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Overflow Metabolism

Overflow Metabolism
  • Author : Alexei Vazquez
  • Publisher :Unknown
  • Release Date :2017-10-27
  • Total pages :84
  • ISBN : 0128123354
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Summary : Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

The significance of overflow metabolism in the physiology and g...

The significance of overflow metabolism in the physiology and g...
  • Author : Oense Martinus Neijssel
  • Publisher :Unknown
  • Release Date :1976
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Insect-Plant Interactions

Insect-Plant Interactions
  • Author : Elizabeth A. Bernays
  • Publisher :Unknown
  • Release Date :2019-10-01
  • Total pages :176
  • ISBN : 100069755X
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Summary : First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Basic Biotechnology

Basic Biotechnology
  • Author : Colin Ratledge,Bjorn Kristiansen
  • Publisher :Unknown
  • Release Date :2006-05-25
  • Total pages :666
  • ISBN : 0521840317
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Summary : Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are applied; from starting substrate to final product. A distinctive feature of this text are the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production
  • Author : Kazuyuki Shimizu
  • Publisher :Unknown
  • Release Date :2017-07-12
  • Total pages :325
  • ISBN : 1351650106
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Summary : The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on the land or sea locations and subject to the climate change. Biofuel and biochemical production from renewable bio-resources has thus been paid recent attention from environmental protection and energy production points of view, where the current chemical and energy producing plants can be also utilized with slight modification. The so-called 1st generation biofuels have been produced from corn starch and sugarcane in particular in USA and Brazil. However, this causes the problem of the so-called "food and energy issues" as the production scale increases. The 2nd generation biofuel production from lingo-cellulosic biomass or wastes has thus been paid recent attention. However, it requires energy intensive pretreatment for the degradation of lingo-cellulosic biomass, and the fermentation is slow due to low growth rate, and thus the productivity of biofuels and bio-chemicals is low. The 3rd generation biofuel production from photosynthetic organisms such as cyanobacteria and algae has been also paid attention, because such organisms can grow with only sun light and CO2 in the air, but the cell growth rate and thus the productivity of the fuels is significantly low. The main part or core of such production processes is the fermentation by micro-organisms. In particular, it is critical to properly understand the cell metabolism followed by the efficient metabolic engineering. The book gives comprehensive explanation of the cell metabolism and the metabolic regulation mechanisms of a variety of micro-organisms. Then the efficient metabolic engineering approaches are explained to properly design the microbial cell factories for the efficient cell growth and biofuel and biochemical production.

Evolution, Development and Complexity

Evolution, Development and Complexity
  • Author : Georgi Yordanov Georgiev,John M. Smart,Claudio L. Flores Martinez,Michael E. Price
  • Publisher :Unknown
  • Release Date :2019-06-25
  • Total pages :454
  • ISBN : 3030000753
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Summary : This book explores the universe and its subsystems from the three lenses of evolutionary (contingent), developmental (predictable), and complex (adaptive) processes at all scales. It draws from prolific experts within the academic disciplines of complexity science, physical science, information and computer science, theoretical and evo-devo biology, cosmology, astrobiology, evolutionary theory, developmental theory, and philosophy. The chapters come from a Satellite Meeting, "Evolution, Development and Complexity" (EDC) hosted at the Conference on Complex Systems, in Cancun, 2017. The contributions have been peer-reviewed and contributors from outside the conference were invited to submit chapters to ensure full coverage of the topics. This book explores many issues within the field of EDC such as the interaction of evolutionary stochasticity and developmental determinism in biological systems and what they might teach us about these twin processes in other complex systems. This text will appeal to students and researchers within the complex systems and EDC fields.

Issues in Chemical, Biological, and Medical Engineering: 2013 Edition

Issues in Chemical, Biological, and Medical Engineering: 2013 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2013-05-01
  • Total pages :660
  • ISBN : 1490106308
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Summary : Issues in Chemical, Biological, and Medical Engineering: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Biosystems Engineering. The editors have built Issues in Chemical, Biological, and Medical Engineering: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biosystems Engineering in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemical, Biological, and Medical Engineering: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Metabolic Engineering

Metabolic Engineering
  • Author : Sang Yup Lee,E. Terry Papoutsakis
  • Publisher :Unknown
  • Release Date :1999-09-29
  • Total pages :450
  • ISBN : 9780824773908
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Summary : This unique reference/text presents the basic theory and practical applications of metabolic engineering (ME). It offers systematic analysis of complex metabolic pathways and ways of employing recombinant DNA techniques to alter cell behavior, metabolic patterns, and product formation. Treating ME as a distinct subfield of genetic engineering, the book demonstrates new means of enabling cells to produce valuable proteins, polypeptides, and primary and secondary metabolites. Written by more than 35 leading international experts in the field, this book discusses metabolic engineering in plant and mammalian cells, bacteria, and yeasts and assesses metabolic engineering applications in agriculture, pharmaceuticals, and environmental systems. It illuminates the potential of the "cell factory" model for production of chemicals and therapeutics and examines methods for developing new antiviral and antibacterial molecules and effective gene and somatic-cell therapies. Metabolic Engineering also addresses the use of metabolic flux analysis, metabolic control analysis, and online metabolic flux analysis.

