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Visualization of Nucleic Acids

Visualization of Nucleic Acids
  • Author : Gerard Morel
  • Publisher :Unknown
  • Release Date :1995-03-30
  • Total pages :384
  • ISBN : 0849347815
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Summary : This book presents a review of the principle approaches for visualizing DNA and RNA. Using scanning tunneling and atomic force microscopes, the three-dimensional image of the surface of nucleic acids can be seen at atomic-scale resolutions. Spreading methods provide useful details on structural features of isolated molecules, but the major constituent of living matter is water, and the cryomicroscope makes it possible to look at DNA in its aqueous environment. Genes can be detected simultaneously in situ in chromosomes using fluorescent probes, and also at the electron microscopic level. In cells, nucleic acids are localized and quantified by dyes; electron microscopy is used with cytochemical, immunocytological, nuclease, and in situ hybridization methods. The main potential applications for pathological studies are shown with particular aspects such as viral nucleic acids and in situ PCR.

Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
  • Author : G. Michael Blackburn
  • Publisher :Unknown
  • Release Date :2006-01-01
  • Total pages :470
  • ISBN : 9780854046546
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Summary : The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Spherical Nucleic Acids

Spherical Nucleic Acids
  • Author : Chad A. Mirkin
  • Publisher :Unknown
  • Release Date :2020-09-01
  • Total pages :1806
  • ISBN : 9780429578069
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Summary : Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation. It is a reprint volume that compiles 101 key papers from high-impact journals in this research area published by the Mirkin Group at Northwestern University, Illinois, USA, within the International Institute for Nanotechnology, and collaborators. Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.

Proteins and Nucleic Acids

Proteins and Nucleic Acids
  • Author : Isidore Gersh
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :412
  • ISBN : 9780323151504
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Summary : Submicroscopic Cytochemistry, Volume I: Proteins and Nucleic Acids presents laboratory findings and theoretical aspects involved or derived from submicroscopic cytochemistry study of proteins and nucleic acids. It is a two-volume book, encompassing 14 chapters covering three major topics: the pattern of distribution of nucleic acids at the molecular level in various cells and states of activity and in relation to protein synthesis; the molecular and macromolecular organization of cellular membranes; and the origin and distribution of the major macromolecular aggregates of connective tissue. After a brief introduction to the aspects of submicroscopic cytochemistry, the book discusses morphology, with emphasis on the distribution of cell components and their organization in cells at the macromolecular level. It then presents developed methods to preserve and selectively identify proteins, nucleic acids, lipids, acid mucopolysaccharides, and molecular aggregates very nearly in the position they occupied in the living state. Chapters 8 to 12 describe DNA molecular patterns during cell differentiation and cell maturation, and the alteration of these patterns in certain mouse cells. A discussion on DNA molecular patterns during metaplasia of stratified squamous mouse epithelium and of spinal ganglion cells during regeneration is provided. The concluding chapters examine DNA organization during mitotic cycle in Drosophila eggs and the persistence of chromosome individuality during interphase. This book is a valuable source of information for cytochemists, cell biologists, cell researchers, and protein nucleic acid enthusiasts who wish to expand their knowledge on comprehensive cytochemistry laboratory study.

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
  • Author : Stephen Neidle
  • Publisher :Unknown
  • Release Date :2010-07-26
  • Total pages :302
  • ISBN : 0080553524
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Summary : This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software. Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA) Includes a complete list of resources, including relevant online databases and software Defines technical lingo for novices

The Nucleic Acids

The Nucleic Acids
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1966
  • Total pages :229
  • ISBN : MINN:31951D02703273C
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Summary :

Radiation-induced Changes in Tissue Nucleic Acids

Radiation-induced Changes in Tissue Nucleic Acids
  • Author : L. J. Cole,M. E. Ellis
  • Publisher :Unknown
  • Release Date :1956
  • Total pages :28
  • ISBN : UOM:39015095217934
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Summary :

Photochemistry of Nucleic Acids, and Its Bioilogical Implications

Photochemistry of Nucleic Acids, and Its Bioilogical Implications
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1964
  • Total pages :229
  • ISBN : UOM:39015092340283
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Summary :

Advanced Organic Chemistry of Nucleic Acids

Advanced Organic Chemistry of Nucleic Acids
  • Author : Zoe A. Shabarova,Alexey A. Bogdanov
  • Publisher :Unknown
  • Release Date :2008-07-11
  • Total pages :603
  • ISBN : 9783527615926
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Summary : Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.

