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Pediatrics in Systemic Autoimmune Diseases

Pediatrics in Systemic Autoimmune Diseases
  • Author : Rolando Cimaz,Thomas J.A. Lehman
  • Publisher :Unknown
  • Release Date :2016-06-08
  • Total pages :606
  • ISBN : 9780444635976
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Summary : Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. Includes completely updated chapters and five new chapters Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties Brings the reader up-to-date and allows easy access to individual topics in one place Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume 16

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume 16
  • Author : James Galloway
  • Publisher :Unknown
  • Release Date :2020-03-16
  • Total pages :226
  • ISBN : 9780444642172
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Summary : Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field.

Endocrine Manifestations of Systemic Autoimmune Diseases

Endocrine Manifestations of Systemic Autoimmune Diseases
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008-06-05
  • Total pages :340
  • ISBN : 0080559328
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Summary : This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics. *The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy *The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis

Pediatric Neurology

Pediatric Neurology
  • Author : Daniela. Pohl,Susanne. Benseler
  • Publisher :Unknown
  • Release Date :2013-04-23
  • Total pages :544
  • ISBN : 9780128079324
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Summary : Systemic disorders with possible involvement of the nervous system include a variety of diseases with presumed inflammatory and autoimmune pathomechanisms, among them Behçet disease, sarcoidosis, systemic lupus erythematosus, juvenile idiopathic arthritis, scleroderma, and Sjögren syndrome. This disease group encompasses systemic inflammatory disorders with a genetically defined dysregulation of the innate immune system as well as systemic autoimmune disorders characterized by alterations of the adaptive immunity such as autoantibodies and autoreactive T cells. Although more commonly diagnosed in adults, all of these diseases can manifest in childhood and some as early as infancy. Neurological involvement may represent the initial manifestation, and nearly every neurological symptom can be caused by inflammatory/autoimmune diseases. In a child with (sub)acute onset of otherwise unexplained neurological findings, consideration of inflammatory/autoimmune disorders may be of crucial therapeutic and prognostic importance. In the absence of disease-specific clinical features, the initial diagnostic workup is broad. Basic blood tests include inflammatory markers and autoantibodies. Cerebral magnetic resonance imaging and a lumbar puncture with measurement of opening pressure as well as cerebrospinal fluid analysis are indicated in most patients with central nervous system (CNS) involvement. Skin, muscle, or organ biopsies (e.g., renal) may provide additional information. Especially in patients with isolated CNS involvement, a brain biopsy may be indicated. Timely recognition and treatment of CNS inflammation may improve or even reverse clinical symptoms and prevent secondary brain injury.

Vascular Manifestations of Systemic Autoimmune Diseases

Vascular Manifestations of Systemic Autoimmune Diseases
  • Author : Ronald A. Asherson,Ricard Cervera,Douglas A. Triplett,Steven B. Abramson
  • Publisher :Unknown
  • Release Date :2001-01-25
  • Total pages :624
  • ISBN : 1420040391
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Summary : Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all

The Autoimmune Diseases

The Autoimmune Diseases
  • Author : Noel R. Rose,Ian R. Mackay
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :727
  • ISBN : 0125969201
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Summary : The Autoimmune Diseases is composed of 25 chapters dealing with different aspects of some specific autoimmune diseases. The book begins with the elucidation of the genetic predisposition to autoimmune diseases. Subsequent chapters explore numerous kinds of autoimmune diseases. Other chapters describe the antireceptor antibodies and the sensitivity and specificity of autoantibody testing. This book is designed to provide a deeper understanding of this increasingly important field of medical science for physicians and investigators involved in the diagnosis, treatment, or research of autoimmune ...