Bioreaction Engineering Principles

Bioreaction Engineering Principles
  • Author : Jens Nielsen,John Villadsen,Gunnar Lidén
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :528
  • ISBN : 1461507677
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Summary : This is the second edition of the text "Bioreaction Engineering Principles" by Jens Nielsen and John Villadsen, originally published in 1994 by Plenum Press (now part of Kluwer). Time runs fast in Biotechnology, and when Kluwer Plenum stopped reprinting the first edition and asked us to make a second, revised edition we happily accepted. A text on bioreactions written in the early 1990's will not reflect the enormous development of experimental as well as theoretical aspects of cellular reactions during the past decade. In the preface to the first edition we admitted to be newcomers in the field. One of us (JV) has had 10 more years of job training in biotechnology, and the younger author (IN) has now received international recognition for his work with the hottest topics of "modem" biotechnology. Furthermore we are happy to have induced Gunnar Liden, professor of chemical reaction engineering at our sister university in Lund, Sweden to join us as co-author of the second edition. His contribution, especially on the chemical engineering aspects of "real" bioreactors has been of the greatest value. Chapter 8 of the present edition is largely unchanged from the first edition. We wish to thank professor Martin Hjortso from LSU for his substantial help with this chapter.

Fundamentals of Food Biotechnology

Fundamentals of Food Biotechnology
  • Author : Byong H. Lee
  • Publisher :Unknown
  • Release Date :2014-12-01
  • Total pages :544
  • ISBN : 1118384911
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Summary : Food biotechnology is the application of modern biotechnologicaltechniques to the manufacture and processing of food, for examplethrough fermentation of food (which is the oldest biotechnologicalprocess) and food additives, as well as plant and animal cellcultures. New developments in fermentation and enzyme technologicalprocesses, molecular thermodynamics, genetic engineering, proteinengineering, metabolic engineering, bioengineering, and processesinvolving monoclonal antibodies, nanobiotechnology and quorumsensing have introduced exciting new dimensions to foodbiotechnology, a burgeoning field that transcends many scientificdisciplines. Fundamentals of Food Biotechnology, 2nd edition is basedon the author’s 25 years of experience teaching on a foodbiotechnology course at McGill University in Canada. The book willappeal to professional food scientists as well as graduate andadvanced undergraduate students by addressing the latest excitingfood biotechnology research in areas such as genetically modifiedfoods (GMOs), bioenergy, bioplastics, functionalfoods/nutraceuticals, nanobiotechnology, quorum sensing andquenching. In addition, cloning techniques for bacterial and yeastenzymes are included in a “New Trends and Tools”section and selected references, questions and answers appear atthe end of each chapter. This new edition has been comprehensively rewritten andrestructured to reflect the new technologies, products and trendsthat have emerged since the original book. Many new aspectshighlight the short and longer term commercial potential of foodbiotechnology.

Phaeocystis, major link in the biogeochemical cycling of climate-relevant elements

Phaeocystis, major link in the biogeochemical cycling of climate-relevant elements
  • Author : M.A. van Leeuwe,J. Stefels,S. Belviso,C. Lancelot,P.G. Verity,W.W.C. Gieskes
  • Publisher :Unknown
  • Release Date :2007-06-24
  • Total pages :330
  • ISBN : 1402062141
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Summary : This volume offers a selection of papers presented at the final meeting of Working Group # 120 "Phaeocystis, major link in the biogeochemical cycling of climate-relevant elements", of the Scientific Committee on Oceanic Research (SCOR). It features papers by various top authors in the field, covering topics that reach from the organism level to ecosystem dynamics. It also includes a synthesis of all the presentations of the meeting.

Brewing Yeast and Fermentation

Brewing Yeast and Fermentation
  • Author : Christopher Boulton,David Quain
  • Publisher :Unknown
  • Release Date :2008-04-15
  • Total pages :656
  • ISBN : 0470999403
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Summary : Now Available for the First Time in Paperback! This unique volume provides a definitive overview of modern and traditional brewing fermentation. Written by two experts with unrivalled experience from years with a leading international brewer, coverage includes all aspects of brewing fermentation together with the biochemistry, physiology and genetics of brewers' yeast. Brewing Yeast and Fermentation is unique in that brewing fermentation and yeast biotechnology are covered in detail from a commercial perspective. Now available for the first time in paperback, the book is aimed at commercial brewers and their ingredient and equipment suppliers (including packaging manufacturers). It is also an essential reference source for students on brewing courses and workers in research and academic institutions. Definitive reference work and practical guide for the industry. Highly commercially relevant yet academically rigorous. Authors from industry leading brewers.

