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Organic Synthesis Using Biocatalysis

Organic Synthesis Using Biocatalysis
  • Author : Animesh Goswami,Jon D. Stewart
  • Publisher :Unknown
  • Release Date :2015-09-06
  • Total pages :438
  • ISBN : 9780124115422
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Summary : Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Biocatalysis in Organic Synthesis

Biocatalysis in Organic Synthesis
  • Author : Nicholas J Turner,Luke Humphreys
  • Publisher :Unknown
  • Release Date :2018-02-15
  • Total pages :429
  • ISBN : 9781788013420
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Summary : The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Stereoselective Biocatalysis

Stereoselective Biocatalysis
  • Author : Ramesh N. Patel
  • Publisher :Unknown
  • Release Date :2000-01-03
  • Total pages :946
  • ISBN : 0824782828
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Summary : This book offers an explanation of the specific ways that biocatalysis outperforms chemical catalysis by: utilizing ambient temperature and atmospheric pressure to minimize problems of isomerization, racemization, and epimerization; employing microbial cells and enzymes that can be immobilized and reused over many cycles; and overexpressing enzymes for greater economy and efficiency.

Future Directions in Biocatalysis

Future Directions in Biocatalysis
  • Author : Tomoko Matsuda
  • Publisher :Unknown
  • Release Date :2017-08-11
  • Total pages :460
  • ISBN : 9780444637505
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Summary : Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic. This book is an indispensable tool for new researchers in the field to help identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. It provides invaluable hints and clues for conducting new research on enzymes, with final sections outlining future directions in biocatalysis further expanding the science into new applications. Gives future directions in the area of biocatalysis research Presents research topics based on their uniqueness, originality, and novelty Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists Shows that there is no boundary between organic chemistry and biochemistry

Biocatalysis in the Pharmaceutical and Biotechnology Industries

Biocatalysis in the Pharmaceutical and Biotechnology Industries
  • Author : Ramesh N. Patel
  • Publisher :Unknown
  • Release Date :2006-09-26
  • Total pages :893
  • ISBN : 9781420019377
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Summary : Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science
  • Author : Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
  • Publisher :Unknown
  • Release Date :2020-12-01
  • Total pages :312
  • ISBN : 9780128219003
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Summary : Green Sustainable Process for Chemical and Environmental Engineering and Science: Plant-Derived Green Solvents: Properties and Applications provide a comprehensive review on the green solvents such as bio solvents, terpenes, neem, alkyl phenols, cyrene, limenone, and ethyl lactate, etc. which are derived from plant sources. Chapters discuss introduction, properties, and advantages to the practical use of plant-derived solvents. Plants-derived solvents are an excellent choice for real-world applications to reduce the environmental and health safety considerations. This book is the result of commitments by top researchers in the field of biosolvents from various backgrounds and fields of expertise. This book is a one-stop reference for plant solvents and overviews up-to-date accounts in the field of modern applications and the first book in this research community. Introduces properties and application of green solvents from plants Gives an in-depth accounts on plant-derived solvents for various applications Outlines the benefits and possibilities of plant-derived solvents vs conventional solvents Outlines eco-friendly green solvents synthesis, properties and applications Key references to obtain great results in plant-derived green solvents

Biocatalysis

Biocatalysis
  • Author : W.-D. Fessner
  • Publisher :Unknown
  • Release Date :2003-09-05
  • Total pages :254
  • ISBN : 9783540681168
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Summary : Here, leading contributors from the forefront of this exciting technology present authoritative and timely reviews on the state of the art of biocatalysis. They cover the whole spectrum from the discovery of novel enzymes - by modern screening, evolutionary or immunological approaches - through immobilization techniques for technical processes, to their use in the asymmetric synthesis of important target compounds.

Organic Synthesis with Enzymes in Non-Aqueous Media

Organic Synthesis with Enzymes in Non-Aqueous Media
  • Author : Giacomo Carrea,Sergio Riva
  • Publisher :Unknown
  • Release Date :2008-04-09
  • Total pages :328
  • ISBN : 9783527621736
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Summary : Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Enzymes in Synthetic Organic Chemistry

Enzymes in Synthetic Organic Chemistry
  • Author : Wong,Whitesides
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :389
  • ISBN : 9780080505824
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Summary : This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.

Biocatalysis for the Pharmaceutical Industry

Biocatalysis for the Pharmaceutical Industry
  • Author : Junhua (Alex) Tao,Guo-Qiang Lin,Andreas Liese
  • Publisher :Unknown
  • Release Date :2009-07-23
  • Total pages :250
  • ISBN : 9780470823156
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Summary : Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2
  • Author : John Whittall,Peter W. Sutton
  • Publisher :Unknown
  • Release Date :2012-04-25
  • Total pages :368
  • ISBN : 9781118307861
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Summary : Biocatalysts are increasingly used by chemists engaged in finechemical synthesis within both industry and academia. Today, thereexists a huge choice of high-tech enzymes and whole cellbiocatalysts, which add enormously to the repertoire of syntheticpossibilities. Practical Methods for Biocatalysis and Biotransformations2 is a "how-to" guide that focuses on the practicalapplications of enzymes and strains of microorganisms that arereadily obtained or derived from culture collections. The sourcesof starting materials and reagents, hints, tips and safety advice(where appropriate) are given to ensure, as far as possible, thatthe procedures are reproducible. Comparisons to alternativemethodology are given and relevant references to the primaryliterature are cited. This second volume – which can be usedon its own or in combination with the first volume - concentrateson new applications and new enzyme families reported since thefirst volume. Contents include: introduction to recent developments and future needs inbiocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficientalkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation andphosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations2 is an essential collection of biocatalytic methods forchemical synthesis which will find a place on the bookshelves ofsynthetic organic chemists, pharmaceutical chemists, and processR&D chemists in industry and academia.

