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ODE/PDE α-synuclein Models for Parkinson’s Disease

ODE/PDE α-synuclein Models for Parkinson’s Disease
  • Author : William E. Schiesser
  • Publisher :Unknown
  • Release Date :2018-02-13
  • Total pages :228
  • ISBN : 9780128148020
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Summary : ODE/PDE Alpha-Synuclein Models for Parkinson’s Disease discusses a mechanism for the evolution of Parkinson’s Disease (PD) based on the dynamics of the protein α-synuclein, a monomer that has been implicated in this disease. Specifically, α-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the α-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms Includes PDE routines based on the method of lines (MOL) for computer-based implementation of ODE/PDE models Offers transportable computer source codes for readers, with line-by-line code descriptions relating to the mathematical model and algorithms Authored by a leading researcher and educator in ODE/PDE models

Network Spread Models of Neurodegenerative Diseases

Network Spread Models of Neurodegenerative Diseases
  • Author : Ashish Raj,Yasser Iturria Medina
  • Publisher :Unknown
  • Release Date :2019-04-18
  • Total pages :116
  • ISBN : 9782889457687
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Summary : It is a real pleasure to introduce the excellent papers contributed by leading experts to our Research Topic proposing various network models of dementia spread. The focus is strongly on disease-specific mathematical modeling rather than general graph theory. The emerging field of network neuroscience visualizes the brain as a graph consisting of nodes representing regions and edges as connections between them. This complex network supports efficient communication along neural projections, but also, unfortunately, the transmission and progression of Alzheimer’s and other neurodegenerative disorders. If we could know the brain’s network organization, could we then predict how degenerative processes might develop on this network? As these papers demonstrate, the answer is, increasingly, yes.

Adaptive Method of Lines

Adaptive Method of Lines
  • Author : A, Vande Wouwer,Ph. Saucez,W.E. Schiesser
  • Publisher :Unknown
  • Release Date :2001-04-18
  • Total pages :432
  • ISBN : 9781420035612
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Summary : The general Method of Lines (MOL) procedure provides a flexible format for the solution of all the major classes of partial differential equations (PDEs) and is particularly well suited to evolutionary, nonlinear wave PDEs. Despite its utility, however, there are relatively few texts that explore it at a more advanced level and reflect the method's current state of development. Written by distinguished researchers in the field, Adaptive Method of Lines reflects the diversity of techniques and applications related to the MOL. Most of its chapters focus on a particular application but also provide a discussion of underlying philosophy and technique. Particular attention is paid to the concept of both temporal and spatial adaptivity in solving time-dependent PDEs. Many important ideas and methods are introduced, including moving grids and grid refinement, static and dynamic gridding, the equidistribution principle and the concept of a monitor function, the minimization of a functional, and the moving finite element method. Applications addressed include shallow water flow, combustion and flame propagation, transport in porous media, gas dynamics, chemical engineering processes, solitary waves, and magnetohydrodynamics. As the first advanced text to represent the modern era of the method of lines, this monograph offers an outstanding opportunity to discover new concepts, learn new techniques, and explore a wide range of applications.

Bio-nanoimaging

Bio-nanoimaging
  • Author : Vladimir Uversky,Yuri Lyubchenko
  • Publisher :Unknown
  • Release Date :2013-11-05
  • Total pages :552
  • ISBN : 9780123978219
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Summary : Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs Includes over 200 color images to illustrate the power of various nanoimaging technologies Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

Computational Mathematics in Engineering and Applied Science

Computational Mathematics in Engineering and Applied Science
  • Author : W.E. Schiesser
  • Publisher :Unknown
  • Release Date :2014-07-22
  • Total pages :608
  • ISBN : 9781498710664
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Summary : Computational Mathematics in Engineering and Applied Science provides numerical algorithms and associated software for solving a spectrum of problems in ordinary differential equations (ODEs), differential algebraic equations (DAEs), and partial differential equations (PDEs) that occur in science and engineering. It presents detailed examples, each

5th International Conference on Biomedical Engineering in Vietnam

5th International Conference on Biomedical Engineering in Vietnam
  • Author : Vo Van Toi,Tran Ha Lien Phuong
  • Publisher :Unknown
  • Release Date :2014-11-18
  • Total pages :518
  • ISBN : 9783319117768
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Summary : This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

Vasculopathies

Vasculopathies
  • Author : Marc Thiriet
  • Publisher :Unknown
  • Release Date :2018-11-29
  • Total pages :888
  • ISBN : 9783319893150
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Summary : This volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.