Advances in Microbial Physiology

Advances in Microbial Physiology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007-09-06
  • Total pages :326
  • ISBN : 9780080560649
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Summary : Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to “traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series.

Continuous Culture

Continuous Culture
  • Author : P. Kyslik,Edwin Alfred Dawes
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :271
  • ISBN : 09876543XX
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Summary : This is a research-level symposium proceedings, reviewing the latest research in the continuous culture of microorganisms as applied to industrial microbiology, biotechnology, waste disposal, and the food and pharmaceutical industries. Biochemical/physiological/genetic aspects of continuous culture are presented as well as practical applications.

GFP Whole Cell Microbial Biosensors

GFP Whole Cell Microbial Biosensors
  • Author : Frank Delvigne
  • Publisher :Unknown
  • Release Date :2013-01-09
  • Total pages :52
  • ISBN : 1606504177
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Summary : Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters. Recent developments in bioreactor technologies follow the scaling-out principle, i.e. carrying out several cultures in parallel with controlled conditions for screening purposes. Several mini-bioreactor concepts, i.e. bioreactor with working volume of 1 to 100 mL with controlling devices, have been developed following this principle. In general, chemical engineering similarities between conventional stirred bioreactors and their miniature equivalent are well characterized. However, the actual scaling-up rules are not able to cope with the complexity of the microbial stress response. Indeed, microbial stress response still remains not completely understood considering the process perturbations and the environmental fluctuations accompanying the scaling-up to industrial bioreactors. At this time, this kind of response can only be experimentally predicted by using scale-down bioreactors, i.e. lab-scale bioreactors designed in order to reproduce mixing imperfections that have to be expected at large-scale. However, the use of such an approach is time consuming and requires an experimented staff to elaborate the scaling-down protocols. Indeed, bioprocess development involves several steps which cannot be necessarily linked with each other considering the different cultivation equipment used.

10th International Symposium on Process Systems Engineering - PSE2009

10th International Symposium on Process Systems Engineering - PSE2009
  • Author : Rita Maria de Brito Alves,Claudio Augusto Oller do Nascimento,Evaristo Chalbaud Biscaia
  • Publisher :Unknown
  • Release Date :2009-08-05
  • Total pages :2165
  • ISBN : 9780444534736
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Summary : This book contains the proceedings of the 10e of a series of international symposia on process systems engineering (PSE) initiated in 1982. The special focus of PSE09 is how PSE methods can support sustainable resource systems and emerging technologies in the areas of green engineering. * Contains fully searchable CD of all printed contributions * Focus on sustainable green engineering * 9 Plenary papers, 21 Keynote lectures by leading experts in the field

Modelling and Optimization of Biotechnological Processes

Modelling and Optimization of Biotechnological Processes
  • Author : Lei Zhi Chen,Sing Kiong Nguang,Xiao Dong Chen
  • Publisher :Unknown
  • Release Date :2006-01-12
  • Total pages :123
  • ISBN : 9783540306344
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Summary : Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di?culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti?cial intelligencemethods,inparticular,geneticalgorithmsandneuralnetworks,for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the ?nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti?cial intelligence, system identi?cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the ?nal product is achieved using modi?ed genetic algorithms to determine optimal feed rate pro?les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e?ective methodology for optimizing biotechnological processes.

Flavonoid Metabolism

Flavonoid Metabolism
  • Author : Helen A. Stafford
  • Publisher :Unknown
  • Release Date :1990-02-28
  • Total pages :360
  • ISBN : 9780849360855
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Summary : This comprehensive review discusses the biosynthesis and catabolism of flavonoids and their regulation in plants. This interesting work approaches the subject matter from both a historical and methodological point of view. It places emphasis on key regulatory enzymic steps in the two pathways leading to the flavonoid basic units as well as the overall pathway within the flavonoid group. This special volume focuses on the known cell-free enzymology at the C15 level, as well as isotopic tracer studies involving the still unknown enzymic steps. This up-to-date text is an excellent resource for all plant physiologists, biological chemists, phytochemists and chemical ecologists.

The Journal of General Physiology

The Journal of General Physiology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1948
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Carbon Substrates in Biotechnology

Carbon Substrates in Biotechnology
  • Author : J. D. Stowell
  • Publisher :Unknown
  • Release Date :1987
  • Total pages :206
  • ISBN : 09876543XX
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Summary :

Metabolites and Metabolism

Metabolites and Metabolism
  • Author : Edwin Haslam
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :161
  • ISBN : 09876543XX
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Summary :