The Effect of Nitrogen Mustards on the Metabolism of Nucleic Acids in the Hematopoietic Tissue of the Rabbit

The Effect of Nitrogen Mustards on the Metabolism of Nucleic Acids in the Hematopoietic Tissue of the Rabbit
  • Author : P. B. Lowrence,C. E. Carter
  • Publisher :Unknown
  • Release Date :1949
  • Total pages :15
  • ISBN : UOM:39015086436873
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Nucleic Acids

Nucleic Acids
  • Author : Victor A. Bloomfield,Donald M. Crothers,Ignacio Tinoco,John E. Hearst,Peter A. Killman,David E. Wemmer,Douglas H. Turner
  • Publisher :Unknown
  • Release Date :2000-04-17
  • Total pages :794
  • ISBN : 0935702490
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Summary : NucleicAcids presents an up-to-date and comprehensive account of thestructures and physical chemistry properties of nucleic acids,with special emphasis on biological function. With a targetedaudience of 1)molecular biologists, 2)physical biochemists, and3)physical chemists, the book has been carefully organized toreach three different audiences while requiring only introductoryphysical chemistry and molecular biology as prerequisites. NucleicAcidswill serve as a textbook in physical biochemistry andbiophysical chemistry classes, as well as a supplemental text incourses on nucleic acid biochemistry or molecular biology, and asa personal reference for students and researchers in thesefields. KeyFeatures Organized according to a systematic consideration of techniques used in the study of nucleic acid structure and properties. Key topics--such as protein-DNA and protein-drug complexes, conformational transitions, characterization of nucleic acids by gel and solution techniques, and behavior of supercoiled DNA--are covered in great detail as veritable mini-monographs. Heavily illustrated with diagrams, graphs, and molecular structures, including nearly 2 dozen color figures. Includes numerous figures, tables and an extensive bibliography to facilitate use as a reference volume.

21st Symposium on Nucleic Acids Chemistry

21st Symposium on Nucleic Acids Chemistry
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :305
  • ISBN : UOM:39015051238080
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Summary :

Mass Spectrometry of Nucleosides and Nucleic Acids

Mass Spectrometry of Nucleosides and Nucleic Acids
  • Author : Joseph H. Banoub,Patrick A. Limbach
  • Publisher :Unknown
  • Release Date :2009-12-21
  • Total pages :504
  • ISBN : 1420044036
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Summary : Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Imaging and Manipulation of Single Nucleic Acids with Convex Lens-induced Confinement

Imaging and Manipulation of Single Nucleic Acids with Convex Lens-induced Confinement
  • Author : Daniel Berard
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :229
  • ISBN : OCLC:1112735377
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Summary : "Understanding the biophysics of DNA and RNA at the single-molecule level is critical to advancing the fields of molecular biology, diagnostics, and pharmaceuticals, and developing new treatments for genetic disorders. Single-molecule microscopy techniques have generated new knowledge of the interactions between nucleic acids and proteins, drugs, and other nucleic acid molecules. However, these techniques have either limited observation times, are limited to low concentrations, or require molecular tethering. Recently, Convex Lens-induced Confinement (CLiC) has emerged to address these challenges. In CLiC, molecules are introduced between two glass surfaces that are gradually pressed together to confine molecules in a nanoscale gap between them. In this thesis, we implement CLiC to trap, manipulate, and image single DNA and RNA polymers. First, we combine CLiC with nanofluidic grooves embedded in the bottom glass surface to demonstrate gentle loading and linearization of long DNA polymers within the grooves, which become closed nanochannels upon application of confinement. We study the DNA extension as a function of applied confinement. We then introduce grooves with circular geometries to suppress DNA drift due to the confinement gradient inherent in the CLiC chamber geometry, and use confinement to enhance self-ligation of long linear DNA. Next, we demonstrate an alternative method to stretch DNA using a thin wire rotating in solution. DNA close to the wire surface are stretched by the rotation. This method has potential applications in stretching very long, fragile DNA. We then present a miniaturized, microfabricated version of the CLiC imaging chamber with improved mechanical performance and pneumatic control of the confinement, and use it to demonstrate linearization of DNA in nanogrooves with a reduced confinement gradient. Finally, we replace nanogrooves with micropits and apply CLiC to detect the binding of antisense oligonucleotides (ASOs) to a small target RNA molecule, with the eventual goal of developing a platform to study and optimize ASO binding at the single-molecule level. The methods developed here can be applied to study a wide range of biological processes, including DNA transcription, translation, and repair, molecular search processes, and gene editing tools such as CRISPR-Cas9. The results presented in this thesis show how we can use nanoconfinement to measure the interactions and mechanical properties of individual macromolecules." --

