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Aging Research in Yeast

Aging Research in Yeast
  • Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
  • Publisher :Unknown
  • Release Date :2011-11-19
  • Total pages :368
  • ISBN : 9400725612
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Summary : This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Elevated DNA Damage, Oxidative Stress, and Impaired Response Defense System Inflicted in Patients With Myocardial Infarction

Elevated DNA Damage, Oxidative Stress, and Impaired Response Defense System Inflicted in Patients With Myocardial Infarction
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : OCLC:1053742688
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Summary : Background: Ischemic tissue damage in myocardial infarction (MI) is allied with the exaggerated production of reactive oxygen species (ROS) beyond the countering capability of chain-breaking radical scavengers, fallouts in the form of oxidatively burdened myocardial tissue. Methods: One hundred and twenty five patients with MI were included in the study to evaluate the dynamics of redox status of patients by monitoring the antioxidant potential, biomarkers of oxidative stress, lipid indices, RBC membrane damage when compared to healthy individuals in patients with MI congregated on the basis of Global Registry of Acute Coronary Events (GRACE) score, risk factors, and age. Results: Higher levels of malondialdehyde, 8-hydroxy-2-deoxyguanosine, lipid indices, ROS content, and membrane deterioration in erythrocytes were seen in patients with MI. Furthermore, reduced activities of erythrocyte antioxidant enzymes and lower concentrations of antioxidant molecules, plus reduced total antioxidant capacity, were observed in plasma of all patients with MI with respect to control. However, elevation in oxidative stress was found to be significantly marked in patients having GRACE score >100, risk factors, and MI >45 years when compared to patients with GRACE score ≤100, without risk factors, and MI ≤45 years, respectively. Conclusion: These findings indicate the existence of increased oxidative damage and reduced antioxidant potential in patients with MI have a potent relationship with their GRACE risk score, risk factors, and age.

Oxidative Stress and Vascular Disease

Oxidative Stress and Vascular Disease
  • Author : John F. Keaney Jr.
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :373
  • ISBN : 9781461546498
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Summary : One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Oxidative Stress Biomarkers and Antioxidant Protocols

Oxidative Stress Biomarkers and Antioxidant Protocols
  • Author : Donald Armstrong
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :336
  • ISBN : 9781592591732
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Summary : Oxidative stress has been linked to a variety of medical problems, including cardiovascular disease, cancer, arthritis, diabetes, and aging. Drawing on the growing volume of research into the impact of oxidative stress on pathophysiological mechanisms, Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the perturbations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format by accomplished investigators from prestigious universities, institutes, and laboratories around the world, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltammetry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols (Humana, 2002), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays. Cutting-edge and highly practical, Oxidative Stress Biomarkers and Antioxidant Protocols provides many powerful new tools for detecting oxidative stress and for investigating the possibilities for therapeutic intervention monitoring in a variety of serious diseases.

Cigarette Smoke and Oxidative Stress

Cigarette Smoke and Oxidative Stress
  • Author : Barry B. Halliwell,Henrik E. Poulsen
  • Publisher :Unknown
  • Release Date :2007-05-24
  • Total pages :407
  • ISBN : 9783540322320
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Summary : The mechanism by which cigarette smoke causes or contributes to inflammatory diseases like chronic obstructive pulmonary disease, cardiovascular disease and cancer remains unclear. Recent developments in our knowledge of cellular signaling suggest that cigarette smoke may cause oxidative stress in cellular systems. The assessment, consequences and possible modulation of these effects are discussed in this book which will interest oncologists and researchers in Biochemistry.

