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PAKs, RAC/CDC42 (p21)-activated Kinases
- Author : Hiroshi Maruta
- Publisher :Unknown
- Release Date :2013-01-23
- Total pages :276
- ISBN : 9780124072107
Summary : This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.
Regulation of Cardiac Contractility
- Author : R. John Solaro
- Publisher :Unknown
- Release Date :2011-04-01
- Total pages :50
- ISBN : 9781615041756
Summary : Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders.
Conformational Dynamics and Activation of the P21 Activated Kinase
- Author : Michelle Marie Pirruccello
- Publisher :Unknown
- Release Date :2007
- Total pages :360
- ISBN : UCAL:C3511214
Summary :
Leucine-Rich Repeat Kinase 2 (LRRK2)
- Author : Hardy J. Rideout
- Publisher :Unknown
- Release Date :2017-03-28
- Total pages :271
- ISBN : 9783319499697
Summary : This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Structural and Functional Analysis of the P21-(CDC42/RAC)-activated Kinase Pak
- Author : Claire Tse Chien Chong
- Publisher :Unknown
- Release Date :2000
- Total pages :234
- ISBN : OCLC:969447497
Summary :
The Journal of Cell Biology
- Author : Anonim
- Publisher :Unknown
- Release Date :2005
- Total pages :229
- ISBN : UOM:39015058968473
Summary : No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Microtubule Dynamics
- Author : Anne Straube
- Publisher :Unknown
- Release Date :2017-04-30
- Total pages :319
- ISBN : 1493961853
Summary : Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtubule interactions in vitro, techniques to investigate the ultrastructure of microtubules and associated proteins, assays to study microtubule nucleation, turnover, and force production in cells, as well as approaches to isolate novel microtubule-associated proteins and their interacting proteins. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Definitive and practical, Microtubule Dynamics: Methods and Protocols provides the key protocols needed by novices and experts on how to perform a broad range of well-established and newly-emerging techniques in this vital field.
Conquering RAS
- Author : Asfar Azmi
- Publisher :Unknown
- Release Date :2016-08-11
- Total pages :294
- ISBN : 9780128035412
Summary : Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities Showcases recent advancements in RAS research under one comprehensive volume Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research
Scientific Report
- Author : Scripps Research Institute
- Publisher :Unknown
- Release Date :2005
- Total pages :229
- ISBN : NWU:35558005231564
Summary :
Cytoskeleton and Small G Proteins
- Author : Ph Jeanteur
- Publisher :Unknown
- Release Date :1999-01-21
- Total pages :234
- ISBN : 3540648089
Summary : The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.
Molecular Biology of the Cell
- Author : Anonim
- Publisher :Unknown
- Release Date :2007
- Total pages :229
- ISBN : UOM:39015068688129
Summary :
Structural Studies of Cdc42Hs and Its Interaction with P21 Activated Kinase Binding Domain
- Author : Wei Guo
- Publisher :Unknown
- Release Date :2000
- Total pages :280
- ISBN : CORNELL:31924087253617
Summary :
Signaling Pathways Involved in Insulin-stimulated Glucose Transport
- Author : Shian-Huey Chiang
- Publisher :Unknown
- Release Date :2001
- Total pages :229
- ISBN : UOM:39015053748532
Summary :
Research Report
- Author : Anonim
- Publisher :Unknown
- Release Date :1999
- Total pages :229
- ISBN : CHI:58625848
Summary :
Proceedings of the National Academy of Sciences of the United States of America
- Author : National Academy of Sciences (U.S.)
- Publisher :Unknown
- Release Date :2007
- Total pages :229
- ISBN : WISC:89099183618
Summary :
Inhibitors of the Ras Superfamily G-proteins, Part A
- Author : Anonim
- Publisher :Unknown
- Release Date :2013-09-10
- Total pages :364
- ISBN : 0124167497
Summary : This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
ESSAYS IN BIOCHEMISTRY;
- Author : James G. Wakefield,Carolyn A. Moores,Nigel Hooper
- Publisher :Unknown
- Release Date :2018
- Total pages :114
- ISBN : 1855782235
Summary :
Regulation of Gene Expression in the Tumor Environment
- Author : Menashe Bar-Eli
- Publisher :Unknown
- Release Date :2008-08-25
- Total pages :148
- ISBN : 9781402083419
Summary : It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.
Characterization of the Role of P21 GTPase Rac in Mediating V-Abl Tyrosine Kinase Downstream Signaling and Biological Effects
- Author : Elaine Tsao Lea-Chou
- Publisher :Unknown
- Release Date :1999
- Total pages :200
- ISBN : UCSD:31822018276519
Summary :
American Journal of Respiratory and Critical Care Medicine
- Author : Anonim
- Publisher :Unknown
- Release Date :2007
- Total pages :229
- ISBN : NWU:35558005560061
Summary :
Abstracts of Papers Presented at the 1996 Meeting on Retroviruses, May 21-May 26, 1996
- Author : Anonim
- Publisher :Unknown
- Release Date :1996
- Total pages :375
- ISBN : UCLA:L0074758624
Summary :