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development
  • Author : Junhua (Alex) Tao,Romas Joseph Kazlauskas
  • Publisher :Unknown
  • Release Date :2011-06-09
  • Total pages :496
  • ISBN : 1118028295
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Summary : This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Biocatalysis in Organic Synthesis

Biocatalysis in Organic Synthesis
  • Author : Kurt Faber
  • Publisher :Unknown
  • Release Date :2015
  • Total pages :676
  • ISBN : 3131746718
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Summary : The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Applied Biocatalysis

Applied Biocatalysis
  • Author : John Whittall,Peter W. Sutton
  • Publisher :Unknown
  • Release Date :2020-08-21
  • Total pages :560
  • ISBN : 9781119487029
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Summary : Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.

Industrial Biotransformations

Industrial Biotransformations
  • Author : Andreas Liese,Karsten Seelbach,Christian Wandrey
  • Publisher :Unknown
  • Release Date :2008-07-11
  • Total pages :428
  • ISBN : 9783527614172
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Summary : Industrial Biotransformations - a user-friendly and application-oriented up-to-date overview of one-step biotransformations of industrial importance. The data conferring each process is arranged in a convenient format to survey so that the processes can easily be compared. Each set of data is accompanied by key literature citations. As far as flow sheets of the processes are available, these are given reduced to their significant elements. An extensive index classified by substrates, products, enzymes, and companies provides direct access to each process organized in the order of enzyme classes. The reader will find all significant parameters characterizing the biotransformation itself and the process.

Industrial Biocatalysis

Industrial Biocatalysis
  • Author : Peter Grunwald
  • Publisher :Unknown
  • Release Date :2014-12-11
  • Total pages :1232
  • ISBN : 9789814463898
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Summary : Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

Green Biocatalysis

Green Biocatalysis
  • Author : Ramesh N. Patel
  • Publisher :Unknown
  • Release Date :2016-06-27
  • Total pages :792
  • ISBN : 9781118822296
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Summary : This book describes the enzyme-driven syntheses of industrially important compounds and chiral intermediates for chemicals and pharmaceuticals. The chapters describe recent technological advances in enzymatic and microbial transformations and are written by internationally renowned scientists and professors. The synthesis of industrially important molecules is described from the starting substrate to the final product and includes detailed mechanisms. This book addresses the use of various types of reactions catalyzed by microbial cells or enzymes derived from microbes in the production of industrially useful compounds and a variety of drugs. The production of chiral alcohols, amines, unnatural amino acids, esters, carboxylic acids, epoxides, hydroxylated compounds and drug metabolites as well as recent advances in enzyme catalyzed acylation, dehalogenation, esterification, oxidation-reduction, transamination, deamination, C-N, C-C, C-O bond formation, Baeyer-Villegar reaction and aldol as well as acyloin condensation reactions are covered. Cutting-edge topics such as directed evolution by gene shuffling and enzyme engineering to improve biocatalysts will be presented. Enzyme immobilization and reusability studies and enzymatic protection and deprotection are addressed as well.

New Trends in Green Chemistry

New Trends in Green Chemistry
  • Author : V.K. Ahluwalia,M. Kidwai
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :263
  • ISBN : 9781402031755
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Summary : Organic chemistry has played a vital role in the development of diverse molecules which are used in medicines, agrochemicals and polymers. Most ofthe chemicals are produced on an industrial scale. The industrial houses adopt a synthesis for a particular molecule which should be cost-effective. No attention is paid to avoid the release of harmful chemicals in the atmosphere, land and sea. During the past decade special emphasis has been made towards green synthesis which circumvents the above problems. Prof. V. K. Ahluwalia and Dr. M. Kidwai have made a sincere effort in this direction. This book discusses the basic principles of green chemistry incorporating the use of green reagents, green catalysts, phase transfer catalysis, green synthesis using microwaves, ultrasound and biocatalysis in detail. Special emphasis is given to liquid phase reactions and organic synthesis in the solid phase. I must congratulate both the authors for their pioneering efforts to write this book. Careful selection of various topics in the book will serve the rightful purpose for the chemistry community and the industrial houses at all levels. PROF. JAVED IQBAL, PhD, FNA Distinguished Research Scientist & Head Discovery Research Dr. Reddy's Laboratories Ltd.

Molecules That Changed the World

Molecules That Changed the World
  • Author : K. C. Nicolaou,Tamsyn Montagnon
  • Publisher :Unknown
  • Release Date :2008-03-17
  • Total pages :385
  • ISBN : 3527309837
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Summary : K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read.

Enzyme Biocatalysis

Enzyme Biocatalysis
  • Author : Andrés Illanes
  • Publisher :Unknown
  • Release Date :2008-06-19
  • Total pages :392
  • ISBN : 9781402083617
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Summary : This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Introduction to Biocatalysis Using Enzymes and Microorganisms

Introduction to Biocatalysis Using Enzymes and Microorganisms
  • Author : S. M. Roberts,Nicholas J. Turner,Tel,Andrew J. Willetts,Michael K. Turner
  • Publisher :Unknown
  • Release Date :1995-01-27
  • Total pages :195
  • ISBN : 0521436850
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Summary : This book gives an introduction to biotransformations, the practice of harnessing biological catalysts for the preparation of useful chemicals.