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Nuclear Architecture and Dynamics

Nuclear Architecture and Dynamics
  • Author : Christophe Lavelle,Jean-Marc Victor
  • Publisher :Unknown
  • Release Date :2017-10-27
  • Total pages :618
  • ISBN : 9780128035030
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Summary : Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds

Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics
  • Author : Anita Göndör
  • Publisher :Unknown
  • Release Date :2016-10-25
  • Total pages :496
  • ISBN : 9780128034026
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Summary : Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Nuclear Dynamics

Nuclear Dynamics
  • Author : K. Nagata,K. Takeyasu
  • Publisher :Unknown
  • Release Date :2007-12-03
  • Total pages :279
  • ISBN : 4431301305
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Summary : The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Dynamics and Manipulation of Nuclear Architecture and Gene Expression

Dynamics and Manipulation of Nuclear Architecture and Gene Expression
  • Author : Katharina Thanisch
  • Publisher :Unknown
  • Release Date :2015
  • Total pages :229
  • ISBN : OCLC:985428148
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Summary :

Chromatin

Chromatin
  • Author : Ralf Blossey
  • Publisher :Unknown
  • Release Date :2017-08-04
  • Total pages :172
  • ISBN : 9781498729383
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Summary : An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.

Genomic Imprinting

Genomic Imprinting
  • Author : Rolf Ohlsson
  • Publisher :Unknown
  • Release Date :2013-06-29
  • Total pages :330
  • ISBN : 9783540691112
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Summary : The form and function of every living organism on the earth depends on the complex regulation of gene expression. This is carried out by controlling and interdigitating spatial and temporal patterns of gene activity during the life time of eukaryotic organisms. This is most dramatically apparent during early stages of development, when new types of cells and organs are being formed, often during very short time spans. To achieve this, it is vital that developmentally important genes can be kept in inactive or active states which are stably inherited in the soma. Indeed, it is now wellknown that the propen sity for a gene to be transcribed or silenced is stably propagated through many cell generations, even from parent to progeny. This phenomenon constitutes a type of extragenetic or epigenetic memory of cell identity and developmental potential which has been fundamental to the evolution of complex lifeforms, such as the reader of this book. This monograph focuses on a particular aspect of the epigenetic control of gene function: genomic imprinting. This defines a phenomenon where some genes or whole chromosomes can be silenced, activated, or even deleted depending on their parental origin. The impact of genomic imprinting is most clearly seen in the areas of cancer, clinical genetics, and development. Many of the processes associated with genomic imprinting can be observed in plants, yeast and man, for example, and may constitute, therefore, principles which are very conserved on an evolutionary scale.

Visualizing the Dynamics of 4D Nuclear Architecture During Enhancer-Promoter Transcription Activation Using Live Imaging Techniques

Visualizing the Dynamics of 4D Nuclear Architecture During Enhancer-Promoter Transcription Activation Using Live Imaging Techniques
  • Author : Leah Kim
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :31
  • ISBN : OCLC:1196208376
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Summary : The transcription machinery requires spatiotemporal coordination of its regulatory elements for precise gene expression. It is believed that the dynamics in the nuclear architecture like enhancer:promoter looping interaction is essential for the regulation of the transcription machinery. However, the detail of the change in 4D nuclear architecture during transcription is poorly understood. Here we seek to visualize a pair of enhancer and its associated target gene based on a real time, live cell imaging that uses optimized CRISPR-Cas9 and MS2/PP7 system. Our prior work on measuring TFF1 transcription bursting in MCF7 cells confirmed the efficiency and sensitivity of our imaging techniques. In this study, we aim to visualize c-MYC enhancer(c-MYCe) and c-MYC gene in live HeLa cells based on our preliminary data proving that c-MYC enhancer is a functional enhancer. We plan to measure the relative timing of signal, the duration of activity, and the distribution of intensity over the course of activity. The spatial kinetics between c-MYCe and c-MYC over time will be measured, and their motion relative to transcriptional activity (on/off signal) will be examined. Collectively, we hope to advance the understanding of the precise 4D dynamics of the events underlying enhancer-mediated transcription regulation.

