indicate the strengths, weaknesses and indications for each; and to show how they may be used together in the management of depression as it presents from primary to tertiary care and at different stages.