Autoimmune Diseases in Pediatric Gastroenterology

Autoimmune Diseases in Pediatric Gastroenterology
  • Author : Faruk Hadziselimovic
  • Publisher :Unknown
  • Release Date :2002-09-30
  • Total pages :262
  • ISBN : 0792387783
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Summary : This book is the proceedings of the Falk Symposium No. 127 on `Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an immune response against the host: hence, an autoimmune response. Chronic autoimmune hepatitis occurs predominantly in young people, and especially in women. Immunological changes are conspicuous. Tissue antibodies are found in a large number of patients. This is a disease of disordered immunoregulation marked by a deficit in suppressor T cells causing the production of autoantibodies against specific hepatocyte surface antigen. Liver membrane protein is found in the sera of patients with autoimmune chronic acute hepatitis and with primary biliary cirrhosis (PBC). The latter condition of progressive granulomatous destruction of intrahepatic bile ducts is, in many respects, analogous to the graft-versus-host syndrome where the immune system has become sensitized to foreign HLA-molecules. Primary sclerosing cholangitis (PSC) is another condition of unknown origin. All parts of the biliary tree can be involved in a chronic, fibrosing, inflammatory process that results in obliteration of the biliary tree and ultimately in biliary cirrhosis. About half of the patients also suffer from ulcerative colitis and rarely from Crohn's disease. Circulating antibodies to some antigens are found in obstructed portal tracts, as well as increased concentrations of biliary immune complexes in patients with PBC. In all three previous Falk symposia on paediatric gastroenterology, attention was focused on the role of the innate immune system in the aetiology of IBD. It has become increasingly clear in recent years that the innate system has a much more important and fundamental role in host defence. The decision to initiate an immune response is one of the major roles of the innate system. Mutations within this system could transform it into becoming constitutively active, resulting in an inflammatory reaction and thus eliciting an autoimmune response. Following an introduction to the basic phenomena of autoimmunity, the proceedings discuss clinical aspects of autoimmune diseases. In particular, current knowledge and the state of the art about the diagnosis and treatment of the autoimmune diseases of the gastrointestinal tract are described by world-renowned experts. The book also contains the short presentations on selected topics, as well as abstracts of the mini-posters read by title, which were included in the symposium.

Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Antiphospholipid Syndrome in Systemic Autoimmune Diseases
  • Author : R. Cervera,Ricard Cervera
  • Publisher :Unknown
  • Release Date :2009-04-01
  • Total pages :266
  • ISBN : 0080932347
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Summary : Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy and memory loss and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, from psychiatry to orthopedics. This book provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved as well as clinical manifestations in both “the thrombotic and “non-thrombotic manifestations of this important disease. * Comprehensive review of this major disease * Includes information on treatment options available

Pediatric Annals

Pediatric Annals
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :229
  • ISBN : UCLA:L0090614074
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Summary :

Autoimmune Diseases

Autoimmune Diseases
  • Author : Munther A Khamashta,Manuel Ramos-Casals
  • Publisher :Unknown
  • Release Date :2011-05-26
  • Total pages :416
  • ISBN : 0857293583
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Summary : Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

Clinical Pediatric Endocrinology

Clinical Pediatric Endocrinology
  • Author : Solomon A. Kaplan
  • Publisher :Unknown
  • Release Date :1990
  • Total pages :470
  • ISBN : UOM:39015015318010
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Summary :

Systemic Corticosteroids for Inflammatory Disorders in Pediatrics

Systemic Corticosteroids for Inflammatory Disorders in Pediatrics
  • Author : Rolando Cimaz
  • Publisher :Unknown
  • Release Date :2015-06-03
  • Total pages :184
  • ISBN : 9783319160566
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Summary : This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover historical notes, general concepts on treatment with corticosteroids with regard to indications and side effects, and basic pharmacologic properties of these compounds. The rest of the book is devoted to the specific use of steroids in the different pediatric subspecialties. Despite advances with newer effective immunosuppressive and anti-inflammatory drugs, corticosteroids still remain the mainstay of therapy for many disorders. Leading authors in their field have summarized these concepts to provide an authoritative, comprehensive guide to help clinicians safely and effectively use corticosteroids in their pediatric patients.

Textbook of Pediatric Rheumatology

Textbook of Pediatric Rheumatology
  • Author : James T. Cassidy,Ross E. Petty
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :792
  • ISBN : UOM:39015062423507
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Summary : Clinical reference designed to aid in the care of children with rheumatic diseases. Offers guidelines for interpreting the signs, symptoms and laboratory abnormalities that accompany these disorders. Includes numerous halftone illustrations and tables, radiographs, and other figures.

