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Neurogenic Inflammation in Health and Disease

Neurogenic Inflammation in Health and Disease
  • Author : Gábor Jancsó
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :346
  • ISBN : 9780444532299
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Summary : Morphological and functional studies revealed a complex system of primary sensory neurons which parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel which transmits pain. * Neurogenic inflammation in historical perspective * Cardiac protection by nociceptive afferents * Molecular mechanisms of nociception * Sensory mechanisms in migraine pathophysiology * Vagal signalling of visceral inflammation * Neurogenic mechanisms in arthritis * Therapeutic implications of vanilloid-type compounds

NGF and Related Molecules in Health and Disease

NGF and Related Molecules in Health and Disease
  • Author : L. Aloe,L. Calza
  • Publisher :Unknown
  • Release Date :2003-12-10
  • Total pages :570
  • ISBN : 0080497500
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Summary : The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.

Environmental Health Perspectives

Environmental Health Perspectives
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :229
  • ISBN : MINN:30000003295593
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Summary :

Report of the Advisory Committee on Research on Women's Health

Report of the Advisory Committee on Research on Women's Health
  • Author : Office of Research on Women's Health,United States. Advisory Committee on Research on Women's Health,National Institutes of Health (U.S.). Office of Research on Women's Health
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :367
  • ISBN : UOM:39015050739138
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Summary :

Cell Surface Peptidases in Health and Disease

Cell Surface Peptidases in Health and Disease
  • Author : A.J. Kenny,C.M. Boustead
  • Publisher :Unknown
  • Release Date :1997-07
  • Total pages :384
  • ISBN : CORNELL:31924080084951
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Summary : Cells bristle with a battery of surface enzymes, of which the peptidases form the largest and best studied group. These ectopeptidases play crucial roles in many diverse biological functions, including the termination of peptide signals in the nervous system and at peripheral sites. Some of their key physiological roles, such as those of angiotensin- and endothelin-converting enzymes in generating vasoconstrictive agents and endopeptidase-24.11 in activating natriuretic peptides, enkephalins and tachykinins, have made them prime targets for the pharmaceutical industry. Interest among immunologists and haematologists was aroused when several were shown to be identical to cell-surface markers (CD antigens) on human leukocytes. Virologists have been excited to find that some double as receptors for certain viruses.

The American Review of Respiratory Disease

The American Review of Respiratory Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1987-10
  • Total pages :229
  • ISBN : NWU:35558001324041
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Summary : Includes Abstracts section, previously issued separately.

The Periodontal Ligament in Health and Disease

The Periodontal Ligament in Health and Disease
  • Author : B. K. B. Berkovitz,B. J. Moxham,Hubert N. Newman
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :446
  • ISBN : UOM:39015034413107
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Summary :

The Brain and Host Defense

The Brain and Host Defense
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009-12-24
  • Total pages :358
  • ISBN : 0444535454
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Summary : It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Mast Cell and Basophil Differentiation and Function in Health and Disease

Mast Cell and Basophil Differentiation and Function in Health and Disease
  • Author : Stephen J. Galli,Karl Frank Austen
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :348
  • ISBN : UOM:39015014484169
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Summary :

The British National Bibliography

The British National Bibliography
  • Author : Arthur James Wells
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :229
  • ISBN : STANFORD:36105211722678
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Summary :

American Journal of Respiratory and Critical Care Medicine

American Journal of Respiratory and Critical Care Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :229
  • ISBN : NWU:35558004862906
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Summary :

Human Microbiota in Health and Disease

Human Microbiota in Health and Disease
  • Author : Bryan Tungland
  • Publisher :Unknown
  • Release Date :2018-05-25
  • Total pages :680
  • ISBN : 9780128146507
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Summary : Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion on all the aspects associated with the early colonization of gut microbiota, its development and maintenance, and its symbiotic relationship with the host in promoting health. Chapters illustrate the complex mechanisms and metabolic signaling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, all while mediating inflammatory processes involved in the etiology of many chronic disease conditions. With today's common use of pharmaceutical medicine in treating symptoms and frequent overuse of antibiotics in chronic disease within mainstream medical practice, our understanding of the etiological mechanisms of dysbiosis-induced chronic disease and natural approaches to prevention and potential cures for these diseases is of vital importance to overall human health. Details the complex relationship between human microbiota in the gut, oral cavity and skin as well as their colonization, development and impact of factors that influence the relationship Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification and pro- and prebiotics in preventing chronic disease

Transient Receptor Potential Channels

Transient Receptor Potential Channels
  • Author : Md. Shahidul Islam
  • Publisher :Unknown
  • Release Date :2011-02-04
  • Total pages :1095
  • ISBN : 9400702655
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Summary : Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.

