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Non-Enzymatic Protein Modifications in Health, Disease and Ageing

Non-Enzymatic Protein Modifications in Health, Disease and Ageing
  • Author : Izabela Sadowska-Bartosz,Grzegorz Bartosz
  • Publisher :Unknown
  • Release Date :2018-11-15
  • Total pages :252
  • ISBN : 0128143053
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Summary : There is increased understanding of the fate of intracellular and extracellular proteins, including the many types of posttranslational modifications that proteins undergo. Among these modifications, non-enzymatic protein modifications play a special role. These are unavoidable products of side reactions of reactive metabolites, and often damage proteins and induce loss of function. Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, both introducing non-enzymatic protein modifications, and reviewing the state of the art, presenting updates and current trends. The book covers various aspects of the subject, including formation and removal of modified proteins, their roles in disease, preventative methods, and possible roles in cellular signalling. Finally, the book not only provides well-established facts, but also discusses current hypotheses and controversies. Provides the basic chemical knowledge necessary to understand non-enzymatic protein modifications, of particular use to researchers looking for an introduction to and overview of the field Combines a systematic chemical introduction to non-enzymatic protein modifications with a review of the state of the art Presents together, types of non-enzymatic protein usually reported and reviewed separately Considers current hypotheses and controversies alongside the facts

Providing Healthy and Safe Foods As We Age

Providing Healthy and Safe Foods As We Age
  • Author : Institute of Medicine,Food and Nutrition Board,Food Forum
  • Publisher :Unknown
  • Release Date :2010-11-29
  • Total pages :192
  • ISBN : 9780309158831
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Summary : Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.

Molecular Basis and Emerging Strategies for Anti-aging Interventions

Molecular Basis and Emerging Strategies for Anti-aging Interventions
  • Author : Syed Ibrahim Rizvi,Ufuk Çakatay
  • Publisher :Unknown
  • Release Date :2018-11-02
  • Total pages :386
  • ISBN : 9789811316999
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Summary : This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Protein Metabolism and Homeostasis in Aging

Protein Metabolism and Homeostasis in Aging
  • Author : Nektarios Tavernarakis
  • Publisher :Unknown
  • Release Date :2011-01-11
  • Total pages :249
  • ISBN : 9781441970022
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Summary : Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America
  • Author : National Academy of Sciences (U.S.)
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :229
  • ISBN : MINN:31951P00155733A
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Summary :

The Aging Kidney in Health and Disease

The Aging Kidney in Health and Disease
  • Author : Juan F. Macías-Núñez,J. Stewart Cameron,Dimitrios G. Oreopoulos
  • Publisher :Unknown
  • Release Date :2007-11-24
  • Total pages :553
  • ISBN : 9780387726595
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Summary : This volume will be a reliable source on the management of the elderly with renal disease. There is an ever-increasing proportion of the aging population affected by renal disease and hypertension, and physicians are faced with atypical clinical presentations of renal disease in the aged as compared to younger people. This volume combines the fields of nephrology and geriatrics and presents a multidisciplinary approach to the topic.

Cellular Mechanics and Biophysics

Cellular Mechanics and Biophysics
  • Author : Claudia Tanja Mierke
  • Publisher :Unknown
  • Release Date :2020-10-30
  • Total pages :900
  • ISBN : 9783030585327
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Summary : This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.

Lung Macrophages in Health and Disease

Lung Macrophages in Health and Disease
  • Author : Sandra Hodge
  • Publisher :Unknown
  • Release Date :2009-09-12
  • Total pages :120
  • ISBN : 9781608050208
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Summary : "This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. The book consists of 8 chapters which provide a full coverage of macrophage function in both healthy and chronically diseased lungs, "

Departments of Labor, Health and Human Services, Education, and related agencies appropriations for 1990

Departments of Labor, Health and Human Services, Education, and related agencies appropriations for 1990
  • Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :229
  • ISBN : UOM:39015019140709
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Summary :

Examining the Causal Relationship Between Genes, Epigenetics, and Human Health

Examining the Causal Relationship Between Genes, Epigenetics, and Human Health
  • Author : Wambuguh, Oscar J.
  • Publisher :Unknown
  • Release Date :2019-03-22
  • Total pages :603
  • ISBN : 9781522580676
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Summary : For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.