Oxidative Stress in Skeletal Muscle

Oxidative Stress in Skeletal Muscle
  • Author : Abraham Z. Reznick,L. Packer,C. K. Sen
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :340
  • ISBN : 3764358203
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Summary : This volume presents for the first time the most up-to-date research findings in the field. Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction. This makes the muscle vulnerable to oxidative stress, as concomitantly with the increase of oxygen flow there is an increase of oxygen free radicals, which are a byproduct of muscle respiration. A number of studies in the last decade have documented the involvement of oxygen free radicals in exercising muscles. The consequences of muscle oxidative stress have resulted mainly in increased muscle protein oxidation, elevation of lipid peroxidation, and depletion of muscle antioxidants. The mechanisms of this oxidative stress are under extensive investigation in laboratories around the world and are topics of the chapters in this volume. Understanding these mechanisms may help to improve the well-being and function of muscles in various physiological conditions, in muscle pathologies, and in tissue-ageing. This book is intended for professionals who are interested in muscle function, physiology, pathophysiology and well-being, such as therapists, trainers and medical professionals as well as for researchers in the field of muscle physiology. Series: Molecular and Cell Biology Updates (MCBU) Contents: 1. Free Radical and Oxidative Damage in Biology and Medicine: An Introduction / B. Halliwell 2. Oxidative Metabolism in the Skeletal Muscle / O. Hanninen 3. Strategies to Assess Oxidative Stress / A.Z. Reznick, L. Packer, C.K. Sen 4. The Course of Exercise Induced Skeletal Muscle Fiber Injury / J. Komulainen, V. Vihko 5. Free Radical Mechanisms in Exercise-Related Muscle Damage / M.J. Jackson 6. The Effect of Exercise, Aging and Caloric Restriction on Protein Oxidation and DNA Damage in Skeletal Muscles / Z. Radak, S. Goto 7. Antioxidant Enzyme Response to Exercise and Training in the Skeletal Muscle / L.L. Ji 8. Glutathione, a Key Regulator of Skeletal Muscle Antioxidant Defense / C.K. Sen 9. Vitamin E and its Effect on Skeletal Muscle / M. Meydani, R. Fielding, K.R. Martin 10. Differential Susceptibility of Skeletal Muscle Proteins to Free Radical Induced Oxidative Damage in Vitro / J.W. Haycock, G. Falkous, D. Mantle 11. Oxidative Stress and Calcium Transport in Skeletal and Cardiac Sarcoplasmic Reticulum / V.E. Kagan, V.B. Ritov, N.V. Gorbunov, E. Menshikova, G. Salama 12. Oxidative Stress in Immobilization-Induced Skeletal Muscle Atrophy / H. Kondo 13. Effect of Growth Hormone on Oxidative Stress in Immobilized Muscles of Old Animals / I. Roisman, N. Zarzhevesky, A.Z. Reznick 14. The Diaphragm and Oxidative Stress / S. Powers, J.M. Lawler, H.K. Vincent 15. Oxidative Damage after Ischaemia-Reperfusion in Muscle / A. Hochman 16. Oxidative Damage in Rat Skeletal Muscle following L-Tryptophan and Atherogenic-rich diet / E. Livne, N. Ronen, S. Mokady, A.Z. Reznick, B. Gross 17. Oxidative Stress and Muscle Wasting in Cachexia / M. Buck, M. Chojkier 18. Free Radicals and Antioxidants in the Pathogenesis of Alcoholic Myopathy / V.R. Preedy, M. Reilly, D. Mantle, T.J. Peters 19. Drug Induced Muscle Damage / G. Brazeau 20. Free Radicals and Animal Muscle Diseases / J. Arthur 21. Clinical Trials of Antioxidants in Muscle Disease / R.H.T. Edwards, M.J. Jackson

Methods in Biological Oxidative Stress

Methods in Biological Oxidative Stress
  • Author : Kenneth Hensley,Robert A. Floyd
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :215
  • ISBN : 9781592594245
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Summary : Methods in Biological Oxidative Stress is practical in scope, and outlines modern techniques for measuring oxidative stress and detecting oxidizing agents both in vitro and in vivo. Free radicals and reactive oxidizing agents, once ignored as meaningful biochemicals entities, are now recognized as causes or contributing factors in dozens if not hundreds of disease states, and free radical metabolism of xenobiotics is increasingly important to pharmacologists. This is the first book to detail experimental methods for detecting free radicals and reactive oxygen species or their byproducts. Subjects covered include techniques used routinely in laboratories developed by the authors, as well as HPLC-electrochemical measurement of protein oxidation products, particularly nitrotyrosine and dityrosine; HPLC-electrochemical detection of DNA oxidation products; HPLC measurement of salicylate products, a means of detecting OH radicals in vivo; electron paramagnetic resonance. Contributions are from recognized experts in the field of oxidative stress, who have developed novel strategies for studying biological oxidations.