Pediatrics

Pediatrics
  • Author : Tina S. Haynes
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :280
  • ISBN : 189372008X
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Summary :

Textbook of Pediatric Rheumatology E-Book

Textbook of Pediatric Rheumatology E-Book
  • Author : James T. Cassidy,Ross E Petty,Ronald M. Laxer,Carol B Lindsley
  • Publisher :Unknown
  • Release Date :2010-10-15
  • Total pages :816
  • ISBN : 9781437735963
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Summary : Textbook of Pediatric Rheumatology examines the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, detailing the presentation, differential diagnosis, course, management, and prognosis of every major condition. Drs. James T. Cassidy, Ross E. Petty, Ronald M. Laxer, and Carol B. Lindsley discuss recent developments in diagnosis, treatment, genetics, immunology, imaging, and more. Diagnose and treat effectively through exhaustive reviews of the complex symptoms and signs and lab abnormalities that characterize these clinical disorders. Choose treatment protocols based on the best scientific evidence available today. Apply the knowledge and experience of the leading experts in the field. Keep current with coverage of new topics including macrophage activation syndrome, pediatric sarcoidosis, uveitis, imaging, and occupational and physical therapy. Tap into detailed discussions of recent advances in the field, new research on the immunologic mechanisms of inflammatory disease, and new developments on biologic treatments for arthritis in ten new chapters. Master complex concepts and key techniques with a full-color design and full-color illustrations.

Textbook of Pediatric Rheumatology

Textbook of Pediatric Rheumatology
  • Author : James T. Cassidy,Ross E. Petty
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :610
  • ISBN : UOM:39015032102488
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Summary : This text emphasizes the presentation, disease course, treatment and prognosis of the major conditions in the field, including: juvenile rheumatoid arthritis, spondyloarthropathy, juvenile dermatomyositis and scleroderma.

The 5 Minute Pediatric Consult

The 5 Minute Pediatric Consult
  • Author : M. William Schwartz
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :893
  • ISBN : UOM:39015038523877
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Summary : Arranged by chief complaints specific diseases syndromes tables on immunizations/infant formulas/Glasgow coma scale.

Endocrinology: Adult and Pediatric E-Book

Endocrinology: Adult and Pediatric E-Book
  • Author : J. Larry Jameson,Leslie J. De Groot
  • Publisher :Unknown
  • Release Date :2015-02-25
  • Total pages :2700
  • ISBN : 9780323321952
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Summary : Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Consult this title on your favorite e-reader.

Pediatric Ophthalmology and Strabismus

Pediatric Ophthalmology and Strabismus
  • Author : Kenneth Weston Wright,Edward G. Buckley
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :902
  • ISBN : UOM:39015034398407
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Summary : Discusses strabismus & amblyopia/anterior segment disease/ systemic disease w/eye involvement/neuro-ophthalmology/etc.

Pediatric Nursing

Pediatric Nursing
  • Author : Jane Ball,Ruth McGillis Bindler
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :984
  • ISBN : UOM:39015055585296
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Summary : Pediatric nursing, like all of health care, is changing rapidly. Nurses must learn what helps them to provide safe and effective care today, while integrating new knowledge and skills needed for nursing practice in the future. "Pediatric Nursing, Third Edition "is a resource that provides that comprehensive foundation - detailing the core of pediatric nursing practice while also providing the critical thinking skills necessary for future challenges. Features: New As They Grow boxes illustrate the anatomic and physiologic differences between children and adults New Pathophysiology Illustrated boxes visually explain the pathophysiology of certain conditions as they affect children Clinical Manifestation tables describe the etiology, presentation, and clinical therapy for selected conditions Medications Used to Treat boxes feature drug information for specific conditions Free Student CD-ROM and Companion Website featuring audio glossary, animations, NCLEX reviews, case studies, care map activities, links, and more.

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Idiotypes in Medicine: Autoimmunity, Infection and Cancer
  • Author : R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :1997-11-19
  • Total pages :540
  • ISBN : 0080534430
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Summary : This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.