Systems Biology of Metabolic and Signaling Networks

Systems Biology of Metabolic and Signaling Networks
  • Author : Miguel A. Aon,Valdur Saks,Uwe Schlattner
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :375
  • ISBN : 9783642385056
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Summary : Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Posttraumatic Stress Disorder and Related Diseases in Combat Veterans

Posttraumatic Stress Disorder and Related Diseases in Combat Veterans
  • Author : Elspeth Cameron Ritchie
  • Publisher :Unknown
  • Release Date :2015-10-27
  • Total pages :373
  • ISBN : 9783319229850
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Summary : This book takes a case-based approach to addressing the challenges psychiatrists and other clinicians face when working with American combat veterans after their return from a war zone. Written by experts, the book concentrates on a wide variety of concerns associated with posttraumatic stress disorder (PTSD), including different treatments of PTSD. The text also looks at PTSD comorbidities, such as depression and traumatic brain injury (TBI) and other conditions masquerading as PTSD. Finally, the authors touch on other subjects concerning returning veterans, including pain, disability, facing the end of a career, sleep problems , suicidal thoughts, violence, , and mefloquine “toxidrome”. Each case study includes a case presentation, diagnosis and assessment, treatment and management, outcome and case resolution, and clinical pearls and pitfalls. Post-Traumatic Stress Disorder and Related Diseases in Combat Veterans is a valuable resource for civilian and military mental health practitioners, and primary care physicians on how to treat patients returning from active war zones.

Principles of Artificial Neural Networks

Principles of Artificial Neural Networks
  • Author : Daniel Graupe
  • Publisher :Unknown
  • Release Date :2013-07-31
  • Total pages :500
  • ISBN : 9789814522755
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Summary : Artificial neural networks are most suitable for solving problems that are complex, ill-defined, highly nonlinear, of many and different variables, and/or stochastic. Such problems are abundant in medicine, in finance, in security and beyond. This volume covers the basic theory and architecture of the major artificial neural networks. Uniquely, it presents 18 complete case studies of applications of neural networks in various fields, ranging from cell-shape classification to micro-trading in finance and to constellation recognition — all with their respective source codes. These case studies demonstrate to the readers in detail how such case studies are designed and executed and how their specific results are obtained. The book is written for a one-semester graduate or senior-level undergraduate course on artificial neural networks. It is also intended to be a self-study and a reference text for scientists, engineers and for researchers in medicine, finance and data mining. Contents:Introduction and Role of Artificial Neural NetworksFundamentals of Biological Neural NetworksBasic Principles of ANNs and Their Early StructuresThe PerceptronThe MadalineBack PropagationHopfield NetworksCounter PropagationLarge Scale Memory Storage and Retrieval (LAMSTAR) NetworkAdaptive Resonance TheoryThe Cognitron and the NeocognitronStatistical TrainingRecurrent (Time Cycling) Back Propagation Networks Readership: Graduate and advanced senior students in artificial intelligence, pattern recognition & image analysis, neural networks, computational economics and finance, and biomedical engineering. Keywords:Neural Networks;Mathematical Derivations;Source Codes;Medical Applications;Data Mining;Cell-Shape Recognition;Micro-Trading

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research
  • Author : P. Michael Conn
  • Publisher :Unknown
  • Release Date :2008-03-07
  • Total pages :778
  • ISBN : 9781597452854
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Summary : The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Handbook of Robotic and Image-Guided Surgery

Handbook of Robotic and Image-Guided Surgery
  • Author : Mohammad H. Abedin-Nasab
  • Publisher :Unknown
  • Release Date :2019-09-25
  • Total pages :752
  • ISBN : 9780128142462
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Summary : Handbook of Robotic and Image-Guided Surgery provides state-of-the-art systems and methods for robotic and computer-assisted surgeries. In this masterpiece, contributions of 169 researchers from 19 countries have been gathered to provide 38 chapters. This handbook is 744 pages, includes 659 figures and 61 videos. It also provides basic medical knowledge for engineers and basic engineering principles for surgeons. A key strength of this text is the fusion of engineering, radiology, and surgical principles into one book. A thorough and in-depth handbook on surgical robotics and image-guided surgery which includes both fundamentals and advances in the field A comprehensive reference on robot-assisted laparoscopic, orthopedic, and head-and-neck surgeries Chapters are contributed by worldwide experts from both engineering and surgical backgrounds

Groundwater Arsenic Remediation

Groundwater Arsenic Remediation
  • Author : Parimal Pal
  • Publisher :Unknown
  • Release Date :2015-05-15
  • Total pages :326
  • ISBN : 9780128013779
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Summary : Arsenic abatement from groundwater in locations with a central water distribution system is relatively simple. The real challenge is selecting the most effective and affordable treatment and scale up option for locations which lack the appropriate infrastructure. Groundwater Arsenic Remediation: Treatment Technology and Scale UP provides the latest breakthrough groundwater treatment technologies and modeling and simulation methods for project scale up and eventually field deployment in locations which lack the proper central water distribution system to ensure arsenic free groundwater. Covers the different removal methods, such as chemical, adsorption, separation by membranes, and membrane distillation Includes the state-of-the-art modeling & simulation methods for optimization and field deployment Provides economic and comparative analysis of each arsenic treatment technology

Mechanics of Flow-Induced Sound and Vibration

Mechanics of Flow-Induced Sound and Vibration
  • Author : William K. Blake
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :670
  • ISBN : OCLC:1066570433
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Summary :