Nuclear Export of Viral RNAs

Nuclear Export of Viral RNAs
  • Author : J. Hauber,P.K. Vogt
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :134
  • ISBN : 9783642565977
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Summary : In eukaryotic cells, the nuclear genome and its transcriptional apparatus is separated from the site of protein synthesis by the nuclear envelope. Thus, a constant flow of proteins and nucleic acids has to cross the nuclear envelope in both directions. This transport in and out of the nucleus is mediated by nuclear pore complexes (NPCs) and occurs in an energy and signal-dependent manner. Thus, nucleocytoplasmic translocation of macro molecules across the nuclear envelope appears to be a highly specific and regulated process. Viruses that replicate their genome in the cell nucleus are therefore forced to develop efficient ways to deal with the intracellulZlr host cell transport machinery. Historically, investigation of Polyomavirus replication allowed identification ofsequences that mediate nuclear import, which led subsequently to our detailed understanding of the cellular factors that are involved in nuclear import. Transport ofmacromolecules in the opposite direction, however, is less well understood. The investigation of retroviral gene expression in recent years pro vided the first insights into the cellular mechanisms that regulate nuclear export. In particular, the detailed dissection of the function of the human immunodeficiency virus type I (HIV-I) Rev trans-activator protein identified CRMI, as a hona fide nuclear export receptor. CRM I appears to be involved in the nucleocytoplasmic translocation of the vast majority of viral and cellular proteins that have subsequently been found to contain a Rev-type leucine-rich nuclear export signal (NES).

Spin Dynamics

Spin Dynamics
  • Author : Malcolm H. Levitt
  • Publisher :Unknown
  • Release Date :2013-05-20
  • Total pages :744
  • ISBN : 9781118681848
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Summary : Spin Dynamics: Basics of Nuclear Magnetic Resonance, Second Edition is a comprehensive and modern introduction which focuses on those essential principles and concepts needed for a thorough understanding of the subject, rather than the practical aspects. The quantum theory of nuclear magnets is presented within a strong physical framework, supported by figures. The book assumes only a basic knowledge of complex numbers and matrices, and provides the reader with numerous worked examples and exercises to encourage understanding. With the explicit aim of carefully developing the subject from the beginning, the text starts with coverage of quarks and nucleons and progresses through to a detailed explanation of several important NMR experiments, including NMR imaging, COSY, NOESY and TROSY. Completely revised and updated, the Second Edition features new material on the properties and distributions of isotopes, chemical shift anisotropy and quadrupolar interactions, Pake patterns, spin echoes, slice selection in NMR imaging, and a complete new chapter on the NMR spectroscopy of quadrupolar nuclei. New appendices have been included on Euler angles, and coherence selection by field gradients. As in the first edition, all material is heavily supported by graphics, much of which is new to this edition. Written for undergraduates and postgraduate students taking a first course in NMR spectroscopy and for those needing an up-to-date account of the subject, this multi-disciplinary book will appeal to chemical, physical, material, life, medical, earth and environmental scientists. The detailed physical insights will also make the book of interest for experienced spectroscopists and NMR researchers. • An accessible and carefully written introduction, designed to help students to fully understand this complex and dynamic subject • Takes a multi-disciplinary approach, focusing on basic principles and concepts rather than the more practical aspects • Presents a strong pedagogical approach throughout, with emphasis placed on individual spins to aid understanding • Includes numerous worked examples, problems, further reading and additional notes Praise from the reviews of the First Edition: "This is an excellent book... that many teachers of NMR spectroscopy will cherish... It deserves to be a ‘classic’ among NMR spectroscopy texts." NMR IN BIOMEDICINE "I strongly recommend this book to everyone...it is probably the best modern comprehensive description of the subject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION

