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• Author : Maie A. St. John,No hee Park
• Publisher :Unknown
• Release Date :2020-06-29
• Total pages :266
• ISBN : 9780128209295

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Summary : Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

• Author : Claudiu Supuran,Simone Carradori
• Publisher :Unknown
• Release Date :2020-09-15
• Total pages :228
• ISBN : 9780128209288

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Summary : pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

• Author : Goli Samimi,Christina Annunziata
• Publisher :Unknown
• Release Date :2020-11-19
• Total pages :188
• ISBN : 9780128198414

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Summary : Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

• Author : Luc Friboulet
• Publisher :Unknown
• Release Date :2021-01-18
• Total pages :216
• ISBN : 9780128217795

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Summary : Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

• Author : Andrew Freywald,Franco Vizeacoumar
• Publisher :Unknown
• Release Date :2020-12-04
• Total pages :308
• ISBN : 9780128213117

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Summary : Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

• Author : John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman
• Publisher :Unknown
• Release Date :2003-01-07
• Total pages :602
• ISBN : 0080533841

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Summary : By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

• Author : Antonio Cardesa,Pieter J. Slootweg,Nina Gale,Alessandro Franchi
• Publisher :Unknown
• Release Date :2017-02-08
• Total pages :854
• ISBN : 9783662496725

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Summary : This book provides a comprehensive description of the pathology of the head and neck region, concentrating especially on those pathologic entities that are unique to or characteristic of the head and neck. The new edition retains the ten chapters of the first edition, all updated and improved, and additionally contains seven entirely new chapters and a more detailed subject index. The number of illustrations has been substantially increased, and various lesions absent in the original edition have been included. Throughout, attention is paid to correlation of pathology with epidemiology, clinical features, pathogenesis, and molecular genetics. Differential diagnosis is addressed, and information is also provided on staging, prognosis, and therapy. The authors include foremost experts in the field, some of whom are senior members of the Working Group on Head and Neck Pathology of the European Society of Pathology.

• Author : Frederick L, Greene,David L. Page,Irvin D. Fleming,April G. Fritz,Charles M. Balch,Daniel G. Haller,Monica Morrow
• Publisher :Unknown
• Release Date :2013-11-21
• Total pages :421
• ISBN : 9781475736564

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Summary : The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

• Author : Peter Watt
• Publisher :Unknown
• Release Date :2012-10-01
• Total pages :416
• ISBN : 9781743349649

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Summary : "the home grown version of Wilbur Smith" The Sunday Age Beyond the Horizon continues the much-loved saga of the Duffys and Macintoshes, told with Peter Watt's trademark mastery of grand scope, family drama and enthralling adventure. It is 1918, a year when the War will end, but an even greater killer will arise. On the bloody fields of the Western Front and the battle-scarred desert plains of the Middle East, Tom and Matthew Duffy are facing the enemy. Even as they are trapped on the front lines, they must also find the courage to fight for the women they love when all hope is lost. Back in Australia, George Macintosh is outraged by the stipulations of his father's will that provide for his despised nephew, and is determined to eliminate any threats to his power. And in a sacred cave in the far Outback, old Wallarie foresees a tide of unspeakable death sweeping through his homeland. As all nations come to terms with the devastating consequences of the Great War, a new world will be born. But not everyone will live to see it. PRAISE FOR THE SERIES "A rousing and revealing yarn" Weekend Australian "the historical detail brings the ... 19th century to rip-roaring life" The Australian "Watt's fans love his work for its history, adventure and storytelling" Brisbane News

• Author : Anonim
• Publisher :Unknown
• Release Date :2018-11-21
• Total pages :292
• ISBN : 9780128127384

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Summary : Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment

• Author : Holly J. Bertone
• Publisher :Unknown
• Release Date :2013-10-05
• Total pages :118
• ISBN : 9781492144182

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Summary : Holly Bertone was diagnosed with breast cancer on her 39th birthday, and was engaged two days later. In 48 hours, those eight magic words, "You have breast cancer," and "Will you marry me?" converged to change her life forever. Follow Holly's year-long journey from diagnosis and engagement to being sick and bald on her wedding day. This is Holly's story as she battles breast cancer and struggles with overcoming the subsequent self-esteem issues. The writing is raw - you will get an uncensored view of breast cancer treatment and what it's really like. She uses humor and laughter to redefine beauty as she loses part of her breast, all of her hair, and is launched into early menopause. With pop culture references and her quirky sense of humor, Holly's heartwarming story of love and strength is encouragement for all women going through cancer treatment. A percentage of sales will go to Holly's favorite breast cancer charities.

• Author : Krassimir Metodiev
• Publisher :Unknown
• Release Date :2015-11-18
• Total pages :312
• ISBN : 9789535122104

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Summary : This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors.

