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Overcoming Challenges in Antibacterial Drug Discovery and Development

Overcoming Challenges in Antibacterial Drug Discovery and Development
  • Author : Aarti Raja
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : OCLC:1120945115
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Summary :

Peptide-based Drug Discovery

Peptide-based Drug Discovery
  • Author : Ved Srivastava
  • Publisher :Unknown
  • Release Date :2017-06-26
  • Total pages :588
  • ISBN : 9781782627326
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Summary : With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Peptide Drug Discovery and Development

Peptide Drug Discovery and Development
  • Author : Miguel Castanho,Nuno Santos
  • Publisher :Unknown
  • Release Date :2011-10-24
  • Total pages :390
  • ISBN : 9783527636747
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Summary : Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

International Intellectual Property in an Integrated World Economy

International Intellectual Property in an Integrated World Economy
  • Author : Frederick M. Abbott,Thomas Cottier,Francis Gurry
  • Publisher :Unknown
  • Release Date :2019-02-07
  • Total pages :1056
  • ISBN : 9781454895831
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Summary : International Intellectual Property in an Integrated World Economy, Fourth Edition by Frederick M. Abbott, Thomas Cottier, and Francis Gurry, provides a comprehensive treatment of the international intellectual property system across the spectrum of intellectual property rights and interests. It introduces the institutional architecture at the multilateral, regional/plurilateral, bilateral and national levels. For each form of IP, it addresses the technical legal rules and illustrative jurisprudence, as well as economic and social welfare implications. Each of the authors has played a role in the development and implementation of the international rules, and they bring their experience to bear in introducing students to the field. New to the Fourth Edition: The latest developments in bilateral and regional agreements regulating intellectual property, including NAFTA 2.0 (USMCA), CPTPP, and CETA Important new judicial decisions, including the U.S. Supreme Court decision adopting international exhaustion of patents and CJEU decisions addressing trademarks, geographical indications, and copyright Developments in IP and human rights; IP and competition law; and IP and health The WTO panel report in the Australia-Tobacco case Professors and students will benefit from: An approach to the international IP system that situates the rules within the broader context of international law and the public policy objectives that governments, industry, and interest groups are seeking to achieve Case law from international dispute settlement bodies, as well as from national and regional courts Discussion of patent, trademark, geographical indication, copyright, design, trade secret, and data protection; as well as plant variety protection, protection of genetic resources and traditional knowledge, and the role of open source An explanation of the new European Union Unitary Patent system Exploration of the increasingly important role of emerging market IP systems Materials to help students understand the disputes between the United States and China involving IP, investment, and transfer of technology Inclusion of important jurisprudential developments

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
  • Author : Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker
  • Publisher :Unknown
  • Release Date :1992-03-31
  • Total pages :409
  • ISBN : 0792316290
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Summary : Proceedings of the 22nd Annual Cancer Symposium, Detroit, Michigan, April 26-28, 1990.

Drug Discovery and Development - E-Book

Drug Discovery and Development - E-Book
  • Author : Raymond G Hill
  • Publisher :Unknown
  • Release Date :2012-07-20
  • Total pages :368
  • ISBN : 9780702053160
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Summary : The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development
  • Author : Qing Yan
  • Publisher :Unknown
  • Release Date :2010-04-26
  • Total pages :365
  • ISBN : STANFORD:36105211741215
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Summary : This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis
  • Author : Marc Stadler,Petra Dersch
  • Publisher :Unknown
  • Release Date :2016-12-21
  • Total pages :496
  • ISBN : 9783319492841
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Summary : This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Drug Repositioning: Current Advances and Future Perspectives

Drug Repositioning: Current Advances and Future Perspectives
  • Author : Yuhei Nishimura,Hideaki Hara
  • Publisher :Unknown
  • Release Date :2019-01-11
  • Total pages :229
  • ISBN : 9782889456963
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Summary : Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents

Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents
  • Author : Alfred Burger
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :8
  • ISBN : UOM:39015039074490
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Summary :

Drug Discovery from Nature

Drug Discovery from Nature
  • Author : S. Grabley,R. Thiericke
  • Publisher :Unknown
  • Release Date :1998-11-26
  • Total pages :347
  • ISBN : 3540648445
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Summary : This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Interagency Coordination in Drug Research and Regulation

Interagency Coordination in Drug Research and Regulation
  • Author : United States. Congress. Senate. Committee on Government Operations. Subcommittee on Reorganization and International Organizations
  • Publisher :Unknown
  • Release Date :1963
  • Total pages :3228
  • ISBN : MINN:31951D021591461
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Summary : Reviews cooperative efforts among Federal and international agencies responsible for medical research on experimental drugs and regulation of pharmaceutical industry marketing practices. Includes review of thalidomide marketing and use.

Drug Discovery and Development

Drug Discovery and Development
  • Author : H. P. Rang,Daniel Vasella
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :346
  • ISBN : UOM:39015063653672
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Summary : 'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

New Drug Discovery and Development

New Drug Discovery and Development
  • Author : Daniel Lednicer
  • Publisher :Unknown
  • Release Date :2006-10-20
  • Total pages :240
  • ISBN : 9780470068267
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Summary : A case history approach to drug synthesis and discovery Discover the origins of some of today’s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval. This is a great reference for students in medicinal chemistry, researchers in pharmaceuticals, and medical practitioners.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher :Unknown
  • Release Date :2014-02-06
  • Total pages :118
  • ISBN : 9780309292498
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Summary : Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Retrometabolic Drug Design and Targeting

Retrometabolic Drug Design and Targeting
  • Author : Nicholas Bodor,Peter Buchwald
  • Publisher :Unknown
  • Release Date :2012-08-29
  • Total pages :418
  • ISBN : 9781118407769
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Summary : Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

Experimental Biology and Medicine

Experimental Biology and Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : UCLA:L0090568890
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Summary :

Transforming Clinical Research in the United States

Transforming Clinical Research in the United States
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
  • Publisher :Unknown
  • Release Date :2010-10-22
  • Total pages :150
  • ISBN : 0309163358
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Summary : An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise.

Flow Cytometry in Drug Discovery and Development

Flow Cytometry in Drug Discovery and Development
  • Author : Virginia Litwin,Philip Marder
  • Publisher :Unknown
  • Release Date :2011-04-20
  • Total pages :360
  • ISBN : 9780470922781
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Summary : This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.

Drug Design Strategies

Drug Design Strategies
  • Author : David J. Livingstone,Andrew M. Davis
  • Publisher :Unknown
  • Release Date :2011-11
  • Total pages :498
  • ISBN : 9781849731669
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Summary : Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress.

Plunkett's Biotech & Genetics Industry Almanac

Plunkett's Biotech & Genetics Industry Almanac
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : UOM:39076002492010
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Summary : The only complete guide to the technologies and companies in the biotech and genetics industry.