Nuclear Strategy in the Modern Era

Nuclear Strategy in the Modern Era
  • Author : Vipin Narang
  • Publisher :Unknown
  • Release Date :2014-05-25
  • Total pages :360
  • ISBN : 9780691159836
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Summary : The world is in a second nuclear age in which regional powers play an increasingly prominent role. These states have small nuclear arsenals, often face multiple active conflicts, and sometimes have weak institutions. How do these nuclear states—and potential future ones—manage their nuclear forces and influence international conflict? Examining the reasoning and deterrence consequences of regional power nuclear strategies, this book demonstrates that these strategies matter greatly to international stability and it provides new insights into conflict dynamics across important areas of the world such as the Middle East, East Asia, and South Asia. Vipin Narang identifies the diversity of regional power nuclear strategies and describes in detail the posture each regional power has adopted over time. Developing a theory for the sources of regional power nuclear strategies, he offers the first systematic explanation of why states choose the postures they do and under what conditions they might shift strategies. Narang then analyzes the effects of these choices on a state's ability to deter conflict. Using both quantitative and qualitative analysis, he shows that, contrary to a bedrock article of faith in the canon of nuclear deterrence, the acquisition of nuclear weapons does not produce a uniform deterrent effect against opponents. Rather, some postures deter conflict more successfully than others. Nuclear Strategy in the Modern Era considers the range of nuclear choices made by regional powers and the critical challenges they pose to modern international security.

Nuclear Envelope

Nuclear Envelope
  • Author : David Evans,Chris Hutchison,John Bryant
  • Publisher :Unknown
  • Release Date :2004-09-01
  • Total pages :320
  • ISBN : 9781134279838
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Summary : The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

Nuclear Command and Control Norms

Nuclear Command and Control Norms
  • Author : Salma Shaheen
  • Publisher :Unknown
  • Release Date :2018-09-28
  • Total pages :188
  • ISBN : 9780429790799
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Summary : This book offers a new analytical framework for studying nuclear command and control (C2), based on a comparative study of four nuclear weapons states (NWS). The subject of nuclear operations management has long been shrouded in secrecy, and whilst the importance of nuclear C2 cannot be disputed, there are few academic studies into how and why states develop these systems. This volume includes a comparative study of the development of nuclear C2 by four different NWS (Britain, China, India, and Pakistan) and demonstrates that, despite several differences, there is a central set of factors that remain constant. The analytical framework used in this study identifies key factors that can potentially shape the evolution and stability of nuclear C2. These factors include geostrategic (threat) environment, international norms, leadership, and control of nuclear operations (civil-military control). The book also analyses the interaction among different stakeholders within the nuclear C2 enterprise. It recognises that politicians, the military and scientists all have key but different roles to play, and the way these stakeholders have learned to co-exist with each other is explored. This volume offers a set of dynamics that could form a global norm for nuclear C2, serving as a standard for new entrants into the nuclear club. This book will be of much interest to students of nuclear proliferation, global governance, and International Relations in general.

Critical Dynamics

Critical Dynamics
  • Author : Uwe C. Täuber
  • Publisher :Unknown
  • Release Date :2014-03-06
  • Total pages :488
  • ISBN : 9780521842235
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Summary : A comprehensive and unified introduction to describing and understanding complex interacting systems.

Genome Organization And Function In The Cell Nucleus

Genome Organization And Function In The Cell Nucleus
  • Author : Karsten Rippe
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :594
  • ISBN : 9783527640003
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Summary : By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.