Smell and Taste in Health and Disease

Smell and Taste in Health and Disease
  • Author : Thomas V. Getchell,Linda Bartoshuk,Richard L. Doty,James Byron Snow
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :883
  • ISBN : UOM:39015021992196
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Summary : Detailed reference to basic science & clinical aspects behavioral components effects of systemic diseases & drugs.

Allergy

Allergy
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :229
  • ISBN : UCLA:L0078127651
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Summary :

Capillary Fluid Exchange

Capillary Fluid Exchange
  • Author : Joshua Scallan,Virginia Heathorn Huxley,Ronald J. Korthuis
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :86
  • ISBN : 9781615040667
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Summary : The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation

Stress in Health and Disease, An Issue of Psychiatric Clinics of North America,

Stress in Health and Disease, An Issue of Psychiatric Clinics of North America,
  • Author : Daniel L. Kirsch
  • Publisher :Unknown
  • Release Date :2014-12-27
  • Total pages :281
  • ISBN : 9780323326773
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Summary : Stress in the DSM is referred to only in the sense of post traumatic stress disorder (PTSD). However, some research studies estimate up to two thirds of illnesses seen by general practitioners are ‘stress related’–GI problems, sleep disturbance, mental concentration, headaches, fatigue, shortness of breath, high blood pressure, dermatitis, illnesses from lowered immune system, and vague aches and pains – all can be symptoms and outcomes of the elusive stress factor. This issue of Psychiatric Clinics of North America discusses the scientific medical facets of stress, written by mental health and medical practitioners. It looks at the brain-body connection of stress – what the body does to result in stress and varying results stress has on the body. This fascinating cross-discipline look at stress is intended for psychiatrists, general practitioners, cardiologists, GI specialists, neurologists, sleep medicine specialists, respiratory specialists, and others who diagnose and treat patients with stress suspected as part of the illness equation or with self-reported stress. Topics include: Measurement of stress; Anxiety and stress-how they work together; Relationship between genetics and stress; Role of glia in stress; Sleep and stress; Diet and stress; Supplements and stress; Effect of severe stress on early brain development, attachment, and emotions; Role of stress and fear on the development of psychopathology; Expressions of stress in psychiatric illness; Dermatologic manifestations of stress in normal and psychiatric populations; Humor and the psychological buffers of stress; Stress expression in children and adolescents; Stress in service members; Stress in the geriatric population.

Pathophysiology of the Gut and Airways

Pathophysiology of the Gut and Airways
  • Author : Paul L. R. Andrews,John G. Widdicombe
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :124
  • ISBN : CHI:44116143
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Summary : Part of a series designed to clarify the complex and difficult areas of physiology, this book deals with the pathophysiology of gut and airways. Topics covered include hypersecretion in the airways, and the pathophysiology of cystic fibrosis in the gastrointestinal tract.

Inflammatory Bowel Disease

Inflammatory Bowel Disease
  • Author : Joseph B. Kirsner
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :800
  • ISBN : UOM:39015048934429
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Summary : World-renowned experts present state-of-the-art information in the clinical understanding of inflammatory bowel disease in the 5th Edition of this best-selling text. Scholarly and pragmatic, this text features authoritative information on the medical and surgical management of IBD with the support of over 390 illustrations. Features many new chapters, including those covering intestinal permeability in health and disease, the intestinal response to acute inflammation and injuries, and current concepts of IBD etiology and pathogenesis.

Asthma

Asthma
  • Author : Peter J. Barnes,Ian W. Rodger,Neil C. Thomson
  • Publisher :Unknown
  • Release Date :1992
  • Total pages :782
  • ISBN : UOM:39015028429556
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Summary : The Second Edition of this highly successful text includes all the virtues of the first--all aspects of research on the causative mechanisms of asthma and its treatment as well as exhaustive and extensive chapter references. The book has expanded in line with recent research findings. Of special note is the inclusion of important advances in the understanding of the basic inflammatory process in asthma--the role of individual cells, and the role of multiple inflammatory mediators. Comprehensive coverage of both basic science and clinical aspectrs of asthma Exhaustively referenced throughout

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
  • Author : Stephen Sonis,Alessandro Villa
  • Publisher :Unknown
  • Release Date :2019-09-14
  • Total pages :458
  • ISBN : 9780128137635
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Summary : Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care