Advanced Cardiac Imaging

Advanced Cardiac Imaging
  • Author : Koen Nieman,Oliver Gaemperli,Patrizio Lancellotti,Sven Plein
  • Publisher :Unknown
  • Release Date :2015-07-16
  • Total pages :804
  • ISBN : 9781782422945
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Summary : Advances in Cardiac Imaging presents the latest information on heart disease and heart failure, major causes of death among western populations. In addition, the text explores the financial burden to public healthcare trusts and the vast amount of research and funding being channeled into programs not only to prevent such diseases, but also to diagnose them in early stages. This book provides readers with a thorough overview of many advances in cardiac imaging. Chapters include technological developments in cardiac imaging and imaging applications in a clinical setting with regard to detecting various types of heart disease. Presents a thorough overview of cardiac imaging technology Addresses specific applications for a number of cardiac diseases and how they can improve diagnoses and treatment protocols Includes technological developments in cardiac imaging and imaging applications in a clinical setting

Mathematical Models in Population Biology and Epidemiology

Mathematical Models in Population Biology and Epidemiology
  • Author : Fred Brauer,Carlos Castillo-Chavez
  • Publisher :Unknown
  • Release Date :2013-03-09
  • Total pages :417
  • ISBN : 9781475735161
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Summary : The goal of this book is to search for a balance between simple and analyzable models and unsolvable models which are capable of addressing important questions on population biology. Part I focusses on single species simple models including those which have been used to predict the growth of human and animal population in the past. Single population models are, in some sense, the building blocks of more realistic models -- the subject of Part II. Their role is fundamental to the study of ecological and demographic processes including the role of population structure and spatial heterogeneity -- the subject of Part III. This book, which will include both examples and exercises, is of use to practitioners, graduate students, and scientists working in the field.

On the Power of Fuzzy Markup Language

On the Power of Fuzzy Markup Language
  • Author : Giovanni Acampora,Vincenzo Loia,Chang-Shing Lee,Mei-Hui Wang
  • Publisher :Unknown
  • Release Date :2012-12-14
  • Total pages :188
  • ISBN : 9783642354885
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Summary : One of the most successful methodology that arose from the worldwide diffusion of Fuzzy Logic is Fuzzy Control. After the first attempts dated in the seventies, this methodology has been widely exploited for controlling many industrial components and systems. At the same time, and very independently from Fuzzy Logic or Fuzzy Control, the birth of the Web has impacted upon almost all aspects of computing discipline. Evolution of Web, Web2.0 and Web 3.0 has been making scenarios of ubiquitous computing much more feasible; consequently information technology has been thoroughly integrated into everyday objects and activities. What happens when Fuzzy Logic meets Web technology? Interesting results might come out, as you will discover in this book. Fuzzy Mark-up Language is a son of this synergistic view, where some technological issues of Web are re-interpreted taking into account the transparent notion of Fuzzy Control, as discussed here. The concept of a Fuzzy Control that is conceived and modeled in terms of a native web wisdom represents another step towards the last picture of Pervasive Web Intelligence.

Nanocomposites for Musculoskeletal Tissue Regeneration

Nanocomposites for Musculoskeletal Tissue Regeneration
  • Author : Huinan Liu
  • Publisher :Unknown
  • Release Date :2016-02-23
  • Total pages :406
  • ISBN : 9781782424758
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Summary : Nanocomposites for Musculoskeletal Tissue Regeneration discusses the advanced biomaterials scientists are exploring for use as tools to mimic the structure of musculoskeletal tissues. Bone and other musculoskeletal tissues naturally have a nanocomposite structure, therefore nanocomposites are ideally suited as a material for replacing and regenerating these natural tissues. In addition, biological properties such as biointegration and the ability to tailor and dope the materials make them highly desirable for musculoskeletal tissue regeneration. Provides a comprehensive discussion on the design and advancements made in the use of nanocomposites for musculoskeletal tissue regeneration Presents an In-depth coverage of material properties Includes discussions on polymers, ceramics, and glass

Principles of Treatment in Parkinson's Disease

Principles of Treatment in Parkinson's Disease
  • Author : Anthony Henry Vernon Schapira,Charles Warren Olanow
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :372
  • ISBN : 9780750654289
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Summary : This succinct volume offers an up-to-date review and comparison of the treatment options available for Parkinson's disease, and provides evidence-based recommendations on appropriate treatments for specific cases. Offers expert guidance on the best treatment options from authorities in the field. Delivers expert guidance on drug therapies, physical therapies, and surgical interventions. Discusses conditions such as depression · hallucinations · cognition · and sleep disorders. Explores neuroprotection in Parkinson's disease. Provides insights into future therapies.

Amyloid Fibrils and Prefibrillar Aggregates

Amyloid Fibrils and Prefibrillar Aggregates
  • Author : Daniel Erik Otzen
  • Publisher :Unknown
  • Release Date :2013-06-04
  • Total pages :464
  • ISBN : 9783527654208
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Summary : Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

Probabilistic Boolean Networks

Probabilistic Boolean Networks
  • Author : Ilya Shmulevich,Edward R. Dougherty
  • Publisher :Unknown
  • Release Date :2010-01-21
  • Total pages :267
  • ISBN : 9780898716924
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Summary : The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.