Basic Structural Dynamics

Basic Structural Dynamics
  • Author : James C. Anderson,Farzad Naeim
  • Publisher :Unknown
  • Release Date :2012-07-16
  • Total pages :320
  • ISBN : 9781118279090
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Summary : A concise introduction to structural dynamics and earthquake engineering Basic Structural Dynamics serves as a fundamental introduction to the topic of structural dynamics. Covering single and multiple-degree-of-freedom systems while providing an introduction to earthquake engineering, the book keeps the coverage succinct and on topic at a level that is appropriate for undergraduate and graduate students. Through dozens of worked examples based on actual structures, it also introduces readers to MATLAB, a powerful software for solving both simple and complex structural dynamics problems. Conceptually composed of three parts, the book begins with the basic concepts and dynamic response of single-degree-of-freedom systems to various excitations. Next, it covers the linear and nonlinear response of multiple-degree-of-freedom systems to various excitations. Finally, it deals with linear and nonlinear response of structures subjected to earthquake ground motions and structural dynamics-related code provisions for assessing seismic response of structures. Chapter coverage includes: Single-degree-of-freedom systems Free vibration response of SDOF systems Response to harmonic loading Response to impulse loads Response to arbitrary dynamic loading Multiple-degree-of-freedom systems Introduction to nonlinear response of structures Seismic response of structures If you're an undergraduate or graduate student or a practicing structural or mechanical engineer who requires some background on structural dynamics and the effects of earthquakes on structures, Basic Structural Dynamics will quickly get you up to speed on the subject without sacrificing important information.

The Nuclear Pore Complex and Chromatin Domain Dynamics

The Nuclear Pore Complex and Chromatin Domain Dynamics
  • Author : Guilia Jale Gurun Ruben
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :264
  • ISBN : UCAL:W265307
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Summary :

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : UIUC:30112033253656
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Summary :

Nuclear Dynamics

Nuclear Dynamics
  • Author : K. Nagata,K. Takeyasu
  • Publisher :Unknown
  • Release Date :2007-12-03
  • Total pages :279
  • ISBN : 4431301305
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Summary : The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Magneto-Fluid Dynamics

Magneto-Fluid Dynamics
  • Author : Paul Lorrain,Francois Lorrain,Stephane Houle
  • Publisher :Unknown
  • Release Date :2007-10-31
  • Total pages :319
  • ISBN : 9780387472904
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Summary : This book provides an understanding of the physics at work in sunspots and solar coronal loops, and offers a new approach to Magneto-Fluid-Dynamics (or Magneto-Hydro-Dynamics).The book stresses the use of electric currents in Magneto-Fluid-Dynamics. As a rule, authors discuss magnetic field lines without referring to the required electric currents. It also stresses the importance of electric space charges inside conductors that move in magnetic fields.

Nuclear Mechanics and Genome Regulation

Nuclear Mechanics and Genome Regulation
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010-10-12
  • Total pages :392
  • ISBN : 0123810108
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Summary : In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

Biochemical and Structural Dynamics of the Cell Nucleus

Biochemical and Structural Dynamics of the Cell Nucleus
  • Author : Eugenia Wang
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :282
  • ISBN : 9780323157889
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Summary : Biochemical and Structural Dynamics of the Cell Nucleus is a collection of papers dealing with the biology of the cell nucleus. The collection describes the methods used in isolating and defining the chemistry and functional interactions of the nuclear components. Some papers also discuss the diversity of the roles that these components play in regulating cellular phenotypes, differentiation, and proliferation. One paper discusses the possible role for lamin A in muscle differentiations, where due to its presence and the appearance of A-type lamins during the differentiation of a number of cell types, lamin A or any of its isoelectric variants cannot specifically be responsible for the induction of muscle specific gene expression. The work of Loewinger and McKeon (1988) can show evidence of the role for lamin A in the differential expression of muscle-specific genes during the process of myogenesis if the investigator uses an alternative method. Several papers also discuss the dynamics of assembly and disassembly of the nuclear lamina and envelope, DNA- and RNA-binding proteins, as well as the nucleocytoplasmic transport. The collection can prove valuable to biochemists, cellular biologists, microbiologists, and molecular biologists.