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Nitric Oxide Donors

Nitric Oxide Donors
  • Author : Peng George Wang,Tingwei Bill Cai,Naoyuki Taniguchi
  • Publisher :Unknown
  • Release Date :2005-08-16
  • Total pages :407
  • ISBN : 3527603840
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Summary : Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.

Nitric Oxide Donors

Nitric Oxide Donors
  • Author : Amedea Seabra
  • Publisher :Unknown
  • Release Date :2017-03-17
  • Total pages :364
  • ISBN : 0128134593
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Summary : Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

Nitric Oxide (Donor/Induced) in Chemosensitization

Nitric Oxide (Donor/Induced) in Chemosensitization
  • Author : Benjamin Bonavida
  • Publisher :Unknown
  • Release Date :2017-06-28
  • Total pages :248
  • ISBN : 012811021X
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Summary : Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

Role of Free Radicals in the Bioactivation of Nitric Oxide Donors

Role of Free Radicals in the Bioactivation of Nitric Oxide Donors
  • Author : Samir Lutf M. Y. Aleryani
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :226
  • ISBN : 09876543XX
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Summary :

Antiinflammatory and Antithrombotic Effects of Nitric Oxide Donors

Antiinflammatory and Antithrombotic Effects of Nitric Oxide Donors
  • Author : Alessandra Meneguzzi
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :93
  • ISBN : 09876543XX
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Summary :

Novel Nitric Oxide Donors for Use in Medicinal Applications

Novel Nitric Oxide Donors for Use in Medicinal Applications
  • Author : Melinda Kay Carnahan
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :162
  • ISBN : 09876543XX
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Summary : "The medicinal benefits of the nitric oxide (NO) donor compounds termed diazeniumdiolates are well established and include antithrombic, cytostatic, and vasorelaxant activities. Additionally, fendiline, a coronary vasodilator, increases intracellular NO concentrations via interaction with the Ca2 cascade. Modification of fendiline with NO generates a new, lipophilic member of the diazeniumdiolate family, fendiline diazeniumdiolate (FDL-NONa), which has increased potential as a pharmaceutical NO donor and multiple applications in the coronary health market. This bifunctional vasodilator, when dissolved in methanol and buffer solution, releases NO to generate a half-life of 1.6 hours at 37°C and pH 7.4. Extension of this half-life can be achieved by varying the water insoluble particulate size of the donor in PBS. Furthermore, excellent binding of FDL-NONa to both glass and metal surfaces provides a direct correlation between coating thickness and NO release while decomposition of the compound in vivo generates species which pose no health concern. In additional [sic] to numerous functions within the cardiovascular system, NO has also been established as an indispensable participant in the wound healing cascade. Based on these findings, multiple NO-based wound dressings have been developed for employment in impaired wound healing scenarios. One example is the ascorbic acid/nitrate patch, which has displayed very promising results in both diabetic and lechmaniasis wounds, however has several drawbacks including donor half-life, patch stability and product manufacturing costs. To correct these problems, a new two-layer, PAN-NO (polyacrylonitrile modified with nitric oxide) pouch has been developed. Modification of previously electrospun PAN nanofibers results in the formation of a new polymeric PAN-NO patch that provides a 30 min increase in patch half-life, with extension of the total release time by 4 to 5 h and a nearly 17x increase in NO release from the four-layer, ascorbic acid/nitrite patch when modified in sodium trimethylsilanolate/1,4-dioxane or a 4 h increase in patch half-life, with an extension of the total release time by 27 to 28 h and a comparable NO/mg release when modified in sodium methoxide. Insertion of either form of PAN-NO into a heat-sealed, ascorbic acid poudh forms a second generation, NO-donating wound dressing, with reduced manufacturing costs and improved NO release kinetics."--Abstract.

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
  • Author : Lucia Morbidelli,Benjamin Bonavida
  • Publisher :Unknown
  • Release Date :2019-02-09
  • Total pages :372
  • ISBN : 0128172797
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Summary : Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Nitrosation Reactions and the Chemistry of Nitric Oxide

Nitrosation Reactions and the Chemistry of Nitric Oxide
  • Author : D.L.H. Williams
  • Publisher :Unknown
  • Release Date :2004-12-16
  • Total pages :280
  • ISBN : 9780080473604
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Summary : Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until around 1990. * Provides an update on previously published literature on nitric oxide chemistry * Contains chapters on reagents for nitrosation, nitrosation at nitrogen, aliphatic and aromatic carbon, oxygen, sulfur and metal centres * Looks at hot research topics such as synthesis, properties and reactions of s-nitrosothiols