• Author : John Green
• Publisher :Unknown
• Release Date :2013
• Total pages :305
• ISBN : 9781408848180

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Summary : Special edition slipcase edition of John Green's Paper Towns, with pop-up paper town. From the bestselling author of The Fault in our Stars. Quentin Jacobsen has always loved Margo Roth Spiegelman, for Margo (and her adventures) are the stuff of legend at their high school. So when she one day climbs through his window and summons him on an all-night road trip of revenge he cannot help but follow. But the next day Margo doesn't come to school and a week later she is still missing. Q soon learns that there are clues in her disappearance . . . and they are for him. But as he gets deeper into the mystery - culminating in another awesome road trip across America - he becomes less sure of who and what he is looking for. Masterfully written by John Green, this is a thoughtful, insightful and hilarious coming-of-age story.

• Author : James A. Radosevich
• Publisher :Unknown
• Release Date :2016-08-23
• Total pages :1070
• ISBN : 9402400869

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Summary : This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.

• Author : Lawrence C. Panasci,Moulay A. Alaoui-Jamali
• Publisher :Unknown
• Release Date :2004-03-19
• Total pages :363
• ISBN : 9781592597352

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Summary : A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

• Author : Yann Martel
• Publisher :Unknown
• Release Date :2009-03-19
• Total pages :368
• ISBN : 0307371123

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Summary : Life of Pi is a masterful and utterly original novel that is at once the story of a young castaway who faces immeasurable hardships on the high seas, and a meditation on religion, faith, art and life that is as witty as it is profound. Using the threads of all of our best stories, Yann Martel has woven a glorious spiritual adventure that makes us question what it means to be alive, and to believe.

• Author : Joel Faintuch,Salomao Faintuch
• Publisher :Unknown
• Release Date :2019-01-03
• Total pages :504
• ISBN : 9780128152508

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Summary : Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource. The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike. Provides comprehensive coverage on diagnosis, therapy, pharmacotherapy and disease prevention in context of the microbiome and metabolome Focuses on the proposed physiological or pathological conditions Presents an up-to-date, useful reference

• Author : Melanie Ehrlich
• Publisher :Unknown
• Release Date :2000
• Total pages :508
• ISBN : UOM:39015049699302

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Summary :

• Author : Alfred Bester
• Publisher :Unknown
• Release Date :2018-01-08
• Total pages :224
• ISBN : 9781596879881

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Summary : #4 in the Millennium SF Masterworks series, a library of the finest science fiction ever written. The first Hugo Award winner for best novel in 1953. “One of the all-time classics of science fiction.”—Isaac Asimov “Bester's two superb books have stood the test of time. For nearly sixty years they’ve held their place on everybody’s list of the ten greatest sf novels” —Robert Silverberg In a world policed by telepaths, Ben Reich plans to commit a crime that hasn’t been heard of in 70 years: murder. That’s the only option left for Reich, whose company is losing a 10-year death struggle with rival D’Courtney Enterprises. Terrorized in his dreams by The Man With No Face and driven to the edge after D’Courtney refuses a merger offer, Reich murders his rival and bribes a high-ranking telepath to help him cover his tracks. But while police prefect Lincoln Powell knows Reich is guilty, his telepath's knowledge is a far cry from admissible evidence. Alfred Bester was among the first important authors of contemporary science fiction. His passionate novels of worldly adventure, high intellect, and tremendous verve, The Stars My Destination and the Hugo Award winning The Demolished Man, established Bester as a s.f. grandmaster, a reputation that was ratified by the Science Fiction Writers of America shortly before his death. Bester also was an acclaimed journalist for Holiday magazine, a reviewer for the Magazine of Fantasy and Science Fiction and even a writer for Superman.

• Author : Dorothy Richardson
• Publisher :Unknown
• Release Date :2014-09-11
• Total pages :280
• ISBN : 9781770485389

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Summary : The first chapter-volume of Dorothy Richardson’s thirteen-volume novel series Pilgrimage, Pointed Roofs is a coming of age story. The protagonist is Miriam Henderson, seventeen years old. Pointed Roofs tells the tale of Miriam’s first adventure as an adult, teaching English at a finishing school in Hanover, Germany. Though the tale is simple, it is not simply told; to capture the intensity of Miriam’s seemingly mundane experiences, Richardson developed a new narrative technique labelled “stream of consciousness” by the author May Sinclair. Pointed Roofs is a compelling account of a young woman’s dawning consciousness of what it means to be independent, an individual, and a woman in the early twentieth century. This Broadview Edition places Richardson’s inventive narrative technique in the context of early twentieth-century literary modernism, showing the “startling newness,” in May Sinclair’s words, of Richardson’s writing. Letters from Richardson to friends, publishers, and critics show the complex relationships between her work and life.

• Author : John H. Sampson
• Publisher :Unknown
• Release Date :2017-02-06
• Total pages :404
• ISBN : 9780128026250

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Summary : Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors