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Osteosarcopenia: Bone, Muscle and Fat Interactions

Osteosarcopenia: Bone, Muscle and Fat Interactions
  • Author : Gustavo Duque
  • Publisher :Unknown
  • Release Date :2019-11-06
  • Total pages :383
  • ISBN : 9783030258900
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Summary : This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Osteosarcopenia

Osteosarcopenia
  • Author : Gustavo Duque,Bruce R. Troen
  • Publisher :Unknown
  • Release Date :2021-08-01
  • Total pages :240
  • ISBN : 9780128204207
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Summary : Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia

Advances in Clinical Chemistry

Advances in Clinical Chemistry
  • Author : Gregory S. Makowski
  • Publisher :Unknown
  • Release Date :2020-01-10
  • Total pages :340
  • ISBN : 9780128208014
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Summary : Advances in Clinical Chemistry, Volume 94, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest technologies relating to the field of clinical chemistry, with specific chapters in this new release covering Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome, Clotting factors - Clinical biochemistry and their roles as plasma enzymes, Myokines: The endocrine coupling of skeletal muscle and bone, Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance, and more. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory

Sarcopenia

Sarcopenia
  • Author : Alfonso J. Cruz-Jentoft,John E. Morley
  • Publisher :Unknown
  • Release Date :2021-06-28
  • Total pages :464
  • ISBN : 9781119597872
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Summary : An in-depth examination of sarcopenia’s underexplored yet widespread impact within the field of gerontology Sarcopenia is common in older men and women, and yet awareness of its clinical relevance is still relatively low. Only formally included in the International Classification of Diseases in 2016, the condition may impact societies with serious health-related and financial consequences unless consistent, effective methods of identification and management are adopted. This second edition of Sarcopenia provides geriatricians and other healthcare professionals with a revised and expanded examination of this understudied and underdiagnosed condition. Edited by two leading authorities on the subject, it covers the epidemiology and diagnosis of sarcopenia, as well as treatment options and possible prevention strategies. Eight newly written chapters build upon existing knowledge with fresh data on topics including sarcopenia’s biomarkers and its impact on the healthcare economy. This important text: Defines sarcopenia and explains its clinical relevance Covers all recent scientific evidence Outlines treatment options Considers prevention strategies Discusses sarcopenia as a public health priority Features eight new chapters covering topics such as sarcopenia’s clinical management, its biomarkers, and its financial impact Containing vital information for clinicians and other professionals working in geriatric care, nursing homes, nutrition, cancer, endocrinology, surgery, sports medicine and many other specialties, Sarcopenia, second edition, is a groundbreaking and essential new resource.

Postmenopausal Diseases and Disorders

Postmenopausal Diseases and Disorders
  • Author : Faustino R. Pérez-López
  • Publisher :Unknown
  • Release Date :2019-07-10
  • Total pages :484
  • ISBN : 9783030139360
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Summary : Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes the development of quick and easy-to-use assessment tools and predictive markers of age-related co-morbidities. As such, the book is a valuable resource for researchers and clinicians alike.

Marcus and Feldman's Osteoporosis

Marcus and Feldman's Osteoporosis
  • Author : David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman
  • Publisher :Unknown
  • Release Date :2020-10-08
  • Total pages :1946
  • ISBN : 9780128130742
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Summary : Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2019-11-20
  • Total pages :1640
  • ISBN : 9780128160763
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Summary : Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Orthogeriatrics

Orthogeriatrics
  • Author : Paolo Falaschi,David R. Marsh
  • Publisher :Unknown
  • Release Date :2016-09-19
  • Total pages :211
  • ISBN : 9783319432496
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Summary : This book focuses on orthogeriatrics, a topic that has received little attention in the literature to date. As active members of the Fragility Fracture Network (FFN), the editors and most of the authors of this book have gathered all essential expertise on hip fracture management in a single volume. The 14 chapters provide a complete overview of how to approach fractures in elderly patients, starting with the epidemiology of hip fractures and subsequently addressing osteoporosis, surgery, anesthesia, medical management of frailty, and peri-operative complications. Attention is also given to rehabilitation and nursing, as well as to the psychological evaluation of the patient and the caregivers, thus emphasizing the importance of a multidisciplinary approach. Thanks to its clinical and practice-oriented nature, the book will especially be of interest to residents and young geriatricians, as well as orthopaedic surgeons, anesthesiologists and nurses dealing with elderly fracture patients in all parts of the world.

Multidisciplinary Approach to Osteoporosis

Multidisciplinary Approach to Osteoporosis
  • Author : Andrea Lenzi,Silvia Migliaccio
  • Publisher :Unknown
  • Release Date :2018-09-04
  • Total pages :330
  • ISBN : 9783319751108
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Summary : This book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age.

