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Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
  • Author : Xin Tang
  • Publisher :Unknown
  • Release Date :2020-06-19
  • Total pages :766
  • ISBN : 9780128153192
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Summary : In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field. Summarizes roles of KCCs and NKCCs in regulating inhibitory and excitatory neurotransmission Reviews the molecular and cellular biology of neuronal chloride transporters Links neuronal chloride transporter deficiencies to autism, epilepsy, depression, and more Identifies role of transporter deficiencies in pain as well as brain and spinal cord injury Discusses drug research targeting neuronal chloride transporters for nervous system diseases

Ion Channels in Health and Disease

Ion Channels in Health and Disease
  • Author : Geoffrey S. Pitt
  • Publisher :Unknown
  • Release Date :2016-10-04
  • Total pages :392
  • ISBN : 9780128020173
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Summary : Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Red Cell Membrane Transport in Health and Disease

Red Cell Membrane Transport in Health and Disease
  • Author : Ingolf Bernhardt,J. Clive Ellory
  • Publisher :Unknown
  • Release Date :2003-04-17
  • Total pages :748
  • ISBN : 3540442278
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Summary : 51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans,Eric Delpire
  • Publisher :Unknown
  • Release Date :2009-08-22
  • Total pages :630
  • ISBN : 0080922031
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Summary : The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Chlorine Compounds: Advances in Research and Application: 2011 Edition

Chlorine Compounds: Advances in Research and Application: 2011 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :203
  • ISBN : 9781464924415
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Summary : Chlorine Compounds: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chlorine Compounds. The editors have built Chlorine Compounds: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chlorine Compounds in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chlorine Compounds: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Neuroscience Research and Application: 2011 Edition

Issues in Neuroscience Research and Application: 2011 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :3141
  • ISBN : 9781464963605
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Summary : Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Epithelial Anion Transport in Health and Disease

Epithelial Anion Transport in Health and Disease
  • Author : Novartis Foundation
  • Publisher :Unknown
  • Release Date :2006-08-25
  • Total pages :273
  • ISBN : UOM:39015069162645
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Summary : This book offers a comprehensive account of the function of this family of anion transporters in transepithelial fluid and electrolyte secretion and contains valuable insight into the diseases that arise when these are peturbed.

The olivo-cerebellar system

The olivo-cerebellar system
  • Author : Egidio D'Angelo,Elisa Galliano,Chris I De Zeeuw
  • Publisher :Unknown
  • Release Date :2016-04-29
  • Total pages :229
  • ISBN : 9782889198269
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Summary : During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Other major aspects that this Research Topic covers and discusses include the development and circuit organization of the olivo-cerebellar network, the established and recent theories of learning and motor control, and the emerging role of the cerebellum in cognitive processing. By touching on such varied and encompassing subjects, this Frontiers Special Topic aims to highlight the state of the art and stimulate future research. We hope that this unique collection of high-quality articles from experts in the field will provide scientists with a powerful basis of knowledge and inspiration to enucleate the major issues deserving further attention.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans,Eric Delpire
  • Publisher :Unknown
  • Release Date :2009-08-22
  • Total pages :630
  • ISBN : 0080922031
GET BOOK HERE

Summary : The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Taurine in Health and Disease

Taurine in Health and Disease
  • Author : Ryan J. Huxtable,Dietrich Michalk
  • Publisher :Unknown
  • Release Date :2013-11-21
  • Total pages :458
  • ISBN : 9781489914712
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Summary : Taurine, or 2-aminoethane sulfonic acid, has long been known to be the major organic product formed from the breakdown of the sulfur-containing amino acids, methionine and cysteine. It is excreted as such in the urine or as bile acid conjugates in the bile. Research over the last 25 years, however, has uncovered an amazing variety of phenomena involving taurine. Despite the fact that the mechanism of action of taurine in some of these phenomena remains to be elucidated, it is clear that taurine is of far more physiological relevance than being the mere metabolic debris of sulfur amino acid catabolism. It also has numerous pharmacological actions that are beginning to be developed, as exemplified by some of the studies reported in this volume. This volume reports the proceedings of the latest of a series of international symposia, continuing on from the initial meeting held in Tucson, Arizona, in 1975. The latest symposium was the first to be held in Germany, in Cologne from August 29 through September 1, 1993. It continued the multidisciplinary approach that has been the norm for taurine symposia. We hope the publication of the proceedings will stimulate further investigations on this simple but fascinating compound.