Tenth Symposium on Nucleic Acids Chemistry

Tenth Symposium on Nucleic Acids Chemistry
  • Author : Angela E. Pritchard
  • Publisher :Unknown
  • Release Date :1982
  • Total pages :286
  • ISBN : UCAL:B4165305
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Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules

Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules
  • Author : Christopher Janson,Matthew During
  • Publisher :Unknown
  • Release Date :2007-03-06
  • Total pages :274
  • ISBN : 9780387329567
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Summary : This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.

Structural Analysis of Nucleic Acids

Structural Analysis of Nucleic Acids
  • Author : Chirikjian
  • Publisher :Unknown
  • Release Date :1981
  • Total pages :594
  • ISBN : UCAL:B4530561
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Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
  • Author : G. Michael Blackburn,Michael J. Gait
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :528
  • ISBN : 0199635331
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Summary : Since the discovery of the DNA double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Nowhere is this more apparent than in the increasing efforts to determine the DNA sequence of the human genome and the development of new diagnostics of genetic disease. Recent sophistication of nucleic acids synthesis has been key to the establishment of the biotechnology industry and our improving knowledge of nucleic acid structures and interactions is noticeably influencing the design of novel drugs.This second and completely revised edition draws on the expertise of the same international group of authors to set the basics of the nucleic acids in the context of the expanding horizons set by modern structural biology, RNA enzymology, drug discovery and biotechnology.

The Chemical Biology of Nucleic Acids

The Chemical Biology of Nucleic Acids
  • Author : Günter Mayer
  • Publisher :Unknown
  • Release Date :2011-06-17
  • Total pages :478
  • ISBN : 9781119957263
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Summary : With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

The Physiological action and therapeutic uses of yeast nucleic acid

The Physiological action and therapeutic uses of yeast nucleic acid
  • Author : Victor Clarence Vaughan
  • Publisher :Unknown
  • Release Date :1897
  • Total pages :105
  • ISBN : STANFORD:24503307016
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Handbook of Nucleic Acid Purification

Handbook of Nucleic Acid Purification
  • Author : Dongyou Liu
  • Publisher :Unknown
  • Release Date :2009-01-14
  • Total pages :584
  • ISBN : 9781420070972
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Summary : An Indispensable Roadmap for Nucleic Acid Preparation Although Friedrich Miescher described the first isolation of nucleic acid in 1869, it was not until 1953 that James Watson and Francis Crick successfully deciphered the structural basis of DNA duplex. Needless to say, in the years since, enormous advances have been made in the study of nucleic acids, and these have become a cornerstone for all branches of modern biological sciences. The Handbook of Nucleic Acid Purification provides researchers and students with an all-encompassing volume on nucleic acid extraction strategies. Due to the complexities within prokaryotic and eukaryotic cells, purification of the nucleic acids often forms a vital first step in the study of molecular biology of living organisms as well as in the evolutionary/phylogenetic analysis of ancient specimens. Bringing together contributions from leading researchers, the handbook presents a comprehensive catalog of nucleic acid isolation methods. It includes dedicated sections on strategies for viruses, bacteria, fungi, parasites, insects, mammals, and plants, as well as for ancient samples, with an additional emphasis on sample preparation methods for direct molecular applications. Each chapter in this handbook: Explores the biological background important to understanding specific organisms and specimens Reviews principles and current techniques for efficient isolation Discusses challenges and future trends relating to improved recovery of nucleic acids Besides providing an updated, reliable reference for anyone with an interest in molecular biology, this book offers a practical guide for clinical, forensic, and research scientists involved in molecular analysis of biological specimens. It also constitutes a convenient resource for students in other areas of biological sciences, and an indispensable roadmap for both new and experienced researchers wishing to acquire or sharpen their skills in nucleic acid preparation.