Oxidative Stress and Digestive Diseases

Oxidative Stress and Digestive Diseases
  • Author : Toshikazu Yoshikawa
  • Publisher :Unknown
  • Release Date :2001-01-01
  • Total pages :182
  • ISBN : 9783805572309
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Summary : In the 1980s, biochemists and biologists were attracted by the role of reactive oxygen species in the irreversible damage or modification of the structure of biological molecules. However, in the 1990s, reactive oxygen species have been recognized to be involved in reversible structural alterations of molecules: The homeostatic modulation of oxidant levels is a highly efficient mechanism that allows all cells to tightly control their redox status within a very narrow range. Especially the activity of the Rel/NF-kB family of transcriptional factors that regulate responses in inflammation, reperfusion injury and apoptosis is controlled by intracellular reactive oxygen species levels. Our understanding of how these transcriptional factors are negatively or positively regulated by oxidative stress has since greatly increased. Questions for future investigation center on the modulation of oxidative stress by personal genome information for the prevention of several pathologic states.

Oxidative Stress and Neuroprotection

Oxidative Stress and Neuroprotection
  • Author : S.H. Parvez,Peter Riederer
  • Publisher :Unknown
  • Release Date :2006-12-26
  • Total pages :264
  • ISBN : 9783211333280
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Summary : This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson’s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson’s therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.

Oxidative Stress and Free Radical Damage in Neurology

Oxidative Stress and Free Radical Damage in Neurology
  • Author : Natan Gadoth,Hans Hilmar Göbel
  • Publisher :Unknown
  • Release Date :2010-11-19
  • Total pages :323
  • ISBN : 1603275142
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Summary : The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Free Radicals, Oxidative Stress, and Antioxidants

Free Radicals, Oxidative Stress, and Antioxidants
  • Author : Tomris Özben
  • Publisher :Unknown
  • Release Date :1998-04-30
  • Total pages :395
  • ISBN : 0306458136
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Summary : There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.

Oxidative Stress in Plants

Oxidative Stress in Plants
  • Author : Dirk Inze
  • Publisher :Unknown
  • Release Date :2001-10-18
  • Total pages :336
  • ISBN : 9780203303146
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Summary : Plants depend on physiological mechanisms to combat adverse environmental conditions, such as pathogen attack, wounding, drought, cold, freezing, salt, UV, intense light, heavy metals and SO2. Many of these cause excess production of active oxygen species in plant cells. Plants have evolved complex defense systems against such oxidative stress. The

Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome
  • Author : Helmut Sies
  • Publisher :Unknown
  • Release Date :2007-07-27
  • Total pages :344
  • ISBN : 142004379X
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Summary : Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased stress and inflammation, appears to play a central role in the progression of the syndrome. Evidence of inflammatory processes in accumulated fat appears to be an early initiator of metabolic syndrome. Likewise, the more active angiotensin system in obesity may contribute to even greater oxidative stress that serves as a key signaling event in vascular remodeling. These factors strengthen obesity's association with oxidative stress. Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome is designed to encourage the development of evidence-based nutritional and pharmacological therapies that can attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome. The book offers a deep understanding of the molecular mechanisms that underlie the process. Edited by leading authorities on oxidative stress, the book's chapters report on cutting-edge research that explores intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. It also brings together research on the molecular mechanisms inherent in the progression of metabolic stress, includes phenotypic perspectives, and discusses dietary factors, including the role of micronutrients. The chapter authors, each a leading expert in his or her field, discuss different components of metabolic stress and obesity and their associations with oxidative stress and inflammation. The book fills a unique role as a base of knowledge for researchers seeking to develop nutritional and or pharmacological therapies, as well as clinicians seeking a better understanding of this increasingly common disease process.

Oxidative Stress

Oxidative Stress
  • Author : Helmut Sies
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :507
  • ISBN : 9781483289113
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Summary : Oxidative Stress is intended as an in-depth account of knowledge and problems in the field of oxygen-related damage in biological systems. The topics range from an assessment of molecular events in in vitro model systems to complex problems in clinical medicine. Organized into two parts with a total of 18 chapters, this book begins with an introduction to oxidative stress, elucidating specific topics on reactive oxygen species, detoxification system, and nature of oxidative damage. The first part focuses on models used with cells and tissues in the study of oxidative stress, whereas the second part describes the processes elicited by oxidative stress.

An Introduction to Vitamins, Minerals and Oxidative Stress

An Introduction to Vitamins, Minerals and Oxidative Stress
  • Author : Stefan A. Hulea
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :216
  • ISBN : 9781599429465
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Summary : This book presents in simple and concise terms the biological functions of vitamins and minerals, what makes them essential to life and why they must be replenished daily from food. The best food sources for these micronutrients and the daily recommended intakes of vitamins and minerals are also presented. Information on these important micronutrients is all presented in one place (Part I) as opposed to the current text books where it is scattered throughout the text, making its retrieval tedious and time-consuming. In addition, the trace elements get an adequate coverage in contrast to the current texts. The second part introduces the reader to the concept of oxidative stress and the role of free radicals (mainly of oxygen and nitrogen) in the regulation of several biological processes like cellular redox homeostasis, programmed cell death and aging as well as their involvement in many pathological conditions such as cardiovascular disease, cancer, autoimmune and neurodegenerative diseases. Readers will also learn how reactive molecular species are generated, what their targets are and how cells defend themselves against the deleterious action of free radicals. Despite the growing interest in the research of free radicals involvement in human pathology the current text books treat the subject only sparingly. Our text addresses this issue by giving the topic the attention it deserves.

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases
  • Author : Luc Montagnier,Rene Olivier,Catherine Pasquier
  • Publisher :Unknown
  • Release Date :1997-10-06
  • Total pages :576
  • ISBN : 1420002929
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Summary : Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis

Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis
  • Author : Gines Maria Salido,Juan Antonio Rosado
  • Publisher :Unknown
  • Release Date :2009-03-08
  • Total pages :235
  • ISBN : 9781402098734
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Summary : Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis, presents a concise synthesis of the current knowledge and recent advances in the mechanisms of apoptosis in different cells and the role of oxidative stress and Ca2+ signalling. Particular attention is given to the different features of apoptosis in distinct cell types, ranging from hepatocytes to cardiovascular and blood cells, nervous cells or spermatozoa. Cutting-edge and user-friendly, this volume serves as a comprehensive resource for those interested in the fascinating biological processes associated to programmed cell death or apoptosis. The book is divided in two major chapter sections: general mechanisms of the apoptotic pathways and the role of oxidative stress and intracellular Ca2+ homeostasis and a more specific section dedicated to the specificities of apoptosis in a number of excitable and non-excitable cells. All of the contributions are from specialists in the field and the reviews presented, systemically examine the most exciting and innovative aspects of the apoptotic pathways in their particular areas of expertise.

Bio-Assays for Oxidative Stress Status

Bio-Assays for Oxidative Stress Status
  • Author : W.A. Pryor
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :296
  • ISBN : 9780080929927
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Summary : This work contains over thirty chapters by leading researchers in the field of oxidative biology, originally presented as articles in an extended Forum in the highly-cited journal, Free Radical Biology & Medicine. The papers in this Forum (or Symposium-in-print) spanned seven issues of the journal, over many months. This is the first time that all of these expert contributions are presented in one place. Reliable methods for measuring OSS in organisms are essential. These would, amongst other things, offer applications as early warning signals for cancer and heart disease - eventually giving a range of measurable oxidation products best related to any given disease state. Additional observations relevant to OSS include: how much do measures of OSS vary in a group of humans? Does OSS decrease as a result of life-change factors and does it increase with age? With disease? With stress? Can a non-invasive, reliable, reputable measure of OSS be identified? This informative book provides the reader with the latest status of studies into OSS, currently used examples of BOSS, and answers to at least some of the questions posed above.

Oxidative Stress in Vertebrates and Invertebrates

Oxidative Stress in Vertebrates and Invertebrates
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2011-10-24
  • Total pages :416
  • ISBN : 9781118148112
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Summary : This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Oxidative Stress

Oxidative Stress
  • Author : Helmut Sies
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :507
  • ISBN : 9781483289113
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Summary : Oxidative Stress is intended as an in-depth account of knowledge and problems in the field of oxygen-related damage in biological systems. The topics range from an assessment of molecular events in in vitro model systems to complex problems in clinical medicine. Organized into two parts with a total of 18 chapters, this book begins with an introduction to oxidative stress, elucidating specific topics on reactive oxygen species, detoxification system, and nature of oxidative damage. The first part focuses on models used with cells and tissues in the study of oxidative stress, whereas the second part describes the processes elicited by oxidative stress.

Oxidative Stress in Plants

Oxidative Stress in Plants
  • Author : Dirk Inze
  • Publisher :Unknown
  • Release Date :2001-10-18
  • Total pages :336
  • ISBN : 9780203303146
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Summary : Plants depend on physiological mechanisms to combat adverse environmental conditions, such as pathogen attack, wounding, drought, cold, freezing, salt, UV, intense light, heavy metals and SO2. Many of these cause excess production of active oxygen species in plant cells. Plants have evolved complex defense systems against such oxidative stress. The