Nitric Oxide, Part C: Biological and Antioxidant Activities

Nitric Oxide, Part C: Biological and Antioxidant Activities
  • Author : Lester Packer,Enrique Cadenas
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :589
  • ISBN : 9780121822026
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Summary : General Description of the Volume: Nitric Oxide, recently designated "Molecule of the Year," impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume will be a valuable resource for the experienced researcher as well as for those newly entering the field. This volume continues the coverage of new and important tools for the elucidation of Nitric Oxide action initiated in Volumes 268 and 269 of Methods in Enzymology. Techniques for researching the physiology and toxicity of nitric oxide in cellular and organismal systems are highlighted. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Biological Activity * NO Donors: Nitrosothiols and Nitroxyls * Peroxynitrite * Oxidant and Antioxidant Action

Nitric Oxide (NO) and Cancer

Nitric Oxide (NO) and Cancer
  • Author : Benjamin Bonavida
  • Publisher :Unknown
  • Release Date :2010-06-16
  • Total pages :250
  • ISBN : 9781441914323
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Summary : Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

Nitric Oxide and the Cardiovascular System

Nitric Oxide and the Cardiovascular System
  • Author : Joseph Loscalzo,Joseph A. Vita
  • Publisher :Unknown
  • Release Date :2000-03-29
  • Total pages :601
  • ISBN : 1592590020
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Summary : Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Photoactive Nitric Oxide Donors

Photoactive Nitric Oxide Donors
  • Author : Genevieve M. Halpenny
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :450
  • ISBN : 09876543XX
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Summary :

Pathophysiology and Clinical Applications of Nitric Oxide

Pathophysiology and Clinical Applications of Nitric Oxide
  • Author : Gabor M. Rubanyi
  • Publisher :Unknown
  • Release Date :2003-09-02
  • Total pages :660
  • ISBN : 0203303725
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Summary : Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Synthesis and Characterization of Dendrimer-based Nitric ...

Synthesis and Characterization of Dendrimer-based Nitric ...
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :229
  • ISBN : 09876543XX
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The Biology of Nitric Oxide

The Biology of Nitric Oxide
  • Author : S. Moncada
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :353
  • ISBN : 09876543XX
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Summary : These are the proceedings of 4th International Meeting on the Biology of Oxides, 1995. The book provides an overview of the current status of the field with contributions from over 450 specialists including the areas of enzymology, molecular cloning, and the biochemical actions of NO.

Study of Polymeric Donors for Antimicrobial Nitric Oxide Delivery

Study of Polymeric Donors for Antimicrobial Nitric Oxide Delivery
  • Author : Wanzheng Fu
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Nitric Oxide Hybrids & Machine-assisted Synthesis of Meclinertant. Nitric Oxide Donors/COX-2 Inhibitors and Flow Synthesis of Meclinertant

Nitric Oxide Hybrids & Machine-assisted Synthesis of Meclinertant. Nitric Oxide Donors/COX-2 Inhibitors and Flow Synthesis of Meclinertant
  • Author : Claudio Battilocchio
  • Publisher :Unknown
  • Release Date :2015
  • Total pages :229
  • ISBN : 9788898533541
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Nitric Oxide Synthase: Characterization and Functional Analysis

Nitric Oxide Synthase: Characterization and Functional Analysis
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1996-09-18
  • Total pages :354
  • ISBN : 9780080536378
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Summary : Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field. Comprehensive protocols included for detection of NO and related compounds by chemical, immunohistochemical, and in situ hybridization techniques Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution

Nitric Oxide

Nitric Oxide
  • Author : Louis J. Ignarro
  • Publisher :Unknown
  • Release Date :2000-09-13
  • Total pages :1017
  • ISBN : 9780080525037
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Summary : Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Placental-Fetal Growth Restriction

Placental-Fetal Growth Restriction
  • Author : Christoph Lees,Gerard H. A. Visser,Kurt Hecher
  • Publisher :Unknown
  • Release Date :2018-08-02
  • Total pages :294
  • ISBN : 1107101395
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Summary : Master the effective evaluation of placental-fetal growth restriction (PFGR), whilst reducing the risk of perinatal mortality and morbidity in patients worldwide.

Nitric Oxide

Nitric Oxide
  • Author : Paul Kubes
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :171
  • ISBN : 09876543XX
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Summary :