Osteoporosis in Older Persons

Osteoporosis in Older Persons
  • Author : Gustavo Duque,Douglas P. Kiel
  • Publisher :Unknown
  • Release Date :2016-07-11
  • Total pages :282
  • ISBN : 9783319259765
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Summary : This new edition includes the most up-to-date information about the pathophysiology and new therapeutic alternatives for osteoporosis of advanced age. It is written by investigators (clinicians and basic scientists) in the field of aging bone research. It was just recently that a new syndrome, osteoporosis of advanced age, was recognized as a new entity with its own pathophysiology and potential treatments. Unfortunately, and despite the fact that hip fractures are mostly a consequence of this process, and apart from the first edition of this book, there are few publications about this subject. The first edition of this book demonstrated that there is a need to understand the particular features of osteoporosis in older persons, which is the main aim of this book. The institutions where the authors are affiliated are highly recognized as the main centers in aging bone research. As an innovation, the second edition includes some aspects of muscle and bone interaction focusing of the impact of age-related muscle loss (sarcopenia) on the pathogenesis of falls and fractures in older persons. As in the previous edition, this book is expected to be the reference guide for geriatricians, gerontologists, and bone biologists as well as medical trainees in order to understand the mechanisms of senile osteoporosis with a practical approach to the treatment of its consequences.

Hot Topics in Endocrine and Endocrine-Related Diseases

Hot Topics in Endocrine and Endocrine-Related Diseases
  • Author : Monica Fedele
  • Publisher :Unknown
  • Release Date :2013-05-08
  • Total pages :276
  • ISBN : 9789535110804
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Summary : This book covers a selected number of hot topics in endocrine and hormone-related pathologies, discussed by eminent scientists and clinicians coming from different countries of the world. It deals with advanced recent trends in the field, including neuroendocrine and pituitary tumors, thyroid dysfunctions, diabetes and a series of endocrine-related diseases, such as those related to the anabolic effects of testosterone, obesity, cancer, the liver complications of diabetes and the pediatric nonalcoholic fatty liver disease. The readers should be able to have a basic, as well as critic and advanced, overview of these selected hot pathologies of the endocrine system.

Adipose Tissue Protocols

Adipose Tissue Protocols
  • Author : Gérard Ailhaud
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :338
  • ISBN : 9781592592319
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Summary : Adipose tissue is now recognized as a widely dispersed secretory organ that exhibits autocrine, paracrine, and endocrine properties, and plays a significant role in obesity, the most common health problem in industrialized countries. In Adipose Tissue Protocols, Gerard Ailhaud and a team of laboratory experts and clinicians describe in step-by-step detail the major techniques needed for the study of adipose tissue and cells. Drawn from both in vivo and in vitro studies, these readily reproducible methods cover a broad range of techniques, including the choice of adipose tissue depot and of morphological techniques for work on both brown adipose tissue (BAT) and white adipose tissue (WAT). Major treatment is accorded the isolation, subcellular fractionation, and transfection of low density adipocytes, as well as the metabolic aspects of nutrient uptake and key assays of nutrient and ion fluxes. Also covered are: biopsies and quantification of lipid-related mRNAs; cultures of adipose precursor cells from WAT and BAT; measurements of adipose secretory products; assessment of WAT metabolism in vivo; and assays of lipid-related enzymes. Innovative and highly practical, Adipose Tissue Protocols offers endocrinologists, physiologists, cell biologists, and pharmacologists a gold-standard collection of proven methods for effective nutritional, physiological, and molecular-level research on adipose tissue."

Rheumatic Disease in Geriatrics

Rheumatic Disease in Geriatrics
  • Author : Gleb Slobodin,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :2020-05-25
  • Total pages :404
  • ISBN : 9783030442347
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Summary : This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

An Essay on the Shaking Palsy

An Essay on the Shaking Palsy
  • Author : James Parkinson
  • Publisher :Unknown
  • Release Date :1817
  • Total pages :66
  • ISBN : NWU:35558004985954
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Summary :

Nutritional Influences on Bone Health

Nutritional Influences on Bone Health
  • Author : Connie M. Weaver,Robin M. Daly,Heike A. Bischoff-Ferrari
  • Publisher :Unknown
  • Release Date :2016-08-01
  • Total pages :335
  • ISBN : 9783319324173
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Summary : The 9th International Symposium is the only regular meeting in the bone field to be exclusively devoted to nutrition, bone and muscle, and it allows the authors of this book to review the new scientific data, discuss new concepts, and update the knowledge on several nutrients. The Symposium provides a unique opportunity to connect health professionals, researchers and industry across many disciplines, including nutrition and dietetics, exercise science, gerontology, nursing, general practice, academia and the food and fitness industry. Most causes for osteoporosis, like genetics, age, menopause, and associated diseases with their treatments, are not modifiable. The investigation of the influence of nutrition on bone health is important as a key modifiable factor of the development of bone and the prevention of osteoporosis. It is the privilege of this symposium to gather every three years with scientists from all over the world working in this field.

