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Nanoparticle Therapeutics

Nanoparticle Therapeutics
  • Author : Prashant Kesharwani,Kamalinder K. Singh,Rajneet Kaur Khurana,Kanchan Kohli
  • Publisher :Unknown
  • Release Date :2021-03-01
  • Total pages :570
  • ISBN : 9780128209189
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Summary : Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states. This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful. Brings together the novel applications of nanotechnology in biological fields Explores perspectives on technologies through highly organized tables, illustrative figures and flow charts Addresses key multidisciplinary challenges faced by nanotechnologists to foster collaboration among biologists, chemists, physicists, engineers and clinicians

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics
  • Author : Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye
  • Publisher :Unknown
  • Release Date :2019-07-08
  • Total pages :432
  • ISBN : 9780128173312
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Summary : Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

RNA Nanotechnology and Therapeutics

RNA Nanotechnology and Therapeutics
  • Author : Peixuan Guo,Farzin Haque
  • Publisher :Unknown
  • Release Date :2013-07-09
  • Total pages :611
  • ISBN : 9781466505667
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Summary : Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

Multifunctional Nanoparticles for Drug Delivery Applications

Multifunctional Nanoparticles for Drug Delivery Applications
  • Author : Sonke Svenson,Robert K. Prud'homme
  • Publisher :Unknown
  • Release Date :2012-02-22
  • Total pages :374
  • ISBN : 9781461423058
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Summary : This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
  • Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
  • Publisher :Unknown
  • Release Date :2017-04-04
  • Total pages :256
  • ISBN : 9780081005637
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Summary : Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents
  • Author : Manju Rawat Singh,Deependra Singh,Nagendra Singh Chauhan,Jagat Kanwar
  • Publisher :Unknown
  • Release Date :2020-03
  • Total pages :320
  • ISBN : 9780128196663
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Summary : Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications.

Nanoscience and Technology

Nanoscience and Technology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9789814466868
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Summary :

Biomedical Application of Nanoparticles

Biomedical Application of Nanoparticles
  • Author : Bertrand Henri Rihn
  • Publisher :Unknown
  • Release Date :2017-09-05
  • Total pages :328
  • ISBN : 9781498750028
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Summary : Biomedical Application of Nanoparticles explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune system and targeted cells. Risk assessment of nanoparticles for human is described, including: cellular paradigms, transcriptomics and toxicogenomics. Finally, the applications of nanoparticles in medicine and antioxidant regenerative therapeutics are presented in several chapters with emphasis on how nanoparticles enhance transport of drugs across biological membrane barriers and therefore may enhance drug bioavailability.

Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics
  • Author : Kinam Park
  • Publisher :Unknown
  • Release Date :2020-03-05
  • Total pages :782
  • ISBN : 9780081029848
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Summary : Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion. Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer Discusses how the properties of specific biomaterials make them important in cancer treatment Covers synthetic vaccines, proteins and polymers for cancer therapeutics

DNA Engineered Noble Metal Nanoparticles

DNA Engineered Noble Metal Nanoparticles
  • Author : Ignác Capek
  • Publisher :Unknown
  • Release Date :2015-03-23
  • Total pages :672
  • ISBN : 9781119120933
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Summary : There is a growing interest in the use of nanoparticles modifiedwith DNAs, viruses, peptides and proteins for the rational designof nanostructured functional materials and their use in biosensorapplications. The challenge is to control the organization ofbiomolecules on nanoparticles while retaining their biologicalactivity as potential chemical and gene therapeutics. Thesenoble metal nanoparticles/biomolecules conjugates have specificproperties and therefore they are attractive materials fornanotechnology in biochemistry and medicine. In this book, the author review work performed dealing with theDNA structure and functionalities, interactions between DNA, noblemetal nanoparticles, surface active agents, solvents and otheradditives. Particular attention is given to how the DNA’schain length and the DNA conformation affect the interaction andstructure of the nanoconjugates and nanostructures that are formed.Also discussed are the recent advances in the preparation,characterization, and applications of noble metal nanoparticlesthat are conjugated with DNA aptamers and oligomers. The advantagesand disadvantages of functionalized nanoparticles through variousdetection modes are highlighted, including colorimetry,fluorescence, electrochemistry, SPR, and, mass spectrometry for thedetection of small molecules and biomolecules. The functionalizednoble metal nanoparticles are selective and sensitive for theanalytes, showing their great potential in biosensing. Furthermore,this book reviews recent progress in the area of DNA-noble metalnanoparticles based artificial nanostructures, that is, thepreparation, collective properties, and applications of variousDNA-based nanostructures are also described.