Exercise as a Countermeasure to Human Aging

Exercise as a Countermeasure to Human Aging
  • Author : Bradley Elliott,Lawrence D. Hayes,David C. Hughes,Martin Burtscher
  • Publisher :Unknown
  • Release Date :2020-11-12
  • Total pages :229
  • ISBN : 9782889660100
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Summary :

Epigenetics of Aging

Epigenetics of Aging
  • Author : Trygve O. Tollefsbol
  • Publisher :Unknown
  • Release Date :2009-11-11
  • Total pages :469
  • ISBN : 1441906398
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Summary : Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders
  • Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
  • Publisher :Unknown
  • Release Date :2020-02-14
  • Total pages :515
  • ISBN : 9781799813187
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Summary : Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Reviews and Perspectives in Physiology 2002

Reviews and Perspectives in Physiology 2002
  • Author : Physiological Society (Great Britain),The Physiological Society
  • Publisher :Unknown
  • Release Date :2002-07-29
  • Total pages :138
  • ISBN : 0521525810
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Summary : Brings together the Perspectives and Topical Reviews published during 2000 in The Journal of Physiology.

Vital Dust

Vital Dust
  • Author : Christian De Duve
  • Publisher :Unknown
  • Release Date :1995-01-03
  • Total pages :384
  • ISBN : UCSD:31822028296507
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Summary : Is the emergence of life on Earth the result of a single chance event or combination of lucky accidents, or is it the outcome of biochemical forces woven into the fabric of the universe? And if inevitable, what are these forces, and how do they account not only for the origin of life but also for its evolution toward increasing complexity? Vital Dust is a groundbreaking history of life on Earth, a history that only someone of Chrisitian de Duve's stature and erudition could have written.

Advances in Clinical Chemistry

Advances in Clinical Chemistry
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2015-10-12
  • Total pages :324
  • ISBN : 9780128033159
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Summary : Advances in Clinical Chemistry, Volume 72, the latest installment in this internationally acclaimed series contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. Contains the expertise of international contributors Provides the latest cutting-edge technologies in the field Authored by world-renowned clinical laboratory scientists, physicians, and research scientists

The Journal of Experimental Medicine

The Journal of Experimental Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1987
  • Total pages :229
  • ISBN : UCAL:B4978377
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Summary :

The Chemistry of Food

The Chemistry of Food
  • Author : Jan Velisek,Richard Koplik,Karel Cejpek
  • Publisher :Unknown
  • Release Date :2020-07-21
  • Total pages :1200
  • ISBN : 9781119537656
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Summary : Wiley's landmark food chemistry textbook that provides an all-in-one reference book, revised and updated The revised second edition of The Chemistry of Food provides a comprehensive overview of important compounds constituting of food and raw materials for food production. The authors highlight food’s structural features, chemical reactions, organoleptic properties, nutritional, and toxicological importance. The updated second edition reflects the thousands of new scientific papers concerning food chemistry and related disciplines that have been published since 2012. Recent discoveries deal with existing as well as new food constituents, their origin, reactivity, degradation, reactions with other compounds, organoleptic, biological, and other important properties. The second edition extends and supplements the current knowledge and presents new facts about chemistry, legislation, nutrition, and food safety. The main chapters of the book explore the chemical structure of substances and subchapters examine the properties or uses. This important resource: • Offers in a single volume an updated text dealing with food chemistry • Contains complete and fully up-to-date information on food chemistry, from structural features to applications • Features several visual aids including reaction schemes, diagrams and tables, and nearly 2,000 chemical structures • Written by internationally recognized authors on food chemistry Written for upper-level students, lecturers, researchers and the food industry, the revised second edition of The Chemistry of Food is a quick reference for almost anything food-related as pertains to its chemical properties and applications.

Glycoproteins—Advances in Research and Application: 2013 Edition

Glycoproteins—Advances in Research and Application: 2013 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2013-06-21
  • Total pages :261
  • ISBN : 9781481688246
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Summary : Glycoproteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Protein S. The editors have built Glycoproteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein S in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glycoproteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Oxidative Stress and Chronic Degenerative Diseases

Oxidative Stress and Chronic Degenerative Diseases
  • Author : Jose Antonio Morales-Gonzalez
  • Publisher :Unknown
  • Release Date :2013-05-22
  • Total pages :514
  • ISBN : 9789535111238
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Summary : This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Textbook of Men's Health and Aging

Textbook of Men's Health and Aging
  • Author : Bruno Lunenfeld,Louis JG Gooren,Alvaro Morales,John Morley
  • Publisher :Unknown
  • Release Date :2007-12-20
  • Total pages :766
  • ISBN : 0203089790
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Summary : The first edition of "Textbook of Men's Health" did much to establish and define the scope of the emerging subspecialty of aging men's health. This revised and updated edition, with new sections on basic sciences and sexual dysfunction, has a small but significant change of approach - reflected in the new title. The central mission of the new editi