GABA And Glutamate

GABA And Glutamate
  • Author : Janko Samardzic
  • Publisher :Unknown
  • Release Date :2018-03-21
  • Total pages :138
  • ISBN : 9789535138211
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Summary : This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Cellular Calcium and Phosphate Transport in Health and Disease

Cellular Calcium and Phosphate Transport in Health and Disease
  • Author : Felix Bronner,Meinrad Peterlik
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :426
  • ISBN : UOM:39015012591411
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Summary :

Autonomic Neuroimmunology

Autonomic Neuroimmunology
  • Author : John Bienenstock,M. Blennerhassett,E. Goetzl
  • Publisher :Unknown
  • Release Date :2003-02-13
  • Total pages :416
  • ISBN : 9780415306584
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Summary : While it may appear that the nervous and immune systems exist as two separate entities, groundbreaking observations have positively identified anatomic connections between elements of the nervous system and cells of adaptive immunity. Building on this research, Autonomic Neuroimmunology presents a scientific discussion of the current understanding of these vital neuroimmunological interactions and their implications for normal psychology and disease states. Contributors document the cell biological mechanisms for the neuropeptide activation of mast cells, and analyze how one or more adrenergenic and peptidergic messengers modulate immunity. They also explain the pathways by which cholinergic factors may suppress immunological inflammation. The potential implications of organ system-selective neuroimmunology for host defense and diseases are thoroughly discussed for the skin, the intestines, the bladder, and the lungs. With modern neuroimmunology now firmly established as a scientific discipline, this volume supports this promising science as a pathway to novel diagnostic and therapeutic techniques for diseases of the neural, immune, and endocrine systems.

The Control of Food and Fluid Intake in Health and Disease

The Control of Food and Fluid Intake in Health and Disease
  • Author : Michael J. G. Farthing,Dilip Mahalanabis
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :315
  • ISBN : UOM:39015056843637
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Summary : Written by an international group of noted scientists and clinicians, this volume examines the latest findings on the control of nutritional and fluid balance in health and in various disease states. The contributors provide new insights into the role of the brain and gut in regulating nutrient intake, the mechanisms by which fluid homeostasis is disturbed in disease, and the pathogenesis and treatment of acute and chronic diarrhea, dehydration, anorexia, and obesity. Coverage includes discussions of recent developments in oral rehydration therapy, novel interventions for disease-related anorexia, and new approaches to the reduction and control of body fat mass.

Handbook of Ion Channels

Handbook of Ion Channels
  • Author : Jie Zheng,Matthew C. Trudeau
  • Publisher :Unknown
  • Release Date :2015-02-25
  • Total pages :691
  • ISBN : 9781466551428
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Summary : The New Benchmark for Understanding the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs. Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.

Vitamin C in Health and Disease

Vitamin C in Health and Disease
  • Author : Anitra C. Carr,Jens Lykkesfeldt
  • Publisher :Unknown
  • Release Date :2018-08-09
  • Total pages :298
  • ISBN : 9783038970293
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Summary : This book is a printed edition of the Special Issue "Vitamin C in Health and Disease" that was published in Nutrients

Avery's Diseases of the Newborn E-Book

Avery's Diseases of the Newborn E-Book
  • Author : Christine A. Gleason,Sherin Devaskar
  • Publisher :Unknown
  • Release Date :2011-08-12
  • Total pages :1520
  • ISBN : 9781455727148
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Summary : Avery’s Diseases of the Newborn, edited by Christine A. Gleason and Sherin U. Devaskar, is a practical, clinical reference for diagnosing and managing of all the important diseases affecting newborns. Thoroughly revised by a team of new editors, this edition provides new perspectives and updated coverage of genetics, nutrition, respiratory conditions, MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and more. This authoritative reference is ideal as a clinical resource or subspecialty review tool. Treat newborns effectively with focused coverage of diagnosis and management, including pertinent developmental physiology and the pathogenesis of neonatal problems. Meet every challenge you face in neonatology with Avery’s authoritative, comprehensive clinical resource and subspecialty review tool. Navigate quickly and easily with extensive cross-referencing throughout the organ-related sections. Stay current with coverage of hot topics including MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and the developing intestinal microbiome. Tap into the fresh perspectives of new editors who provide extensive updates throughout, particularly on genetic and respiratory disorders. Apply the latest nutritional findings with thorough discussions of this valuable information in the more comprehensive nutrition section. Master the fundamentals of neonatology through the greater emphasis on developmental biology and pathobiology.

Ion Channels in Health and Sickness

Ion Channels in Health and Sickness
  • Author : Fatima Shad Kaneez
  • Publisher :Unknown
  • Release Date :2018-10-10
  • Total pages :202
  • ISBN : 9781789842272
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Summary : Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :229
  • ISBN : UOM:39015035205858
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Summary :

Smell and Taste in Health and Disease

Smell and Taste in Health and Disease
  • Author : Thomas V. Getchell,Linda Bartoshuk,Richard L. Doty,James Byron Snow
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :883
  • ISBN : UOM:39015021992196
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Summary : Detailed reference to basic science & clinical aspects behavioral components effects of systemic diseases & drugs.

Pharmacology

Pharmacology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1993-07
  • Total pages :229
  • ISBN : NWU:35558003114952
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Summary :