Biomolecular Engineering of SiRNA Therapeutics

Biomolecular Engineering of SiRNA Therapeutics
  • Author : Joseph A. Gredell
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :316
  • ISBN : MSU:31293030631307
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Summary :

Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications

Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications
  • Author : Qingxin Mu,Bing Yan
  • Publisher :Unknown
  • Release Date :2019-04-03
  • Total pages :229
  • ISBN : 9782889458103
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Summary : Since the invention of nanomedicine decades ago, considerable progresses have been made, especially with cancer as a target. Nanoparticles have been proven to be powerful imaging tools or potent agents for cancer diagnosis, treatment and prevention. Active research spread from fundamental research to clinical investigations. This topic intends to cover several important aspects in this field including nanocarrier development, gene delivery, intrinsically active nanoparticles, tumor microenvironment, immunology, and toxicity.

Advances in Animal Biotechnology and its Applications

Advances in Animal Biotechnology and its Applications
  • Author : Suresh Kumar Gahlawat,Joginder Singh Duhan,Raj Kumar Salar,Priyanka Siwach,Suresh Kumar,Pawan Kaur
  • Publisher :Unknown
  • Release Date :2018-05-29
  • Total pages :401
  • ISBN : 9789811047022
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Summary : This book explores the recent advancements in cutting-edge techniques and applications of Biotechnology. It provides an overview of prospects and applications while emphasizing modern, and emerging areas of Biotechnology. The chapters are dedicated to various field of Biotechnology including, genome editing, probiotics, in-silico drug designing, nanoparticles and its applications, molecular diagnostics, tissue engineering, cryopreservation, and antioxidants. It is useful for both academicians and researchers in the various disciplines of life sciences, agricultural sciences, medicine, and Biotechnology in Universities, Research Institutions, and Biotech companies. This book provides the readers with a comprehensive knowledge of topics in Genomics, Bionanotechnology, Drug Designing, Diagnostics, Therapeutics, Food and Environmental Biotechnology. The chapters have been written with special reference to the latest developments in the frontier areas of Biotechnology that impacts the Biotech industries.

Scientific American

Scientific American
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :229
  • ISBN : UCSD:31822037769106
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Summary :

Cancer: New Insights for the Healthcare Professional: 2012 Edition

Cancer: New Insights for the Healthcare Professional: 2012 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-12-10
  • Total pages :3784
  • ISBN : 9781464969676
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Summary : Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Metal Nanoparticles for Drug Delivery and Diagnostic Applications

Metal Nanoparticles for Drug Delivery and Diagnostic Applications
  • Author : Muhammad Raza Shah,Muhammad Imran,Shafi Ullah
  • Publisher :Unknown
  • Release Date :2019-10-22
  • Total pages :356
  • ISBN : 9780128169605
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Summary : Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science. Illustrates the progression of nanoparticle therapeutics from basic research to applications Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use

Pharmacology and Therapeutics

Pharmacology and Therapeutics
  • Author : Sivakumar Joghi Thatha Gowder
  • Publisher :Unknown
  • Release Date :2014-07-02
  • Total pages :358
  • ISBN : 9789535116202
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Summary : The book "Pharmacology and Therapeutics" targets every aspect of the mechanisms for the chemical actions of both traditional and novel drugs. This book covers six sections: Molecular Modeling and Bio-molecular Pharmacology, Immunopharmacology, Environmental Pharmacology and Toxicology, Nanotechnology and Chemotherapy, Drugs and Drug Delivery System and Addiction Pharmacology. Each of these sections is interwoven with the theoretical aspects and experimental techniques of physiology, biochemistry, nutrition, cellular and molecular biology, microbiology, immunology, genetics, and pathology. This book will be a significant source to scientists, physicians, health care professionals and students who are interested to explore the effect of chemical agents on human life.