The Osteoporosis Primer

The Osteoporosis Primer
  • Author : Janet E. Henderson,David Goltzman
  • Publisher :Unknown
  • Release Date :2000-08-24
  • Total pages :372
  • ISBN : 0521644461
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Summary : The Osteoporosis Primer provides an excellent introduction that relates the clinical presentation of osteoporosis to its molecular biochemical basis, and reviews therapeutic options.

Skeletal Muscle Development

Skeletal Muscle Development
  • Author : James G. Ryall
  • Publisher :Unknown
  • Release Date :2017-08-25
  • Total pages :226
  • ISBN : 1493972820
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Summary : This detailed volume presents a wide range of techniques that go beyond the standard assays typically used to assess Myogenesis. The content included addresses assays to analyze skeletal muscle gene expression, proliferating muscle cells, the process of myoblast fusion, muscle development (in vivo), as well as muscle repair. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Skeletal Muscle Development serves as an ideal guide to the study of this highly complex yet carefully regulated process.>

Endocrinology of Aging

Endocrinology of Aging
  • Author : Emiliano Corpas,Marc R. Blackman,S. Mitchell Harman,Antonio Ruiz-Torres
  • Publisher :Unknown
  • Release Date :2020-10-06
  • Total pages :790
  • ISBN : 9780128196670
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Summary : Endocrinology of Aging: Clinical Aspects in Diagrams and Images presents chapters in a way that allows the reader to incorporate concepts and complex facts in a visual way. As the global population becomes older, the need for a deeper understanding of geriatric pathology increases, and with it, there becomes a greater need to access educational resources on the endocrinology and metabolism of aging. According to the United Nations, the number of people aged 60 years or over in the world is projected to be 1.4 billion in 2030 and 2.1 billion in 2050, hence this is a timely resource. Divided according to specific endocrine and metabolic systems, providing evidence-based content Addresses physiological changes that alter the pathophysiology of the clinical picture Considers the patient transitioning from young adult to elderly, discussing endocrinological challenges to discern physiology from pathology Focuses on age as an essential factor for diagnostic and endocrine management

Providing Healthy and Safe Foods As We Age

Providing Healthy and Safe Foods As We Age
  • Author : Institute of Medicine,Food and Nutrition Board,Food Forum
  • Publisher :Unknown
  • Release Date :2010-11-29
  • Total pages :192
  • ISBN : 9780309158831
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Summary : Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.

Bone Toxicology

Bone Toxicology
  • Author : Susan Y. Smith,Aurore Varela,Rana Samadfam
  • Publisher :Unknown
  • Release Date :2017-09-27
  • Total pages :474
  • ISBN : 9783319561929
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Summary : The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

Hazzard's Geriatric Medicine and Gerontology, 7E

Hazzard's Geriatric Medicine and Gerontology, 7E
  • Author : Jeffrey B. Halter,Joseph G. Ouslander,Stephanie Studenski,Kevin P. High,Sanjay Asthana,Nancy Woolard,Christine S. Ritchie,Mark A. Supiano
  • Publisher :Unknown
  • Release Date :2016-11-18
  • Total pages :2304
  • ISBN : 9780071833462
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Summary : The gold-standard text on the diagnosis and treatment of disorders affecting the elderly – completely updated with a new full-color presentation A Doody's Core Title for 2017! The definitive treatise on the subject of geriatrics, this comprehensive text combines gerontology principles with clinical geriatrics, offering a uniquely holistic approach to this ever-expanding area of medicine. Written by some of the world’s most respected geriatricians, Hazzard’s Geriatric Medicine and Gerontology, Seventh Edition presents up-to-date, evidence-based information in a rich new full-color design. Unmatched as a textbook, this classic is also valuable to fellows in geriatric medicine. Hazzards’s Geriatric Medicine and Gerontology, Seventh Edition is logically divided into five parts: Principles of Gerontology, Principles of Geriatrics, Geriatric Syndromes, Principles of Palliative Medicine, and Organ Systems and Diseases. Within its pages, you will find balanced, authoritative coverage of every essential topic – from evaluation and management to nutrition and palliative medicine. Here’s why the Seventh Edition is the best edition ever: • NEW full-color design with hundreds of color photographs • NEW chapters: Quality of Care in Older Adults, Common Non-Pain Symptoms in Older Adults, Strategies of Effective Communication Around Advanced Illness, Palliative Medicine in the Continuum of Care Including Hospice, Coagulation Disorders, and Plasma Cell Disorders • MORE chapters on Palliative Medicine • NEW Learning Objectives and Key Points added to each chapter • MORE tables, drawings, and clinical algorithms • EVIDENCE-BASED through the use of the latest clinical practice guidelines , references to systemic reviews, and critically appraised topics • UPDATED to reflect the most current clinical breakthroughs and advances for managing older adults in various settings