Nanoparticles for Biomedical Applications

Nanoparticles for Biomedical Applications
  • Author : Eun Ji Chung,Lorraine Leon,Carlos Rinaldi
  • Publisher :Unknown
  • Release Date :2019-11-19
  • Total pages :440
  • ISBN : 9780128166635
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Summary : Nanoparticles for Biomedical Applications: Fundamental Concepts, Biological Interactions and Clinical Applications brings into one place information on the design and biomedical applications of different classes of nanoparticles. While aspects are dealt with in individual journal articles, there is not one source that covers this area comprehensively. This book fills this gap in the literature. Outlines an in-depth review of biomedical applications of a variety of nanoparticle classes Discusses the major techniques for designing nanoparticles for use in biomedicine Explores safety and regulatory aspects for the use of nanoparticles in biomedicine

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery
  • Author : Ali Demir Sezer
  • Publisher :Unknown
  • Release Date :2014-07-25
  • Total pages :554
  • ISBN : 9789535116288
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Summary : This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Biomedical Applications of Nanoparticles

Biomedical Applications of Nanoparticles
  • Author : Alexandru Mihai Grumezescu
  • Publisher :Unknown
  • Release Date :2019-02-28
  • Total pages :530
  • ISBN : 9780128166307
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Summary : Biomedical Applications of Nanoparticles describes the most interesting and investigated biomedical applications of nanoparticles, emphasizing their therapeutic impact. Progress made in the therapy of severe diseases, such as cancer and difficult infections is strictly correlated to the scientific progress and technological development in the field of materials science. Nanoparticles have numerous therapeutic applications, starting with the design of new drugs, delivery systems, therapeutic materials, and their contribution to the development of preventive strategies. The book highlights the impact of nanoparticles on the therapy of infections, antimicrobial effect and also anti-cancer strategies. Successful examples are given throughout the book, along with analysis in order to improve future outcomes of novel therapies. Highlights the term nanotherapeutics and presents several classifications of nanotherapeutics from different points-of-view Presents the recent progress related to nanotherapeutics in the oral cavity Provides the recent progress in the field of biomedical nanoparticles

RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy

RNA Nanoparticle as a Safe and Effective Drug Delivery Platform for Cancer Therapy
  • Author : Sijin Guo
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :229
  • ISBN : OCLC:1180291735
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Summary : Ribonucleic acid (RNA) nanotechnology is a rapidly emerging field that focuses on the nanostructure design, construction, and application in biotechnology and biomedicine. Unlike other biomacromolecules, RNA is more flexible in structure and more versatile in functionality. On the other hand, RNA is a naturally-occurring biopolymer, making them more biocompatible compared to other nanomaterials. Thus, RNA can serve as a building block to construct nanoparticles as drug delivery platform for cancer therapy. This dissertation primarily describes a fundamental study that explores the immune-compatibility of RNA nanoparticles, as well as the use of thermostable RNA nanoparticles to specifically deliver therapeutics for efficient cancer therapy without causing toxicity. Firstly, RNA polygons that have identical size but varying shapes, or same shape but with different sizes were constructed as study model. The RNA nanoparticles were found to be immunologically inert, indicating that RNA nanoparticles are safe drug carriers without triggering immune responses. On the other hand, they can elicit significant immunomodulation by extending the nanoparticles with special sequences. Specifically, this immunomodulation was found to be size, shape, sequence-dependent, demonstrating the potential of using RNA nanoparticles in immunotherapy. Secondly, the use of a thermostable RNA nanoparticle for solubilizing and high-density loading chemotherapeutic drugs for cancer inhibition is reported. Small chemotherapeutic drugs possess significant anti-cancer activity, but their clinical applications were greatly limited by the poor biocompatibility such as water-insolubility. By chemically conjugating water-insoluble drugs to RNA, the RNA nanoparticles dramatically improved drug water-solubility. An ultra-thermostable RNA four-way junction nanoparticle was able to covalently load twenty-four copies of paclitaxel without nanoparticle dissociation or unfolding. After intravenous administration, the resulting RNA-paclitaxel nanoparticles harboring specific cancer targeting ligand significantly inhibited breast cancer tumor in mice. The toxicity in organs and immune responses in mice were almost undetectable. Besides paclitaxel, this RNA-drug conjugation was applied to another anti-cancer drug, camptothecin, and showed significant inhibitory effect on tumor growth. Furthermore, an acid labile linker was developed within RNA-drug conjugates, aiming at controlling pH-responsive drug release in acidic tumor environment to improve drug efficacy. Thirdly, a three-dimensional RNA cube was constructed and explored as a multi-functional drug carrier by incorporation with different therapeutic modules. This multi-functional RNA cube is able to load chemotherapeutic drug, immunostimulatory molecule, or short-interfering RNA for enhanced cellular effects in vitro. What’s more, the RNA cube can be manipulated to become reconfigurable, suggesting the great potential of drug encapsulation and release for in vivo applications. Collectively, these findings demonstrate that RNA nanoparticles can serve as a biocompatible drug delivery platform for effective cancer therapy with favorable safety profile.